저강도 레이저가 흰쥐 창상 후 급성통증에 미치는 영향

김동현,백수정,김석범,송주민,김진상,Kim Dong-Hyun,Baek Su-Jeong,Kim Suk-Bum,Song Ju-Min,Kim Jin-Sang 대한물리치료학회 2002 대한물리치료학회지 Vol.14 No.2

This study was performed, using c-fos and Substance P, to investigate the effect of GaAlAs laser on acute pain model induced by wound in lumbar region's spinal level. The test group was divided into control and experimental group. Control group is shamed group(c-fos and substance P expression after non-irradiation by a GaAlAs laser), The experimental group was divided into two subgroups: one is experimental group I (c-fos expression after irradiation by a GaAlAs laser), and the other is experimental group II (substance P expression after irradiation by a GaAlAs laser). The results of this study were as following: 1. The numbers of c-fos immunoreactive neuron in spinal cord was increased markedly 1 day after wound, and decreased gradually from 1 day to 2 days in wound with GaAlAs laser irradiation. 2. The changes of the average percentages of substance P immunoreactive neurons in spinal cord was increased markedly 1 day after wound, and decreased gradually from 1 day to 2 days in wound with GaAlAs laser irradiation. Therefore, decreasing the changes of c-fos and substance P expression after irradiation by a GaAlAs laser indicates and GaAlAs laser have effect on pain control.

그린캠퍼스 운영체계에 대한 사례연구 - 미국 그린캠퍼스 지원기관 및 하버드대학을 중심으로 -

김동현,이현,전강은,김세용,Kim, Dong-Hyun,Lee, Hyun,Jeon, Kang-Eun,Kim, Sei-Yong 한국교육시설학회 2013 敎育施設 Vol.20 No.4

The concept of Green campus has recently become an issue with the fact that universities are classified as energy gluttons. This study clearly defines the meaning of domestic green campus, and explores the operating system of green campus and related associations. Then, it draws implications from the case of Harvard University. For the research, reports and research papers of the University are examined thoroughly, and detailed information were confirmed through visiting to the official home page and emails with authorities. The green campus support institutions of the United States are making efforts to integrate overlapping functions and create a synergy effect through internal interchange and information exchange, and substantive collaboration. Also, it is drawing active participation from students and faculties of American universities by publicizing and raising various methods of funding to manage them. The primary factors of Harvard University's success are: voluntary participation from all members, the coordinated operation of the administrative division to be the center of the green campus initiative and the cooperation of each department. Other critical factors of Harvard's success are their fundraising capability, and specialized management institution. The study has significance in that it draws applicable implications on domestic Green campus through in-depth analysis, which surpasses introduction of preceding studies.

하지길이 차이가 요통과 관절경직에 미치는 영향

김동현,김석범,백수정,남태호,김진상,Kim Dong-Hyun,Kim Suk-Bum,Baek Su-Jeong,Nam Tae-Ho,Kim Jin-Sang 대한물리치료학회 2002 대한물리치료학회지 Vol.14 No.4

Human body balances right and left leg centering around pelvis and spine. Therefore, imbalance of lower extremity means disequilibrium of the body. The difference of lower extremity length can cause a number of clinic symptoms including scoliosis, low back pain, sacroiliac pain, and sports injury. In this study, we tried to analyze low back pain and joint stiffness resulting from the difference of lower extremity length. The subjects were 80 male students who are 20-25 years old. The results of this study were as following: 1. Low back pain depending on the difference of lower extremity length One group which the difference of lower extremity length is above 12mm showed average different length as 18.0mm, the other group which one is below 12mm showed as 6.3mm. A group of above 12mm had more severe low back pain than a group of below 12mm. 2. Joint stiffness depending on the difference of lower extremity length A group of above 12mm had more severe joint stiffness than a group of below 12mm.

두께 불균일 압전 초음파 트랜스듀서의 형태에 따른 특성변화 해석

김동현,김정순,김무준,하강렬,Kim, Dong-Hyun,Kim, Jung-Soon,Kim, Moo-Joon,Ha, Kang-Lyeol 한국음향학회 2008 韓國音響學會誌 Vol.27 No.6

압전판의 길이나 폭에 따라 두께가 변화하는 압전 세라믹을 사용하여 광대역 특성을 구현하는 초음파 트랜스듀서에 대하여 압전진동자의 측면에서 본 형태에 따른 전기-음향적 특성해석을 이론적으로 수행하였다. 압전진동자의 길이방향에 따른 두께 변화를 지수함수의 조합으로 표현하고 이 함수를 이용하여 압전진동자의 전기단자에서 본 자유 어드미턴스 및 파워전달함수에 대한 식을 도출하였다. 대표적인 PZT압전 세라믹을 예로 들어 압전 진동자의 측면 형태변화에 따른 비 대역폭을 고찰해본 결과 넓은 대역폭를 얻기 위한 최적의 형태가 존재함을 알 수 있었으며, 압전진동자의 최대두께에 대한 최소두께 비가 자아짐에 따라 대역폭은 100%이상까지도 넓어질 수 있으나 파워전달함수는 반대로 감소하는 경향을 확인할 수 있었다. 또 압전진동자의 길이가 길어질수록 전달함수의 크기는 증가하나 광대역 특성을 갖는 압전진동자의 형태는 매우 한정적이 됨을 확인할 수 있었으며 이는 고효율의 광대역 초음파 트렌스듀서 제작에 있어서는 정밀한 가공이 요구됨을 확인할 수 있었다. The electro-mechanical characteristics were theoretically analyzed for the wideband ultrasonic transducer made of non-uniform thickness piezoelectric vibrator. This paper proposes a combination of exponential functions which describes the thickness variation along the length of the vibrator to derive the input admittance and power transfer function of the transducer. The bandwidth and the power transfer function of the transducer were investigated while the lateral shape of the vibrator changes. The results showed there is an optimum shape for the wideband characteristics of the transducer, and the bandwidth has increased up to over 100% as the ratio of minimum value of thickness to maximum value decreases. However, the power transfer function had a downward trend as the ratio of thickness decreases. Also we confirmed that even though the value of transfer function increases as the length of the piezoelectric vibrator increases, the shape providing wideband characteristics is very limited. It means that precision processing is required to manufacturing a wideband ultrasonic transducer with high efficiency.

간 질환력과 원발성 간암에 관한 환자-대조군 연구

김동현,박병주,유근영,안윤옥,이효석,김정룡,이상일,이무송,안형식,김헌,박태수,Kim, Dong-Hyun,Park, Byung-Joo,Yoo, Keun-Young,Ahn, Yoon-Ok,Lee, Hyo-Suk,Kim, Chung-Yong,Lee, Sang-Il,Lee, Moo-Song,Ahn, Hyung-Sik,Kim, Heon,Park, Tae-Soo 대한예방의학회 1994 Journal of Preventive Medicine and Public Health Vol.27 No.2

The relationship between past liver disease history and the risk of primary liver cancer was analyzed in a hospital-based case-control study conducted in Seoul on 165 patients with histologically or serologically confirmed hepatocellular carcinoma and individually age- and sex-matched 165 controls in hospital for ophthalmologic, otologic, or nasopharyngeal problems. Significant association were observed for liver deseases occurring 5 or more years before liver cancer diagnosis [OR,4.9;95% confidence interval (CI), $1.6{\sim}14.0$) and family history of liver disease(OR, 9.0;95% CI, $2.1{\sim}38.8$). These associations were not appreciably modified by allowance for major identified potential confounding factors. From these results, it is possible to speculate that liver cell injuries caused by various factors might be a common pathway to developing primary liver carcinoma. Considering the significant effect of family history of liver diseases on PLCA risk after adjusting past liver disease history, there might be genetic susceptibility in the carcinogenic mechanism of liver cancer. Further investigations are needed to clarify the effect of family history of liver disease on PLCA risk.

순환기가감방(循環器加減方)이 고지혈증 유발 백서(白鼠)에 미치는 영향

김동현,임승민,안정조,조현경,유호룡,김윤식,설인찬,Kim, Dong-Hyun,Lim, Seung-Min,Ahn, Jung-Jo,Jo, Hyun-Kyung,Yoo, Ho-Ryong,Kim, Yoon-Sik,Seol, In-Chan 대한한방내과학회 2010 大韓韓方內科學會誌 Vol.31 No.3

Objective : This study was performed to investigate the effect of Sunhwangigagambang(SHG) on hyperlipidemia in SD rats induced by high cholesterol diet. Method : After treatment with SHG, cytotoxicity, body weight, liver weight, AST, ALT, ALP, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, glucose, albumin, total protein in serum, malondialdehyde, and gene expression for ACAT and HMG-CoA reductase in hepatic tissue were analyzed. Result : 1. SHG didn't show any cytotoxicity in both human fibroblast cell line and SD rats. 2. SHG significantly inhibited the increase of liver weight by high cholesterol diet compared to the control group. 3. SHG significantly ameliorated the increase of total cholesterol, LDL-cholesterol, and triglyceride and reduction of HDL-cholesterol compared to the control group. 4. SHG significantly reduced glucose level in serum compared to the control group. 5. SHG significantly reduced malondialdehyde in hepatic tissue compared to the control group. 6. SHG significantly down-regulated gene expression of ACAT and HMG-CoA reductase compared to the control group. Conclusion : These results suggest that SHG might be effective in treatment and prevention of hyperlipidemia.

Capsaicin 적용 후 손상된 흰쥐 척수내 c-fos와 HSP70의 발현

김동현,김석범,백수정,김진상,Kim, Dong-Hyun,Kim, Souk-Boum,Baek, Su-Jeong,Kim, Jin-Sang The Korean Society of Physical Therapy 2002 대한물리치료학회지 Vol.14 No.1

C-fos는 원종양유전자(proto-oncogene)인 v-fos의 세포 동족체로써, 성장인자나 신경전달 물질에 의해 수분 내에 다양한 형태의 세포에서 활성화된다. Fos단백질은 스트레스와 통증 과정의 신호전달기전에서 세포활동을 조절하는 3차전령으로 활동한다. 열충격 단백질(Heat shock protein : 이하 HSP)은 계통발생학적으로 초기 척추 동물에서부터 발현되며 생체방어체계의 중요한 인자로 세포가 고열, 외상, 허혈 등의 스트레스에 직면했을 때 발현이 증가하는 단백질로 알려져 있다. 본 연구에서는 캡사이신(capsaicin)으로 말초 신경병변을 유발시킨 후 통각신경활성의 지표로 이용되는 원종양 유전자인 c-fos의 발현과 열 또는 스트레스로 야기되는 손상에 대한 조직의 방어작용으로 발현되는 HSP 70의 발현을 동시에 관찰함으로서, 급성으로 유발된 말초 신경병변의 확인과 동시에 실험동물 체내에서 방어적인 역할을 밝히는 일환으로 이 실험을 실시하였다. 본 실험의 결과는 다음과 같다; 1. 척수 등쪽뿔 천층(Laminae I and II)에서 각각 c-fos와 HSP70을 항원으로 하는 면역조직화학적 방법으로 염색한 표본에서 0.9% NaCI 투여 2시간 후 c-fos와 HSP70의 양성을 나타내는 세포는 전혀 없음을 알 수 있었다. 2. 척수 등쪽뿔 천층에서 c-fos 단백질을 항원으로 하는 면역조직화학적 방법으로 염색한 표본에서 Capsaicin 투여 2시간 후 c-fos 단백질에 양성을 나타내는 세포가 많이 발현됨을 육안적 관찰로서 알 수 있었다. 3. 척수 등쪽뿔 천층에서 HSP70을 항원으로 하는 면역조직화확적 방법으로 염색한 표본에서 Capsaicin 투여 2시간 후 HSP7O의 양성을 나타내는 세포가 보통수준으로 발현됨을 육안적 관찰로서 알 수 있었다. 이 실험의 결과로 볼 때, 화학적인 신경병변 유발물질에 의한 손상을 방어하기 위해서 체내에는 내인성 물질이 형성될 것이라는 추측과 c-fos 가 다른 유전자의 발현을 유도한다는 점을 함께 고려 하였을때, Capsaicin에 의한 말초 신경병변에서 c-fos 발현이 많이 나타나는 것은 손상을 방어하는 물질의 생성에 관여하기 때문이며, 방어물질 중 이 실험에서 본 HSP70도 증가한 내인성 방어물질의 하나라고 할 수 있을 것이다.

하이덴하인 변형 크로이츠펠트-야콥병 1예

김동현,김상윤,양영순,정성해,김지수,황정민,Dong-Hyun Kim,Sang Yun Kim,Young Soon Yang,Seong-Hae Jeong,Ji Soo Kim,Jeong-Min Hwang 대한안과학회 2008 대한안과학회지 Vol.49 No.9

Purpose: To report a case of the Heidenhain variant of sporadic Creutzfeldt-Jakob disease (CJD), predominantly characterized by visual impairment at onset. Case summary: History-taking, ophthalmologic examination, neurologic examination, cerebrospinal fluid examination including 14-3-3 protein analysis, and brain MRI were performed in a 48-year-old man with progressive visual loss and a visual field defect. These symptoms were accompanied by visual illusion and macropsia. Neurologic examination revealed relatively rapidly progressing cognitive impairment, ataxia, aphasia, and myoclonus. The 14-3-3 protein was detectable in otherwise normal CSF samples. The diffusion weighted brain MRI showed increased signal intensity in both occipital lobes, the basal ganglia, the temporal and frontal lobes. He was clinically diagnosed as having a Heidenhain variant of sporadic CJD. Conclusions: In a patient with a rapidly progressive visual loss, visual field defects, visual illusion, and neurologic abnormalities including progressive dementia, ataxia, aphasia, and myoclonus, the Heidenhain variant of CJD should be considered. Because prions, a cause of CJD, exhibit unusual resistance to conventional chemical and physical decontamination methods, it is necessary to have an appropriate management scheme to prevent the spread of infection. J Korean Ophthalmol Soc 2008;49(9):1548-1552

초등 과학영재 수업에서의 언어적 상호작용 사례 분석

김동현 ( Dong Hyun Kim ),김효남 ( Hyo Nam Kim ) 한국과학교육학회 2011 한국과학교육학회지 Vol.31 No.8

The purpose of this study was to analyze and extract the features of verbal interactions between teacher and science-gifted students in their classes. For the purpose of this study, authors observed 27 elementary science classes for the science gifted of three elementary teachers. To analyze the verbal interactions in the classes, the authors have adopted the theoretical background, which was based on Sinclair & Coulthard`s Initiative-Response- Feedback pattern. Verbal interactions in the classes were analyzed by Kim`s framework, which modified Jeong`s framework. IRF patterns were derived from the verbal interactions of science classes for the science gifted. As a result, authors obtained some important features in IRF pattern. The most commonly used IRF pattern was the teacher`s managerial question-student`s short answer pattern, which was due to the regional policy for the science gifted. The teacher`s delayed feedback as well as the teacher`s question was meaningful for student`s thinking ability. If elementary teachers consider the pattern, the strategy should be applied, which is depending on student levels and levels of contents. But three teachers did not show the characteristic verbal interaction regarded as a pattern strategy. In the future, inservice programs about verbal interaction are needed for the science gifted classes.

일반논문 : 공간 인식의 로컬리티와 서사적 재현양상 -『화산도』와 『지상에 숟가락 하나』를 중심으로-

김동현 ( Dong Hyun Kim ) 한민족문화학회 2016 한민족문화연구 Vol.53 No.-

이 글의 목적은 김석범의 『화산도』와 현기영의 『지상에 숟가락 하나』를 중심으로 지역에서의 공간 인식의 양상과 서사적 재현 방식을 살펴보는 것이다. 『화산도』는 이방근과 남승지라는 두 인물을 중심으로 제주 4·3의 전사(前史)와 그 이후의 이야기를 폭넓은 시각으로 다루고 있다. 이 소설의 또 다른 주인공은 바로 거리들이다. 소설은 칠성로와 관덕정을 중심으로 한 성내의 거리를 배경으로 진행된다. 남문로를 거슬러 올라가 자리잡은 유달현의 집이나, 서문교 건너 박산봉의 집, 북국민학교 뒤편의 이방근의 집, 동문다리를 건너 측후소를 조금 지나 자리 잡은 양준오의 집 등 소설 속 인물들 공간은 모두 성내를 중심으로 포진하고 있으며 인물들은 이 거리를 오고 간다. 그리고 이 거리의 풍경들은 매우 구체적으로 그려지고 있다. 『화산도』는 지역의 장소성을 전면에 부각시킴으로써 서사적 구성을 완성시키고 있다. 제주 4·3을 소설로 형상화하면서 김석범이 선택한 전략은 공간의 구체성을 극대화하는 전략이었다. 『화산도』는 해방기 제주를 상상함에 있어 지역의 구체적 장소성으로 지역을 소환하고, 지역을 상상적으로 재구성하고 있다. 현기영에게 있어 관덕정 광장은 섬 공동체가 지니고 있었던 저항 정신의 생산지이다. 장두 이재수에서부터 시작하여 산군 대장 이덕구에 이르기까지 제주의 장두정신은 관덕정 광장이라는 구체적 공간을 무대로 하여 현재와 마주하고 있다. 현기영은 『지상에 숟가락 하나』에서 한걸음 더 나아가 관덕정 광장을 제주 섬 공동체의 신화의 몰락과 반공국가로의 폭력적 편입 과정의 구체적 장소로 지목하고 있다. 관덕정 광장에 전시된 이덕구의 시신이라는 역사적 사실을 현기영은 ‘관권의 불의에 저항한 섬 공동체의 신화의 몰락’으로 인식한다. The purpose of this article is intended to examine the appearance and narrative reproduction method of spatial awareness in the region around 『The Spoon One on the Ground』 and 『Volcano Island』 Kim-suk bum``s 『Volcano Island』 describes the wide-ranging, history of Jeju 4.3 incident through two figures, Lee-Bang-guen and Nam-seung-gee. Another hero of this novel is just street. Novel is proceeding against the background of the distance of the castle with a focus on Chilsung-Ro and Gwandeokjeong. People our space in the novel has been lineup all around the Jeju castle, person, back and forth this distance. And scenery of this city is very specifically drawn. 『Volcano Island』 is to complete the epic structure by levitate the location of the area in front. Gwandeokjeong Square is the spirit of the production area of resistance that community of the island had to Hyun Gi-young. Until To Lee duck-goo starting from Lee Jae-su, spirit of Jeju have to stage a concrete space that Gwandeokjeong Square. Hyun Gi-young is further singled out the Gwandeokjeong Square and downfall and the specific location of violent incorporation process as anti-state of Jeju Island mythology.