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한국의 제2형 당뇨병 환자에서 continuous subcutaneous insulin infusion 치료시 혈당 / 인슐린 지수와 당질/인슐린 비에 관한 연구
김선두(Sun Doo Kim),이길도(Kil Do Lee),김순제(Soon Je Kim),최의광(Ewi Kwang Choi),최수봉(Soo Bong Choi),박선민(Sun Min Park) 대한내과학회 2000 대한내과학회지 Vol.59 No.6
N/A Background : According to the results of Diabetes Control and Complication Trial, the best strategy to prevent and/or delay diabetic complications is to maintain the normal blood glucose levels. This led to emphasize the necessity of intensive management of diabetes. The purpose of the study was to determine blood glucose/insulin index and carbohydrate (CHO)-to-insulin ratios after normalization of blood glucose levels, and to select the factors to influence the blood glucose/insulin index and CHO-to-insulin ratios in Korean type 2 diabetic patients with continuous subcutaneous insulin infusion (CSII) treatment using insulin pump and CHO counting as a meal management. Methods : Fifty-five type 2 diabetic patients who started CSII therapy checked their blood glucose levels before and after three meals, and recorded the amounts of insulin injected in fasting and each meal and the amounts of carbohydrates consumed in each meal. Actual blood glucose/insulin index and CHO-to-insulin ratio were determined using the records, and also they were calculated using Functional Insulin Treatment Training Methods (FITTM) proposed by Howorka. Calculated values were compared to actual values. The meaningful factors to influence the actual values were selected by backward stepwise regression analysis. Results : The average age of the subjects was 49.9±12.5 years, and the duration of diabetes was 8.7±4.5 years. Their body mass index was 22.5±3.6 kg/m2. Daily insulin requirements to normalize the blood glucose levels reached to maximum levels at l0 day CSII treatment, and they were reduced and stabilized after 20 days of the treatment. The quotient K, representing insulin sensitivity, was also decreased after CSII treatment. The basal insulin index was 0.21 IU/kg at 10 days and 0.16 IU/kg at 20 days in our study, and these values were lower than the value from FITTM, 0.35 IU/kg The blood/glucose index was -2.5 mmol/L at 10 day CSII treatment, and it was decreased to -4.4 mmol/L at 20 day treatment to the stable levels. CHO-to-insulin ratio provided by FITTM was 2.59 IU/CHO exchange unit and the ratio was 3.12 IU/CHO exchange unit at 10 days, which was decreased to 1.84 IU/CHO exchange unit at 20 days in our study. CHO-to-insulin ratios at breakfast from carbohydrate counting were higher than those of lunch and dinner, and the ratios were 1.5 to 2.5 IU/CHO exchange unit. According to the stepwise regression analysis, the blood glucose/insulin index was affected by gender, age, body mass index (BMI), fasting blood glucose levels and fasting c-peptide levels, and CHO-to-insulin ratios were influenced by gender, age, BMI, post-prandial blood glucose levels and post-prandial c-peptide levels. Conclusions : CSII treatment can make blood glucose levels maintain in normal ranges in Korean type 2 diabetic patients, and can improve insulin sensitivity. Basal insulin requirements were lower and prandial insulin requirements were higher than those calculated from FITTM. This difference between Korean and the Western can be related to difference of insulin secretion from pancreas and nutrient intake.(Korean J Med 59:602-611, 2000)
김선두(Kim, Seon-Du),최경규(Choi, Kyoung-Kyu),최세진(Choi, Se-Jin) 대한건축학회 2014 大韓建築學會論文集 : 構造系 Vol.30 No.7
In this study, free and restraint drying shrinkage tests of conventional and amorphous steel fiber-reinforced concrete were performed to investigate the shrinkage characteristics. To consider the effect of restraint condition of concrete on shrinkage cracking, three different test setups were used: ring type restraint test according to ASTM C 1581-04, dumbbell type restraint test according to KS F 2595, and modified dumbbell type restraint test with notches. Crack widths and strain profiles acquired from the tests were compared and investigated. The test results showed that the addition of amorphous steel fibers with 0.2-0.4% volume fraction into concrete resulted in 30% reduction of free drying shrinkage, 3-5 days delay of crack development time, and 20-60% reduction of crack width. Thus, it can be concluded that the amorphous steel fibers can be used for the purpose of crack control of concrete shrinkage cracking.
김선두,Kim, Seon-Du 사단법인 한국당뇨협회 2008 당뇨 Vol.219 No.--
최근 들어 좀 더 인체의 생리 리듬에 맞는 좋은 인슐린들이 개발되어 실제로 많이 사용 되고 있습니다. 인슐린을 정확히 이해하고 본인에게 가장 적합한 인슐린을 찾아 적절히 맞는 것이 중요합니다.
비정질 강섬유 보강 일방향 콘크리트 슬래브의 전단성능에 대한 실험적 연구
김선두,최경규,최완철,최세진,Kim, Seon-Du,Choi, Kyoung-Kyu,Choi, Oan-Chul,Choi, Se-Jin 한국건설순환자원학회 2013 한국건설순환자원학회 논문집 Vol.1 No.2
본 연구에서는 비정질 강섬유보강 콘크리트 슬래브의 전단성능을 분석하기 위하여 일면 전단 실험을 수행하였다. 주요 변수는 전단보강방법과 전단보강비이며, 1종류의 무전단보강실험체와 3종류의 전단보강실험체(전단철근, 0.25%, 0.5% 비정질 강섬유보강 실험체)의 일방향 슬래브 실험체를 제작하여 실험하였다. 실험결과, 0.25% 비정질 강섬유보강실험체는 전단 성능이 향상되었지만 0.5% 실험체는 0.25% 보강실험체에 비해 전단성능이 향상되지 않았다. 섬유 보강비에 따른 전단보강 효과를 파악하기 위한 추가적인 연구가 필요하다. In this study, one-way shear tests were performed to investigate the shear capacity of amorphous steel fiber-reinforced concrete slabs. Primary test parameters were the shear reinforcing method(Stirrups or amorphous steel fibers) and shear reinforcement ratio(0.25 and 0.5%). A series of four one-way slab specimens including a specimen without shear reinforcement and three specimens with shear reinforcements(stirrup, 0.25%, and 0.5% amorphous steel fibers) were tested. The test results showed that 0.25% amorphous steel fibers improved the shear capacity, but 0.5% amorphous steel fibers did not improve the shear capacity compared to the specimen with conventional shear reinforcement of 0.25%. Additional study is needed to understand the variation of shear capacity according to fiber volume fraction.