Differences Regarding the Molecular Features and Gut Microbiota Between Right and Left Colon Cancer

김광민,Ernes John T. Castro,심홍진,John Vincent G. Advincula,김영완 대한대장항문학회 2018 Annals of Coloproctolgy Vol.34 No.6

For many years, developmental and physiological differences have been known to exist between anatomic segments of the colorectum. Because of different outcomes, prognoses, and clinical responses to chemotherapy, the distinction between right colon cancer (RCC) and left colon cancer (LCC) has gained attention. Furthermore, variations in the molecular features and gut microbiota between right and LCCs have recently been a hot research topic. CpG island methylator phenotype-high, microsatellite instability-high colorectal cancers are more likely to occur on the right side whereas tumors with chromosomal instability have been detected in approximately 75% of LCC patients and 30% of RCC patients. The mutation rates of oncogenes and tumor suppressor genes also differ between RCC and LCC patients. Biofilm is more abundant in RCC patients than LLC patients, as are Prevotella, Selenomonas, and Peptostreptococcus. Conversely, Fusobacterium, Escherichia/Shigella, and Leptotrichia are more abundant in LCC patients compared to RCC patients. Distinctive characteristics are apparent in terms of molecular features and gut microbiota between right and LCC. However, how or to what extent these differences influence diverging oncologic outcomes remains unclear. Further clinical and translational studies are needed to elucidate the causative relationship between primary tumor location and prognosis.

Enhancing Microalgal Biomass Productivity in Floating Photobioreactors with Semi-Permeable Membranes Grafted with 4-Hydroxyphenethyl Bromide

김광민,김지훈,박한울,이윤우,김기현,강성모,임상민,이철균 한국고분자학회 2020 Macromolecular Research Vol.28 No.2

Microalgal biomass productivity of semi-permeable membrane photobioreactors (SPM-PBRs) highly depends on diffusion of nutrient ions from surrounding environment through SPMs. The objective of this study was to enhance microalgal biomass productivity in floating photobioreactors (PBRs) with semi-permeable membranes (SPMs) grafted with 4-hydroxyphenethyl bromide (4-HPB) by increasing ion permeabilities and reducing biofouling of SPMs. In this study, we investigated the reduction of biofouling and improvement of biomass productivity by grafting 4- HPB onto SPMs which could decrease hydrophobicity. The degree of alkylation could be increased by up to 4.9%, with water contact angles on alkylated SPM surfaces decreased from 102.5o to 58.2o, indicating decreased surface hydrophobicity. Ion and water permeabilities of SPMs were increased in alkylated SPMs by 148% and 200%, respectively, compared to non-treated SPM control. Moreover, biomass productivity of PBRs with alkylated SPMs was 75% (740 mg m-2 day-1) higher than that of the control. Biofouling was also remarkably reduced by up to 40% in 4-HPB grafted SPMs after cultivation of microalgae. These results suggest that decreasing hydrophobicity of SPMs by grafting 4-HPB could enhance biomass productivity in SPM-PBRs through improving ion permeability and reducing biofouling.

Enhanced mass transfer rate and solubility of methane via addition of alcohols for Methylosinus trichosporium OB3b fermentation

김광민,김유진,양정모,하경수,Hakan Usta,이진원,김충익 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.46 No.-

The effect of alcohol on methane–water volumetric mass transfer coefficient (kLa) and solubility ofmethane was investigated in this study. Various alcohols including methanol, ethanol, 1-propanol,butanol, and pentanol were added to aqueous solution and enhancement of both methane–water kLa(from 72 h 1 to 471 h 1) and solubility (from 21.72 mg/L to 30.41 mg/L) was observed, depending onalcohol type and concentration. Among all alcohols, 1-propanol exhibited largest enhancement viabubble coalescence inhibition effect. Enhanced methane–water kLa and methane solubility in aqueoussolution were employed for the fermentation of Methylosinus trichosporium OB3b, and cell growth rateand maximum optical density were increased by 700% and 730%, respectively, by addition of 1-propanol.

Investigation and prediction of the salting-out effect of methane in various aqueous electrolyte solutions

김광민,서경준,이재원,김명길,하경수,김충익 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.34 No.-

The maximum solubility of methane was determined in aqueous solution of Al2(SO4)3, MgSO4, K2SO4,Na2SO4, AlCl3, MgCl2, KCl, NaCl, MgBr2, KBr, and NaBr with various concentration (1, 3 and 5 wt%) atambient pressure. Salting-out effect was observed in all electrolyte solutions, exhibiting lower solubilityof methane compared to that in pure water. In general, electrolyte solutions comprising cations/anionswith high charge valency and small ionic radius exhibited stronger salting-out effect due to large chargedensity of the corresponding ions. Furthermore, anions exhibited larger influence on the degree ofsalting-out compared to cations. Scaled particle theory was employed to corroborate the trend of theexperimental solubility of methane in electrolyte solutions.

Cationic surfactant as methane–water mass transfer enhancer for the fermentation of Methylosinus trichosporium OB3b

김광민,서경준,김유진,양정모,하경수,이진원,김충익 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.53 No.-

In this paper, we conducted an investigation into the use of bubbles modified with cationic surfactants in bubble coalescence inhibition and enhancement of methane-water volumetric mass transfer rate. Various cationic surfactants including hexyltrimethylammonium bromide (HTAB), octyltrimethylam- monium bromide (OTAB), dodecyltrimethylammonium bromide (DTAB), and hexadecyltrimethylam- monium bromide (HDTAB) were added to aqueous solution and the methane-water volumetric mass transfer coefficient (kLa) values were determined for each of the solutions. Enhancement of methanewater kLa was observed from 14 h1 to 69 h1, depending on the cationic surfactant type and concentration. Enhanced methane-water kLa in aqueous solution by addition of cationic surfactants was employed for the fermentation of methanotroph (Methylosinus trichosporium OB3b), and cell growth rate and maximum optical density was increased by 391% and 498%, respectively.

Enhancement of methane–water volumetric mass transfer coefficient by inhibiting bubble coalescence with electrolyte

김광민,이재원,서경준,김명길,하경수,김충익 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.33 No.-

The effect of electrolyte on methane–water volumetric mass transfer coefficient (kLa) was investigated inthis study. Various electrolytes including MgSO4, K2SO4, Na2SO4, MgCl2, KCl, NaCl, MgBr2, NaBr, KBr,Mg(NO3)2, KNO3, and NaNO3 were employed and enhancement of kLa from 103 h 1 (in pure water) to711 h 1 was observed, depending on electrolyte type and concentration. This is the highest methane–water kLa value measured at ambient condition. For all electrolytes, ions with large charge density(charge valency per ionic volume) exhibited larger enhancement in methane–water kLa values. Furthermore, anions exhibited larger influence than cations on the enhancement of kLa. Enhancement ofmethane–water kLa by electrolytes was due to the inhibition of methane bubble coalescence.

비대면 교육환경의 기초시각디자인발상에서 경험의 개념과 역할에 관한 연구

김광민,양재범 한국디자인리서치학회 2021 한국디자인리서치 Vol.6 No.2

This study aims to understand perceptual experiences that students, who learn visual design by taking a remote learning course for beginners and therefore learn in environments where it is difficult to get prompt feedback, rely on by instinct to handle the subject given by an instructor. Further, this study aims to suggest a process model which can be used as a tool for the process to develop ideas and recommends the use of this model as a learning strategy. To achieve these aims, the study focuses on direct or indirect thinking processes that students use to effectively learn in visual design courses for beginners and defines 'closed experience' and 'open experience', both of which play crucial roles in understanding experiences, using non-linear and lateral thinking, and being 'open-minded' during the process to develop ideas. What this study suggested will enable students to repeatedly go round the learning cycle. There are phases to the learning cycle and, in these phases, students will learn about specific stages, which will make them become confident of their ideas, and practice recalling and telling about certain experiences in imagery training. Imagery training will make students get results-in other words, students will develop exceptional, experimental, and absolutely fresh ideas. The findings of this study suggest that going through these phases motivates students to study, encourages them to have stronger will and patience, and makes them more enthusiastic about learning. In this study, a detailed thinking model which allows students to seek meaning was designed using Kolb's Experiential Learning Theory in order to investigate the process, structured thinking through experiences. Another thinking model, which helps students in visual design courses for beginners handle subjects with their experiences, was designed as well. Since this model improves student's literacy and enables a student to infer the meaning easily from the context of the subject, which is given by an instructor as "one way" of teaching, using "various ways" of learning, this model will prove valuable. 본 연구는 즉각적인 피드백이 어려운 비대면 교육환경에서 기초시각디자인을 학습하는 학생들이 교수자가 제시한 논제를 해결하기 위해 본능적으로 의지하는 내면의 인식된 경험을 이해하고, 학습 전략으로서 발상 과정에 활용할 수 있는 프로세스 모형을 제언하는데 목적을 두었다. 이에 본 연구에서 초점을 맞춘 것은 기초시각디자인 교육에서 학습자가 효율적인 학습을 위해 활용하는 직·간접적인 사고로서 경험을 이해시키고, 발상의 과정에서 비선형적이고 수평적인 ‘열린 사고’를 할 수 있는 중요한 근원으로서 ‘닫힌 경험’과 ‘열린 경험’으로 정의하였다. 이런 해석을 통해 학습자는 발상에 자신감과 확신을 얻을 수 있는 구체적인 전개과정을 이해하게 될 것이고, 경험속에서 무엇인가를 인출해 말하는 이미지 트레이닝을 하다 보면 타성이 아닌 실험적인 새로움의 완성이라는 결과를 획득하는 순환적인 학습 경험을 하게 된다. 그리고 이런 과정을 통해 학습욕이 강화되고, 의지와 끈기를 길러주며 학습에 몰두하게 된다는 것을 시사하였다. 이러한 경험의 구조적인 사고로서의 프로세스를 연구하기 위해 kolb의 경험학습을 토대로 의미를 찾아가는 사고모델을 구체적으로 설정하고, 기초시각디자인 교육에서 경험을 통해 논제가 전개되는 발상모형을 설정하였다. 이렇게 설정된 발상모형을 교수자가 제시한 ‘한 가지의 형태’인 논제를 학습자가 ‘다양한 형태’로 의미를 질서있게 읽어낼 수 있는 문해력의 배양으로서 의미가 있을 것이다.

병원간 응급 진료를 위한 멀티미디어 원격 진료 시스템의 설계

김광민,유선국,정석명,김동근,김선호,김남현 대한의료정보학회 2002 Healthcare Informatics Research Vol.8 No.4

In this paper, the real-time telemedicine system based on multimedia data was designed. In order to describe patients to medical specialists, the system included multimedia data. The prototype system designed in this paper effectively integrated multimedia components in a single computer, as well as compromise the compression, interface, medical imaging standards and modular software architectures. The mobile bed was manufactured to improve the movement of the system.Two experiments had been conducted to evaluate the technical functionality and clinical usability. Using the data compression and priority control, the telemedicine system transmitted multimedia data in real-time at the internet and the ethernet network. Inter-hospital experiments and Sang-Am World-Cup Stadium experiments demonstrate the feasibility to be effectively used.

Improved Ion Dissociation of Solid Polymer Electrolyte by High dielectric additives

김광민,한태섭,이희우 한국고분자학회 2014 한국고분자학회 학술대회 연구논문 초록집 Vol.2014 No.10

L2-4 DXA 로 측정되어지는 폐경전후 여성에서의 골밀도 감소

김광민,이득주,한인권 대한폐경학회 1999 대한폐경학회지 Vol.5 No.1

"BMD at lumbar spine was measured with DXA, in a community based two thousand eighty eight women aged 20-79 years and results were analyzed according to age and years since menopause. A significant apparent bone loss was not found before the menopause in spine. Cross-sectional analysis indicated that, after the menopause, spine BMD loss was accelerated within five years following menopause, continued thereafter at the spine and was again accelerated 20 years of menopause in elderly women. Between age 30 and 76 years, BMD decreased by 32% at the spine. Peak Spinal BMD among the healthy women aged 20-40 years was 1.185+-0.132 g/cm2. Their serum FSH level was 7.4+-6.2IU/L, Osteocalcin was 6.7+-3.6ng/ml, and serum alkaline phospatase was 56+-13U/L. As a result, the prevalence of women classified as osteoporotic according to World Health Organization, i.e., with a T score<-2.5 was substantially different in age groups. BMD was inversely associated with osteocalcin and serum alkaline phospatase. In conclusion, there is no accelerated spinal bone loss in pre-menopausal women but accelerated spinal bone loss is apparent within five years of menopause and even 20 year after menopause. "