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대승기탕(大承氣湯) 투여 후 편폐(便閉 ), 번조(煩燥), 불면(不眠)호전된 중풍 환자 치험 1례
김봉석,임희용,최빈혜,김대준,전연이,조종관,변준석,오중한,Kim, Bong-Suk,Lim, Hee-Yong,Kim, Dong-Woo,Choi, Bin-Hye,Kim, Dae-Joon,Jun, Yeon-I,Cho, Chong-Kwan,Byun, Joon-Seok,Oh, Jung-Han 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.2
In the early stage of stroke, the symptoms of constipation, chest discomfort and insomnia may appear in addition to the general symptoms such as specific limb weakness, dysphasia, headache, dizziness etc.. We administered Daeseungkitang(大承氣湯) to the patient diagnosed with cerebral infarction by MRI. He clearly displayed the usual syndromes of stroke(實證), endogenous wind stirring in the liver(肝風內動) and acceleration of upper chest functions(上焦火盛), ascertainned by Oriental Medical methods. After treatment with Daeseungkitang(大承氣湯), the constipation, chest discomfort and insomnia improved along with improvement of general symptoms of stroke.
반하백출천마탕(半夏白朮天麻湯)이 Doxorubicin에 의해 유발(誘發)된 독성(毒性)에 미치는 영향(影響)
김봉석,오중환,임희용,백정한,박치상,김상찬,변준석,황희정,Kim Bong-Suk,Oh Jung-Han,Lim Hee-Yong,Beak Jung-Han,Park Chi-Sang,Kim Sang-Chan,Byun Joon-Seok,Hwang Hui-Jeung 대한한방내과학회 2003 大韓韓方內科學會誌 Vol.24 No.2
Object : The effect of Banhabakchulchunma-tang extracts on the hepatic, splenic and cardiac toxicity induced by Doxorubicin administration(Three injection protocol) were monitored using male ICR mice. Methods : The changes of body weight, clinical signs, necropsy findings and organ weights of liver, spleen and heart were observed with blood GOT and GPT levels. Results : 1. Decrease of body weight and The degrees of anorexia, ataxia and dehydration after Doxorubicin treatment were dose-dependently inhibited by Banhabakchulchunma-tang extracts. 2. Increase of absolute and relative liver and heart weight observed in Doxorubicin treatment group were dose-dependently inhibited by Banhabakchulchunma-tang extracts. In addition, the degrees of liver congestion necrotic spot and the degrees of heart congestion enlargement were dose-dependently decreased after Banhabakchulchunma-tang extracts dosing groups compared to that of doxorubicin treatment group. It is also demonstrated that elevated serum GOT and GPT levels in doxorubicin treatment group were significantly decreased in Banhabakchulchunma-tang extracts dosing groups. 3. Decrease of absolute and relative spleen weight observed in doxorubicin treatment group were dose-dependently inhibited by Banhabakchulchunma-tang extracts. In addition, the degrees of splenic atrophy were significantly and dose-dependently decreased after Banhabakchulchunma-tang extracts dosing groups compared to that of doxorubicin treatment group. Conclusion : the toxicity of doxorubicin treatment(decrease of body weights, clinical signs such as anorexia, ataxia and dehydration, changes of organ weights of liver, spleen and heart, elevation of serum GOT and GPT levels) was inhibited and/or prevented by Banhabakchulchunma-tang extracts. According to these results, it is considered that Banhabakchulchunma-tang has some preventive effect against to doxorubicin induced toxicity.
폐옹(肺癰)으로 진단된 기관지확장증 환자의 위경탕(葦莖湯) 투여 1례
김봉석,오중한,김동우,최빈혜,허진일,손대용,김대준,변준석,임희용,Kim, Bong-Suk,Oh, Jung-Han,Kim, Dong-Woo,Choi, Bin-Hye,Hur, Jin-Il,Son, Dae-Yong,Kim, Dae-Joon,Byun, Joon-Seok,Lim, Hee-Yong 대한한방내과학회 2005 大韓韓方內科學會誌 Vol.26 No.3
A 69 year-old female patient with Bronchiectasis was treated. She was suffering from cough, sputum, fever, sweating, chills and general weakness. Her symptoms were diagnosed as Pe-Ong(肺癰), and she was administered Wikyung-Tang(葦莖湯). After taking Wikyung-Tang(葦莖湯) her symptoms improved. Results suggest that Wikyung-Tang(葦莖湯) is an effective treatment fer Bronchiectasis. Though, results support a role for oriental medical treatment for lung disease, further research into the effectiveness of oriental medical treatments for various lung disease is needed.
이진탕(二陳湯) 가미방(加味方) 투여 후 호전된 기능성 소화불량 환자 3례에 대한 증례보고
김봉석,임희용,김동우,최빈혜,허진일,김대준,조종관,변준석,오중한,Kim, Bong-Suk,Lim, Hee-Yong,Kim, Dong-Woo,Choi, Bin-Hye,Hur, Jin-Il,Kim, Dae-Joon,Cho, Chong-Kwan,Byun, Joon-Seok,Oh, Jung-Han 대한한방내과학회 2005 大韓韓方內科學會誌 Vol.26 No.3
It is well known that functional dyspepsia is one of the most common diseases. Functional dyspepsia, as defined by Rome I and II criteria, is a known and important gastrointestinal disorder. Symptoms of functional dyspepsia are postprandial fullness, postprandial discomfort, epigastric bloating, epigastric lump sensation, early satiety, nausea, vomiting, regurgitation, eruction, hunger pain, postprandial epigastric pain, heartburn, soreness and anorexia. Treatment of these symptoms are recorded in the Donguibogam(東醫寶鑑). This study is a comparative study between initial medical examination and end of medical treatment with LJTG mentioned in the Donguibogam. After treatment with LJTG, patients showed improvement in all symptoms associated with functional dyspepsia, including general condition. The results of this study suggest that LJTG is an effective treatment for functional dyspepsia.
경두개 도플러 초음파를 이용한 현훈 환자의 뇌혈관 혈류 측정에 관한 임상적 연구 (중대뇌동맥, 추골동맥 및 기저동맥을 중심으로)
김봉석,오중한,김동우,최빈혜,장우석,서영호,손대용,변준석,임회용,Kim, Bong-Suk,Oh, Jung-Han,Kim, Dong-Woo,Choi, Bin-Hye,Jang, Woo-Seok,Seo, Young-Ho,Son, Dae-Yong,Byun, Joon-Seok,Lim, Hee-Yong 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.3
Objectives : This study was designed to research whether transcranial doppler ultrasound(TCD) can yield a suitable diagnosis or prognosis for dizziness. Methods : To evaluate the blood flow, we measured the mean velocity(Vm), peak systolic velocity(Vs) and pulsatility index(PI) of the middle cerebral artery(MCA), vertebral artery(VA) and basilar artery(BA) in 54 dizziness patients and 44 normal subjects. To investigate the difference between dizziness patients and normal subjects, we selected 54 dizziness patients diagnosed normal by Brain MRI, and 44 normal subjects who did not have any symptoms of hyperlipemia, hypertension, diabetes melitus, heart disease, or smoking, diagnosed normal by Brain MRI. 30-69 year olds were divided into 30-49 year olds, 50-59 year olds and 60-69 year olds. Results : In normal subjects, there was a significantly higher Vm, Vs in the MCA and BA, and Vs in the VA of female subjects, and there was a significant difference in PI in the MCA and BA increasing with age. In comparison with normal subjects, dizziness patients had a significantly lower Vm in the BA. Male dizziness patients had significantly lower PI in the MCA. 30-49 year olds had significantly lower Vm in the BA. Conclusions : The significant difference in blood flow velocities in the BA between dizziness patients and normal subjects suggests that dizziness is related to blocking of blood flow in the BA and that diagnosis and prognosis can be made through TCD. More detailed study of dizziness patients will be needed.
체외 수정에 의한 임신 중 발견된 과자극 황체 난소 낭종 염전
김봉석 ( Bong Suk Seok ),김윤숙 ( Yoon Sook Kim ),서정호 ( Jeong Ho Seo ),송은석 ( Eun Suk Song ),김종민 ( Jong Min Kim ),이동운 ( Dong Woon Lee ),최홍준 ( Hong Jun Choi ),박혜인 ( Hye In Park ),배동한 ( Dong Han Bae ),양승하 ( Se 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.6
Ovarian torsion is the fifth most common condition in gynecologic surgical emergencies, with an incidence of 2.7% occuring mainly in women of reproductive age. It is an uncommon but well recognized complication of ovarian stimulation, especially when ovar
Capsaicin의 AGS Cell에 대한 Mitochondria를 경유한 Apoptosis 유도 효과
김봉석 ( Bong Suk Kim ),변준석 ( Joon Seok Byun ),권해원 ( Hae Won Kwon ) 대구한의대학교 제한동의학술원 2015 東西醫學 Vol.40 No.4
Objectives:Apoptosis is a key regulator of tissue homeostsis, which critically depends on the balance between proliferation and cell death. Methods:Capsaicin induces apoptosis in AGS cells, human stomach adenocarcinoma cell line. Result:AGS cells showed dose-dependent manner apoptotic cell death. Increased apoptotic cell death, exposured to Capsaicin, resulted from induction of Bad translocation from cytosol to mitochondria, activation of mitochondrial Bax, inhibition of Bcl2, induction of AIF translocation from mitochondria to nuclear, induction of cytochrome-c release from mitochondria to cytosol, activation of caspase and PARP cleavage. Conclusions:These results suggest that Capsaicin may be potential therapeutic approach in the clinical management of stomach adenocarcinoma.
보중익기합대칠기탕(補中益氣合大七氣湯)과 Doxorubicin의 병용이 MKN-45의 항암효과에 미치는 영향
이윤희,김봉석,오중한,임희용,김동우,최빈혜,변준석,Lee Yun-Hee,Kim Bong-Suk,Oh Jung-Han,Lim Hee-Yong,Kim Dong-Woo,Choi Bin-Hye,Byun Joon-Seok 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.1
In order to evaluate the anti-tumor and synergic effect of BoJungIkKeeHapDaeChilKi-Tang on doxorubicin, the inhibitory concentration(IC), IC50 and IC90 of single use of doxorubicin and BoJungIkKeeHapDaeChilKi-Tang with their concomitant treatment against MKN-45(Human stomach carcinoma) was observed using MTT(Microculture Tetrazolium test) assay. In addition, their anti-tumor effects were also observed in the xenograft nude mice models agianst MKN-45 cell lines. BoJungIkKeeHapDaeChilKi-Tang has only mimic direct anti-tumor effect against to MKN-45 cell lines but they were decreased general depressed signs induced by implantation of tumor cell lines and increased the total WBC and lymphocyte numbers. So, it is considered or expected that BoJungIkKeeHapDaeChilKi-Tang extracts were reduced by the critical toxicity of doxorubicin and shows favorable synergic effect with doxorubicin and BoJungIkKeeHapDaeChilKi-Tang extracts.
순기화중탕(順氣和中湯)과 Doxorubicin의 병용이 Colon-26의 항암효과에 미치는 영향
신민규,김봉석,오중한,임희용,김동우,최빈혜,김상찬,변준석,Shin Min-Kyu,Kim Bong-Suk,Oh Jung-Han,Lim Hee-Yong,Kim Dong-Woo,Choi Bin-Hye,Kim Sang-Chan,Byun Joon-Seok 대한한의학방제학회 2004 大韓韓醫學方劑學會誌 Vol.12 No.2
In order to evaluate the anti-tumor and synergic effect of Soonkiwhajungtang with doxorubicin, the inhibitory concentration(IC), $IC_{50}\;and\;IC_{90}$ of single use of doxorubicin and Soonkiwhajungtang with their concomitant treatment against Colon-26(Murine Rectum Carcinoma) was observed using MTT(Microculture Tetrazolium test) assay. In addition, their anti-tumor effects were also observed in the xenograft nude mice models agianst to Colon-26 cell lines. Soonkiwhajungtang has only mimic direct anti-tumor effect against to Colon-26 cell lines but they were decreased general depressed signs induced by implantation of tumor cell lines and increased the total WBC and lymphocyte numbers. So, it is considered or expected that Soonkiwhajungtang extracts were reduced the critical toxicity of doxorubicin and shows favorable synergic effect with doxorubidn and Soonkiwhajungtang extracts.
보중익기합대칠기탕(補中益氣合大七氣湯)과 Doxorubicin의 병용이 3LL의 항암효과에 미치는 영향
이윤희,김봉석,오중한,임희용,김동우,최빈혜,김상찬,변준석,Lee Yun-Hee,Kim Bong-Suk,Oh Jung-Han,Lim Hee-Yong,Kim Dong-Woo,Choi Bin-Hye,Kim Sang-Chan,Byun Joon-Seok 대한한의학방제학회 2004 大韓韓醫學方劑學會誌 Vol.12 No.1
In order to evaluate the anti-tumor and synergic effect of Bojungikkeehapdaechilkitang with doxorubicin, the inhibitory concentration(IC), $IC_{50}\;and\;IC_{90}$ of single use of doxorubicin and Bojungikkeehapdaechilkitang with their concomitant treatment against 3LL(Lewis lung carcinoma) was observed using MTT(Microculture Tetrazolium test) assay. In addition, their anti-tumor effects were also observed in the xenograft nude mice models agianst to 3LL cell lines. Bojungikkeehapdaechilkitang has only mimic direct anti-tumor effect against to 3LL cell lines but they were decreased general depressed signs induced by implantation of tumor cell lines and increased the total WBC and lymphocyte numbers. So, it is considered or expected that Bojungikkeehapdaechilkitang extracts were reduced the critical toxicity of doxorubicin and shows favorable synergic effect with doxorubicin and Bojungikkeehapdaechilkitang extracts.