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유전공학을 이용한 인테인-아밀로이드 베타(Aβ) 융합 단백질의 발현
김도명,박정호 大田産業大學校 2001 한밭대학교 논문집 Vol.18 No.-
Alzhemer's disease(AD) is a neurodegenerative disorder of the elderly characterized clinically by progressive dementia. A considerable weight of evidence now supports a major role for amyloid plaque formation in the etiology of Alzheimer's diease. Plaques are composed predominantly of insoluble fibers of the amyloid β-peptide(Aβ) and Aβ has been shown to be toxic to neuronal cells. A large amount of Aβ is needed to carry out researches about Aβ-involved diseases. We have tried to produce Aβ by using the recombinant DNA technology. It was difficult to express Aβ itself, therefore intein fused Aβ protein was successfully expressed & purified by using plasmid pTYB11.