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쥐의 만성 녹내장 모델에서 글루타민산염 수용체들의 발현
김지현,박찬기,Jie Hyun Kim,B,S,Chan Kee Park 대한안과학회 2006 대한안과학회지 Vol.47 No.3
Purpose: To investigate the changes of glutamate receptor expressions in the retina of the chronic ocular hypertension model of chronic glaucoma. Methods: We performed quantification and localization of glutamate receptors (GluRs): NMDA receptor (NR)1, glutamate receptor (GluR)2/4, glutamate receptor (GluR)6/7 and metabotrophic glutamate receptor (mGluR)6 by Western blot analysis and immunofluorescence staining in retinal tissues after inducing chronic elevation of intraocular pressure (IOP) by cauterizing three episcleral vessels. Results: The expression of NR1, GluR2/4 and GluR6/7 were increased significantly but mGluR6 was not, compared to the control group. NR1 expressed in the retinal ganglion cell layer (GCL) and inner nuclear layer (INL) of the retinal tissue. GluR2/4 and GluR6/7 both expressed GCL and INL in the retina, but mGluR 6 expressed INL, GCL and outer nuclear layer (ONL) of the retina. Conclusions: The increased expression of glutamate receptors is associated with excitotoxic cell death in the experimental glaucoma model. NMDA receptor expression in retinal ganglion cells suggests that it may play an important role in the selective death of retinal ganglion cells.
김지현,이용찬,Kim, Jie-Hyun,Lee, Yong-Chan 대한위암학회 2009 대한위암학회지 Vol.9 No.3
내시경 절제술은 림프절 전이의 위험도가 낮은 조기위암에 대한 근치적 국소 치료로 받아들여지고 있다. 최근 조기위암의 림프절 전이에 대한 연구결과들과 내시경 수기 및 부속기구의 발전에 기초하여 내시경 절제의 적용 범위는 확대되는 추세이다. 현재 조기위암의 내시경 절제의 확대 적응증으로는 궤양이 동반되지 않는 경우의 점막암이나, 궤양이 동반된 3 cm 이하의 점막암, 궤양이 없는 3 cm 이하의 미분화 점막암, 3 cm 이하의 궤양을 동반하지 않은 분화가 좋은 미세점막하암으로 림프혈관 침범이 없는 경우이다. 이 중 미분화암은 분화가 좋은 암과 비교하여 다른 생물학적 행태를 가진다는 관점에서 내시경 절제의 확대 적응증으로 포함하는 것에 있어 논란이 있는 상태이다. 따라서, 본 종설에서는 미분화 조기위암의 생물학적 행태와 내시경 절제술 결과에 기초하여 미분화 조기위암에서의 내시경 절제술 적용에 관하여 논해보고자 한다. Endoscopic resection is one of the curative options for early gastric cancer. However, based on large-scale data about the risk of lymph node metastasis in early gastric cancer, endoscopic resection has been attempted for the following: differentiated intramucosal gastric cancer, regardless of size and without ulcers; differentiated intramucosal cancer, 30 mm in size with ulcers; minute submucosal differentiated cancer <30 mm in size; and undifferentiated intramucosal cancer, <20 mm in diameter without venous or lymphatic involvement. However, undifferentiated early gastric cancer exhibits different biologic behavior from differentiated early gastric cancer. Thus, the application of endoscopic resection for undifferentiated early gastric cancer remains controversial. In this review, we discuss the application of endoscopic resection for undifferentiated early gastric cancer based on analysis of biologic behavior and data of endoscopic resection.
김지현 ( Jie Hyun Kim ),김범진 ( Beom Jin Kim ),김상욱 ( Sang Wook Kim ),김성은 ( Sung Eun Kim ),김연수 ( Yeon Soo Kim ),성혜영 ( Hye Young Sung ),오태훈 ( Tae Hoon Oh ),정인두 ( In Du Jeong ),박무인 ( Moo In Park ) 대한소화기학회 2014 대한소화기학회지 Vol.64 No.3
Gastroesophageal reflux disease (GERD) is one of the most common problems in gastrointestinal disorders. With the increase in our understanding on the pathophysiology of GERD along with the development of proton pump inhibitors, the diagnostic and therapeutic approaches to GERD have changed dramatically over the past decade. However, GERD still poses a problem to many clinicians since the spectrum of the disease has evolved to encompass more challenging presentations such as refractory GERD and extraesophageal manifestations. This has led to significant confusion regarding the optimal approach to these patients. This article aims to discuss current issues on GERD. (Korean J Gastroenterol 2014;64:127-132)
아스피린과 항혈소판제 병합요법은 상부위장관 출혈을 증가시키나?
김지현 ( Jie Hyun Kim ) 대한소화기학회 2011 대한소화기학회지 Vol.57 No.4
The Effect of Aspirin Alone or Aspirin Plus Additional Antiplatelets Therapy on Upper Gastrointestinal Hemorrhage (Korean J Gastroenterol 2011;57:213-220)
교육서비스품질이 고객만족 및 재이용에 미치는 영향에 관한 실증적 연구 -E평생교육센터 중심으로-
김지현 ( Jie Hyun Kim ),이상복 ( Sang Bok Ree ) 한국품질경영학회 2011 품질경영학회지 Vol.39 No.1
In this research, we study on to find the inter-relation among education service quality and customer satisfaction and re-use focusing on E life-long education center. Education service quality consists of four factors such as training center`s facility, trainer, employee`s service and operating service. As like the results of this research, we found that three factors of education service quality such as facility, trainer and operating service give a positive effect to customer satisfaction and also we found that customer satisfaction gives a positive effect to re-use.
B.2 : 경영품질(2) : B.2.1 ; 교육서비스품질, 고객만족 및 재구매 영향에 관한 연구모형 검증 연구
김지현 ( Jie Hyun Kim ),이상복 ( Sang Bok Ree ) 한국품질경영학회 2011 한국품질경영학회 학술대회 Vol.2011 No.1
In this research, we study on to find the inter-relation among education service quality and customer satisfaction and re-purchase focusing on E life-long education center. Education service quality consists of four factors such as training center`s facility, trainer, employee`s service and operating service. As like the results of this research, we found that three factors of education service quality such as facility, trainer and operating service give a positive effect to customer satisfaction and also we found that customer satisfaction gives a positive effect to re-use.