Association between Low-level Mercury Exposure and Neurobehavioral Functions in Korean Adults Living in a Coastal City

김록범,김병권,김유미,홍영습,유창헌,김대선 환경독성보건학회 2013 환경독성보건학회지 Vol.28 No.-

Objectives The aim of this study was to determine the association between low-level mercuryexposure and neurobehavioral functions in adults living in coastal regions of Korea. Methods We selected 172 adults aged 20-65 years living in a city in the coastal region of Korea. A sociodemographic survey was conducted, mercury levels in the blood, urine, andhair were measured, and the associations according to computerized neurobehavioral testswere determined using univariate analysis. After adjustment for associated variables, a multivariatelinear regression analysis was performed. Results The geometric mean mercury levels in the blood, urine, and hair were 5.41 μg/L(range, 0.00-15.84 μg/L), 1.17 μg/g-creatinine (range, 0.00-32.86 μg/g-creatinine), and 1.37mg/kg (range, 0.42-6.56 mg/kg), respectively. Variables that were associated with simplereaction time according to the neurobehavioral test results were age and urine mercury level. Variables associated with choice reaction time were the recent use of Korean traditionalmedicine and urine mercury level. Variables associated with the right-hand finger tappingspeed test were age, gender, smoking behavior, education level, monthly household income,and urine mercury level. Variables associated with the left-hand finger tapping speedtest were age, gender, education level, and urine mercury level. After adjustment for associatedvariables, there was no significant association between urine mercury level and simplereaction time (β=25.96; p =0.47), choice reaction time (β=50.37; p =0.32), or the numberof left-hand finger taps (β=-1.54; p =0.21). However, urine mercury level was significantlyassociated with the number of right-hand finger taps (β=-3.86; p =0.01). Conclusions We found no evidence that low-level mercury exposure in adults is associatedwith deficits in neurobehavioral functions. A longer follow-up study is required to confirmthis conclusion.

Trends in the Incidence of Hospitalized Acute Myocardial Infarction and Stroke in Korea, 2006-2010

김록범,김병권,김유미,서정욱,임영실,김희숙,이혜진,문지영,Keon Yeop Kim,신지연,박형근,송정국,박기수,정백근,박찬경,신희영,강종원,오경재,이영훈,성인환,유원섭,홍영습 대한의학회 2013 Journal of Korean medical science Vol.28 No.1

This study attempted to calculate and investigate the incidence of hospitalized acute myocardial infarction (AMI) and stroke in Korea. Using the National Health Insurance claim data, we investigated patients whose main diagnostic codes included AMI or stroke during 2006 to 2010. As a result, we found out that the number of AMI hospitalized patients had decreased since 2006 and amounted to 15,893 in 2010; and that the number of those with stroke had decreased since 2006 and amounted to 73,501 in 2010. The age-standardized incidence rate of hospitalized AMI, after adjustment for readmission, was 41.6 cases per 100,000-population in 2006, and had decreased to 29.4 cases in 2010 (for trend P < 0.001). In the case of stroke was estimated at 172.8 cases per 100,000-population in 2006, and had decreased to 135.1cases in 2010 (for trend P < 0.001). In conclusion, the age-standardized incidence rates of both hospitalized AMI and stroke in Korea had decreased continuously during 2006 to 2010. We consider this decreasing trend due to the active use of pharmaceuticals, early vascular intervention, and the national cardio-cerebrovascular disease care project as the primary and secondary prevention efforts.

국가 암 조기검진 대상자의 암 검진 수검의도 관련 요인

김록범,박기수,홍대용,이철헌,김장락,Kim, Rock-Bum,Park, Ki-Soo,Hong, Dae-Yong,Lee, Cheol-Heon,Kim, Jang-Rak 대한예방의학회 2010 예방의학회지 Vol.43 No.1

Objectives: To identify factors associated with cancer screening intention using the Theory of Planned Behavior (TPB). Methods: Among 55,920 eligible persons for National Cancer Screening Program (NCSP) in J city, 1,100 individuals were contacted. Of these, 797 were interviewed using a structured questionnaire. Thirty-six responses were excluded due to incomplete data. The remaining 761 completed questionnaires were analyzed to find factors associated with cancer screening intention. Results: Cancer screening intention was significantly associated with behavioral attitude (p<0.01) and subjective norm (p<0.01), but not with perceived behavioral control (p=0.29) in the TPB model. These three constructs explained 29.7% of cancer screening intention in multiple linear regression analysis. External factors such as socio-demographic status, health and health behavior variables explained 8.9% of screening intention. Among them, household monthly income, past cancer screening experience, exercise and daily eating habit were significantly associated with screening intention. Conclusions: Cancer screening intention may be influenced by focusing attitude, subjective norm in TPB model and other external factors. However, further studies are warranted to identify factors influencing cancer screening intention and behavior.

The Trend in Incidence and Case-fatality of Hospitalized Acute Myocardial Infarction Patients in Korea, 2007 to 2016

김록범,김혜심,강대룡,최지유,최낙천,황석재,황진용 대한의학회 2019 Journal of Korean medical science Vol.34 No.50

Background: The trend in the incidence of hospitalized acute myocardial infarction (AMI) and the difference between regions has not been reported in Korea since 2010. Thus, we aimed to inspect recent trends and regional differences in the incidence of AMI and case- fatality between 2007 and 2016. Methods: Data from the medical utilization cohort from 2002 to 2016 were analyzed. New incidence of AMI was identified by checking the diagnosis code, duration of admission, type of test, treatment, and medication. Age-standardized incidence rate by gender, age group, and resident region was calculated from 2007 to 2016. Cumulative case-fatality rate was calculated until 3 years. Results: Age-standardized incidence of hospitalized AMI decreased from 53.6 cases per 100,000 person-years in 2007 to 38.9 cases in 2011. Thereafter, the incidence gradually increased to 43.2 cases in 2016. The trend by gender and age groups was also similar to the total trend. The regional age-standardized incidence was the highest in Daegu (50.3 cases per 100,000 person-years) and the lowest in Sejong (30.2 cases), which were similar to the ischemic heart disease mortality in these regions. The 7-, 30-, and 90-days and 1- and 3-years average case-fatality over 10 years were 3.2%, 6.9%, 9.9%, 14.7%, and 22.4%, respectively. Conclusion: Although case-fatality continuously decreased from 2007 to 2016, hospitalized AMI incidence decreased from 2007 to 2011 and gradually increased from 2011 to 2016, with marked disparity between regions. Effective preventive strategies to decrease AMI incidence are required to decrease cardiovascular disease mortality in Korea

우울증상에 관련된 요인과 우울증상이 지각된 건강수준, 외래의료이용, 삶의 질에 미치는 영향

김록범(Rock Bum Kim),박기수(Ki Soo Park),이진향(Jin Hyang Lee),김봉조(Bong Jo Kim),전진호(Jin Ho Chun) 한국보건교육건강증진학회 2011 보건교육건강증진학회지 Vol.28 No.1

Trend in the incidence of Rheumatoid Arthritis in Korea for 11-years (2006-2017)

강현지,김록범,이한나,서영선,김민교,김현옥,이상일,천윤홍 대한내과학회 2023 대한내과학회 추계학술대회 Vol.2023 No.2

Prevalence of Laryngeal Disease in South Korea: Data from the Korea National Health and Nutrition Examination Survey from 2008 to 2011

우승훈,김록범,최승호,이승원,원성준 연세대학교의과대학 2014 Yonsei medical journal Vol.55 No.2

Purpose: The aim of this study was to evaluate the prevalence of Benign Vocal Fold Lesion (polyp, cysts, nodules) and Leukoplakia in Korea. Materials and Methods: The data from the 2008 to 2011 Korea National Health and Nutrition ExaminationSurveys, which were cross-sectional survey of the civilian noninstitutionalizedpopulation of South Korea. A survey team that included an otolaryngology residents, nurses, and interviewers moved with a mobile examination unit and performedlaryngologic interviews and examinations of vocal folds using rigid telescopiclaryngoscopy on survey participants over 19 years old (n=19636). Results: Laryngoscopic examination revealed normal results in 19251 (98.04%) of those includedin the survey. Abnormal laryngoscopic findings were observed in 1.96% of the population examined, and vocal cord nodules were the most common abnormal finding. The prevalence of vocal cord nodules was 0.99-1.72%, the prevalence of vocal cord polyps was 0.31-0.55%, the prevalence of vocal cysts was 0.04-0.17%, and the prevalence of vocal cord leukoplakia was 0.07-0.21%. There was no significantcorrelation of linear trend of prevalence by year, and there were no significant differences in prevalence between males and females. Conclusion: This is the first nationwide epidemiologic study to assess the prevalence of Benign Vocal Fold Lesion(polyp, cysts, nodules) and Leukoplakia by both the Korean Otolaryngologic Society and the Ministry of Health and Welfare. The results of this large epidemiologicstudy provide valuable information regarding the prevalence of voice disordersand the management of laryngologic diseases.

Gender Differences in Factors Related to Prehospital Delay in Patients with ST-Segment Elevation Myocardial Infarction

김희숙,김록범,이건세,은상준,최시완,김대혁,박태호,윤경호,양동헌,황석재,박기수 연세대학교의과대학 2017 Yonsei medical journal Vol.58 No.4

Purpose: The aim of our study was to investigate gender differences in factors related to prehospital delay and identify whether the knowledge of acute myocardial infarction symptoms affects this delay in Korean patients with ST-elevation myocardial infarction(STEMI). Materials and Methods: A total of 350 patients (286 men, 64 women) with confirmed STEMI were interviewed to investigate socio-demographics, history of disease, symptom onset time, and factors that contributed to delayed decision time in seeking treatment and hospital arrival time from symptom onset. Factors associated with prehospital delay were examined separately by gender using univariate and multivariate analyses. Results: Female patients had higher proportions of ≥60-minute decision time and ≥120-minute arrival time compared to male patients (33.9% vs. 23.1%, 60.9% vs. 52.1%, respectively). However, the difference was not statistically significant (p=0.093 and 0.214, respectively). Previous cardiovascular disease (CVD) was associated with increased decision time in men, whereas, in women, lower educational status caused a greater delay in decision time. Factors associated with hospital arrival time excluding delayed decision time were referral from another hospital, previous CVD, and percutaneous coronary intervention in men, and referral from another hospital in women. Conclusion: Gender differences exist in factors related to prehospital delay. Therefore, public education to reduce prehospital delay should be conducted according to gender with a focus on the pertinent factors.

Reference Range of Respiratory Muscle Strength and Its Clinical Application in Amyotrophic Lateral Sclerosis: A Single-Center Study

박기홍,김록범,양지원,오정환,박수연,김동건,신제영,성정준 대한신경과학회 2016 Journal of Clinical Neurology Vol.12 No.3

Background and PurposezzEvaluating respiratory function is important in neuromuscular diseases. Tis study explored the reference ranges of the maximal inspiratory pressure (MIP), maximal expiratory pressure (MEP), and snif nasal inspiratory pressure (SNIP) in healthy adults, and applied them to amyotrophic lateral sclerosis (ALS) patients. MethodszzMIP, MEP, and SNIP were measured in 67 healthy volunteers aged from 21 to 82 years. Reference ranges were evaluated by multivariate regression analysis using the generalized additive modeling of location, scale, and shape method. Tirty-six ALS patients were reviewed retrospectively, and abnormal values of MIP, MEP, and SNIP were determined according to the reference ranges. ResultszzMIP, MEP, and SNIP were abnormal in 57.1%, 51.4%, and 25.7% of the ALS patients, respectively. MIP and SNIP were signifcantly correlated with the degree of restrictive pattern and respiratory symptoms. Te ALS Functional Rating Scale-Revised score was correlated with SNIP. ConclusionszzTis study has provided the reference range of respiratory muscle strength in healthy adults. Tis range is suitable for evaluating respiratory function in ALS patients.

Relationship between Dietary Mercury Intake and Blood Mercury Level in Korea

유창훈,김병권,김유미,이상아,김록범,서정욱,홍영섭 대한의학회 2014 Journal of Korean medical science Vol.29 No.2

This study was performed to evaluate the effect of dietary factors for mercury exposure by comparing with blood mercury concentration. Study population consisted of 1,866 adults (839 men and 1,027 women) in randomly-selected 30 districts in southeast Korea. Dietary mercury intake was calculated from food frequency questionnaire (FFQ) on seafood items and 24 hr recall record. Blood mercury concentration was measured with atomic absorption spectrometry. Mean age of the subjects was 43.5±14.6 yr. The FFQ showed that mercury-laden fish (tuna, shark) and frequently-eating fish (squid, belt fish, mackerel) were important in mercury intake from fish species. The recall record suggested that fish and shellfish was a highest group (63.1%) of mercury intake and had a wide distribution in the food groups. In comparison with the blood mercury concentration, age group, sex, household income, education, drinking status and coastal area were statistically significant (P<0.001). In multiple regression analysis, coefficient from the FFQ (β=0.003) had greater effect on the blood mercury than the recall record (β=0.002), but the effect was restricted (adjusted R2=0.234). Further studies with more precise estimation of dietary mercury intake were required to evaluate the risk for mercury exposure by foods and assure risk communication with heavily-exposed group.