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Korean species of Gracillaria Haworth, 1828 (Lepidoptera: Gracillariidae)
김다솜,이지영,변봉규 국립중앙과학관 2022 Journal of Asia-Pacific Biodiversity Vol.15 No.3
In this study, four species of the genus Gracillaria Haworth, 1828 (Lepidoptera: Gracillariidae), are recognized from Korea. Among them, two species, G. albicapitata Issiki, 1930 and G. arsenievi (Ermolaev, 1977), are reported for the first time from Korea. All the known species are enumerated with their available information. Adults and genitalia of all species are redescribed and illustrated.
김다솜,오은실,김춘옥,최청암,장민정,박민수 대한임상약리학회 2016 Translational and Clinical Pharmacology Vol.24 No.4
JOINS, an herbal anti-arthritic drug, was developed for the treatment and pain relief of knee osteo¬arthritis. It was approved for use in Korea by the Ministry of Food and Drug Safety in 2001. The aim of this study was to investigate the effect of JOINS on the pharmacokinetic (PK) profiles of aceclof¬enac in healthy adults. A PK drug-drug interaction study was conducted in 61 healthy subjects by using an open-label, multiple-dose, one sequence, two-period design. Blood samples were collected for plasma concentrations of aceclofenac during the reference period (aceclofenac 100 mg alone) and interaction period (aceclofenac 100 mg + JOINS 300 mg). The area under the curve within a dosing interval (τ) at steady state (AUCτ,ss) and the Cmax at steady state (Cmax,ss) of aceclofenac were analyzed by a non-compartment model using the Phoenix® WinNonlin® software version 6.3 (Pharsight, Mountain View, CA, USA). The 90% CIs of the geometric mean ratios (GMRs) of the AUCτ,ss of aceclofenac with JOINS to without JOINS (D4/D3 and D11/D3) were 0.9593–1.0130 and 0.9745–1.0291, respectively, and the corresponding values for the Cmax,ss of aceclofenac with JOINS to without JOINS (D4/D3 and D11/D3) were 0.8578–0.9795 and 0.8510–0.9717. Aceclofenac alone or co-administered with JOINS was safe and well tolerated with no serious adverse drug reactions or significant differences in the severity of adverse events (AEs) between the two treatment groups. We conclude that co-administration of aceclofenac with JOINS does not influence the PK and safety profiles of aceclofenac.
김다솜,황장선,최종훈 한국공업화학회 2020 한국공업화학회 연구논문 초록집 Vol.2020 No.-
Salmon fish farmers face remarkable problems in fish rearing and handling due to the spread of disease by infectious pancreatic necrosis virus (IPNV). Therefore, we developed a straightforward and sensitive technique to detect IPNV based on recombinant human apoferritin heavy chain (hAFN-H) protein nanoparticles. In this study, the 24 subunits of the hAFN-H were genetically modified to express 6×His-tag and protein-G at their C-terminal site, using Escherichia coli. We thus achieved a two-step signal amplifying strategy that utilizes a recombinant hAFN-H nanoprobe having a protein-G-binding site that targets the Fc region of monoclonal antibodies, and a 6×His-tag that actively interacts with the functionalized Ni-NTA derivatives. The detection of IPNV by this recombinant hAFN-H nanoprobe was linear to virus titers in the range of 101-103 TCID50/mL.