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- 저자 : 김정철(Kim, Jung-Chul) (검색결과 481 건)
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김정철,정주미,은소희,이대열,김정수,Kim, Jung Chul,Choung, Ju Mi,Eun, So Hee,Lee, Dae-Yeol,Kim, Jung Soo 대한소아청소년과학회 2002 Clinical and Experimental Pediatrics (CEP) Vol.45 No.11
목 적 : 홍역은 전염력이 매우 높은 급성 유행성 전염병으로 감염 후 뇌척수염, 홍역 봉입체 뇌염 그리고 아급성 경화성 전뇌염의 3가지 신경계 합병증을 일으킨다. 본 연구에서는 홍역 후 급성 뇌염이 발생한 환아들의 임상 양상, 경과 및 결과와 뇌 SPECT의 양상을 비교 분석하였다. 방 법: 2000년 10월부터 2001년 1월까지 4개월 동안 홍역 후 의식저하, 경련, 마비 등의 특징적인 뇌염증상을 보여서 전북대학교병원 소아과에 입원한 11명의 환아를 대상으로 뇌척수액 검사, 홍역 특이항체 검사, 뇌파검사, 뇌 SPECT와 뇌 자기공명영상을 실시하였다. 결 과: 11명의 대상 환아들의 남녀 비는 남아 4명, 여아 7명으로 여아가 많았으며, 연령은 18개월에서 14세까지로 평균 연령은 10.5세였고, 8세 이상의 연장아가 10명(90.9%)으로 대부분을 차지하였다. 홍역 예방접종은 11명 중 10명은 1차 예방 접종을 실시했으며 1명은 실시하지 않았고, 2차 예방 접종을 실시한 환아는 없었다. 뇌척수액의 백혈구는 $158{\pm}157/{\mu}L$이었고 단백은 $124{\pm}60mg/dL$이었다. 홍역 특이항체는 혈청에서는 IgG/M이 10명에서 양성이었고 1명은 모두 음성이었으며, 뇌척수액에서는 9명에서 IgG가 양성이었고 1명에서는 IgM이 양성이었다. 11명에서 실시한 뇌 SPECT는 모두 비정상 소견을 보였고 뇌 자기공명영상은 7명에서 비정상 소견을, 4명에서는 정상 소견을 보였다. 뇌 SPECT에서 혈류 감소는 전두엽(9명), 측두엽(9명), 두정엽(8명), 시상(8명) 부위가 많았고 이외에 기저핵(5명), 후두엽(4명), 소뇌(2명)에서도 혈류감소가 관찰되었다. 결 론: 홍역과 홍역의 심각한 신경계 합병증을 예방하기 위해서는 지속적으로 2차 예방 접종을 시행하여야 하고 홍역에 대한 감시체계의 확립 및 홍역 유행에 대한 신속한 대처가 요구된다. 뇌 자기공명영상에서 정상인 4명 모두가 SPECT에서는 혈류 감소가 관찰된 점으로 미루어 보아 보이지 않은 뇌의 손상이 있었을 것으로 추측할 수 있으며, 감염후 뇌염이 발생한 환아의 뇌 손상 여부를 평가하는데는 뇌 자기공명영상보다 뇌 SPECT가 보다 예민할 것으로 생각된다. Purpose : Acute measles encephalitis(ME) is characterized by an abrupt onset of fever and obtundation, frequently accompanied by seizures and multifocal neurological signs. The aim of this study was to clarify the clinical manifestation, progression and the brain SPECT patterns in patients with acute ME. Methods : This study included 11 children with acute ME admitted to Chonbuk National University Hospital. Ten patients received a first dose of measles vaccine, one patient did not receive a first dose, and no patients received a second dose. ME was diagnosed based on characteristic clinical pictures, measles antibodies by ELISA and abnormal CSF findings. Brain MRI and brain SPECT were performed in 11 patients with acute ME. Results : There were four males and seven females whose ages at onset ranged between 18 months and 14 years(mean : 10.5 years). The main clinical neurologic pictures were loss of consciousness( 10) and seizure(five). The titer of IgG and IgM antimeasles antibodies in serum were positive in 10 patients. In CSF, nine patients had IgG antibodies and one patient had IgM antibodies. The concentration of protein(mean : $124{\pm}60mg/dL$) and WBC counts(mean : $158{\pm}157/{\mu}L$) in CSF were elevated in all patients. In electroencephalographic examination, nine patients showed increased slow waves. Seven of 11 patients(63.6%) revealed high signal intensity on the brain MRI. In contrast, all patients showed hypoperfusion in brain SPECT examination. According to brain SPECT, the perfusion deficits were frequently observed in the frontal lobe(nine), temporal (nine), parietal(eight) and thalamus(eight). Conclusion : Brain SPECT is more sensitive than MRI for the evaluation of brain damage in early stages of acute ME.
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PET 필라멘트사의 응력완지에 미치는 정신비와 정신온도의 영향
김정철,윤원식,김상용,Kim, Jeong-Cheol,Yun, Won-Sik,Kim, Sang-Yong 한국섬유공학회 1983 한국섬유공학회지 Vol.20 No.6
PET필라멘트사의 제조조건인 연신비와 연신온도가 응력 완화현상에 미치는 영향을 살펴보기 위하여 연신비와 연신온도가 각각 다른 조건의 필라멘트사를 시료로하여 실험하였다. 완화 응력은 연신비가 클수록 증가하고, 연신 온도가 높을수록 감소하였다. 완화 응력 감소율은 연신비가 증가할수록 감소하였으나 연신온도에는 영향을 받지 않았다. 변형율과 완화 응력과의 관계는 Nutting식과 유사한 관계식을 갖고 있었다. 응력 완화를 Zener모델로 표현 했을 때 모델의 각 요소들은 E$_1$, E$_2$,η의 상수들은 연신비가 증가할수록 증가하였다. The effects of draw ratio and draw temperature on the stress relaxation modulus were studied. Samples with the various combinations of 5 draw ratios and 5 draw temperatures were manufactured and measured for the stress relaxation. From the experimental results, it can be seen that relaxation stress increases with draw ratio, but decreases with draw temperature. The slope of stress to time decreases with draw ratio, but remains constant with respect to draw temperature. Relaxation stress increases with crystallinity below draw ratio 3.0, but above 3.0 no relation exists between relaxation stress and crystallinity. Relaxation stress behavior at various imposing strains obeys the equation similar to Nutting's. The coefficients of E$_1$, E$_2$and η of Zener model increase with draw ratio.
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고위험군 유두상 갑상선암 환자에 대한 방사성옥소 최대허용선량 측정법 및 치료법의 검증
김정철,윤정한,제갈영종,범희승<SUP>1<.SUP>,Jung Chul Kim,M.D.,Jung Han Yoon,M.D.,Young Jong Jaegal,M.D. and Hee Seung Bum,M.D.<SUP>1<.SUP> 대한갑상선-내분비외과학회 2002 The Koreran journal of Endocrine Surgery Vol.2 No.2
Purpose: Radioiodine (I-131) therapy is an effective modality to reduce both recurrence and mortality rates in differentiated thyroid cancer. Whether higher doses shows higher therapeutic responses was still debatable. The purpose of this study was to validate curve-fitting (CF) method measuring maximum permissible dose (MPD) by a biological dosimetry using metaphase analysis of peripheral blood lymphocytes. Methods: Therapeutic effects of MPD was also evaluated in 58 patients (49 females and 9 males, mean age 50⁑11 years) of papillary thyroid cancer. Among them 43 patients were treated with ≤7.4 GBq, while 15 patients with ≥9.25 GBq. The former was defined as low-dose group, and the latter high-dose group. Therapeutic response was defined as complete response when complete disappearance of lesions on follow-up I-131 scan and undetectable serum thyroglobulin levels were found. Statistical comparison between groups were done using chi-square test. P value less than 0.05 was regarded as statistically significant. Results: MPD measured by CF method using tracer and therapeutic doses were 13.3⁑1.9 and 13.8⁑2.1 GBq, respectively (P=0.20). They showed a significant correlation (r=0.8, P<0.0001). Exposed doses to blood measured by CF and biological methods were 1.54⁑0.03 and 1.78⁑0.03 Gy (P=0.01). They also showed a significant correlation (r=0.86, P=0.01). High-dose group showed a significantly higher rate of complete response (12/15, 80%) as compared to the low-dose group (22/43, 51.2%) (P=0.05). While occurrence of side effects was not different between two groups (40% vs. 30.2%, P=0.46). Conclusions: measurement of MPD using CF method is reliable, and the high-dose I-131 therapy using MPD gains significantly higher therapeutic effects as compared with low-dose therapy. (Korean J Endocrine Surg 2002;2:97-104)
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청심연자탕으로 호전된 뇌경색을 동반한 심방세동 환자 치험 3례
김정철,오성원,송창훈,이슬희,정종진,김종윤,선승호,Kim, Jung-Chul,Oh, Sung-Won,Song, Chang-Hoon,Lee, Seul-hee,Jeong, Jong-Jin,Kim, Jong-Yun,Sun, Seung-Ho 대한한방내과학회 2006 大韓韓方內科學會誌 Vol.27 No.3
Atrial fibrillation (AF) is a common arrhythmia that is a potent independent risk factor for stroke. The incidence of AF increases with age and most affected people have underlying cardiac disease. An aging society increases the incidence of AF patients. The case was designed to evaluate the improving effect of Chengsim Yeunja-tang (CYT) for atrial fibrillation (AF) with Cb-infarction patients. This patient was treated with CYT and had significant improvement in symptoms and change of EKG. -Heart rate decreased in patients with higher than normal heart rate -RV5+SV1 voltage decreased (LVH improved) -Arrhythmia remained steady. -Palpitation. chest discomfort, dyspnea, headache, dizziness diminished. Results suggest that CYT is an effective treatment for Taeumin AF patients.
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