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김도하,박철각,양연철,정구영,이청숙,이철희,정재락,최대화 대한소화기내시경학회 1999 Clinical Endoscopy Vol.19 No.1
Postappendectomy bleeding is a rare and occasionally catastrophic phenomenon. Bleed-ing in the gastrointestinal tract may occur early or late. The cause of late bleeding included ulceration, vascular malformation or granuloma. We experienced a case of delayed appendiceal stump ulceration and bleeding who underwent an appendectomy 1 year ago. The patient was admitted due to melena. A colonoscopy showed a well-circumscribed deep ulcer containing of silk suture material at the base of appendiceal stump. Biopsy revealed only granulation tissue with nonspecific inflammation. The silk was removed by biopsy forcep and sulfasalazine was tried. A repeat colonoscopy showed the complete ulcer healing 3 months later. We report this case with a review of literatures.
최신 연구 소개 : Insulin Growth Factor 2 유전자에서 Imprinting의 소실: 대장종양 발생 소인에 대한 유전성 생물학적 표지자
김도하 대한소화기학회 2004 대한소화기학회지 Vol.44 No.4
Insulin-like growth factor II 유전자(IGF2)의 유전체 imprinting의 소실(loss of genomic imprinting, LOI)은 정상적으로는 비활성화 되어야 하는 모계에서 유전하는 대립유전자를 비정상적으로 활성화하는데 관여한다. IGF2에서의 LOI는 대장종양의 개인 및 가족 병력과 관계가 있으며, 이러한 사실은 대장종양의 암 발생 기전에서 어떤 역할을 할 것이라고 생각할 수 있다. 현재까지 IGF2의 LOI와 대
김도하(Do Ha Kim),박능화(Neung Wha Park),주광로(Kwang Ro Joo),이선호(Seon Ho Lee),김성률(Sung Ryul Kim),유철인(Cheol In Yoo),서재희(Jae Hee Suh),박재후(Jae Hoo Park) 대한소화기학회 2002 대한소화기학회지 Vol.39 No.4
Background/Aims: Enterogastric reflux of bile has been suspected as a risk factor of foregut cancer. Thus, we measured total intragastric bile acid to determine association between duodenogastric reflux and development of intestinal metaplasia known as premalignant gastric mucosal change. Methods: One hundred and three patients with a functional dyspepsia underwent endoscopy. Subsequently, samples of fasting gastric juice were taken from all patients for analysis of total bile acid. With the specimens from 5 sites of the antrum and body, the degree of intestinal metaplasia was evaluated by the update Sydney System and H. pylori infection was evaluated also by Warthin-Starry staining. Results: There was a significant correlation between the total bile acid level and the degree of intestinal metaplasia (r=0.278, p=0.005). Moreover, multiple linear regression test showed that the concentration of total bile acid was one of the independent risk factors for intestinal metaplasia regardless of age and H. pylori infection. Conclusions: These results suggest that intragastric bile acid may affect histologic premalignant changes of the gastric mucosa and thus, duodenogastric reflux may play a role in gastric carcinogenesis. (Korean J Gastroenterol 2002;39:248-253)
급성 골수성 백혈병에서 고용량 Cytarabine 을 이용한 공고요법
김도하(Do Ha Kim),이규형(Kyoo Hyung Lee),조재근(Jae Kun Cho),김선희(Seon Hee Kim),이제환(Je Hwan Lee),김성배(Sung Bae Kim),김상위(Sang We Kim),서철원(Chul Won Suh),이정신(Jung Shin Lee),김우건(Woo Kun Kim),김상희(Sang Hee Kim) 대한내과학회 1996 대한내과학회지 Vol.51 No.4
N/A Objectives: This study was designed to evaluate the therapeutic efficacy of postremission therapy utilizing high-dose cytarabine in patients with newly diagnosed acute myelogenous leukemia and to assess the toxicities of the therapy. Acute promyelocytic leukemia (FAB M3) is excluded because it has very unique clinicopathologic characteristics. Methods: Those patients who achieved complete remission had first consolidation therapy with conventional dose cytarabine and daunorubicin but second and third consolidation was done with high-dose cytarabine (cytarabine 1gm/㎡ i.v. over 1 hour every 12 hours daily for 5 days) and daunorubicin. Overall survival and disease free survival were compared with previous conventional dose cytarabine and daunorubicin postremission therapy. Results: 1) Complete remission occurred in 62% (28 of 45 patients) and control group 48% (14 of 29 patients) (p=0.15). 2) The median survival of all 45 patients was not different significantly compared with control group (10 months vs 7 months, p=0.08). 3) The median disease free survival of 21 complete responders receiving at least one course of consolidation was 10 months and there was no significant difference compared with control group 7 months (p=0.47). 4) The toxicity including treatment-related motility, neutropenia duration was similar in both groups. Conclusion: Although our high-dose cytarabine consolidation therapy regimen appeared to have acceptable toxicity, its results did not show the superiority to previous conventional dose cytarabine consolidation regimen.
김도하 ( Do Ha Kim ),조몽 ( Mong Cho ),김대현 ( Dae Hyun Kim ),주광로 ( Kwang Ro Joo ),박능화 ( Neung Hwa Park ),양웅석 ( Ung Suk Yang ) 대한내과학회 2003 대한내과학회지 Vol.64 No.4
목적 : 최근 종양억제유전자 중의 하나인 p16 유전자의 불활성화가 여러 암의 발생에 관여되고 있는 것이 확인되었다. 대장암의 발암과정에서 p16 유전자의 불활성화는 p16 promoter의 과메틸화가 중요한 기전으로 보고되었지만 현재까지 국내에서는 이에 대한 보고가 없는 실정이다. 따라서 본 연구에서는 대장선종과 대장암에서 p16 유전자의 메틸화를 조사하여 대장암 발암과정에서의 역할을 살펴보고 나아가 대장암의 여러 임상 양상 및 병기에 영향을 미치는가 Background : De novo methylation and transcriptional silencing of p16 gene is one of the main pathways in inactivation of p16 gene in colon neoplasm. But there has been no study about that in Korea yet. The aims of this study were to determine p16 methyla