1993년도 성남지역에서 유행한 홍역 환아에서의 홍역 특이 항체 반응

김지연,박윤형,김순기,최연화,이환종,손병관,Kim, Ji Youn,Park, Yoon Hyung,Kim, Soon Ki,Choi, Yun Hwa,Lee, Hoan Jong,Son, Byong Kwan 대한소아감염학회 1997 Pediatric Infection and Vaccine Vol.4 No.1

목 적 : 높은 예방접종율에도 불구하고 흥역이 계속 발생하는 것은 1차 백신 실패 또는 2 차 백신 실패 등의 논란을 자아내고 있다. 이에 저자들은 1993년 전국적으로 홍역이 유행하였을 당시 인구 밀집 대도시인 성남지역에서 그 당시 홍역에 이환되었던 일부 소아를 대상으로 특이 혈청학적 검사를 실시하였다. 대상 및 방법 : 1993년 홍역이 유행할 당시 임상진단 기준에 따라서 홍역으로 진단된 초등학교생을 대상으로 학교에 의뢰하여 93년 12월 10일부터 5일간 채혈한 후, 혈청을 분리한 후 $-20^{\circ}C$ 냉장고에 보관한 후 2개월 지나 검사하였다. Behring사의 시약을 사용하여 ELISA(Enzyme linked immunosorbent assay)방법에 의해 혈청내 홍역 특이 IgM 항체 (measles-specific IgM) 및 IgG를 검사하였다. 결 과 : 1) 총 126명 (남녀비=1:1)으로 발병시 연령은 5세 6명, 6세 11명, 7세 20명, 8세 39명, 9세 22명, 10세 11명, 11세 11명, 12세 6명으로 8세 전후에 가장 많은 빈도 보였다. 홍역은 여름에 발생하기 시작한 홍역은 9월부터 증가하기 시작하여 11월에 정점을 이루었다. 2) 홍역환자 126명중 99명(78.6%)에서 MMR접종력이 있었다. MMR접종자 99명 가운데 홍역 특이 IgM 항체에 양성은 80.8%(80/99)에서 관찰되었고, MMR 비접종자 27명 가운데 26명 (96.3%)에서 양성율을 보였다. 3) 홍역 특이 IgG 항체 반응결과 MMR 접종력이 있는 99명 중 90명(90.9%)에서, MMR 비접종군 27명중 23명(85.2%)에서 양성반응을 보였다. 흥역특이 IgG 항체반응은 MMR 접종력이 있는 아동 33명중 30례(90.1%)에서 양성을 보였다. 결 론 : MMR 접종력이 있는 아동의 상당수는 시간에 따른 항체가의 감소로 인해 홍역이 발생하였을 가능성을 배제할 수 없으나, 상당수의 환자가 IgM 항체 양성을 보인 것은 1차 백신 실패가 여전히 중요하다는 것을 의미하는 것으로 생각한다. 이를 확인하기 위해서는 보다 많은 아동을 대상으로 한 연구가 필요할 것으로 생각한다. Measles outbreak in the world was decreased since measles vaccine had been introduced. Although vaccination rate is high, measles was not eradicated and measles reappeared among vaccinated children. We measured measles-specific antibody from the vaccinated and unvaccinated groups who had experienced apparent measles in the Seongnam city in 1993. The results were as follows. 1) The data included total 126 children (M:F=1 : 1). Age distribution of measles outbreak revealed 6 children in 5yr, 11 in 6yr, 20 in 7yr, 39 in 8yr, 22 in 9yr, 11 in 10yr, 11 in 11yr, and 6 in 12yr. 2) MMR vaccination rate was 78.6%(99/126) in the children who had experienced measles. Positive rate of measles-specific IgM Ab was 80.8% (80/99) among the vaccinated group and among 9E.6.% (25/27) the unvaccinated. 3) Positive rate of measles-specific IgG Ab was 90.9% (90/99) among MMR-vaccinated group, and 85.2% (23/27) in unvaccinated group. In conclusion, measles-specific IgM antibody have been detected more than 1 month in most patients. The relatively high proportion of measles-specific IgM positivity may mean primary vaccine failure. To booster the antibody titers and to prevent measles epidemic in school-aged children, revaccination of measles should be considered.

유전자 조작 , 균주분리 수용성 황색색소를 분비하는 Bacillus sp . PY123 균주의 분리 및 특성

김지연,김광현 ( Ji Youn Kim,Kwang Hyeon Kim ) 한국미생물생명공학회 1997 한국미생물·생명공학회지 Vol.25 No.5

급성 골수성 백혈병의 구강 내 발현 및 치료: 증례 보고

김지연,민승기,임호경,서진원,황순정,Kim, Ji-Youn,Min, Seung-Ki,Lim, Ho-Kyung,Suh, Jin-Won,Hwang, Soon-Jung 대한악안면성형재건외과학회 2009 Maxillofacial Plastic Reconstructive Surgery Vol.31 No.6

Proliferation of abnormal hematopoietic cells with impaired differentiation, regulation and programmed cell death leads to leukemia. AML(acute myeloid leukemia) is a malignancy with malfunction of myeloid hematopoietic cells with acute behavior. The oral manifestations of the disease are posterior palate hemorrhage, gingival bleeding and gingival ulceration as a result of infection by normal oral flora and gingival infiltration by leukemic cells. A 49-year-old male patient was referred from local dental clinic. The patient was diagnosed with AML FAB M1 (acute myeloid leukemia French-American-British classification M1 myeloblastic leukemia without maturation). The oral infection focus was removed by a conservative treatment. 2 days after the dental treatment, the patient underwent chemotherapy. At 8-month follow-up, the overall outcome was excellent. Oral manifestations of AML are often the first indications of the malignancy. Therefore it is essential for dentists, especially oral and maxillofacial surgeons, to be aware of the diagnostic signs and complications associated with leukemia for better diagnosis and subsequent treatment and management.

단순 골 낭종의 보존적 치료

김지연,조용진,신규호,Kim, Ji-Youn,Cho, Yong-Jin,Shin, Kyoo-Ho 대한근골격종양학회 2011 대한골관절종양학회지 Vol.17 No.2

Purpose: This study evaluated the results of conservative treatment for simple bone cyst. Materials and Methods: We studied 126 cases of simple bone cyst, which were treated by observation or steroid injection from February 1990 to May 2010. Their mean age at diagnosis was 14 years (${\pm}9$ years, 2-60 years) and the mean follow-up duration for this study were 41 months (${\pm}37$ months, 12-159 months). Observation and steroid injection was applied for conservative management of simple bone cyst and results was scored by modified Neer classification. Results: 31 cases (24.6%) were treated by observation and 95 cases (75.4%) were treated by steroid injection. The 95 patients were treated by a mean of 1.1 (${\pm}0.9$, 0-4) steroid injections and a single steroid injection was given in 65 cases (51.6%). The 102 cases (80.9%) were resulted in modified Neer classification I and II which could be considered as healing of simple bone cyst. Conclusion: Conservative management can be considered as an initial treatment for simple bone cyst with good result. 목적: 단순 골 낭종에 대해 관찰 요법 또는 국소적 스테로이드 주입술을 통한 보존적 치료를 시행한 결과에 대하여 보고하고자 한다. 대상 및 방법: 1990년 2월부터 2010년 5월까지 단순 골 낭종으로 진단된 153명 중 보존적 치료만을 시행한 126명을 대상으로 하였다. 진단시 평균 연령은 14세(${\pm}9$세, 2-60세)였으며 평균 추시 관찰 기간은 41개월(${\pm}37$개월, 12-159개월)이었다. 보존적 치료의 치료 결과에 대해 변형 Neer 분류로 나누어 비교하였다. 결과: 단순 골 낭종으로 진단되어 보존적 치료를 실시한 환자 중 관찰 요법만 실시한 경우는 31예(24.6%)였고, 스테로이드 주입술을 실시한 경우는 95예(75.4%)였다. 보존적 치료 후의 결과는 변형 Neer 분류상 치유에 해당하는 Grade I, II가 102예(80.9%)였다. 결론: 단순 골 낭종의 일차적 치료로 보존적 치료를 고려하여야 한다.

구조물의 동적해석을 위한 수치적분법의 비교와 적용

김지연(Kim Ji Youn),권민호(Kwon Min Ho),박문호(Park Moon Ho),최세휴(Choi Se Hyu) 대한토목학회 2003 대한토목학회 학술대회 Vol.2003 No.10

침지식 중공사막을 결합한 Dynamic state 하수고도처리공정(KSMBR process)의 개발 및 현장적용평가

김지연 ( Ji Yeon Kim ),서인석 ( In Seok Seo ),김홍석 ( Hong Suck Kim ),김연권 ( Youn Kwon Kim ),김병군 ( Byung Goon Kim ),최창규 ( Chang Gyu Choi ),안효원 ( Hyo Won Ahn ),서완석 ( Wan Seok Seo ),장문석 ( Moon Seog Jang ) 한국물환경학회 2006 한국물환경학회지 Vol.22 No.2

Three-dimensional volumetric gray-scale uterine cervix histogram prediction of days to delivery in full term pregnancy

김지연 ( Ji Youn Kim ),( Hai Joong Kim ),( Meong Hi Hahn ),( Hye Jin Jeon ),( Geum Joon Cho ),( Sun Chul Hong ),( Min Jeong Oh ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-

Objective: Our aim was to figure out whether volumetric gray-scale histogram difference between anterior and posterior cervix can indicate the extent of cervical consistency. Methods: We collected data of 95 patients who were appropriate for vaginal delivery with 36th to 37th weeks of gestational age from September 2010 to October 2011 in the Department of Obstetrics and Gynecology, Korea University Ansan Hospital. Patients were excluded who had one of the followings: Cesarean section, labor induction, premature rupture of membrane. Thirty-four patients were finally enrolled. The patients underwent evaluation of the cervix through Bishop score, cervical length, cervical volume, three-dimensional (3D) cervical volumetric gray-scale histogram. The interval days from the cervix evaluation to the delivery day were counted. We compared to 3D cervical volumetric gray-scale histogram, Bishop score, cervical length, cervical volume with interval days from the evaluation of the cervix to the delivery. Results: Gray-scale histogram difference between anterior and posterior cervix was significantly correlated to days to delivery. Its correlation coefficient (R) was 0.500 (P = 0.003). The cervical length was significantly related to the days to delivery. The correlation coefficient (R) and P-value between them were 0.421 and 0.013. However, anterior lip histogram, posterior lip histogram, total cervical volume, Bishop score were not associated with days to delivery (P >0.05). Conclusion: By using gray-scale histogram difference between anterior and posterior cervix and cervical length correlated with the days to delivery. These methods can be utilized to better help predict a cervical consistency.

류마티스 관절염 환자에서 Methotrexate와 관련된 간질성 폐렴

김지연 ( Ji Yeon Kim ),김완욱 ( Wan Uk Kim ),김성일 ( Sung Il Kim ),류완희 ( Wan Hee Yoo ),박성환 ( Sung Hwan Park ),홍연식 ( Yeon Sik Hong ),김석찬 ( Seok Chan Kim ),조철수 ( Chul Soo Cho ),김호연 ( Ho Youn Kim ),이연수 ( Youn So 대한류마티스학회 1998 대한류마티스학회지 Vol.5 No.1

The use of oral methotrexate in a low dose given once weekly has become the mainstay of therapy for active and sustained rheumatoid arthritis. Pneumonitis can be expected to occur in patients taking low doses of methotrexate for rheumatoid arthritis. The pathology suggests that methotrexate pneumonitis is a hypersensitivity reaction although arguments have been put forth that it is idiosyncratic. Treatment of presumed methotrexate pneumonitis, even while waiting for special stains, cultures, or tissue sections from bronchoscopic biopsy, should be glucocorticoids given intravenously or by mouth. Empirical antibiotic treatment can be used until infectious causes are ruled out. In recent years there has been an increase in the number of reports of pulmonary complications associated with low-dose methotrexate therapy for rheumatic diseases. Among these complications interstitial pneumonitis has been most often reported (more than 35 cases since the first report in 1983). We report a case of methotrexate-associated pulmonary complication in rheumatoid arthritis confirmed by trans-bronchoscopic lung biopsy, which resolved by treatment of corticosteroid therapy.

청소년비행과 또래요인의 관계에 대한 재조명

김지연(Kim Ji Youn) 한국민간경비학회 2008 한국민간경비학회보 Vol.11 No.-

  이 연구의 목적은 청소년의 또래관계가 비행에 미치는 영향을 차별적인 또래관계의 영향과 비행을 유인하는 기회라는 측면에 근거하여 새롭게 검증해 보는데 있다. 연구의 수행을 위해서 또래요언을 비행또래접촉, 비구조화된 또래활동이라는 하위변수들로 구성하여 청소년비행에 있어 이러한 하위변수들의 효과를 여러 가지 측면에서 검증하였다.<BR>  선행연구를 기초로 하여 청소년비행에 영향을 미치는 또래요인으로서 어떠한 변수들이 가장 중요한 예측인자로 작용하는가, 이들 변수 간에 어떠한 관계가 있는가, 그리고 비행의 형태에 따라 영향을 미치는 변수의 차이가 존재하는가라는 연구문제를 도출해 내었다.<BR>  이러한 연구문제에 대한 응답을 찾기 위하여 실증연구를 수행하였고, 연구의 수행을 위해서 2007년 9윌 5일부터 9윌 15일까지 열흘 동안 서울 시내 인문계ㆍ실업계 고등학교 가운데 20개의 2학년 학급을 임의로 선정하여 남ㆍ여 학생을 대상으로 설문조사를 실시하였다.<BR>  분석결과 비행에 영향을 미치는 변수들 간에 영향력의 차이가 존재하였고, 변수들의 관계에 따라서도 비행에 미치는 영향력의 차이가 존재하였으며, 비행의 형태에 따라서도 변수들의 영향력에 있어 차이가 존재함을 확인할 수 있었다.   This research examines the effects of peers in juvenile delinquency. The effects of peers can be categorized into contact with deviant peers and non-structured peer activities.<BR>  The inquiry was whether the effects of peers would have influence on juvenile delinquency. In order to complete the research, past documents were referenced. Based on the theoretical background suggested by the references, an experiment to prove the validity was carried out.<BR>  The analysis model was reconstructed from the previous models about peer relationship. Prior to the experiment, documents were referenced in order to find out various theories and previous experiments on delinquency of juveniles, and the influence of the factors, which include opportunity, routine activities, and friends. To examine the multicollinearity in variables in misconduct, the Correlation Analysis was used. After that, Multiple Regression Analysis was executed to find the relative impacts in variables.<BR>  The fact that the variables of non-structured peer activities and contact with deviant peers are proven to be effective variables in explanation of relations between the variables and the delinquency. Based on these results, it is now possible to consider of the solutions for the juvenile delinquency.

항공사 모바일 애플리케이션의 주요 품질요인이 지각된 가치 및 브랜드 충성도에 미치는 영향

김지연(Kim, Ji Youn),민소라(Min, So Ra),최정일(Choi, Jeongil) 한국서비스경영학회 2019 서비스경영학회지 Vol.20 No.2

This study aims to investigate quality factors affecting the brand loyalty and perceived value for airline application users. For the empirical analysis, the research model is validated by SPSS 18.0 using 250 survey data that is collected from airline application users. As a result of the analysis, the reliability, information, security level and ease of use positively affect the perceived functional value, the reliability and ease of use positively affect the perceived emotional value, and information, responsiveness positively affect the social value among quality factors of airline application, and the perceived emotional value and social value have a positive effect on brand loyalty. The reliability, information and ease of use also have a positive effect on brand loyalty. It was also found that the responsiveness showed no effect on the functional value, the information, responsiveness and security level showed no effect on the emotional value, the reliability, security level and Ease of use showed no effect on the social value, the perceived functional value showed no effect on brand loyalty. The Responsiveness and security level showed no effect on brand loyalty. This study shows a theoretical implication for enhance application functionality. It was suggested to make more various air travel information which can plan the travel of the unit separately and make it visible in the application site.