전이 췌장암 환자의 Gemcitabine과 방암탕 가감방 및 건칠단 병용투여 치험 1례

김은혜,윤성수,이지영,윤성우,Kim, Eun Hye,Yoon, Sung Soo,Lee, Jee Young,Yoon, Seong Woo 대한암한의학회 2018 大韓癌韓醫學會誌 Vol.23 No.2

Objectives: This study was aimed to report a patient with metastatic pancreatic cancer treated with modified Bangam-tang and Gunchil-dan in conjunction with gemcitabine. There were better survival-related outcomes compared to gemcitabine alone. Methods: The patient with metastatic pancreatic cancer received gemcitabine as palliative chemotherapy since June 2016 concurrent with modified Bangam-tang and Gunchil-dan since October 2016 to October 2017. To evaluate the effect of treatment, tumor markers (carbohydrate antigen 19-9 (CA19-9) and carcinoembryonic antigen (CEA)), Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1, and overall survival were checked. Adverse events were evaluated according to the Common Terminology Criteria for Adverse Events (CTCAE) version 5.0. Results: After 12 months with the combination treatment, levels of CA19-9 were decreased from 8747 to 265.7 ng/ml and CEA from 42.2 to 6.5 U/ml. Clinical partial response state was shown until May 2, 2017 and stable disease state was maintained from August 4, 2017. In March 2018, the patient got an operation including pancreatectomy and diagnosed with no evidence of disease state in September, 2018. In conclusion, it showed the overall survival of 29 months from June, 2016 to November, 2018. Serious adverse events were not identified. Conclusions: This study suggested that combined treatment with modified Bangam-tang and Gunchil-dan may show better outcome in patient with metastatic pancreatic cancer than gemcitabine alone.

청소년이 지각한 사회적 자본이 유데모니아에 미치는 영향: 인권의식을 매개로

김은혜,손한결,Kim, Eun Hye,Sohn, Han Gyeol 한국학교ㆍ지역보건교육학회 2021 한국학교지역보건교육학회지 Vol.22 No.3

Objectives: The purpose of this study was to examine the mediating effect of human rights consciousness on the relationship between social capital and eudaimonia perceived by adolescents. Methods: The participants of this study were 9,021 adolescents, with data taken from the 6^th year(2018) panel survey. All variables were evaluated by self-report of adolescents. The data were analyzed by SPSS 21.0 and AMOS 21.0. Results: First, social capital perceived by adolescents had a direct effect on eudaimonia. Second, social capital perceived by adolescents had an indirect effect on the eudaimonia through human rights consciousness. Conclusions: This study highlighted that human rights consciousness was identified as important mediator in the relationship between capital perceived by adolescents and eudaimonia. These results can be used as an important contribution to further research and educational practices for promoting the eudaimonia in adolescents.

항암화학요법 유발 말초신경병증에 대한 한약의 치료 효과: 체계적 문헌고찰 및 메타 분석

김은혜,윤지현,이지영,윤성우,Kim, Eun Hye,Yoon, Jee-hyun,Lee, Jee Young,Yoon, Seong Woo 대한암한의학회 2020 大韓癌韓醫學會誌 Vol.25 No.2

Objective: This study was aimed to report the therapeutic effects of herbal medicine on chemotherapy-induced peripheral neuropathy (CIPN). Methods: The prior studies were searched from the databases included PubMed, Cochrane Library, EMBASE, CNKi, CiNii, KISS, NDSL, KMBASE, and OASIS until September 2020. The main search keywords were chemotherapy, peripheral neuropathy, and herbal medicine, and only randomized controlled trials that analyzed the therapeutic efficacy of herbal medicine were included. The Cochrane's Risk of Bias was used for assessment of the risk of bias and the Review Manager 5.3 program was used for meta-analysis. Meta-analyses were grouped by the administration routes of herbal medicines (oral administration or topical use). Results: Nine studies with a total of 563 participants were included. Compared with usual care, the effective rate was higher in oral administrated herbal medicine (RR 1.67, 95% CI 1.25 to 2.23; p<0.001, I2=31%). In addition, topical herbal medicine showed an significantly higher effective rate than placebo (RR 2.20, 95% CI 1.52 to 3.18; p<0.001, I2=0%) and usual care (RR 2.24, 95% CI 1.74 to 2.89; p<0.001, I2=66%). There was no severe adverse effect in all participants. Conclusions: Herbal medicine appears to improve neuropathy caused by chemotherapy in cancer patients more than conventional therapy of CIPN. However, as there is heterogeneity between the included studies and a lack of blinding, further well-designed researches are more needed.

겹치기 마찰교반접합 된 Al6061/HT590 합금의 기계적 특성 평가

김은혜,이광진,송국현,Kim, Eun-Hye,Lee, Kwang-Jin,Song, Kuk-Hyun 대한용접접합학회 2015 대한용접·접합학회지 Vol.33 No.2

This study was carried out to evaluate mechanical properties of the jointed Al6061/HT590 alloys by friction stir welding (FSW). FSW was conducted under the conditions with tool rotating speed of 500 RPM and traveling speed of 300 mm/min., where Ar gas was introduced to prevent the materials from corrosion during the welding process. Electron back-scattering diffraction (EBSD) was used to characterize microstructures such as grain size, misorientation angle and crystal orientation. Evolution of intermetallic compounds in Al6061 during the process were examined in terms of morphology, size and aspect ratio at three distinct zones Al base material, heat affected zone and stir zone, where transmission electron microscope (TEM) was used. It was revealed that FSW gave rise to refinement of grains as well as growth of intermetallic compounds in Al6061. The morphological changes of intermetallic compounds exerted an influence on mechanical properties, resulting in occurrence of fracture in the part of the base material instead of the jointed parts (heat affected zone and stir zone). This study systematically evaluated the microstructural evolutions during the FSW for joining Al6061 with HT590 and their effect on mechanical properties.

마찰접합 된 A6063 합금의 미세조직과 기계적 특성 평가

김은혜,조형환,송국현,Kim, Eun-Hye,Cho, Hyung-Hwan,Song, Kuk-Hyun 한국재료학회 2017 한국재료학회지 Vol.27 No.5

This study was carried out to evaluate the developed microstructures and mechanical properties of friction welded A6063 alloy. For this work, specimens were prepared at a size of 12 mm ${\O}{\times}80mm$, and friction welding was carried out at a rotation speed of 2,000 RPM, friction pressure of $12kgf/cm^2$ and upset pressure of $25kgf/cm^2$. To perform an analysis of the grain boundary characteristic distributions, such as the grain size, orientation and misorientation angle distributions, the electron back-scattering diffraction method was used. In addition, in order to identify the dispersed intermetallic compounds of the base and welded materials, transmission electron microscopy was used. The experimental results found that the application of friction welding on A6063 led to significant grain refinement of the welded zone relative to that of the base material. Besides this, intermetallic compounds such as AlMnSi and $Al_2Cu$ were found to be dispersed with more refined size relative to that of the base material. This formation retains the mechanical properties of the welds, which results in the fracture aspect at the base material zone. Therefore, based on the developed microstructures and mechanical properties, the application of friction welding on A6063 could be used to obtain a sound weld zone.

고등학생의 방과후학교참여 특성변인이 방과후학교만족도에 미치는 영향

김은혜 ( Kim Eun Hye ),곽종형 ( Kwak Jong Hyung ) 한국사회복지경영학회 2017 사회복지경영연구 Vol.4 No.1

본 연구의 목적은 고등학생의 방과후학교참여 특성변인이 방과후학교만족도에 얼마나 영향이 있었는지를 검증하는데 있으며 구체적인 연구문제는 다음과 같다. 첫째, 고증학생의 국어방과후학교참여 특성변인이 국어방과후학교만족도에 어떠한 영향을 미치는가. 둘째, 고등학생의 수학방과후학교참여 특성변인이 수학방과후학교만족도에 어떠한 영향을 미치는가. 셋째, 고등학생의 영어방과후학교참여 특성변인이 영어방과후학교만족도에 어떠한 영향을 미치는가이다. 수원, 안산지역의 고등학교 1학년 학생들 240명을 대상으로 SPSS 22.0 프로그램을 이용하여 영향관계 분석을 위하여 회귀분석을 실시하였으며, 고등학생의 국어·수학·영어 관련 방과후학교만족도를 분석하였으며, 결론은 다음과 같다. 첫째, 고등학생의 국어방과후학교참여 특성변인 중에서 국어방과후학교참여 변인만이 국어방과후학교만족도에 영향을 미쳤다. 둘째, 고등학생의 수학방과후학교참여 특성변인 중에서 학생의 수학성적변인만이 수학방과후학교만족도에 영향을 미쳤다. 셋째, 고등학생의 영어방과후학교만족도에 영향을 미치는 영어방과후학교참여 특성변인은 학생의 영어성적과 영어방과후학교참여이다. 따라서 방과후학교를 활성화시키기 위해 계속 노력해야 할 것으로 보인다. The purpose of this study is to explore how much the information about the after- school participation affects the satisfaction scale of after-school program. To achieve this goal the specific research question was posed: What is the effect like that the information about the after-school participation in Korean language, Math and English has on the satisfaction scale of after-school classes of them? Regression analysis was conducted with SPSS 22 program. The results are as follows; the participation in after-school program is the influential factor of the satisfaction scale of after-school class of Korean language whereas the student`s test score affects satisfaction scale of after-school class of Math. In the case of English class both the participation and the grade affect the satisfaction scale.

이모티콘 이용에 대한 동조 욕구와 독특성 추구 욕구가 유료이모티콘 구매 의도에 미치는 영향 : 한·중 간 문화 비교

김은혜(Kim, Eun-hye),이희태(Lee, Hee Tae),정보희(Jung, Bo-hee) 한국상품학회 2020 商品學硏究 Vol.38 No.1

본 연구는 모바일 인스턴트 메신저(Mobile Instant Messenger; MIM) 내 이모티콘 이용 동기로 이모티콘 이용에 대한 동조욕구와 독특성 추구 욕구를 제안하고, 이들 동기가 유료 이모티콘 구매의도에 어떠한 영향을 미치는지에 대해 한국 및 중국 소비자를 대상으로 비교연구를 진행하였다. 연구의 주요 분석결과를 요약하면 다름과 같다. 이모티콘 사용에 대한 소비자의 동조 욕구는 이모티콘 구매의도에 유의미한 정(+)의 영향을 미치고 있음을 확인할 수 있었다. 즉 이모티콘 사용에 대한 동조 욕구가 높을수록 구매의도도 높아짐을 실증적으로 검증하였다. 그러나 이러한 동조의 효과는 한국에서만 나타나고 있으며, 중국에서는 발생하지 않았다. 반면, 독특성 추구 욕구가 이모티콘 이용 행동에 미치는 영향은 한국과 중국 모두에서 유의미하게 나타났다. 즉 MIM 내 이모티콘 이용에 있어 독특성 추구 욕구가 높을수록 이모티콘 구매의도도 높게 나타났다. 마지막으로 MIM 내 이모티콘 이용 동기로서 동조 욕구와 독특성 추구 욕구가 이모티콘 구매의도에 미치는 영향은 문화 차이(한국 vs. 중국)에 의해 조절됨을 확인하였다. 보다 구체적으로 한국 소비자가 중국소비자에 비해 이모티콘 사용에 대한 동조 욕구와 독특성 추구 욕구가 구매의도에 미치는 영향이 더 크게 나타났다. 마지막으로 이러한 결과를 바탕으로 한 본 연구의 이론적, 실무적 함의에 대해 논의하였다. Based on social influence perspectives, we aimed to empirically investigated the effect of needs for conformity and needs for uniqueness as one of important emoticon usage motives on emoticon purchase intentions for MIM(mobile instant messenger). Also we verified the moderating role of cultural difference(Korea vs. China) on the relationship between these emoticon usage motives(e.g. needs for conformity and needs for uniqueness of using emoticon) and emoticon purchase intentions. As a result of the analysis, needs for conformity positively impacts on emoticon purchase intentions only for Korean. However, there was no significant main effect of needs for conformity on emoticon purchase intentions for Chinese. Needs for uniqueness of using emoticon positively affect emoticon purchase intentions in both Korean and Chinese consumers. The finding also showed that the effect of needs for conformity and needs for uniqueness of using emoticon on emoticon purchase intentions was moderated by cultural difference between Korea and China. In line with our predictions, the main effect of needs for conformity and needs for uniqueness of using emoticon on emoticon purchase intention was larger for Korean consumers than for China consumers. Practical, theoretical implication and this paper’s limitations are also discussed.

소셜미디어 시대의 설화 활용 문학교육방안: 노원구 지역설화를 중심으로

김은혜(Kim, Eun Hye),정소연(Chung, So Yeon) 학습자중심교과교육학회 2019 학습자중심교과교육연구 Vol.19 No.13

본 연구는 2000년과 2005년의 『인구주택총조사』를 토대로 한 인구이동 분석을 바탕으로 글로벌리즘에서 글로컬리즘으로 변화하고 있는 사회적 흐름을 해석하였고, 멀티미디어에서 소셜미디어로 변화한 현대사회의 문학교육방안을 모색하였다. 농촌 에서 도시로 인구가 밀집되던 산업화 시기와 달리 현대사회는 오히려 수도권에서 비수도권으로 인구가 분산되는 인구이동 경향을 보인다. 또한 소셜미디어는 청소년들에게 친숙한 소통방식으로서 일상생활 문화의 한 부분으로 자리매김하고 있는데, 지 역설화는 ‘상호소통, 공통의 관심사 촉발, 커뮤니티 형성’이라는 소셜미디어의 특성을 가장 긴밀하게 공유하는 문학의 하위 갈래로서 현대적인 방식의 교수-학습과 문학생활화를 가능하게 만든다. 따라서 본 논의는 구비문학, 특히 지역설화를 활용한 문학교육을 통하여 청소년 학습자에게 사회적·문화적 정체성을 부여하고, 다른 문화를 접촉·수용하는 과정에서 확고한 정체성을 바탕으로 사회 통합을 주체적으로 주도해나 갈 수 있는 능력을 함양시키기 위한 방법을 모색하고 있다. 지역설화를 활용한 문학교육은 청소년의 정체성, 관용정신을 함양시키는 전인적 차원의 교육적 효용을 높이며, 소셜미디어 시대를 살아가는 청소년 학습자에게 익숙하고 친밀한 문학공부 방법을 제시한다. Based on the population movement analysis based on the “Population Housing Survey” in 2000 and 2005, this study analyzed the social trends that are changing from globalism to glocalism, and explored the methods of literature education in the modern society that have changed from multimedia to social media. Unlike the era of industrialization, modern society tends to spread its population from the Seoul metropolitan area to the non-capital areas. It is very important for learners to consolidate their identity in this social trend. In the process of contacting and embracing other cultures, they will be able to lead the integration of society by themselves when their firm identity is based on. Especially regional folktale helps youth learners to express their own individuality by giving them social and cultural identities, a period of forming their identity. Social media has also established itself as a part of everyday culture as a communication style that is familiar to teenagers, making it possible for modern methods of teaching-learning and regional folktale shares the characteristics of social media: mutual communication, triggering common interests, and forming a community. Using local folktale, the education system enhances the educational utility of the whole level that fosters the identity and tolerance of young people, and presents a familiar and intimate way of studying literature for young learners living in the age of social media. As part of that method, we propose the creation and sharing of localized content, the creation and sharing of UCCs linking villages. We hope this discussion will be a development discussion that will provide new ideas for learner-oriented education.

다문화 청소년의 자아존중감, 신체만족도, 학교생활적응 간의 종단적 상호인과관계

김은혜(Kim, Eun Hye),최려나(Cui, Lina),노충래(Nho, Choong Rai) 한국아동복지학회 2021 한국아동복지학 Vol.70 No.3

본 연구는 다문화 청소년의 자아존중감, 신체만족도, 학교생활적응 간의 종단적 상호인과관계를 살펴보고 이에 따른 다문화 청소년 복지의 함양을 위한 방안을 모색하는 것이다. 이를 위해 다문화청소년패널데이터(MAPS) 중 초·중학생의 전환기 시기인 3∼5차년도 데이터를 자기회귀교차지연모형을 통해 분석하였으며, 다문화 아동 1,307명이 연구대상이다. 연구결과, 첫째, 초등학교 6학년부터 중학교 2학년까지의 세 변인인 자아존중감, 신체만족도, 학교생활적응의 자기회귀경로에서, 이전 시점의 자아존중감, 신체만족도, 학교생활적응이 각각 이후 시점에 유의하게 영향을 미치는 것으로 나타났다. 둘째, 자아존중감과 신체만족도 간에는 종단적 상호인과관계가 유의하게 영향을 미쳤으며, 또한 자아존중감과 학교생활적응 간에도 종단적 상호인과관계가 있음을 확인하였다. 하지만 신체만족도와 학교생활적응 간에서는 학교생활적응은 신체만족도에 유의한 영향을 미쳤으나, 신체만족도는 학교생활적응에 유의한 영향을 미치지 않는 것으로 나타났다. 이러한 결과를 바탕으로 다문화 아동·청소년 복지의 함의를 논하였다. The purpose of this study was to explore longitudinal reciprocal effects between self-esteem, body satisfaction, and school adjustment and to discuss implications for the social welfare of adolescents from multicultural families. For this purpose, we used data from the third (2012), the fourth (2013), and fifth (2014) waves of the Multicultural Adolescents Panel Study (MAPS). An autoregressive cross-lagged model was used to test reciprocal effects, and 1,307 adolescents responded to the three above-mentioned waves of MAPS. The findings were as follows. First, self-esteem, body satisfaction, and school adjustment in the third wave had significant effects on self-esteem, body satisfaction, and school adjustment in the fourth and fifth waves, respectively. Second, there was a statistically significant longitudinal reciprocal relationship between self-esteem and body satisfaction. In addition, self-esteem had a significant longitudinal reciprocal relationship with school adjustment. However, school adjustment had a statistically significant longitudinal effect on body satisfaction, but not vice versa. On the basis of the results, we offer suggestions to improve self-esteem, school adjustment, and body satisfaction among adolescents from multicultural families.

노인의 교구 활동을 통한 회상요법 프로그램 적용에 따른 인지기능 변화

김은혜(Kim Eun-Hye),김형균(Kim Hyung-Gyun) 공주교육대학교 초등교육연구원 2021 敎育論叢 Vol.58 No.2

이 연구는 노인의 교구(퍼즐·블록) 활동을 통한 회상요법 프로그램 적용에 따른 인지기능 변화를 살펴보는 데 그 목적을 두었다. 본 연구를 위해 인천광역시에 거주하고 있는 특정 구 소재의 주간 보호 센터를 이용하는 노인 14명을 연구의 참여자로 선정하였다. 양적 연구를 위하여 IBM SPSS. 21. 프로그램을 이용하여 t 검정과 빈도분석을 하였다. 이 연구의 결과를 요약하면 다음과 같다. 첫째, 교구 활동프로그램을 적용한 후 노인의 인지기능검사를 한 결과는 사후검사에서 사전검사 한 것에 비해 인지기능 평균이 높게 나타났고, 인지기능 6가지 하위 영역 모두에서 유의미한 차이가 있는 것으로 나타났다. 둘째, 회상을 중심으로 교구 활동을 적용함으로써 노인의 인지기능이 증가하였고 긍정적인 효과를 보았다. 전반기 단계에서 대상자들이 서로에게 관심을 보이지 않았으며, 자신에 관한 이야기도 표현하지 않는 모습을 보였다. 중반기 단계에서는 서로 공감해주며 위로해 주는 모습이 보였으며, 언어적 표현이 증가하는 모습을 볼 수 있었다. 후반기 단계에서도 서로 간의 배려와 유대관계가 형성되었고, 교구(퍼즐·블록) 활동을 통해 함께 공유하며 적극적으로 참여하는 모습을 볼 수 있었다. 셋째, 교구 활동을 통해 회상요법 프로그램이 노인의 정서적 반응에 변화를 주는 것으로 볼 수 있다. 이러한 결과는 노인에게 있어서 지나온 생애를 회상하며 교구를 활용함으로 집단 내에서 상호작용 때문에 흥미 유발과 즐거움을 제공하고 인지적, 정서적으로 영향을 준 것으로 볼 수 있다. 교구 활동(퍼즐·블록)을 통한 회상요법 프로그램이 노인의 인지기능 향상과 유지에 변화가 있었다는 이 연구의 결과를 바탕으로, 노화로 인해 치매가 의심되는 노인들에게 인지기능 유지를 위한 유용한 프로그램으로 활용되기를 기대한다. For this study, 14 elderly people who use the day care center in a specific district in Incheon Metropolitan City were selected as participants in the study. The test tools used questionnaires senior cognitive function tests (MMSE-K), life satisfaction measures (LSS), and a series of records of individual behavioral changes in the Recalling Act. In this study, we collected data by session while conducting parish activities and recall therapy programs through qualitative research used IBM SPSS. 21. program for quantitative research and conducted t-testing and frequency analysis. The results of this study are summarized as follows. First, the results of MMSE-K showed a higher cognitive average compared to the pre-inspection, There were significant differences in all six sub-regions of cognitive function. Second, as a result of each session s program, the subjects showed no interest in each other in the first half of the year, nor did they express stories about themselves. And he did not voluntarily participate in the conversation. However, through parish activities, tension was relaxed and we began to get interested in each other little by little. The mid-term stage was seen to sympathize with and comfort each other, and verbal expressions were increasing. In the second half of the year, consideration and ties were formed between each other and through parish(puzzle·block) activities, they could be seen sharing and actively participating with each other. Third, through the teaching aid activities, recall therapy programs can be seen as changing the emotional response of the elderly. These results can be seen as recalling the past life for the elderly and using teaching aids, providing interest and enjoyment by interaction within the group and influencing them cognitively and emotionally. As a result of these studies, recall therapy programs through the teaching aid(puzzle·block) activity have changed the cognitive function of the elderly. We hope that it will be used as a useful program to maintain cognitive function for senior citizens who are suspected of dementia due to aging.