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우리나라 신문 기사를 통해 살펴본 알레르기질환 (1920-1972년)
김규언 ( Kyu Earn Kim ) 대한천식알레르기학회(구 대한알레르기학회) 2018 Allergy Asthma & Respiratory Disease Vol.6 No.S
Purpose: This study aimed to investigate which Korean newspaper articles were reported on allergic diseases before the establishment of the Korean Academy of Asthma, Allergy and Clinical Immunology (KAAACI). Methods: This study was performed in 3 newspapers, Chosun Ilbo, DongA Ilbo, and JoongAng Ilbo, which were founded and used the databases established before the establishment of KAAACI in 1972. The databases were searched using 42 keywords associated with allergic diseases (allergy, asthma, rhinitis, etc.). Results: Among the 42 keywords, there were only 7 that were able to search: allergy, urticaria, asthma, dermatitis, rhinitis, pollen and eczema. The total number of articles related to allergic diseases were 62, as follows: allergy (n=21), urticaria (n=15), asthma (n=8), dermatitis (n=8), rhinitis (n=5), pollen (n=3), and eczema (n=2). There were 31 articles in Chosun Ilbo, 9 in DongA Ilbo, and 22 in JoongAng Ilbo. The first allergic disease published in the newspapers was asthma on the article entitled “Treat the cause of asthma” (on page 8 of November 10, 1960 DongA Ilbo). The first article that used the term allergy appeared in a column entitled, “Childhood illness and allergy” (on page 4 of May 30, 1960 DongA Ilbo). Conclusion: Since 1920, articles related to allergic diseases published in the Korean newspapers increased every year. These articles may have appeared due to the increase in the prevalence of allergic disease and the pioneering efforts of senior allergy researchers. (Allergy Asthma Respir Dis 2018;6 Suppl 1:S85-89)
김규언(Kyu Earn Kim),강혜영(Hye Young Kang),한부현(Boo Hyun Han),이수영(Soo Young Lee),정병주(Byung Ju Jeoung),이기영(Ki Young Lee) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 1994 소아알레르기 및 호흡기학회지 Vol.4 No.2
N/A EIA represents a transient airflow obstruction following strenuous exercise and can cause physical and psychological problems in children. It is very important to prevent EIA with pharmacologic or non-pharmachologic methods. To compare the preventive effects of such methods, it is essential that these methods be tried for same individual. We compared the preventive effects of inhaled beta2-agonist, oral beta2-agonist, cromolyn sodium and warm-up by cross-over study on EIA in 45 children (27 boys and 18 girls aged 6 to 15 years). They were diagnosed as EIA by exercise loading test (up and down stairs method for 6 minutes). The changes in pulmonary function were measured by peak expiratory flow rate (FEFR). The results are as follows: 1. The preventive effects were 93.3% in inhaled beta2-agonist, 66.7% in warm-up, 62.2% in cromolyn sodium, and 33.3% in oral beta2-agonist. 2. When we analyzed the preventive effects according to the severity of EIA, we had the following results: warm-up, cromolyn sodium, and oral beta2-agonist were only effective in mild EIA, while inhaled beta2-agonist was effective in all cases of EIA. In conclusions, regardless of severity of EIA inhaled beta2-agonist was the most effective in the prevention of EIA. And warm-up and cromolyn sodium were followed. Oral beta2-agonist was effective only in mild cases of EIA.
반복적인 두드러기를 주소로 내원한 4세 남아에서 발견된 글루텐 알레르기 1례
김규언 ( Kyu Earn Kim ),박현빈 ( Hyun Bin Park ),최봉석 ( Bong Seok Choi ),김미나 ( Mi Na Kim ),홍정연 ( Jeong Yeon Hong ),이경은 ( Kyung Eun Lee ),이용주 ( Young Ju Lee ),백지영 ( Ji Young Beak ),김경원 ( Kyung Won Kim ),손명현 ( 대한소아알레르기호흡기학회 2010 소아알레르기 및 호흡기학회지 Vol.20 No.4
Wheat is the most widely cultivated grain and an important source of food and dietary protein. Wheat proteins are classified based on extraction in different solvents, which are albumin, globulin, prolamin (gliadin) and glutenin. The term `gluten` contains approximately equal amounts of gliadin and glutenin and is the major determinant of the properties of wheat flour conferring cohesiveness and viscoelasticity that allows its dough to be processed into many kinds of food. Gluten is known to be responsible for triggering celiac disease and wheat allergy. Wheat allergy is primarily an IgE-mediated response. Clinical manifestations of wheat allergy are similar to those of other food allergies, with symptoms on the skin, gut and respiratory tract. Recent studies have shown that IgE to gliadin can be an indicator for risk of severe immediate reaction-like anaphylaxis and wheat- dependent, exercise-induced anaphylaxis (WDEIA). However, current in vitro test reagents for the diagnosis of wheat allergy mainly contain water-soluble wheat protein and a small amount of gluten, so there are some limitations to diagnose gluten allergy. Furthermore, there is no acceptable method to measure gluten in food products for preparing effective gluten-free diet. To overcome these limitations and to improve quality of life of wheat allergy sufferers, more work is needed. We report a case of a 4-year-old boy with gluten allergy who presented with urticaria after ingestion kneaded wheat flour with a brief review of the literature. [Pediatr Allergy Respir Dis(Korea) 2010;20:292-296]
김규언(Kyu Earn Kim),정병주(Byung Ju Jeoung),이기영(Ki Young Lee) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 1995 소아알레르기 및 호흡기학회지 Vol.5 No.2
N/A Food allergy is one of the common allergic diseases and the incidence and principal foods are different among countries. Therefore we reviewed clincal history in 3,320 children with atopic asthma and performed skin test with food allergens. L. Of the 3,320 children with asthma, 379 (11.4%) had clinical history of food allergy. These 379 patients showed a total of 554 allergic reactions to 58 foods (1.5 allergic reactions/patient). 2. The ten most common foods implicated in allergic reactions were egg (22.7%), pork(14.8%), peach(14.0%), mackerel(12.7%), chicken(11.1%), milk(10.0%), buckwheat(7.4%), crab(6.3%), wheat(4.7%) and tomato(4.7%) in order of frequency. 3. Although the common foods implicated in allergic reactions were similar amomg the various age groups, peach was the most common food in children over 10 years old. 4. The rate which positive skin test corresponded to the clincaI history was collectively very low (22.6%), but it was the highest in buckwheat (92.9%). In conclusion, the incidence of food allergy is 11.4% and the ten most common foods are as follows; egg, pork, peach, mackerel, chicken, milk, buckwheat, crab, wheat and tomato in order of frequency
김환수 ( Hwan Soo Kim ),김윤희 ( Yoon Hee Kim ),이희선 ( Hee Seon Lee ),한윤기 ( Yoon Ki Han ),박영아 ( Young Ah Park ),김경원 ( Kyung Won Kim ),손명현 ( Myung Hyun Sohn ),김규언 ( Kyu Earn Kim ) 대한천식알레르기학회 2015 Allergy Asthma & Respiratory Disease Vol.3 No.4
Purpose: The goal of asthma control is to maintain well-controlled state. In this study, we investigated whether childhood asthma control test (C-ACT) may reflect lung function and whether fractional exhaled nitric oxide (FeNO) can be used to improve the accuracy of C-ACT in reflecting the asthma control level. Methods: We reviewed the medical records of 155 patients with asthma underwent lung function tests and C-ACT upon visiting our outpatient clinic. We compared lung function test results according to the C-ACT score stratified by atopy and also examined FeNO according to C-ACT and the Global Initiative for Asthma (GINA) guidelines. The diagnostic accuracy of well-controlled asthma by C-ACT, FeNO, and C-ACT+FeNO was examined. We also calculated the cutoff value of FeNO and C-ACT for well-controlled asthma. Results: Peak expiratory flow (PEF) showed a significant correlation with the C-ACT score. Stratified by atopy, PEF, and forced expiration in one second (FEV1) showed significant correlations with the C-ACT score in the atopic asthma group. There was no difference in FeNO between subjects with C-ACT≥20 and <20, but FeNO was significantly higher in the uncontrolled asthma according to the GINA guidelines. The diagnostic accuracy of well-controlled asthma was higher when FeNO was combined with the C-ACT score than C-ACT or FeNO. Our study showed that the cutoff values of C-ACT and FeNO 19 and 18.3 ppb (parts per billion), respectively, for well-controlled asthma. Conclusion: C-ACT showed a significant correlation with PEF, and atopic asthma group showed significant correlations with PEF and FEV1. A combination of C-ACT with FeNO might reflect asthma control status more accurately. (Allergy Asthma Respir Dis 2015;3:261-266)
김정한(Chung Han Kim),김상정(Sang Jung Kim),김용관(Yong Kwan Kim),이영진(Young Jin Lee),김규언(Kyu Earn Kim),이기영(Ki Young Lee) 대한소아알레르기호흡기학회 1996 소아알레르기 및 호흡기학회지 Vol.6 No.2
The bronchial cast formation is a rare phenomenon which occurs exceptionally in association with pneumonia, asthma, mucoviscidosis, bronchial mucoid impaction, alveolar proteinosis, and bronchiectasis. Such diseases can produce severe obstructive conditions with excessive mucous and mucopurulent secretions in the bronchi and alveoli leading to formation of variable size of cast, In this report, we describe a child with bronchial cast and subsequent atelectasis who was treated with flexible bronchofiberscope to remove it.
김수연 ( Soo Yeon Kim ),김윤희 ( Yoon Hee Kim ),설인숙 ( In Suk Sol ),김민정 ( Min Jung Kim ),윤서희 ( Seo Hee Yoon ),김경원 ( Kyung Won Kim ),손명현 ( Myung Hyun Sohn ),김규언 ( Kyu?earn Kim ) 대한천식알레르기학회(구 대한알레르기학회) 2016 Allergy Asthma & Respiratory Disease Vol.4 No.4
Purpose: The revised Berlin definition (BD) showed better predictive validity for mortality in adults with acute respiratory distress syndrome (ARDS). We examined the validity of BD for pediatric ARDS as compared to the American-European Consensus Conference definition (AECCD). Methods: This single-center, retrospective study included 127 patients aged 1 month to 19 years who were admitted to the medical intensive care unit due to acute lung injury (ALI, n=31) or ARDS (n=96) using the AECCD. All patient characteristics and mortality rates were compared between the individual severity groups according to the BD and AECCD. Results: Sixty-four patients (50%) died. Mortality rates increased across the severity groups according to both definitions (26% in mild, 42% in moderate, and 75% in severe by the BD [P<0.001]; 26% in ALI non-ARDS and 58% in ARDS by the AECCD [P=0.002]). The mortality risk increased only for ‘severe ARDS’ (hazard radio for mortality, 2.56; 95% confidence intervals [CI], 1.14-5.78; P=0.023) after adjusting for confounding factors. The BD better predicted mortality, with an integrated area under the receiver operating characteristic curve (iAUC) of 0.651 (95% CI, 0.571-0.725), than the AECCD, with an iAUC of 0.584 (95% CI, 0.523-0.637). The pediatric risk of mortality (PRISM) III and pediatric index of mortality 3 scores were significantly different across BD severity groups, whereas only PRISM III scores were different according to the AECCD. Conclusion: The BD applied to children with ARDS. It could be adopted to severity classifications and predict pediatric ARDS mortality better than the AECCD. (Allergy Asthma Respir Dis 2016:4:257-263)