수원의 한 대학병원에서 10년간 경험한 아나필락시스 환자 분석

김무정 ( Moo Jung Kim ),최길순 ( Gil Soon Choi ),엄수정 ( Soo Jung Um ),성준모 ( Jun Mo Sung ),신유섭 ( Yoo Seob Shin ),박한정 ( Han Jung Park ),예영민 ( Young Min Ye ),남동호 ( Dong Ho Nahm ),이수영 ( Su Young Lee ),박해심 ( Hae 대한천식알레르기학회 2008 천식 및 알레르기 Vol.28 No.4

Background: Anaphylaxis is a systemic hypersensitivity reaction consisting of various etiologies and clinical features. In Korea, reports regarding anaphylaxis are very few. Objective: To evaluate the general characteristics and clinical features of anaphylaxis, especially with regard to the severity of it. Method: A retrospective study was conducted in inpatients, outpatients and patients encountered at the emergency department at the Ajou University Hospital during 1997~2008. The medical records of a total of 158 patients who met diagnostic criteria for anaphylaxis were reviewed. Result: Drugs (51.2%) was the most common cause of anaphylaxis followed by insect stings (25.3%), foods (10.8%) and exercise (6.3%) in our hospital. The common manifestations were dyspnea (70.3%), urticaria (57.6%), dizziness (48.1%) and hypotension (46.2%). There were 65 patients (41.1%) with moderate anaphylaxis and 93 patients (58.9%) with severe anaphylaxis. The patients with older age or underlying cardiovascular disease had more severe anaphylaxis (P<0.05, respectively). Although there were no significant correlation between the severity and etiology of anaphylaxis, some drugs such as antibiotics, NSAIDs, and radiocontrast media tended to develop severe anaphylaxis. Conclusion: We confirmed that drugs, insect stings, foods, and exercise are the major causes of anaphylaxis. In addition, the patients with older age or a cardiovascular disease had a tendency to develop severe anaphylaxis. (Korean J Asthma Allergy Clin Immunol 2008;28:298-304)

만성 두드러기 환자에서 설문 조사를 통해 살펴본 음식물과 임상 증상과의 관련성

김무정 ( Moo Jung Kim ),최길순 ( Gil Soon Choi ),예영민 ( Young Min Ye ),이현영 ( Hyun Young Lee ),성준모 ( Jun Mo Sung ),남동호 ( Dong Ho Nahm ),박해심 ( Hae Sim Park ) 대한천식알레르기학회 2009 천식 및 알레르기 Vol.29 No.3

Background: Many patients with chronic urticaria (CU) have suspected foods as eliciting factors and have eliminated these diets. However, there have been few studies of the relationship between CU and food intolerance in Korea. Objective: We sought to evaluate the causal relationship between CU and food intolerance by the questionnaire method, which was compared according to aspirin sensitivity. Method: A total of 235 patients diagnosed as having CU were enrolled and classified into the 2 groups: according to histories and the oral aspirin, challenge test results aspirin intolerant chronic urticaria (AICU) and aspirin tolerant chronic urticaria (ATCU). The questionnaires were used to investigate the presence of foods eliciting urticaria. The urticaria severity score and the visual analogue scale for urticaria were measured. Food hypersensitivity was determined by skin prick tests. Serum total eosinophil counts, the total IgE level anti-nuclear antibody and antithyroid autoantibody were measured. Result: Of the 235 patients with CU, 119 (50.6%) answered that their symptoms were aggravated by food, in which the causative common foods were fish (45.4%), seafood (44.5%), meat (43.7%) and instant food (33.6%) in a decreasing order of frequency. There was no significant difference in the frequency of food intolerance between AICU and ATCU patients. However a significant association was noted with vegetable in AICU patients (6.2% for AICU patients vs. 2.1% for ATCU patients, P=0.025), while a significant association was noted with instant food in ATCU patients (14.7% for ATCU patients vs. 16.9% for AICU patients, P=0.008). CU patients with food intolerance, especially AICU patients, tended to have higher symptom scores, atopy rates and prevalences of allergic diseases than those without. Among 138 patients who underwent skin prick tests, only 47 (34.1%) showed positive responses to suspected food allergens. Conclusion: It is suggested that more than 50% of CU patients may have a possible association between foods and their symptoms. Careful history taking is needed for proper management of CU patients, especially AICU patients with associated allergic diseases or atopy. (Korean J Asthma Allergy Clin Immunol 2009;29:186-193)

혈액투석 중에 발생한 헤파린에 의한 전신 두드러기

박한정 ( Han Jung Park ),성준모 ( Jun Mo Sung ),김무정 ( Moo Jung Kim ),최길순 ( Gil Soon Choi ),예영민 ( Young Min Ye ),박해심 ( Hae Sim Park ) 대한천식알레르기학회 2009 천식 및 알레르기 Vol.29 No.1

Heparin is used for thromboprophylaxis in patients on hemodialysis, hemofiltration or continuous renal replacement therapies. Heparin-related immediate-type hypersensitivity reactions such as urticaria, angioedema or bronchospasm are very rare, and only a few cases of anaphylaxis-like responses have been described. We experienced the case of a 67-year-old female patient with an end-stage renal disease who presented generalized urticaria induced by heparin during hemodialysis. She began to experience recurrent itching and generalized urticaria after 2 weeks of the initiation of hemodialysis. The episodes started within 30 minutes of hemodialysis with heparin infusion; either sodium heparin or dalteparin (low molecular weight heparin) was used. Utilization of different dialyzers was unable to avoid the episodes, and these symptoms could be reduced when she was treated with heparin-free hemodialysis. She had no previous history of allergic diseases. In order to confirm the causative agent, we measured serum specific IgE antibodies against ethylene oxide, latex and formaldehyde using immunoCAP (Phadia, Sweden) and obtained negative results. Although skin prick tests and intradermal tests to the used heparin showed negative results, the intravenous provocation test using 1,500 U of heparin (with a bolus-loading dose of 1,000 U and a continuous intravenous infusion of 500 U for 3 hours) reproduced an immediate-onset generalized urticaria with itching sensation. We report herein a case of heparin-induced urticaria during hemodialysis in Korea. Because of increasing use of heparin in medical practice, physicians should be aware of possible immediate hypersensitivity reactions to this medication. (Korean J Asthma Allergy Clin Immunol 2009;29:69-73)

Improvement of Runner Plant Production by Increasing Photosynthetic Photon Flux during Strawberry Transplant Propagation in a Closed Transplant Production System

Sung Kyeom Kim(김성겸),Mi Seon Jeong(정미선),Seon Woo Park(박선우),Moo Jung Kim(김무정),Hae Young Na(나해영),Changhoo Chun(전창후) 한국원예학회 2010 원예과학기술지 Vol.28 No.4

국내 육성 품종인 ‘매향’ 딸기의 육묘 기간 중 광합성유효광량자속의 환경 조절을 통하여 러너 및 러너플랜트의 발생과 생산 효율을 증대시키고자 하였다. 딸기 육묘에 이용된 증식체의 엽수와 관부 직경은 각각 3.1±0.4와 7.0±1.1㎜였다. 광합성유효광량자속을 각각 140, 210 및 280μmolㆍm?²ㆍs?¹로 설정한 9기의 인공광 이용형 육묘 모듈에서 35일 동안 육묘하였다. 러너플랜트 생산 효율은 증식체당 일일 0.27주로 처리구 중 유의하게 가장 높았으며 관행의 딸기 육묘 방식의 러너플랜트 생산 효율과 비교하여도 크게 증진되었음을 확인하였다. 폐쇄형 육묘 시스템을 활용하여 육묘 기간 중의 PPF를 280μmolㆍm?²ㆍs?¹로 조절하면 국내 육성 품종인 ‘매향’의 러너 발생 및 러너플랜트 생산을 증진시킬 수 있음이 확인되었다. 따라서 최근 국내에서 육성된 신품종 딸기의 급속 보급을 위한 증식체계 구축에 본 연구 기술이 활용되면 육성된 품종의 조급 보급이 가능할 것으로 판단된다. The formation and elongation of runners, growth of runner plants, and transplant propagation rates of 'Maehyang' strawberry were investigated at various photosynthetic photon flux (PPF) levels. Strawberry plants having 3.1 ± 0.4 leaves and 7.0 ± 1.1 ㎜ of crown diameter were used as propagules and were cultured for 35 days in 9 transplant production modules using fluorescent lamps as artificial lighting sources. Applied PPF levels were 137.4 ± 2.1, 217.0 ± 1.0, and 274.7 ± 8.4 μmolㆍm?²ㆍs?¹ as measured on the surfaces of empty shelves. The numbers of runners and runner plants per propagule were the greatest at 280 μmolㆍm?²ㆍs?¹ PPF. The runner plant propagation rate was 0.27 plant/day/propagule at 280 μmolㆍm?²ㆍs?¹, which was significantly greater than that of conventional propagation methods. Results indicate that high PPF levels promotes the formation of runners and runner plants of strawberry and that the rapid propagation method with high PPF levels can be feasible for production of vigorous transplants in a closed transplant production system.

감자에 의한 접촉성 두드러기

박한정 ( Han Jung Park ),성준모 ( Jun Mo Sung ),김무정 ( Moo Jung Kim ),최길순 ( Gil Soon Choi ),신유섭 ( Yoo Seob Shin ),예영민 ( Young Min Ye ),박해심 ( Hae Sim Park ) 대한천식알레르기학회 2008 천식 및 알레르기 Vol.28 No.2

Immediate hypersensitivity to raw potato has been presented as one or a combination of wheezing, rhinorrhea, sneezing, contact urticaria and contact dermatitis. We experienced a case of contact urticaria caused by raw potato in a 25-year-old female patient with allergic rhinitis and conjunctivitis. She had experienced itching and generalized urticaria after application of raw potato on her face 10 years earlier. Allergy skin tests showed positive results to common inhalant allergens, including D. pteronyssinus, D. farina, ragweed pollen, mugwort pollen and several kinds of grass pollens, but showed a negative result to raw potato e×tract. However, the provocation test by applying raw potato on her forearm produced an immediate onset of contact urticaria with itching sensation. High serum-specific IgE to raw potato compared to normal healthy controls was detected by ELISA. We first report here in a case of raw potato-induced contact urticaria in Korea, which suggested an IgE-mediated mechanism. (Korean J Asthma Allergy Clin Immunol 2008;28:148-151)

Comparison of Bioactive Compounds Contents in Different Fruit Tissues of June-bearing Strawberry Cultivars

Sung Kyeom Kim(김성겸),Ro Na Bae(배로나),Hyunseung Hwang(황현승),Moo Jung Kim(김무정),Hye Ryeong Sung(성혜령),Changhoo Chun(전창후) 한국원예학회 2010 원예과학기술지 Vol.28 No.6

‘매향’, ‘설향’, ‘금향’, ‘아키히메’와 ‘레드펄’ 딸기 과실 부위에서 환원당, 유기산, 아스코르빈산, 안토시아닌 및 엘라직산의 함량을 비교하였다. 환원당, 유기산, 아스코르빈산 및 안토시아닌 함량은 딸기 표피에서 다른 부위의 함량 보다 유의하게 높았으나 엘라직산의 함량은 딸기 수과에서 높았다. ‘매향’ 딸기의 표피 및 과육에서 아스코르빈산 함량은 각각 69.2와 42.2㎎?100g<SUP>-1</SUP> FW로 다른 품종에 비해 높았다. 그리고 ‘금향’ 딸기의 표피 및 수과에서 안토시아닌 함량은 각각 74.0㎎?100g<SUP>-1</SUP> FW과 36.7㎎?100g<SUP>-1</SUP> DW으로 타 품종에 비해 유의하게 높았으며 ‘설향’ 딸기 수과에서 엘라직산의 함량은 215.5㎎?100g<SUP>-1</SUP> DW로 타 품종에 비해 유의하게 높았다. 딸기 과실의 부위에 따라 바이오 활성 화합물들의 함량은 크게 차이가 있었으며 ‘매향’, ‘설향’ 및 ‘금향’ 딸기 품종은 바이오 활성 화합물들의 함량이 높아 소비자들에게는 고품질 딸기로 인식될 수 있어 국내 육성 품종 딸기의 보급이 확산될 것으로 기대된다. 그리고 본 기초적 결과들은 딸기 가공 분야 및 영양학 연구 분야에도 유용하게 활용될 것으로 판단된다. We evaluated the bioactive compounds including carbohydrates (CH), organic acids (OA), ascorbic acid (AA), anthocyanin (AC), and ellagic acid (EA) in the achenes, epidermis, and flesh of fully ripe strawberry fruits of the ‘Maehyang’, ‘Seolhyang’, ‘Keumhyang’, ‘Akiheme’, and ‘Red pearl’ cultivars. The total contents of CH, OA, AA, and AC were significantly greater in the epidermis than in other tissues, while the EA content was significantly greater in the achenes than in other tissues. The AA content of the epidermis ranged from 49.1-69.2 ㎎?100 g<SUP>-1</SUP> FW and was significantly greater than the content of the flesh, while AA was not detected in the achenes of any of the tested strawberry cultivars. The AA contents of the epidermis and flesh of the ‘Maehyang’ were 69.2 and 42.2 mg?100 g<SUP>-1</SUP> FW, respectively, and were greater than those of the other cultivars. The AC contents in the epidermis and achenes of the ‘Keumhyang’ were 74.0 ㎎?100 g<SUP>-1</SUP> FW and 36.7 ㎎?100 g<SUP>-1</SUP> DW, respectively, greater than those of the other cultivars. The EA content of the achenes of the ‘Seolhyang’ was 215.5 ㎎?100 g<SUP>-1</SUP> DW, significantly greater than those of the other cultivars. Results indicate that the antioxidant levels and other chemical compounds of strawberry fruits vary significantly among different fruit tissues. Our results also suggest that the recently introduced Korean ‘Maehyang’, ‘Seolhyang’, and ‘Keumhyang’ contain higher levels of antioxidants than other major June-bearing strawberry cultivars. These cultivars are feasible selections for both growers and consumers.

골프 퍼팅 거리에 따른 임팩트시 상지와 볼의 운동학적 분석

최성욱 ( Sung Wook Choi ),김무정 ( Moo Jung Kim ) 고려대학교 스포츠과학연구소 2008 스포츠문화과학연구 Vol.14 No.-

본 연구는 퍼팅거리에 따른 상지와 임팩트시 퍼터헤드와 볼의 구간별 퍼터헤드의 이동변위, 소요시간, 속도, 어깨 각변위, 탑스핀량, 론치앵글에 대한 운동학적 분석을 실시하여, 골프퍼팅의 기술향상에 필요한 기초자료제공에 목적이 있다. 부상의 경험이 없는 4명의 프로선수들을 대상으로 인조잔디위에서 1m, 3m, 5m거리의 퍼팅을 각10회씩 총30회를 실시하였고, 영상분석과 동시에 임팩트존의 분석을 실시하였다. 분석을 통해 나온 데이터는 일원 반복측정 분산분석과 대응표본 t-검증을 실시하여 통계적 유의성을 분석하여 다음과 같은 결론을 얻었다. (1) 퍼팅 스트로크의 전체 소요시간은 퍼팅거리가 길어짐에 따라 증가하였다. (2) 퍼터헤드의 이동변위는 백스윙구간에서 큰 증가를 보였고, 팔로스로우구간은 1m퍼팅보다 3m퍼팅에서 크게 증가를 보였다 (3) 퍼터헤드의 속도는 다운스윙구간에서 큰 폭의 증가를 나타냈다. (4) 어깨의 각 변위는 1m퍼팅과 3m퍼팅에서는 큰 차이가 나타나지 않았으며, 5m퍼팅에서는 큰 차이를 나타냈다. (5) 임팩트시 퍼터헤드의 속도와 볼의 속도는 퍼팅거리가 길어짐에 따라 증가를 보였으며, 볼의 탑스핀량과 론치앵글은 퍼팅거리가 길어짐에 따라 감소되는 현상을 나타냈다. The purpose of this study was to kinematically analyze the differences between 1 m, 3m, and 5m putting stroke motions. Four male professional golfers participated in this study. Experiment was conducted on the artificial grass mat in the laboratory. Kinematic data were collected by the Kwon3D video motion analysis system. Analytic tools were paired sample t-test and one-way repeated measures of ANOVA. The result of the study were as follows: 1. Putter head moving distance per phase is relevant to putting distance. Moving distance of follow-through is longer than those of downswing and backswing. 2. Three putting distances are similar in total putting moving time. Putting moving time per phase takes time in the order of backswing, follow-through, and downswing regardless of putting distance. 3. Putter head average velocity per phase is relevant to putting distance. Average velocity of downswing is faster than those of backswing and follow-through. 4. Shoulder angle per event of finish is relevant to putting distance. Shoulder angle of finish is increased by increasing putting distance. 5. Top spin at the moment of impact is relevant to putting distance. Top spin is decrease by increasing putting distance.

Comparison of Bioactive Compounds Contents in Different Fruit Tissues of June-bearing Strawberry Cultivars

김성겸,배로나,황현승,김무정,성혜령,전창후,Kim, Sung-Kyeom,Bae, Ro-Na,Hwang, Hyun-Seung,Kim, Moo-Jung,Sung, Hye-Ryeong,Chun, Chang-Hoo Korean Society of Horticultural Science 2010 원예과학기술지 Vol.28 No.6

'매향', '설향', '금향', '아키히메'와 '레드펄' 딸기 과실 부위에서 환원당, 유기산, 아스코르빈산, 안토시아닌 및 엘라직산의 함량을 비교하였다. 환원당, 유기산, 아스코르빈산 및 안토시아닌 함량은 딸기 표피에서 다른 부위의 함량 보다 유의하게 높았으나 엘라직산의 함량은 딸기 수과에서 높았다. '매향' 딸기의 표피 및 과육에서 아스코르빈산 함량은 각각 69.2와 $42.2mg{\cdot}100g^{-1}$ FW로 다른 품종에 비해 높았다. 그리고 '금향' 딸기의 표피 및 수과에서 안토시아닌 함량은 각각 $74.0mg{\cdot}100g^{-1}$ FW과 $36.7mg{\cdot}100g^{-1}$ DW으로 타 품종에 비해 유의하게 높았으며 '설향' 딸기 수과에서 엘라직산의 함량은 $215.5mg{\cdot}100g^{-1}$ DW로 타 품종에 비해 유의하게 높았다. 딸기 과실의 부위에 따라 바이오 활성 화합물들의 함량은 크게 차이가 있었으며 '매향', '설향' 및 '금향' 딸기 품종은 바이오 활성 화합물들의 함량이 높아 소비자들에게는 고품질 딸기로 인식될 수 있어 국내 육성 품종 딸기의 보급이 확산될 것으로 기대된다. 그리고 본 기초적 결과들은 딸기 가공 분야 및 영양학 연구 분야에도 유용하게 활용될 것으로 판단된다. We evaluated the bioactive compounds including carbohydrates (CH), organic acids (OA), ascorbic acid (AA), anthocyanin (AC), and ellagic acid (EA) in the achenes, epidermis, and flesh of fully ripe strawberry fruits of the 'Maehyang', 'Seolhyang', 'Keumhyang', 'Akiheme', and 'Red pearl' cultivars. The total contents of CH, OA, AA, and AC were significantly greater in the epidermis than in other tissues, while the EA content was significantly greater in the achenes than in other tissues. The AA content of the epidermis ranged from $49.1-69.2mg{\cdot}100g^{-1}$ FW and was significantly greater than the content of the flesh, while AA was not detected in the achenes of any of the tested strawberry cultivars. The AA contents of the epidermis and flesh of the 'Maehyang' were 69.2 and $42.2mg{\cdot}100g^{-1}$ FW, respectively, and were greater than those of the other cultivars. The AC contents in the epidermis and achenes of the 'Keumhyang' were $74.0mg{\cdot}100g^{-1}$ FW and $36.7mg{\cdot}100g^{-1}$ DW, respectively, greater than those of the other cultivars. The EA content of the achenes of the 'Seolhyang' was $215.5mg{\cdot}100g^{-1}$ DW, significantly greater than those of the other cultivars. Results indicate that the antioxidant levels and other chemical compounds of strawberry fruits vary significantly among different fruit tissues. Our results also suggest that the recently introduced Korean 'Maehyang', 'Seolhyang', and 'Keumhyang' contain higher levels of antioxidants than other major June-bearing strawberry cultivars. These cultivars are feasible selections for both growers and consumers.

원발성 중추신경계 림프종에서 리툭시맵과 테모졸로미드 병합치료

이윤석 ( Yoon Suk Lee ),김무정 ( Moo Jung Kim ),박정일 ( Jung Il Park ),이현우 ( Hyun Woo Lee ),박준성 ( Joon Seong Park ),조경기 ( Kyung Gi Cho ),김효철 ( Hugh Chul Kim ) 대한내과학회 2008 대한내과학회지 Vol.75 No.1S

최소단위 서비스를 이용한 U - City 통합플랫폼 내에서의 상황 처리 시나리오 개발 방법론 및 개발 도구 구현

송훈구(Hun - Gu Song),김무정(Moo - Jung Kim),현기홍(Ki - Hong Hyeon),이후석(Hoo - Seok Lee) 한국IT서비스학회 2012 한국IT서비스학회지 Vol.11 No.1

USM(Unit Service Management System) is the development tool and methodology to handling the event process in a U - City integrated platform by using the minimum unit services. USM can be one of the SOA development methodology. Minimum unit service has a minimum business logic that can be executed with input and output parameters. Minimum unit service consists of three parts:service profile, service input and output parameters and service execution information. USM provides two types of the execution method. One is module execution and the other is web service execution. The development of the event sinario by the USM development methodology can reduce the cost and duration of the u - service development by raising the rate of reusing minimum unit service.