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Histamine - gammaglobulin 으로 치료한 천식환아에서의 치료전후의 혈청 IgE , IgG 및 혈중 총호산구 변화
김규언,김학용,최종위,이기영 대한천식알레르기학회 1984 천식 및 알레르기 Vol.4 No.1
Histaminemaglobulin is used as nonspecific immunotheraphy to the patients who can not be hyposensitized with specific allergens due to negaive skin test and who are infants or very young qhildren with asthma. Fourtne children with asthm a were studied and their mean age were 6 2/12 years. Serum levels of IgE, IgG and total eosinophil count were me asured after 9 subcutaneous injections at 10 days interval and the levels were compared with those before administration. IgE (238.17 + 42.65 U/ml), IgG (782.76 + 37.68 mg/dl) and total eosinophil count (498.41 + 83.14/mm) before therapy and IgE (195.68 + 34.15 U/ml), IgG (814.44 + 38.42 mg/dl), total eosinophil count (411.37 + 62.55 mm) after therapy showed no significant change (P > 0.05). Those changes among the patients who showed improving tendency (26 patients, 63.4%) and those who showed no response (15 patients, 36.6%) also were not significant (P > 0.05). It is suggested that the evaluation of the effectiveness of histamine-gammaglobulin therapy can be based upon clinical symptoms and that the changes of serum immunoglobulin levels and total eosinophil count have no aignificance.