고 (故) 김기범교수 약력 , 저작목록

김기범 연세대학교 사회과학연구소 1978 社會科學論集 Vol.9 No.-

The New Way to Define Key Oncogenic Drivers of Small Cell Lung Cancer

김기범 한국발생생물학회 2023 발생과 생식 Vol.27 No.1

Small-cell lung cancer (SCLC) continues to be the deadliest of all lung cancer types. Its high mortality is largely attributed to the unchangeable development of resistance to standard chemo/radiotherapies, which have remained invariable for the past 30 years, underlining the need for new therapeutic approaches. Recent studies of SCLC genome revealed a large number of somatic alterations and identified remarkable heterogeneity of the frequent mutations except for the loss of both RB and P53 tumor suppressor genes (TSGs). Identifying the somatic alterations scattered throughout the SCLC genome will help to define the underlying mechanism of the disease and pave the way for the discovery of therapeutic vulnerabilities associated with genomic alterations. The new technique made it possible to determine the underlying mechanism for the discovery of therapeutic targets. To these ends, the techniques have been focused on understanding the molecular determinants of SCLC.

비트코인 네크워크에서의 암호화된 봇넷 C&C 통신기법

김기범,조영호,Kim, Kibeom,Cho, Youngho 한국인터넷정보학회 2022 인터넷정보학회논문지 Vol.23 No.5

Botnets have been exploited for a variety of purposes, ranging from monetary demands to national threats, and are one of the most threatening types of attacks in the field of cybersecurity. Botnets emerged as a centralized structure in the early days and then evolved to a P2P structure. Bitcoin is the first online cryptocurrency based on blockchain technology announced by Satoshi Nakamoto in 2008 and is the most widely used cryptocurrency in the world. As the number of Bitcoin users increases, the size of Bitcoin network is also expanding. As a result, a botnet using the Bitcoin network as a C&C channel has emerged, and related research has been recently reported. In this study, we propose an encrypted botnet C&C communication mechanism and technique in the Bitcoin network and validate the proposed method by conducting performance evaluation through various experiments after building it on the Bitcoin testnet. By this research, we want to inform the possibility of botnet threats in the Bitcoin network to researchers.

HVOF 용사 건의 이동속도가 WC-Co 코팅층의 두께 형성 및 표면 특성에 미치는 영향

김기범,김갑배,정종민,김권후 한국열처리공학회 2022 熱處理工學會誌 Vol.35 No.5

In order to process materials such as engineering plastics, which are difficult to mold due to their high strength compared to conventional polymer materials, it is necessary to improve the hardness and strength of parts such as screws and barrels of injection equipment in extrusion system. High-velocity oxygen fuel (HVOF) process is well known for its contribution on enhancement of surface properties. Thus in this study, using the HVOF process, WC coating layers of different thicknesses were bonded to the surface of S30C substrate by controlling the movement speed of the spray nozzle and each property was evaluated to decide the optimization condition. Through the results, the thickness of WC coating layer increased from 0 to 200 μm maximum, along with the decrement of nozzle movement speed and the surface hardness get increased. Especially, the coated layer with the thickness over 180 μm under the nozzle speed 500 mm/s had high hardness than thinner layer. In addition, the amount of wear consumed per unit time was also significantly reduced due to the formation of the coating layer

Corrigendum to “Taxonomic review of the subfamily Rhyssinae Morley (Hymenoptera: Ichneumonidae) with seven newly recorded species from South Korea” [J Asia-Pac Biodivers 11(2018): 123–131]

김기범,강규원,이종욱 국립중앙과학관 2018 Journal of Asia-Pacific Biodiversity Vol.11 No.2

We report seven ichneumonids species new to South Korea. These species belong to the subfamilyRhyssinae. Among them, three genera are newly recorded for the first time from South Korean fauna. Keys to South Korean species and genera, diagnoses of nine newly recorded species and digital imagesare provided.

금융자산 가격들의 경기예측력 연구

김기범,구자천,구본일 한국금융학회 2018 금융연구 Vol.32 No.1

Throughout the media, it is often said that the steepening of the yield curves has indicated confidence in economic growth and that there has been a relationship between equities and the yield curve. In the early 1990s, usually in the US, forecasts of future economic activity highlighted the usefulness of financial market price variables. Previous researches have also shown that the financial market variables lead the real economic activity by a few quarters and can therefore help predicting future business cycle. Because liberalization of the Korea financial market started in the 1990s, it is believed that not many studies have been conducted to analyze the predictive power of financial market variables. This study aims to enhance the understanding of financial market variables as predictors of Korea’s real economic activity. To this end, we regress the annualized cumulative and marginal percentage change in the monthly Industrial Production Index on the financial market variables in the stock and bond market by adopting the econometric method of Estrella and Hardouvelis (1991). The financial market variables consist of two parts. First is composed of Korea’s term spreads, credit spreads and KOSPI return as domestic variables. Second is US term spread as a foreign variable. We can think of the local business cycles in the countries as having two components; a part affected by movements in the world business cycle, and a country specific component (Campbell, 1991). The main results are summarized as follows. First, on the annualized cumulative percentage change in the monthly Korea’s Industrial Production Index, KOSPI return or credit spreads are likely to provide short-term forecast for less than six months. It turns out that the term spread has long-term predictability over the past year. Second, there was a shift in the predictive power of the term spread when we divided the entire period before and after 2007. Compared with the previous period, it was found that the predicted power of the period spread was relatively better after 2007. Third, even if the call rate is included in the model as a monetary policy variable, the predictive power of the term spread has not been decreased. Finally, we considered the US term spread to see if the foreign financial market variables have further information on changes in the future Korean economy. It was revealed that the forecast power did not exist before 2007, but the prediction power was most widely held about the future economic situation in Korea for about 18 months since 2007. To sum up the results, The first and third results are thought to be similar to the results of previous studies, such as Estrella and Hardouvelis (1991). The second is judged to be that the quality of information distributed by the financial market has improved as Korea’s financial market has become more liberalized. The fourth is believed to be in line with the earlier domestic studies showing that the integration between Korea’s real economy and the United States has grown since 2007. 본 연구는 기간 스프레드, 신용 스프레드 및 주식 수익률과 같은 채권과 주식시장의 가격변수가미래 경제상황에 대한 정보를 갖고 있는지를 분석했다. 미래 경제상황의 변화에 대한 척도로는1996년 1월부터 2017년 7월까지의 산업생산지수의 전기대비 증가율을 활용했고 분석 방법은Estrella and Hardouvelis(1991)가 제시한 선형예측모형을 적용했다. 연구 결과는 다음과 같다. 첫째, 미래 경제활동의 추세적인 측면에서 신용 스프레드는 6개월, 주가 수익률은 1년 이내의단기적인 예측력을 갖는 데 반하여, 기간 스프레드는 1년 이상의 장기적인 예측력을 갖는 것으로나타났다. 둘째, 전체 기간을 2007년 이전과 이후로 구분할 때 기간 스프레드가 갖는 예측력의변화가 존재했다. 이전 시점과 비교하여 2007년 이후에는 기간 스프레드의 예측력이 상대적으로더 커진 것으로 나타났다. 셋째, 정책변수로서 콜금리를 모형에 포함시키더라도 기간 스프레드의예측력은 줄어들지 않는 것으로 나타났다. 마지막으로 해외 금융시장 변수가 미래 우리나라경제상황의 변화에 대한 추가적인 정보를 갖고 있는지 알아보기 위하여 미국의 기간 스프레드를고려했다. 그 결과, 2007년 이전에는 예측력이 존재하지 않았으나 2007년 이후로는 우리나라의미래 경제상황에 대하여 18개월 정도의 시차를 갖는 예측력이 존재하는 것으로 나타났다.

新HSK 필수 단어의 新HSK 시험 반영률에 관한 연구

김기범 인문사회 21 2020 인문사회 21 Vol.11 No.5

The purpose of this study is to find a percentage of how much the required words of the new HSK are reflected in the new HSK test, and to find countermeasures and apply them to teaching methods to effectively prepare for the new HSK test. For this purpose, the frequency of the emergence of the required word in the third-grade test was checked, and the figures of non-essential words were obtained. As a result, out of the total 653 words appearing in the third-degree test, 505 words (approximately 77%) appeared in the required word. The same method was applied to fourth-degree test. As a result, out of the total 1,121 words appearing in the fourth-degree test, 909 words (approximately 81%) appeared in the required word. Studies have shown that the Percentage of essential words reflected in the test is significantly higher, 77% and 81%, respectively. In addition, the results provide a good basis for emphasizing learners to acquire essential words. This study is a basic study to prepare for the new HSK and will require more comparative analysis of test samples in the future. 본 연구는 신HSK시험에 효과적으로 대비하고자 신HSK 필수단어가 신HSK 시험에 얼마나 반영되는지 수치를 구하고, 대응방안을 찾아 교수법에 적용시키는데 목적이 있다. 이를 위해 3급 시험에서 3급 필수 단어의 출현빈도를 체크하고, 필수 단어가 아닌 것들의 수치(통계)를 구하였다. 그 결과 3급 시험에 출현하는 전체 단어 653개 중에서, 3급 필수 단어는 505개 (약 77%)가 출현했다. 마찬가지 방법을 4급에도 적용하였다. 그 결과 4급 시험에 출현하는 전체 단어 1,121개 중에서, 4급 필수 단어는 909개(약 81%)가 출현했다. 본 연구 결과 필수 단어가 시험에 반영되는 수치가 각각 77%, 81%로서 상당히 높다는 것을 증명하였다. 아울러 이 결과는 학습자들에게 필수 단어 습득을 강조하는데 좋은 근거가 된다. 이 연구는 신HSK시험 대비를 위한 기초 연구로서 향후에는 좀 더 많은 시험과 비교분석이 필요함을 시사하고 있다.

혈관 내 신형 폐보조장치의 기체전달 및 용혈 특성

김기범,권대규,정경락,이삼철 대한의용생체공학회 2003 의공학회지 Vol.24 No.2

본 연구는 진동형 장치의 활용을 통해 혈관 내 폐 보조장치의 기체전달 효율을 향상시키고자 시도하였으며, 진동에 따른 혈액의 용혈 문제에 있어서 한계 용혈이 발생하는 영역을 선정하고자 하였다. 가진 주파수가 0 Hz일 때를 기준으로 하여 중공사 수의 변화에 따라 산소전달속도를 측정하였다. 최대의 산소전달속도를 나타내는 중공사 모듈에서 가진 주파수의 변화에 따른 산소전달속도를 측정하고 혈액의 용혈도를 측정하였다. 측정결과 액체 유속의 변화에 따라 최대 산소전달속도를 나타내는 중공사 모듈은 type 6으로 이때의 중공사 개수는 675개이다. 또한, 중공사를 가진하지 않았을 때 최대의 산소전달속도를 보여주는 모듈은 type 6이었다. 모듈 type 6의 가진 주파수의 변화에 따른 산소전달속도는 7 Hz에서 최대산소전달속도를 나타내었으며 최대산소전달속도를 나타내는 7 Hz의 가진 주파수에서의 혈액 용혈도를 측정한 결과 혈액의 용혈도는 낮았다. 그러므로 최대 흔들림이 일어나는 7 Hz를 한계 용혈 주파수로 결정할 수 있었다. The purpose of this work was to assess and quantify whether the beneficial effects in long-term gas exchange at exciting frequency were obtained at different frequencies as well and then to develop a vibrating intravascular lung assist device(VIVLAD), for Patients suffering from acute respiratory distress syndrome(ARDS) or chronic respiratory problems. We investigate the optimal condition of the frequency band excited with new vibrator at state of limit hemolysis when blood hemolysis came to through a membrane vibration action. The experimental design and procedures were given for a device used to assess the effectiveness of membrane vibrations. Quantitative experimental measurements were performed to evaluate the performance of the device . and to identify membrane vibration dependence on blood hemolysis. We developed an analytical solution for the hydrodynamics of flow through a bundle of sinusoidally vibrated hollow fibers that is used to provide some insight into how wall vibrations might enhance the performance of the VIVLAD. In the result, it was measured that the effect of various excited frequencies in gas transfer rate and hemolysis from the maximum gas transfer rate at no vibration when the maximum gas transfer rates showed at module type 6, module type 6 consisted of 675 hollow fiber membranes The maximum oxygen transfer rate was caused by the occurrence of maximum amplitude and transfer of vibration to hollow fiber membranes when it was excited by the frequency band of 7Hz at each blood flow rate. because this frequency became the End mode resonance frequency of the flexible in blood flow. Also, when module type 6 was excited at an excited frequency of 7Hz. blood hemolysis was low. Therefore, we decided that the limit of hemolysis frequency is 7Hz . because maximum amplitude occurred at this frequency.

지역내 의료자원이 중증 정신질환자의 의료이용에 미치는 영향

김기범 한국보건행정학회 2021 한국보건행정학회 학술대회 논문집 Vol.2021 No.1

교사 평가를 위한 API 질문지의 구인타당성 검증

김기범 한국스포츠리서치 2005 한국 스포츠 리서치 Vol.16 No.6