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산화질소가 Guinea Pig 의 Oddi 괄약근 운동에 미치는 영향에 관한 연구
김재선(Jae Seon Kim),현진해(Jin Hai Hyun),박영태(Young Tae Bak),김창덕(Chang Duck Kim) 대한내과학회 1996 대한내과학회지 Vol.50 No.1
N/A Objectives: Recent studies indicate that intric oxide (NO) is a novel inhibitory neurotransmitter involved in several functions of many gastrointestianl organs. But only a few studies regarding its effect on sphincter of Oddi (SO) function were done until now. The aims of this study were to determine the effect of NO on motility of SO in L-arginine, a substrate of NO, inhibits SO motility, if NO is an important transmitter controlling the motility of SO. Methods: After laparotomy, a pressure-monitoring perfusion catheter was introduced into the lumen of SO through common bile duct and another catheter into the 2nd portion of duedenum through low body of stomach, and tonic pressure and phasic contractions of SO were monitored with TDS 8000 Manometry System(Sandhill Scientific, USA) during baseline period and after infusing a specific NO synthase inhibitor, N-nitro-L-arginine(Sigma: L-NNA, 5 mg/kg body weight), and cholecystokinin-8(Squibb: CCk, 25 or 50pmol/kg body weight). Results: 1) Tonic pressure and phasic contractions were significantly increased after administration of the NO synthase inhibitor. The response to CCk was enhanced by the NO synthase inhibitor. 2) Addigion of the substrate of NO suppressed the NO synthase inhibitor-induced increase of the tonic pressure and phasic contractions, and also suppressed the NO synthase inhibitor-induced enhancement of the response to CCK. 3) Administration of only NO substrate did not significantly change the tonic pressure and phasic contractions of resting stage and the response to CCK. Conclusion: These findings suggest that NO is an important neurotransmitter that is responsible for the inhibitory neural regulation of the SO motility. But the administration of the substrate of NO, L-arginine, alone does not seem to be useful for the management of SO dysfunction
대장 용종에서 cyclooxygenase - 2 와 vascular endothelial growth factor ( VEGF ) 의 발현
이창우(Chang Woo Lee),이구(Goo Lee),김동훈(Dong Hoon Kim),전훈재(Hoon Jai Chun),서정일(Jeong Ill Suh),양창헌(Chang Heon Yang),김수근(Soo Keun Kim),김창덕(Chang Duck Kim),류호상(Ho Sang Ryu),현진해(Jin Hae Hyun),김한겸(Han Kyeon Kim) 대한내과학회 2001 대한내과학회지 Vol.61 No.3
N/A Background : Recent studies showed that non-steroidal antiinflammatory drug may reduce the risk of colorectal cancers. So its potential target, cyclooxygenase (COX)-2 in colorectal cancers has been widely investigated. However, the rate and patterns of COX-2 expression in colorectal polyps have been quite variable among study groups. Furthermore, its role has not been established. The study aim is to investigate the expressions of COX-2 and vascular endothelial growth factor (VEGF) and to evaluate the role of COX-2 in colorectal polyps. Methods : Fifty-seven colorectal polyps from endoscopic polypectomy or surgical resection were enrolled. Polyps were as follows; 9 were hyperplastic polyps, 14 mild, 26 moderate dysplasia, 8 high grade adenomas (5 severe dysplasia, a carcinoma in situ, and two intramucosal carcinomas). They were stained for COX-2 and VEGF by immunohistochemistry. The intensity of staining according to histologic grades and size of polyp was semi-quantitatively assessed. Results : COX-2 was expressed in 18 cases (31.8%) by dysplastic epithelium and 29 cases (50.9%) by interstitial cells. Epithelial COX-2 expressions were significantly related to histologic grades and size, and begun at moderate dysplasia actually. Interstitial COX-2 was little related to histologic grades and size. VEGF was expressed in 35 cases (61.4%). There was close relationship between epithelial COX-2 and VEGF expressions. Conclusion : COX-2 is expressed both in dysplastic epithelium and interstitial cells of colorectal polyps. Our results suggest that epithelial COX-2 expression may be playing a role in tumorigenesis of colorectal polyp, possibly involved in angiogenesis with VEGF.(Korean J Med 61:240-248, 2001)
건강 성인에서 라니티딘(300mg)과 오메프라졸(10mg, 20mg)의 위식도역류 및 위내 pH에 대한 효과
김영선(Young Sun Kim),송치욱(Chi Wook Song),김윤홍(Yoon Hong Kim),김혜랑(Hye Rang Kim),김윤배(Yun Bae Kim),허병원(Byung Won Hur),이정환(Jung Whan Lee),진윤태(Yoon Tae Jeen),김창덕(Chang Duck Kim),류호상(Ho Sang Ryu),현진해(Jin Hai Hy 대한소화기기능성질환·운동학회 2000 Journal of Neurogastroenterology and Motility (JNM Vol.6 No.2
N/A Background/Aims : This study was done to compare the effects of Omeprazole (OMD) 10 or 20 mg with Ranitidine(RAN) 300 mg on intragastric acidity and gastroesophageal reflux in healthy subjects. Methods : Ten healthy male volunteers were studied after administrations of 5 days dosing with either RAN 300 mg, OMD 10 mg or 20 mg, once each morning. On the 5th day, intragastric pH and lower esophageal pH were measured by a dual channel antimony pH catheter for 10 hours. Results : Gastroesophageal reflux was reduced after administrations of RAN 300 mg, OMD 10 mg or 20 mg (p<0.05) and there was no significant difference among the three drugs (p>0.05). The gastric holding time of pH >4 was significantly prolonged over fasting and postprandial periods after RAN 300 mg, OMD 10 mg or 20 mg administrations (p<0.05). OMD 20 mg showed the most potent effect on gastric acid suppression (p<0.05), but there was no significant difference between RAN 300 mg and OMD 10 mg (p>0.05). OMD administrations (10 mg or 20 mg) exhibited a more potent effect on gastric acid suppression during the postprandial period than RAN 300 mg (p<0.05). Conclusions : OMD 10 mg was as potent as RAN 300 mg on inhibition of gastric acid, but less potent than OMD 20 mg. There was no difference among the three drugs in regard to gastroesophageal reflux in healthy subjects.
우리나라 담석증의 역학에 관한 연구 ; 전국적 다기관 협동 조사 성적
김명환 ( Myung Hwan Kim ),오희철 ( Hee Choul Ohrr ),정재복 ( Jae Bock Chung ),김창덕 ( Chang Duck Kim ),강진경 ( Jin Kyung Kang ),고문수 ( Moon Soo Koh ),김남재 ( Nam Jae Kim ),김대곤 ( Dae Ghon Kim ),김성국 ( Sung Kook Kim ),김 대한소화기학회 1999 대한소화기학회지 Vol.32 No.5
Background/Aims: To understand the epidemiologic characteristics of gallstone disease in Korea and to evaluate the chronological changes of gallstone disease, the authors performed this prospective nationwide cooperative study. Methods: The subjects were 1,263 patients with gallstone. They were hospitalized at 19 hospitals in Korea from February to July, 1997. The study protocals were recorded on 1,263 patients and gallstones were removed from 1,133 patients and their chemical compositions were analyzed. Results: Among total patients with gallstone, the proportions of patients with gallbladder, common bile duct (CBD) and intrahepatic duct (IHD) stones were 64.0%, 21.9%, and 14.1%, respectively. Male to female ratio was 1 versus 1.3. The gallbladder stones were categorized as cholesterol (58.1%), black pigment (25.2%) and brown pigment (12.1%) stones. The CBD stones were classified into brown pigment (76.1% ), cholesterol (18.4%) and black pigment (3.5%) stones.
췌장염에서 발생한 가성동맥류의 임상 양상: 단일기관 경험 및 국내문헌 고찰
김지현 ( Ji Hyun Kim ),김재선 ( Jae Seon Kim ),김창덕 ( Chang Duck Kim ),이홍식 ( Hong Sik Lee ),조영직 ( Young Jig Cho ),이종섭 ( Jong Sup Lee ),최도원 ( Do Won Choi ),한우식 ( Woo Sik Han ),김연호 ( Youn Ho Kim ),연종은 ( Jong E 대한소화기학회 2007 대한소화기학회지 Vol.50 No.2
서론: 만성 또는 급성 췌장염의 합병증으로 발생하는 가성동맥류는 복강이나 후복막 또는 위장관 출혈을 일으켜 치명적인 결과를 초래할 수 있다. 저자들은 췌장염의 합병증으로 발생한 가성동맥류의 임상 특징을 알아보고자 이 연구를 시행하였다. 대상 및 방법: 1995년 1월부터 2006년 3월까지 고려대학교 구로병원과 안암병원에서 췌장염의 합병증으로 가성동맥류를 진단받은 7예를 대상으로 환자의 특성과 임상 경과를 후향 분석하였다. 결과: 성별은 모두 남자였고, 연령은 평균 54.6세(43-67세)였다. 모든 예에서 가성낭이 동반된 만성췌장염에서 가성동맥류가 발생하였고, 음주가 만성췌장염의 원인이었다. 진단 당시의 주 증상은 5예에서 심와부 통증, 1예는 혈변, 1예는 토혈이 복통과 동반되었다. 출혈 양상은 5예에서는 가성낭 내로의 출혈이었으며 1예는 가성낭 내로의 출혈과 동반된 하행결장 누공형성에 따른 출혈, 1예는 가성낭 내로의 출혈과 동반된 췌관 출혈이었다. 증상 발생 후부터 가성동맥류 진단까지의 평균 기간은 7.8일(1-23일)이었다. 6예의 복부 전산화단층촬영에서 가성낭 내의 국소적 조영증강의 특징적인 소견이 관찰되어 진단이 가능하였으며, 3예에서 복부 전산화단층촬영 전에 복부 도플러초음파 검사를 시행하였으며 이 중 2예에서는 가성동맥류를 시사하는 소견이 관찰되지 않았다. 6예에서 초기 치료로 혈관색전술이 시행되었고 모든 예에서 재발은 없었으며 혈관색전술과 관련된 중대한 합병증은 관찰되지 않았으나 1예에서는 합병증으로 비장경색이 발생하였다. 1예는 초기 치료로 원위췌장절제술을 시행하였다. 결론: 췌장염의 합병증으로 발생한 가성동맥류는 다양한 임상 양상을 보이며, 초기 치료로 동맥색전술을 이용한 비수술적인 방법이 효과적이다. Background/Aims: Pseudoaneurysm is a life-threatening complication of chronic or acute pancreatitis. This study was undertaken to evaluate the clinical features of pseudoaneurysm complicating pancreatitis. Methods: We reviewed the medical records of 7 patients diagnosed as pseudoaneurysms with chronic pancreatitis in Korea University Guro and Anam Hospital from January 1995 to March 2006 and analyzed their demographics, clinical courses and outcomes. Results: All patients were men and mean age was 54.6 years (range, 43-67 years). All the cases occurred in the setting of chronic alcoholic pancreatitis complicated by pseudocyst. Abdominal pain was the unique initial clinical symptom in 5 cases, hematemesis in 1 case, and simultaneous abdominal pain with hematemesis in 1 case. Bleeding into pseudocyst developed in 5 cases, flowing into duodenum through pancreatic duct in 1 case and rupture into the descending colon in 1 case. Mean duration between onset of symptom and diagnosis of pseudoaneurysm was 7.8 days (range, 1-23 days). Six cases were diagnosed by abdominal computed tomography disclosing characteristic finding of focal high density area in the pseudocyst. Pulsed doppler abdominal sonography was performed before computed tomography in 3 cases and results were negative in 2 cases. Transcatheter arterial embolizations were initially performed in 6 cases, and there was no recurrent bleeding except one case of splenic infarction. Distal pancreatectomy was initially performed in 1 case. Conclusions: Pseudoaneurysms complicating chronic pancreatitis shows various clinical features. Transcatheter arterial embolization can be recommended as a primary therapeutic modality. (Korean J Gastroenterol 2007;50:108-115)
보리수나무 뿌리혹으로부터 Frankia EuIKI 공생균주의 분리
김성천(Sung Chun Kim),구창덕(Chang Duck Ku),박민철(Min Chul Park),김준호(Chun Ho Kim),송승달(Seung Dal Song),안정선(Chung Sun An) 한국식물학회 1993 Journal of Plant Biology Vol.36 No.2
The root nodules of Elaeagnus umbellata were coralloid-shape due to repeated dichotomous branching of nodule meristem. The filamentous endophyte with vesicle cluster ranging from 30 ㎛ to 60 ㎛ in diameter was present only in the cortical cells. The isolated endophytes in vitro culture showed typical Frankia morphology, consisting of highly branched hyphae ranging from 0.8 ㎛ to 1.0 ㎛ in diameter, terminal and intraphyphal sporangia varing in shape and size up to 60 ㎛ in length and laminated vesicles. Its infectivity and effectivity were confirmed by induction of nitrogen-fixing root nodules on the inoculated seedlings of two Elaeagnus species. Consequently, the isolate was confirmed as a true symbiont of Elaeagnus umbellata root nodule and named Frankia EuIK1.
간세포암 환자의 종양병기 평가에 대한 Up-to-Seven Score의 임상적 유용성
정창호 ( Chang Ho Jung ),서연석 ( Yeon Seok Seo ),이재민 ( Jae Min Lee ),윤석배 ( Seok Bae Yoon ),윤태정 ( Tae Jung Yun ),임선영 ( Sun Young Yim ),안형진 ( Hyonggin An ),엄순호 ( Soon Ho Um ),김창덕 ( Chang Duck Kim ),류호상 ( Ho 대한간암학회 2014 대한간암학회지 Vol.14 No.1
Background/Aims: Up-to-seven criteria was proven to be useful for predicting prognosis after liver transplantation in patients with hepatocellular carcinoma (HCC). The aim of this study was to evaluate that up-to-seven score could be useful method for prediction of prognosis in patients with HCC who did not undergo liver transplantation. Methods: Between January 2006 and December 2008, 216 HCC patients without vascular invasion, lymph node and distant metastasis were analyzed retrospectively. We investigated the prognostic impact of laboratory findings, clinical characteristics, modified UICC T stage, and up-to-seven score in HCC. The survival analyses were performed using Kaplan-Meier Results: Two-hundred sixteen patients with HCC were included. Age was 60.1±11.3 years and 74.5% were male. Chronic hepatitis B was the most common cause of liver disease (60.6%). T stage was T1, T2, and T3 in 36 (16.7%), 118 (54.6%), and 62 (28.7%) patients, respectively. Up-to-even score was 5.5±4.0 and it was <3 (UTS 1), ≥3 and ≤7 (UTS 2), and >7 (UTS 3) in 36 (16.7%), 133 (61.6%), and 47 (21.8%) patients, respectively. The 10 (8.5%) patients of T2 stage were classified into UTS 3 and 25 (40.3%) patients of T3 stage were classified into UTS 2. The prognosis was significantly different in patients with T2 or T3 according to their UTS. Multivariate analysis showed that Child-Pugh score and UTS were significantly associated Conclusions: Up-to-seven score was useful to predict prognosis and to evaluate tumor stage in patients without vascular invasion, lymph node and distant metastasis.