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반복 점진적 방법에 의한 2차원 단백질 분리 영상의 반점 정합
김정자,김동욱,김남균,원용관,Kim, Jung-Ja,Hoang, Minh T.,Kim, Dong-Wook,Kim, Nam-Gyun,Won, Yong-Gwan 대한의용생체공학회 2007 의공학회지 Vol.28 No.5
2 Dimensional Gel Electrophoresis(2DGE) is an essentialmethodology for analysis on the expression of various proteins. For example, information for the location, mass, expression, size and shape of the proteins obtained by 2DGE can be used for diagnosis, prognosis and biological progress by comparison of patients with the normal persons. Protein spot matching for this purpose is comparative analysis of protein expression pattern for the 2DGE images generated under different conditions. However, visual analysis of protein spots which are more than several hundreds included in a 2DGE image requires long time and heavy effort. Furthermore, geometrical distortion makes the spot matching for the same protein harder. In this paper, an iterative algorithm is introduced for more efficient spot matching. Proposed method is first performing global matching step, which reduces the geometrical difference between the landmarks and the spot to be matched. Thus, movement for a spot is defined by a weighted sum of the movement of the landmark spots. Weight for the summation is defined by the inverse of the distance from the spots to the landmarks. This movement is iteratively performed until the total sum of the difference between the corresponding landmarks is larger than a pre-selected value. Due to local distortion generally occurred in 2DGE images, there are many regions in whichmany spot pairs are miss-matched. In the second stage, the same spot matching algorithm is applied to such local regions with the additional landmarks for those regions. In other words, the same method is applied with the expanded landmark set to which additional landmarks are added. Our proposed algorithm for spot matching empirically proved reliable analysis of protein separation image by producing higher accuracy.
IT 시대 장애아동 아버지의 양육 스트레스에 관한 연구
김정자,정복희,오명화,Kim, Jeong-Ja,Chong, Bok-Hee,Oh, Myung-Hwa 한국전자통신학회 2013 한국전자통신학회 논문지 Vol.8 No.2
본 연구는 장애아 아버지의 양육스트레스를 알아보기 위해 실시되었다. 연구의 대상은 G광역시에서 재활치료를 받고 있는 13세 미만의 장애아들 둔 아버지 50명을 대상으로 설문조사를 하여 응답이 불충분한 자료를 제외한 38부를 활용하였다. 설문지의 구성은 장애아동과 아버지의 일반적 특성, 그리고 부모의 양육스트레스(K-PSI-SF)로 하였으며 그 결과는 다음과 같다. 첫째, 장애아 아버지의 양육스트레스는 K-PSI-SF 하위 항목 가운데 부모의 고통이 가장 높았고 다음은 까다로운 아동, 그리고 역기능적 상호작용 순이었다. 둘째, 아동의 특성에 따른 아버지의 스트레스는 진단명과 마비부위에 따라 유의한 차이를 보였다. 셋째, 아버지의 특성에 따른 스트레스는 아버지의 교육수준과 연령에 따라서 유의한 차이를 보였다. The purpose of this study is to investigate the parental distress of disabled children's fathers. The survey was conducted targeting 50 fathers with disabled children who are under 13 years old and undergoing rehabilitation treatment in G city And 38 questionnaires excluding data with inadequate answer were adopted. The questionnaire was composed of general peculiarities of disabled children and their fathers, and K-PSI-SF of parents. The results are as followings. First of all, among the parenting stress of disabled children's fathers, parental distress got the highest score and difficult child and dysfunctional interaction are next in sequence in the sub items of K-PSI-SF. Secondly, fathers' stress upon the children's general characteristics showed the significant difference depending on diagnostic categories and paralysis area. Thirdly, fathers' stress upon fathers' general characteristics showed the significant difference depending on their education level and age.
김정자,이도헌,백윤주,Kim, Jeong-Ja,Lee, Do-Heon,Baek, Yun-Ju 한국정보처리학회 2001 정보처리학회논문지D Vol.8 No.5
바이오정보학(bioinformatic)은 생물학 분야 특히 분자 수준의 유전체 연구에서 발생하는 데이터를 저장, 관리, 분석하여 실험 프로젝트를 지원함은 물론, 기능 예측 및 조절에 대한 실험 설계를 가능하게 하는 제반 컴퓨터 기술을 의미한다. 유전체 연구의 다양한 접근 방식 중 단백체학(proteomics)는 유전체의 최종 산물인 단백질을 직접적으로 다룬다는 측면에서 그 효용성에 대해 많은 기대를 모으고 있다. 본 논문에서는 단백질의 기능을 결정하는 가장 중요한 요소 중 하나인 단백질의 구조를 예측하기 위한 데이터 마이닝 기법을 제안한다. 단백질의 일차 구조인 아미노산 서열에 타나나는 부서열간의 연관성이 해당 단백질의 이차 혹은 삼차 구조를 결정하는 중요한 단서임을 설명하고, 아미노산 부서열간의 연관성을 표현하기 위한 모델로서 서열 연관 규직을 정의한다. 서열 연관 규칙의 유용성을 평가하기 위한 지지도와 신뢰도를 새롭게 정의하고, 주어진 단백질 집단으로부터 유용한 서열 연관 규칙을 발견하기 위한 기법을 제안한다. 아울러, SWISS-PROT 단백질 데이터베이스로부터 입수한 단백질 서열 데이터를 이용하여 제안한 기법의 성능을 평가한다. Bioinformatics is a discipline to support biological experiment projects by storing, managing data arising from genome research. In can also lead the experimental design for genome function prediction and regulation. Among various approaches of the genome research, the proteomics have been drawing increasing attention since it deals with the final product of genomes, i.e., proteins, directly. This paper proposes a data mining technique to predict the structural characteristics of a given protein group, one of dominant factors of the functions of them. After explains associations among amino acid subsequences in the primary structures of proteins, which can provide important clues for determining secondary or tertiary structures of them, it defines a sequence association rule to represent the inter-subsequences. It also provides support and confidence measures, newly designed to evaluate the usefulness of sequence association rules, After is proposes a method to discover useful sequence association rules from a given protein group, it evaluates the performance of the proposed method with protein sequence data from the SWISS-PROT protein database.
신경근전기자극치료가 뇌졸중 환자의 연하장애에 미치는 효과
김정자,이종원,Kim, Jeong Ja,Lee, Jong Won 대한물리치료과학회 2019 대한물리치료과학회지 Vol.26 No.2
Background: The purpose of this study was to provide the basis for the treatment intervention by identifying the treatment effect when rehabilitation intervention is applied to patients with dysphagia due to stroke and by comparing the results of the treatment mediation according to the differences of the treatment methods and frequency. Design: Randomized Controlled Trial. Methods: 30 people diagnosed with dysphagia due to stroke were divided in accordance with the differences in treatment mediation techniques and treatment frequency- traditional swallowing rehabilitation coupled with neuromuscular electrical stimulation group and only neuromuscular electrical stimulation group/ 5 times per week group and 2 times per week group, and ten weeks of treatment intervention was performed. Paired t test was employed to show the efficacy of treatment intervention, Independent sample t test was used to compare the results according to difference and number of treatment intervention techniques. Results: There was a significant positive effect of treatment on traditional swallowing rehabilitation coupled with neuromuscular electrical stimulation group, only neuromuscular electrical stimulation group, 5 times per week group and 2 times per week group (p<0.05). There was no statistically significant difference in treatment effect between traditional swallowing rehabilitation coupled with neuromuscular electrical stimulation group and only neuromuscular electrical stimulation group (p<0.05). There was no statistically significant difference in treatment effect between 5 times per week group and 2 times per week group (p<0.05). Conclusion: There was no significant difference according to the technique or number of treatments of swallowing rehabilitation treatment interventions, but it was confirmed that rehabilitation intervention for dysphagia showed positive treatment effect.
김정자,강다현,양종화,장인선,조부연,홍창완,Kim, Jeong-Ja,Kang, Da-Hyeon,Yang, Jong-Hwa,Jang, In-Seon,Cho, Bu-Yeon,Hong, Chang-Wan 한국임상보건과학회 2019 한국임상보건과학회지 Vol.7 No.2
Purpose. The study was conducted to find out the effects that women in their 20s with abdominal obesity can get from sling-based flanks. Methods. The study used In-Body to determine the weight and body fat rate of women in their 20s who were overweight at H University and used a tape measure to measure the circumference of the abdomen. Plank exercise using slings to reduce weight, body fat and abdominal circumference led to muscle stabilization and abdominal obesity reduction. The collected data were analyzed using the SPSS ver. 23.0 statistics program. Results. The results of the study showed statistically significant differences in the weight, body fat rate and abdominal circumference of the subjects before and after intervention. Conclusions. Steady abdominal muscles exercise help stabilize the abdomen, reduce abdominal body fat rate, and are effective in managing obesity.
Atropine의 가토혈압하강작용(家兎血壓下降作用)에 관하여
김정자,Kim, Jeong-Ja 대한약리학회 1975 대한약리학잡지 Vol.11 No.1
Atropinesterase를 가친 가토(家兎)를 선택(選擇)하여 urethane 마취하(麻醉下)에서 atropine에 대한 혈압반응(血壓反應)을 조사(調査)하여 다음과 같은 성적(成績)을 얻었다. 1) 10, $50{\mu}g/kg$의 atropine은 거의 혈압하강(血壓下降)을 일으키지 않았으나, $250{\mu}g/kg$는 미약(微弱)한 혈압하강(血壓下降)을, $1,250{\mu}g/kg$는 현저(顯著)한 혈압하강(血壓下降)을 일으켰다. 2) Hexamethonium 주입하(注入下) 10, $50{\mu}g/kg$의 atropine도 혈압하강(血壓下降)을 일으키고, $^-250$, $1,250{\mu}g/kg$에 대한 하강반응(下降反應)은 더욱 현저(顯著)하였다. 3) Hexamethonium 또는 hexamethonium+angio-tensin주입하(注入下)에서 나타나는 atropine (10, 50, $250{\mu}g/kg$)에 대한 혈압하강(血壓下降) 반응(反應)은 propaneline, phonoxybenzamine, bretylium 존재하(存在下)에서는 현저(顯著)하게 억제(抑制)되었다. 4) 척수이단(脊髓離斷) 가토(家兎)에서는 hexamethonium+angiotensin주입하(注入下)에서도 atropine (10, 50, $250{\mu}g/kg$)은 거의 혈압하강(血壓下降)을 일으키지 않았다. 상기(上記) 성적(成績)에 의거(依據)하여 atropine은 혈관계(血管系)에 분포(分布)되여 있는 교감신경계(交感神經系)의 신경절(神經節)에 있어서의 충격부달(衝擊傅達)을 억제(抑制)함으로써 혈압하강(血壓下降)을 일으키는 것으로 추측(推測)하였다. 1. Atropine has recently been known to possess a sympathetic ganglion blocking effect. If atropine blocks the sympathetic ganglia innervating the blood vessels, the drug should cause depressor responses. The author attempted to verify this assumption in urethane-anesthetized rabbits having atropinesterase. 2. Ten and $50{\mu}g/kg$ of atropine produced little variation of the blood pressure; $250{\mu}g/kg$ slight depressor responses; $1,250{\mu}g/kg$ distinct ones. Under hexamethonium-infusion, 10 and $50{\mu}g/kg$ produced observable depressor responses; 250 and $1,250{\mu}g/kg$ produced more pronounced ones. 3. In experiments examining influence of phenoxybenzamine and bretylium on the atropine responses, the lowered blood pressure by these agents was raised by simultaneous infusion of angiotensin with hexamethonium. The depressor responses to atropine (10, 50 and $250{\mu}g/kg$) were slight after the administration of phenoxybenzamine and bretylium. 4. Propranolol did not affect the depressor responses to atropine. 5. In spinalized rabbits the lowered blood pressure was raised by the angiotensin-infusion. In these animals receiving the simultaneous hexamethonium-infusion, atropine (10, 50 and $250{\mu}g/kg$) produced little depressor responses. 6. From these results it is inferred that atropine produced the depressor responses by blocking the sympathetic ganglia innervating the blood vessels.
발살바 기법이 몸통 굴곡과 신전에 대한 저항운동에 미치는 영향
김정자,윤혁진,장경만,이희선,이종원,Kim, Jeong-ja,Yoon, Hyuk-jin,Jang, Kyung-man,Lee, Hee-sun,Lee, Jong-won 대한물리치료과학회 2020 대한물리치료과학회지 Vol.27 No.3
Background: The effect of the Valsalva maneuver applied in resistance exercise has shown contradictory results. This study aims to investigate the effect of the Valsalva maneuver on resistance exercise by examining the changes that occur by applying the Valsalva maneuver during trunk flexion and extension resistance exercise in healthy adults. Design: Randomized controlled trial. Methods: 34 healthy adults were conveniently recruited. According to the with or without Valsalva maneuver, the flexion and extension of the trunk were measured and evaluated. Results: Paired t test showed that there was a statistically significant difference in maximum torque of trunk flexion in the resistance exercise with Valsalva maneuver. However, there was no statistically significant difference in trunk extension (p<.05), in the total and average work of trunk flexion and extension (p<.05). Conclusion: The results of this study in which the difference in the amount of exercise according to the application of the Valsalva maneuver was not significant, show that the practice of the Valsalva maneuver, which has a risk of injury, should be avoided in rehabilitation exercises.