Wright의 抗議 : Native Son을 中心으로

김계민 釜山大學校 敎養課程部 1974 論文集(교양과정부) Vol. No.

Point counter point에 나타난 Huxley의 人間觀 : Point counter point에 나타난 Huxley의 인간관

김계민 釜山大學校 敎養課程部 1972 論文集(교양과정부) Vol. No.

자가조절진통 주입펌프 AccumateⓇ 1100의 정확도와 유효성에 대한 비교임상연구

김계민,노규정 대한마취통증의학회 2016 Anesthesia and pain medicine Vol.11 No.1

Background: The accuracy and efficacy of patient-controlled analgesia (PCA) devices are crucial because malfunction of the devices may lead to fatal outcomes. The aim of this study is to evaluate the accuracy and efficacy of AccumateⓇ 1100, an electronic PCA pump, in comparison with GemStarⓇ infusion system. Methods: Fifty patients scheduled for gastrectomy or colon resection were assigned to the Accumate or GemStar group (n = 25 in each group). Intraoperatively, backflow, siphonage, autoclamp function, and lockout time were tested. Postoperatively, PCA using either AccumateⓇ 1100 or GemStarⓇ infusion system according to the assigned group was maintained for 48 hours. For PCA, fentanyl 1,500 ug and ketorolac 180 mg in 100 ml were used (demand bolus 1 ml, background infusion 1 ml/h, lockout time 15 minutes). The accuracy of the total infused dose and the level of satisfaction of the patients and users were assessed. The results were compared between the two groups. Results: Although backflow and auto-clamp backflow were less with GemStarⓇ infusion system, their extent was negligible in both groups. Siphonage was not different between both pumps. Autoclamp and lockout time worked without abnormalities. The relative error of total infused volume over 48 hours was −0.26 ± 1.20% and −0.34 ± 0.48% in the Accumate group and GemStar group, respectively. The Accumate group showed a higher level of satisfaction in terms of the ease of priming (P < 0.05). Conclusions: The accuracy and clinical efficacy of AccumateⓇ 1100 were comparable to those of GemStarⓇ infusion system.

PION TCIⓇ 펌프를 사용한 AquafolTM 목표농도조절주입의 예측수행도

김계민 대한마취통증의학회 2015 Anesthesia and pain medicine Vol.10 No.4

Background: The performance of a target controlled infusion (TCI) system needs to be confirmed in a clinical setting. AquafolTM, a microemulsion propofol, can be used for TCI with its pharmacokinetic parameters. The aim of this study is to evaluate the predictive performance of AquafolTM TCI by using a PION TCIⓇ pump incorporating the previously established pharmacokinetic parameters and ke0. Methods: Thirty adult patients were enrolled in the study. General anesthesia was maintained with TCI of AquafolTM and remifentanil using a PION TCIⓇ pump. During the maintenance of anesthesia with a constant target effect-site concentration of propofol for at least for 20 minutes, blood was drawn and the propofol plasma concentration was measured. The predictive performance of AquafolTM TCI was evaluated by determining the median performance error (MDPE), median absolute performance error (MDAPE), divergence, and wobble from the intra-individual and pooled performance errors. The acceptability of the TCI system was determined based on the pooled predictive performance. Results: A total of 153 propofol blood samples were analyzed. The estimates of pooled MDPE, MDAPE, divergence and wobble were 8.59% (1.61), 19.1% (1.12), −1.12%/h and 9.87% (1.01), respectively. The MDAPE indicating the accuracy of the TCI infusion system was within the clinically acceptable range (< 20–30%) and the bias (MDPE) was also acceptable (< 10–20%). Conclusions: The performance of AquafolTM TCI using a PION TCIⓇ pump was acceptable for the clinical use.

소외적 상황에서의 탈피를 위한 탐구

김계민 부산대학교 인문대학 영어영문학과 1984 영어영문학연구 Vol.4 No.-

쥐에서 Propofol 전투약이 일시적인 중뇌동맥 폐색에 의해 유발된 국소 뇌경색에 미치는 효과

김계민,오용석 대한마취과학회 2000 Korean Journal of Anesthesiology Vol.38 No.4

Background : Propofol is widely used in neurosurgical anesthesia as an intravenous anesthetic agent. There have been some reports on the protective effects of propofol in cerebral ischemia. However conflicting results also exist. This study was designed to test the hypothesis that propofol pretreatment would provide protective effect on the focal cerebral ischemia-reperfusion injury. Methods : Thirty Sprague-Dawley rats were divided into two groups; 15 for a halothane group, 15 for a propofol group. After inducti,on of anesthesia with halothane in 100% oxygen, the tracheas were intubated and mechanical ventilation was maintained. For the entire experimenta1 period normocapnia was maintained and scalp temperature was maintained in the range of 37 ―37.5C. In the propofol group, propofol was infused at the rate of 2 mg/kg/min for 30 min without halothane administration prior to the ischemic period. In the halothane group, propofol was not infused. The left middle cerebral artery was occluded for 90 rninute with an intraluminal monofilament. After ischemia, perfusion was restored and rats were awakened. After 24 hours, the brain was removed and sectioned coronally and immersed in the 20% 2,3,S-triphenyltetraxolium choride solution. Percent mean infarcted area was calculated and compared between groups by Wilcoxon rank sum test. Results : The percent infarcted area of halothane and propofol groups was 18.8 ± 19.2% and 15.7 ±16.4%, respectively. There was no difference between groups in the aspect of percent infarcted area and physiologic variables soch as mean arterial pressure, scalp temperature and serum glucose concentration. Conclusions : The pretreatment of propofol does not produce protective effect on focal cerebral ischemia compared with treatment with halothane. (Korean J Anesthesiol 2000; 38: 735~741)

진정 깊이의 평가방법

김계민,Kim, Gye-Min 대한치과마취과학회 2004 Journal of Dental Anesthesia and Pain Medicine Vol.4 No.2

전신 마취 중 Atropine 의 정주가 정상인의 기도내압, 호흡기 유순도 및 저항에 미치는 영향

김계민,김용락,오용석,박재현,황정원 대한마취과학회 1995 Korean Journal of Anesthesiology Vol.29 No.3

Atropine, an anticholinergic agent, has bronchodilating effects, so it had been used to treat bronchospasm. But, bronchodilating effects in normal man is controversial. In this study, after anesthetizing patients who did not have any respiratory disease, intravenous injection of atropine to the subjects was done, and then we monitored airway pressures to see the changes in respiratory mechanics indirectly. ASA physical status class 1 or 2 patients were studied. Without premedication, intravenous injection of fentanyl 3 mcg/kg, midazolam 0.1 mg/kg, thiopental 3 mg/kg and vecuronium 0.15 mg/kg was done consecutively. Ventilation was controlled by face mask with O₂-N₂O(50%)-isoflurane( $lt; 0.5 vo1.%) for 5 minutes with closed circuit anesthetic machine(Physio-Flex) and then intubation was done. After intubation anesthesia was maintained with O₂-N₂O(50%)-isoflurane( $lt; 0.5 voL%) and ventilation was controlled with tidal volume 9 ml/kg, respiratory rate 11/min and inspiratory tlow rate was maintained constantly for each subject. When airway pressure was stabilized, atropine 0.015 mg/kg was injected intravenously. Thereafter, for 20 minutes peak airway pressure(P), plateau pressure(P(peak)), mean airway pressure(P(plateau)), mean arterial pressure and heart rate were monitored every minute interval. And we calculated dynamic compliance, static compliance and resistance of total respiratory system. Atropine produced significant decrease in P(peak) and increase in dynamic compliance but did not produce significant changes in P(plateau) P(mean) , and static compliance and resistance. In conclusion, atropine has bronchodilating effect in normal subjects anesthetized with isoflurane of low concentration.

자가조절진정

김계민,Kim, Gye-Min 대한치과마취과학회 2002 Journal of Dental Anesthesia and Pain Medicine Vol.2 No.2

한국에서 수술 후 자가조절 통증치료 현황에 대한 분석

김계민 대한마취통증의학회 2016 Anesthesia and pain medicine Vol.11 No.1

Background: Patient-controlled analgesia (PCA) is a widely used method of postoperative analgesia with the advantage of tailored dosing for each individual. In spite of its popularity, there have been few reports on the current state of PCA in Korea. In this study, the data on PCA management and PCA regimens of medical in- stitutions in Korea were collected and analyzed. Methods: Members of the Korean Society for Anesthetic Pharma- cology were questioned as to the state of postoperative PCA management, such as acute pain services (APS) and pain assess- ment. A list of PCA regimens for each institution was also requested and analyzed. Results: Among 65 hospitals, APS was run in 30 and the severity of postoperative pain was assessed in 60. The safety and efficacy of PCA was evaluated only in 9 hospitals. A total 518 PCA regimens were reported (414, 95 and 9 regimens for intravenous, epidural and other routes, respectively). For intravenous PCA, fentanyl only and fentanyl-ketorolac regimens comprised 33.8 and 30.9% of treatments, respectively. In 95.9% of the regimens, background infusion was used. For epidural PCA, fentanyl-ropivacaine or fenta- nyl-levobupivacaine regimens made up the majority (47.4 and 13.7%, respectively). Conclusions: In Korea, APS was used in less than 50% of the hospitals and the evaluation of the safety and efficacy of PCA not carried out in the majority. Background infusion, known to have little advantage in most cases, was widely used in intravenous PCA.