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성장호르몬 결핍성 저신장환아와 말단비대증에서의 인슐린양 성장인자 운반 단백질 양상
김목현,신재훈,김태화 대한내분비학회 1989 Endocrinology and metabolism Vol.4 No.2
It is known that the Insulin-likee growth factor (IGF) exist in human serum complexed to specific binding protein. We have characterized the distribution of IGF-I in different fractions after gelfiltration of serum through sephacryl S-200 in neutral buffer. Normal and acromegalic serum was incubated with 125I-IGF-I; binding was found both in the 150k and 45k dalton regions. In patient with GH dificiency, however, 125I-IGH-I eluted almost exclusively in the 45k region. (J. Kor Soc Endocrinol 4:132~136, 1989)