만성치주염 환자에 대한 저용량 독시싸이클린의 임상적 효과

김윤식,백정원,김창성,최성호,김종관,Kim, Yoon-Sik,Paik, Jeong-Won,Kim, Chang-Sung,Choi, Seong-Ho,Kim, Chong-Kwan 대한치주과학회 2002 Journal of Periodontal & Implant Science Vol.32 No.2

Periodontal disease is a complex infectious disease caused by bacteria in the oral mucosa, which results in gingival inflammation, breakdown of periodontal tissues, bone resorption, and finally tooth loss. Mechanical plaque control methods-scaling and root planing are effective methods to stop the progression of such periodontal disease. It was reported that subantimicrobial dose of doxycycline(SDD) regimen could improve clinical conditions of periodontal tissues without causing the overgrowth of opportunistic organisms that was a typical antibiotic side effect. Therefore pharmacological therapy, used in conjunction with mechanical therapy could be considered a useful treatment modality in the treatment of chronic periodontal disease. In this study, 30 patients diagnosed as moderate to advanced chronic periodontitis were divided into 2 groups. In this double-blind, placebo-controlled study, the patients were administered 20mg doxycycline capsule or placebo capsule b.i.d. for 4months, after scaling and root planing. Clinical parameters-bleeding on probing, pocket depth and clinical attachment level were compared and evaluated between these groups at periods of first visit, 1 month, 2 months, 3 months, 4 months. The results were as follows ; 1. In case of moderate periodontitis, pocket depth showed significant reduction after treatment in both the control & experiment groups, when compared with the baseline values(p<0.01), but in case of advanced periodontitis, only the experiment group showed significant reduction after treatment when compared with the baseline values(p<0.05). Statistically significant reduction in pocket depth was observed in the experiment group compared to the control group(p<0.05). 2. In case of moderate periodontitis, clinical attachment level showed significant reduction after treatment in both the control & experiment groups, when compared with the baseline values(p<0.01), but in case of advanced periodontitis, only the experiment group showed significant reduction after treatment when compared with the baseline values(p<0.05). Statistically significant reduction in clinical attachment level was observed in the experiment group compared to the control group(p<0.05). 3. Bleeding on probing improved after treatment in both the groups. In case of moderate periodontitis, the experiment group showed statistically significant reduction of bleeding on probing when compared with the control group at 1 and 4 months after treatment(p<0.05). In case of advanced periodontitis, treatment resulted in statistically significant reduction of bleeding on probing in both the groups(p<0.05). These results indicate that the use of subantimicrobial dose of doxycycline is a useful supplement to mechanical treatment for periodontal patients in ameliorating the clinical parameters such as periodontal pocket, attachment level, and bleeding on probing.

교통류 모형을 이용한 도로 점용공사 구간의 지체비용 산정방안

김윤식,이민재,Kim, Yunsik,Lee, Minjae 한국건설관리학회 2016 건설관리 : 한국건설관리학회 학회지 Vol.17 No.5

이용자 비용은 SOC 시설물의 효율적 자산관리를 위한 LCCA에서 시설물의 생애주기, 관리자 비용 그리고 할인율과 함께 반드시 고려되어야 하는 주요한 분석 항목이다. 특히, 도로분야에서는 청소 및 유지보수 등의 공사구간(Work zone)으로 인해 이용자들에게 막대한 지체비용이 발생되는 경우가 많으며, 이와 같은 경우 관리자는 보다 합리적인 의사결정을 위해 관리자비용 뿐만아니라 이용자비용까지도 고려해야만 한다. 그러나 최근까지도 대부분의 의사결정 단계에서 이용자 비용은 고려되지 않고 있으며, 이에 관한 연구들도 활발하지 못한 실정이다. 본 연구에서는 교통류 모형과 교통시설 투자 평가 지침의 직접편익 산정 모델을 이용하여 의사결정 단계에서 필요한 이용자 비용 및 지체비용을 산정 하는 방법론을 제안한다. 그리고 2014년 실제 유지보수가 시행되었던 국도 4개구간에 대해 VISSIM을 이용하여 교통류 모형을 추정하고 제안된 방법론을 토대로 이용자 비용 및 지체비용을 산정하였다. 분석결과, AADT 약 3만대의 A구간은 공사구간 발생 전 평균 17,569천원/$km{\times}day$의 이용자 비용이 발생하는 것으로 분석되었으며, 유지보수로 인해 1차로를 차단 할 경우 추가적으로 평균 10,193천원/$km{\times}day$(158%)의 지체비용이 발생하는 것으로 분석 되었다. AADT 약 2만대의 B구간과 D구간에서는 각각 1,507천원/$km{\times}day$(115%), 1,985천원/$km{\times}day$(119%)의 지체비용이 발생되는 것으로 분석되었으며, AADT 약 1만대의 C구간에서는 262천원/$km{\times}day$(105%)의 지체 비용이 발생하는 것으로 나타났다. 본 연구의 결과는 교통류 모형을 시뮬레이션 기반으로 추정함으로서 실제 적용에는 한계가 있다. 향후 실제 관측 자료를 이용한 적정성 높은 모형의 개발과 시뮬레이션 검증을 통해 적용 가능성을 높이는 연구가 필요할 것으로 판단된다. The user cost is an important analysis item which should be considered together with life-cycle of facility, administrator cost and discount rate in LCCA for efficient asset management of SOC facilities. Especially, a significant delay cost occurs often for users in the road field due to a work zone for cleaning and maintenance, and in such case, the administrator should consider the administrator cost as well as the user cost for more rational decision making. However, the user cost has not been considered in most decision making steps until recently and relevant studies also have not been carried out actively. In this study, the methodology to estimate the user cost and delay cost required in the decision making step using the traffic flow model and the direct benefit estimation model in the traffic facility investment evaluation guideline is suggested. And, the traffic flow model was estimated on 4 national highway sections where maintenance was actually carried out in 2014 using VISSIM and, the user cost and the delay cost were estimated based on the suggested methodology. The analysis result showed that the average user cost of $17,569,000KRW/km{\times}day$ occurred on Section A with approximately 30,000 AADT before a work zone occurred, and in case the first lane was blocked for maintenance, the delay cost of $10,193,000KRW/km{\times}day$ (158%) on average occurred additionally. The delay cost of $1,507,000KRW/km{\times}day$ (115%) and $1,985,000KRW/km{\times}day$ (119%) occurred on Sections B and D with approximately 20,000 AADT respectively and the delay cost of $262,000KRW/km{\times}day$ (105%) occurred on Section C with approximately 10,000 AADT. This result of this study was estimated based on the simulation of traffic flow model so that there is a limitation in its actual application. A study ot develop a highly appropriate model using actual observation data and improve the possibility to apply it through the verification using the simulation will be necessary in future.

북해도 흑모화종 개량의 기본요강 및 발전방향

김윤식,Kim, Yun-Sik 한국종축개량협회 2006 種畜改良 Vol.11 No.8

2006년 한우개량 결산과 계획

김윤식,Kim, Yun-Sik 한국종축개량협회 2007 種畜改良 Vol.12 No.1

유전 알고리듬과 반응표면을 이용한 천음속 익형의 최적설계

김윤식,김종헌,이종수,Kim, Yun-Sik,Kim, Jong-Hun,Lee, Jong-Soo 대한기계학회 2002 大韓機械學會論文集A Vol.26 No.12

The design of airfoil had practiced by repeat tests in its first stage, though an airfoil has as been designed based on simulations according to techniques of computational fluid dynamics. Here, using of traditional optimization is unsuitable because a state of flux is hypersensitive to the shape of airfoil. Therefore the paper optimized the shape of airfoil in transonic region using a genetic algorithm (GA). Response surfaces are based on back propagation neural network (BPN) and regression model. Training data of BPN and regression model were obtained by computational fluid dynamic analysis using CFD-ACE, and each analysis has been designed by design of experiments.

산업체에서의 폐열회수 사례

김윤식,Kim, Yun-Sik 한국설비기술협회 1989 설비 : 공조ㆍ냉동ㆍ위생 Vol.6 No.2

H. pylori 감염 진단 시 ¹⁴C-요소호기검사의 임상적 유용성

김윤식,Kim, Yoon-Sik 대한임상검사과학회 2007 대한임상검사과학회지(KJCLS) Vol.39 No.3

Helicobacter pylori (H. pylori) infection is common in korea and high incidence at gastric ulcer and duodenal ulcer. $^{14}C-urea$ breath test ($^{14}C-UBT$) is regarded as a highly reliable and non-invasive method for the diagnosis of H. pylori infection. The purpose of this study was to evaluate the diagnositc performance of a new and rapid $^{14}C-UBT$, which was equipped with Geiger-Muller counter and compared the results with those obtained by gastroduodenoscopic biopsies (GBx). One hundred sixty-eight patients (M : F = 118 : 50) underwent $^{14}C-UBT$, rapid urease test (CLO test), and GBx. The results of $^{14}C-UBT$ were classified as positive (>50 cpm), borderline (25<p<50 cpm), or negative (<25 cpm) and CLO tests were classified as positive or negative according to color change. The results of GBx on giemsa stain were distribution of H. pylori by the Wyatt method. We compared $^{14}C-UBT$ or CLO test results with GBx as a glod standard. In the assessment of the presence of H. pylori infection, the $^{14}C-UBT$ global performance yielded positive predictive value, negative predictive value and accuracy of 93.3% and 83.3%, respectively. However, the CLO test had performance yielded positive predictive value, negative predictive value and accuracy of 76.9%, 50.0%, respectively. In this study $^{14}C-UBT$ is a highly accurate, simple and non-invasive method or the diagnosis of follow up H. pylori infection.

'조선의 발렌티노' 임화와의 대화-근대문학사를 위한 노교수의 변명

김윤식,Kim, Yun-Sik 대한출판문화협회 1998 출판저널 Vol.228 No.-

High - index 대수 미분방정식으로 모델링된 비선형 화학 공정의 구조적 제어성 평가

김윤식,윤인섭 ( Yoon Sik Kim,En Sup Yoon ) 한국화학공학회 1996 화학공학의이론과응용 Vol.2 No.2

가리봉 ( 강원 ) 의 식물상 및 보존대책

김윤식,정규영,강명숙,전의식 ( Yun Shik Kim,Gyu Young Chung,Myoung Suk Kang,Eui Shik Jeon ) 한국환경생물학회 1994 환경생물 : 환경생물학회지 Vol.12 No.2

The flora of Kari-bong (1518.5m) was investigated to compare the flora of Mt. Sorak National Park, located close by this area. The vascular plants, collected from May, 1989 to October, 1992, were consisted of a total 652 taxa; 96 families, 348 genera, 569 species, 2 subspecies, 76 varieties and 5 forms. Among them, 554 taxa (85% of total taxa) were distributed in Mt. Sorak National Park. The Korean endemic plants of this area were 37 taxa, the rare and endangered plants were 27 taxa, the special wild plants designating by Environmental Agency were 12 taxa and the alpine plants were 34 taxa. Because many plants, being necessary to conserve, are distributed, Kari-bong should be include into Mt. Sorak National Park, but if development is indespensable, destruction of natrural ecosystem must be minimized.