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고농도 포도당이 사람 치주인대세포의 Integrin과 Cathepsin 발현에 미치는 영향에 관한 연구
김방수,신제원,홍정표,주성숙,Kim, Bang-Soo,Shin, Je-Won,Hong, Jung-Pyo,Jue, Seong-Suk 대한안면통증구강내과학회 2008 Journal of Oral Medicine and Pain Vol.33 No.1
This experiment was designed to clarify the effect of high concentrations of extracellular glucose on the periodontal ligament cells. The cells were incubated for 24 and 48 hours with ${\alpha}-MEM$ including 1,000 mg/L(control group) and 4,500 mg/L(experimental group) of glucose. Then, the expressions of ${\alpha}5$ integrin, cathepsin-B and -L were examined using RT-PCR method. The results were as follows: 1. ${\alpha}5$ integrin expression was increased after incubation in high glucose media. 2. Cathepsin-B expression was increased after the 24-H incubation with high glucose media, but was decreased after the 48-H incubation. 3. The expression of cathepsin-L was decreased by the high glucose media. Theses results suggest that extracellular glucose at high concentration may be attributed to delayed wound healing in diabetes patients through increase in ${\alpha}5$ integrin and decrease in cathepsins, which lead to accumulation of extracellular matrices and adhesion molecules.
방수미,장문주,김경하,임호영,김여경,남승현,황헌규,배성화,김성현,문영철,김양기,김인호,최원일,정철원,박남희,최남경,박병주,오도연 대한의학회 2014 Journal of Korean medical science Vol.29 No.2
In 2010, we proposed the first Korean Guidelines for the Prevention of Venous Thromboembolism (VTE). It was applicable to Korean patients, by modifying the contents of the second edition of the Japanese guidelines for the prevention of VTE and the 8th edition of the American College of Chest Physicians (ACCP) evidence-based clinical practice guidelines. From 2007 to 2011, we conducted a nationwide study regarding the incidence of VTE after major surgery using the Health Insurance Review and Assessment Service (HIRA) database. In addition, we have considered the 9th edition of the ACCP Evidenced-Based Clinical Practice Guidelines, published in 2012. It emphasized the importance of clinically relevant events as opposed to asymptomatic outcomes with preferences for both thrombotic and bleeding outcomes. Thus, in the development of the new Korean guidelines, three major points were addressed: 1) the new guidelines stratify patients into 4 risk groups (very low, low, moderate, and high) according to the actual incidence of symptomatic VTE from the HIRA databases; 2) the recommended optimal VTE prophylaxis for each group was modified according to condition-specific thrombotic and bleeding risks; 3) guidelines are intended for general information only, are not medical advice, and do not replace professional medical care and/or physician advice.
방수라 ( Soo-ra Bang ),김원영 ( Won-young Kim ),류준석 ( Joon-suk Ryu ),김응모 ( Ung-mo Kim ) 한국정보처리학회 2009 한국정보처리학회 학술대회논문집 Vol.16 No.2
인터넷 시장이 빠르게 성장함에 따라 사용자들의 참여도가 매우 높아졌다. 인터넷 사용자들은 시장의 상품과 더불어 영화와 같은 문화 생활에 관한 의견을 웹 상에 표현하기 시작했고, 현재에 들어 그 양이 방대해 졌다. 본 논문에서는 사용들이 작성한 영화에 관한 리뷰를 모아 방대한 양에서 유용한 정보를 효율적으로 도출하고 요약해서 사용자에게 제공하는 방법을 제안한다.
고흥석,김방수,한병철,김윤석,조진수,박정근,송태의,서상렬,마경란 대한내과학회 1996 대한내과학회지 Vol.50 No.4
Paroxysmal nocturnal hemoglobinuria(PNH) is a rare, nonfamilial disorder of insidious onset and chronic course characterized by abnormal sensitivity of blood cells to the lytic action of complements. This disorder is associated ith a striking predisposition to intravenous thrombosis, of which fatal thrombosis usually involve the brain or portal system. However, arterial thrombosis is rare, and PNH shoud be considered among the unusual causes of ischemic cerebral infarcts in young adults. We experienced a case of cerebral arterial thrombosis associated with PNH in 36-year-old women patient complained of left hemeplegia and easy fatigability for about 17years. Ham's test showed positive reaction of 25% hemolysis. Our patient showed signs of reght middle and anterior cerebral arterial occlusion: this was documented by computed tomographic (CT) scan, magnetic resonance image (MRI) and magnetic resonance(MR) angiography. We present this case with a review of the literature.
Development of donor-acceptor type-based random copolymer for highly efficient polymer solar cells
이유선,방수미,노용진,김은총,나석인 한국공업화학회 2016 한국공업화학회 연구논문 초록집 Vol.2016 No.0
In recent years, as a result of development of novel low band gap donor polymer, the device characteristics of the polymer solar cells such as FF, Voc, and Jsc have shown dramatic increase and the solar cell efficiency has been achieved up to ~ 10%. To increase current density, the further broad absorption spectra to give a decisive effect on performance of devices should be basically required. Accordingly, we synthesized low band gap random copolymers included different monomers donor unit and acceptor unit, which have different absorption. In this work, we demonstrate the highly efficient polymer solar cells using two different novel low band gap polymers as donor materials in the photoactive layer. Also, the effects of two difference random copolymers on the device parameters such as FF, Voc, and Jsc were investigated. As a result, PCE of optimum polymer solar cells with random copolymers showed 5.9% and 7.71%, respectively.