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김성환,임정현,박나형,문창종,박수현,강성수,배춘식,김성호,신동호,김종춘,Kim, Sung-Hwan,Lim, Jeong-Hyeon,Park, Na-Hyeong,Moon, Changjong,Park, Soo-Hyun,Kang, Seong-Soo,Bae, Chun-Sik,Kim, Sung-Ho,Shin, Dong-Ho,Kim, Jong-Choon 대한수의학회 2010 大韓獸醫學會誌 Vol.50 No.2
This study investigated the potential effects of amitraz on the pre- and postnatal development, behavior, and reproductive performance of offspring of parent rats given amitraz during pre-mating, gestation, and lactation. The test chemical was administered via the drinking water containing 0, 40, 120, and 360 ppm to male rats from 2 weeks before mating to the end of 14-day mating period and to females from 2 weeks before mating, throughout mating, gestation and lactation up to weaning. Based on fluid consumption, the male rats received an average of $0,\;5.7{\pm}1.33,\;13.2{\pm}2.08,$ and $35.8{\pm}3.42$ mg/kg/day amitraz, and the female rats received an average of $0,8.7{\pm}4.42,\;20.1{\pm}9.60,\;and\;47.6{\pm}22.38$ mg/kg/day amitraz, respectively. At 360 ppm, an increase in the incidence of abnormal clinical signs, a suppression in the body weight gain, a decrease in the food consumption and litter size, an increase in the post-implantation loss, and a decrease in the seminal vesicle weight were observed in the parent animals. In addition, a suppression in the body weight gain, a decrease in the grip strength, a delay in the negative geotaxis, an increase in the pre- and post-implantation loss, and a decrease in the number of live embryos were observed in the offspring. At 120 ppm, suppressed body weight gain and reduced food consumption were observed in the parent rats. Suppressed body weight gain and decreased grip strength were also observed in the offspring. There were no signs of either reproductive or developmental toxicity at 40 ppm. Under these experimental conditions, the no-observed-adverse-effect level of amitraz for parent rats and their offspring was estimated to be 40 ppm in rats.
알루미노 실리케이트계 내화보드와 C-STUD를 이용한 고강도 콘크리트의 내화성능
김성환,박지선,이세현,Kim, Seong-Hwan,Park, Ji-Sun,Lee, Sea-Hyun 대한건축학회 2011 대한건축학회논문집 Vol.27 No.11
As high-rise buildings are increasingly constructed on recent days, high-strength concrete is also increasingly used. However, since high-strength concrete happens to have a spalling phenomenon, it is currently required to ensure the fire safety of high-strength concrete as soonest as possible. Therefore, a number of research and development projects are in progress for developing a construction method to ensure the fire-proofing performance of high-strength concrete. In this study, discussion has been done on the fire-proofing performance of the member which was constructed by dry-covering high-strength concrete with alumino-silicate fire resistant board and C-STUD.
가미진간식풍탕(加味鎭肝熄風湯)이 손상(損傷)된 배양척수운동신경세포(培養脊髓運動神經細胞)에 미치는 영향(影響)
김성환,심정섭,김강산,강병기,이재익,Kim, Seong-Hwan,Sim, Jeong-Sub,Kim, Kang-San,Kang, Byung-Ki,Lee, Jae-Ik 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.2
The purpose of this study is to examine the toxic effects caused by xanthine oxidase/hypoxanthine(XO/HX) and the effects of herbal extracts such as Jingansikpungtang(JST) and Gamijingansikpungtang(GJST) on the treatment of the toxic effects. For this purpose, experiments with the cultured nerve cells from the spinal motor neurons of new born mice were done. The results of these experiments were as follows. XO/HX, a oxygen radical-generating system, decreased the survival rate of the cultured cells on NR assay. MTT assay, the amount of neurofilaments and increased the amount of total proteinand increased the lipid peroxidation and the amount of LDH JST has the efficacy of increasing the amount of neurofilaments and total protein, and decreasing the lipid peroxidation and the amount of LDH, GJST has efficacy of increasing the amount of neurofilaments and total protein, and decreasing lipid peroxidation and the amount of LDH. From the above results, it is concluded that JST and GJST have marked efficacy as a treatment for the damages caused in the XO/HX mediated oxidative stress. And JST and GJST are thought to have certain pharmacologicall effects. Further clinical study of this pharmacological effects of JST and GJST should be complemented.
김성환,박장현,Kim, Seong-Hwan,Park, Jang-Hyun Institute of Korean Electrical and Electronics Eng 2005 전기전자학회논문지 Vol.9 No.1
본 논문은 단일입력 단일출력 비선형 계통에 대해서 강인한 출력궤환 제어기를 제시한다. 이전의 출력궤환 비선형 제어기가 모두 동적인 관측기 기반으로 설계된 반면 본 논문에서는 출력의 과거값들만을 이용하여 상태변수를 추정하는 새로운 방식을 제안하고 이를 후방차분 상태추정기라 명했다. 실제 상태변수값과 추정치와의 오차를 보상하기 위해서 제어입력에 강인제어항을 추가하였고 그것의 이득을 자동으로 조정하는 적응 알고리듬을 채택했다. 전체 폐루프 시스템은 출력 추종 오차가 점근적으로 안정하도록 그리고 모든 신호가 유계이도록 제어입력과 적응법칙이 설계된다. 제시된 제어기를 역진자 계통에 적용한 모의실험을 통해서 성능을 검증하였다. This paper describes the design of a robust output-feedback controller for a single-input single-output nonlinear dynamical system with a full relative degree. While all the previous research works on the output-feedback control are based on dynamic observers, a new state estimator which uses the past values of the measurable system output is proposed. We name it backward-difference state estimator since the derivatives of the output are estimated simply by backward difference of the present and past values of the output. The disturbance generated due to the error between the estimated and real state variables is compensated using an additional robustifying control law whose gain is tuned adaptively. Overall control system guarantees that the tracking error is asymptotically convergent and that all signals involved are uniformly bounded. Theoretical results are illustrated through a simulation example of inverted pendulum.