경찰공무원의 외상사건 유형과 PTSD 증상의 관계 : 스트레스 대처양식의 조절효과

김자혜,김정규 한국경찰연구학회 2013 한국경찰연구 Vol.12 No.3

본 연구에서는 국내 경찰공무원을 대상으로 외상 사건의 유형과 PTSD 증상간의 관계를 파악하고, 외상 사건에 따른 PTSD 증상에서 대처양식이 가지는 조절효과를 알아보고자 하였다. 450명의 현직 경찰공무원을 대상으로 외상 사건과 PTSD 증상 및 대처양식을 측정하기 위해 외상성 사건 경험 척도, 사건충격척도 개정판(IES-R), 스트레스 대처양식 척도를 사용하여 자료를 수집하였다. 이 가운데 결측치가 포함된 24명의 자료를 제외한 426부의 자료가 최종 분석에 사용되었으며 외상 사건의 유형과 PTSD 증상의 관계를 살펴보기 위해 상관분석과, 중다회귀분석을, 대처양식의 조절효과를 조사하기 위해 위계적 회귀분석을 실시하였다. 본 연구의 결과 첫째, 직접 외상 사건과 간접 외상 사건은 PTSD 증상에 유의한 영항을 주었다. 또한 직접 외상 사건보다 간접 외상 사건이 PTSD 증상에 더 큰 영향을 주었다. 둘째, 외상 사건 정도에 따른 PTSD 증상에서 문제중심적, 정서중심적, 역기능적 대처양식의 조절효과는 모두 유의하지 않았다. 다만, 역기능적 대처를 많이 사용할수록 PTSD 증상에 더 큰 영향을 주는 주효과만이 유의하였다. 이러한 결과는 경찰공무원의 외상 사건 유형의 정도에 따라 PTSD 증상에 미치는 영향이 차이에 주목하였으며 특히, 경찰공무원의 PTSD 증상 연구에 있어서 간접 외상 사건 경험의 중요성을 새롭게 인식하였다. 또한, PTSD 증상의 심리사회적 모형인 스트레스 과정 모델을 토대로 한 경찰공무원의 외상 사건 경험과 대처양식 간의 관계 모형을 통해 대처양식의 조절효과를 분석함으로써 국내 경찰 공무원의 정신 건강에 대한 개입 방향에 있어 본 연구의 결과 및 특성을 바탕으로 보다 실제적인 근거에 기반한 예방 및 위기 개입 프로그램에 대한 기초 연구 자료 및 추후 연구 방향에 대한 제안에 중요한 시사점을 준다.

의약품의 포장에 대한 소비자의 의견

김자혜 한국에프디시규제과학회(구 한국에프디시법제학회) 2009 한국에프디시법제학회 학술대회 Vol.2009 No.1

파브리병에서 효소대치요법의 장기적 효과

김자혜,조자향,최진호,이범희,유한욱,Kim, Ja Hye,Cho, Ja Hyang,Choi, Jin-Ho,Lee, Beom Hee,Yoo, Han-Wook 대한유전성대사질환학회 2014 대한유전성대사질환학회지 Vol.14 No.1

Fabry disease is an X-linked disease caused by deficiency of the lysosomal enzyme alpha-galactosidase A. Affected males present anhydrosis, acroparesthesia and angiokeratoma, and subsequently cardiac, cerebral and renal complications are followed. Females and atypical variants show heterogeneous clinical symptoms. In 2001, two recombinant enzymes were approved for Fabry disease: agalsidase alpha and agalsidase beta. Since the introduction of enzyme replacement therapy (ERT), the number of long-term follow-up studies has been reported. Long-term ERT showed effectiveness on renal function in patients with chronic kidney disease, decrease or stabilization of left ventricular mass, and improvement of pain and quality of life. However, there were limited effects on cerebrovascular events and their mortality. Current literatures on the clinical effect of ERT have reported limited datain adult patients who have already advanced disease. Therefore, further study for pre-symptomatic patients and atypical variants is needed to verify the impact of ERT. This review summarized recent progresses in ERT and limitations of long-term effect of ERT in patients with Fabry disease.

한방병원에 내원한 이명환자의 특성 및 삶의 질 분석

김자혜,김민희,신상호,고우신,김훈,윤화정,Kim, Ja-Hye,Kim, Min-Hee,Shin, Sang-Ho,Ko, Woo-Shin,Kim, Hoon,Yoon, Hwa-Jung 대한한방안이비인후피부과학회 2006 한방안이비인후피부과학회지 Vol.19 No.2

Backgroun : Tinnitus is common disorder with many possible causes and a symptom of many different diseases but has no effective treatment. Approximately 20% of tinnitus patients experience the disorder to a degree that their quality of lift and productivity are impaired. Objective : This study was conducted to investigate the characteristic of the tinnitus patients and the impact of tinnitus on quality of life. Methods : 103 patients un recruited in this study who was ill with tinnitus. They wrote out the queslicumaire about tinnitus and the Tinnitus Handicap Inventory(THI). Result : THI score have relation to set the period of birth, the loudness of tinnitus and the items of attending symptoms. Conclusion In this study, tinnitus have influence on patients' quality of life. We expect this study to provide the base data for the effective treatment and the high qualify of patients' life.

이명(耳鳴)의 한방(韓方) 치료(治療)에 의한 삶의 질 개선(改善) 효과(效果)

김자혜,김민희,신상호,고우신,김규곤,윤화정,Kim, Ja-Hye,Kim, Min-Hee,Shin, Sang-Ho,Ko, Woo-Shin,Kim, Kyu-Kon,Yoon, Hwa-Jung 대한한방안이비인후피부과학회 2006 한방안이비인후피부과학회지 Vol.19 No.3

Background : Tinnitus is a common symptom in outpatients of Otolarygology but has no correct diagnosis and effective treatment. Patients with tinnitus experienced the disorder to a degree that their quality of life and productivity are impaired. Objective : This study was conducted to investigate the change of THI score, the number of attending symptoms for the Korean medical treatment. And we investigated that the interrelationship is in existence as sex, age. Methods : Fatty patients were recruited in this study who was ill with tinnitus. They wrote out the questionnaire about tinnitus and the Tinnitus Handicap Inventory(THI) before and after treatment. The Korean medical treatment include a herb remedy, acupuncture. Result : THI score changed before and after treatment remarkably, and the number of attending sysmptoms also decreased noticeably. Relativity of questionnaires before and after treatment has difference as sex and age. Conclusion : Before and after treatment, the patients's THI score change significantly. In this study, the Korean medicine has effect on patients's quality of life with tinnitus. We expect that this study inform the effect of Korean Medicine about tinnitus and THI is the good questionnaire for measureing quality of patients' life with tinnitus for Korean medical doctors.

기획특집_요약 2009 낙농자조금 우유소비 촉진을 위한 조사 연구 - 우유의 구매 및 소비행태에 관한 연구 -

김자혜,Kim, Ja-Hye 한국낙농육우협회 2010 낙농·육우 Vol.30 No.2

Pathophysiology and clinical characteristics of hypothalamic obesity in children and adolescents

김자혜,최진호 대한소아내분비학회 2013 Annals of Pediatirc Endocrinology & Metabolism Vol.18 No.4

The hypothalamus plays a key role in the regulation of body weight by balancing the intake of food, energy expenditure, and body fat stores, as evidenced by the fact that most monogenic syndromes of morbid obesity result from mutations in genes expressed in the hypothalamus. Hypothalamic obesity is a result of impairment in the hypothalamic regulatory centers of body weight and energy expenditure, and is caused by structural damage to the hypothalamus, radiotherapy, Prader-Willi syndrome, and mutations in the LEP, LEPR, POMC, MC4R and CART genes. The pathophysiology includes loss of sensitivity to afferent peripheral humoral signals, such as leptin, dysregulated insulin secretion, and impaired activity of the sympathetic nervous system. Dysregulation of 11β-hydroxysteroid dehydrogenase 1 activity and melatonin may also have a role in the development of hypothalamic obesity. Intervention of this complex entity requires simultaneous targeting of several mechanisms that are deranged in patients with hypothalamic obesity. Despite a great deal of theoretical understanding,effective treatment for hypothalamic obesity has not yet been developed. Therefore,understanding the mechanisms that control food intake and energy homeostasis and pathophysiology of hypothalamic obesity can be the cornerstone of the development of new treatments options. Early identification of patients at-risk can relieve the severity of weight gain by the provision of dietary and behavioral modification, and antiobesity medication. This review summarizes recent advances of the pathophysiology,endocrine characteristics, and treatment strategies of hypothalamic obesity.

Efficacy of growth hormone therapy in adults with childhood-onset growth hormone deficiency

김자혜,조자향,유한욱,최진호 대한소아내분비학회 2014 Annals of Pediatirc Endocrinology & Metabolism Vol.19 No.1

Purpose: Growth hormone (GH) plays a key role in the regulation of bodycomposition, lipid metabolism, and quality of life in adults with GH deficiency (GHD). This study investigated changes in laboratory findings and body compositionafter GH recommencement for adult GHD and analyzed correlation between GHinterruption period and endocrine or anthropometric parameters. Methods: A total of 45 patients (17 females and 28 males) diagnosed withchildhood-onset GHD (CO-GHD) were investigated and all patients had organicbrain lesions. Patients diagnosed CO-GHD were retested to confirm adult GHD atage 20.4±5.0 years (18.0–32.1 years). Recombinant human GH was administered ata dose of 0.44 mg/day. Clinical and laboratory parameters such as weight, height,body mass index (BMI), serum insulin-like growth factor 1 (IGF-1), serum totalcholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein(LDL) cholesterol, and triglyceride levels, were compared between baseline and12 months after treatment using paired t-test. In addition, correlation between GHinterruption period and clinical parameters including BMI, lipid profile, IGF-1, andIGFBP-3, was analyzed. Results: Of 45 patients, 33 patients had GH interruption period of 4.3±3.6 years(0.7–12.5 years). Serum HDL-cholesterol level increased significantly, whereas LDLcholesteroldecreased after 1 year of GH replacement therapy. However, bodyweight and BMI showed no significant changes after 1 year of GH replacementtherapy. There were no significant correlations between GH interruption period andlipid profile or anthropometric parameters. Conclusion: BMI and body weight were not affected by GH replacement. However,GH replacement in adults with GHD offers benefits in lipid metabolism.

텔레비전 광고에서 나타난 남성문화

김자혜 한국사회학회 1996 한국사회학회 사회학대회 논문집 Vol.- No.-

초점 - 유사석유제품 유통 근절을 위한 소비자운동은 계속돼야 한다

김자혜,Kim, Ja-Hye 대한석유협회 2009 석유와 에너지 Vol.274 No.-