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생체분해성 망막압정을 이용한 망막고정에 대한 실험적 연구
김용백,민병무,김창식,박근성,김승영,길숙종,조항진,이성복,노승무,송규상,강대영,조준식,양준묵,정경수,최선웅,이진호,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1
Biodegradable retinal fixation devices obtain mechnical fixation of the retina with desirable chorioretinal scarring and with the potential for local, sustained release of antimetabolites and steroids to inhibit proliferative vitreoretinopathy. We manufactured a biodegradable retinal tack with barb that was designed in order to prevent intrusion from implantation of retinal tacks. This study was carried to evaluate the efficacy for retinal fixation and the capability for sustained release of drugs with a newly designed biodegradable retinal tack Biodegradable retinal tacks were made of polymers of glycolic acids and were designed with barbs in a shape to prevent the disinsertion. Biodegradale retinal tacks are divided into 3 parts, a conical portion that is inserted into the sclera, a cylinder portion that remains in the vitreous, and a neck portion between the pin and the cylinder. The tapered conical end was manufactured to allow easy insertion through the retina and choroid into the sclera. A cylinder portion was manufactured with a tapered angle that fixes firmly into the orifice of 19 gauge spinal needle. A neck portion, 0.4 mm in diameter, was designed to prevent disinsertion from following implantation of retinal tack. The applicator was a 19 gauge spinal needle and its orifice was prepared to 15°angle to accept the tapered cylinder portion of the retinal tack. The retinal tacks, secured in the needles, were passed through the formed vitreous and inserted into the retina, choroid, and sclera and were released by pushing the internal needle, usually within 2-3mm of the medullary ray of the posterior rabbit retina A retinal tack was placed in each of 8 pigmented rabbit eyes. Slit-lamp biomicroscopy, indirect ophthalmoscopy and fundus photography were performed periodically from 1 day to 8 weeks after surgery. Eight eyes were enucleated and studied by light microscopy at 8 weeks. Biomicroscopic evaluation of the animals revealed edemas adjacent to the retinal surfaces immediately after insertion of the biodegradable retinal tacks in all the animals. These edemas disappeared after 1 week. The first noticeable change in the size of retinal tacks was shown after 2weeks. The size of the retinal tacks gradually got smaller, decreasing to about one-half at 4 weeks and about one-third at 8 weeks. All retinal tacks remained in inserted places without any movement for an 8 week period. On light microscopy, epiretinal proliferations were seen to extend into the vitreous cavity. Cellular capsules that lined the inner aspect of the scleral defect caused by tack insertion were found. However the adjacent retina had a normal cytologic appearance and architecture in all specimens. We manufactured a biodegradable retinal tack that is designed to prevent intrusion from implantation of retinal tacks. All biodegradable retinal tacks reduce in size with time, but no retinal tacks extruded from the inserted place. The newly designed biodegradable retinal tack can be used for retinal fixation and may be used as a vehicle for the introduction of pharmacologic agents to prevent the cellular events that promote proliferative vitreoretinopathy.
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생체분해성 고분자를 이용한 사시수술용 제형개발 및 효용성에 대한 연구
민병무,김용백,김승영,김창식,박근성,길숙종,조항진,이성복,노승무,송규상,강대영,조준식,양준묵,정경수,최선웅,이진호,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1
A new device, muscle clamping system was developed to facilitate exact quatifying technique A strabismus surgery, and reduce the risk of complications. The device is composed of a lower fixing body with three jaws and an upper supporting body. They are used to clip an extraocular muscle and fix it to the sclera with a single bite. Superior rectus recession on 16 rabbit eyes were performed with this new device. Conjunctival injection, muscle adhesion strength, and light microscopic findings were examined at 1, 2, 4 and 8 weeks postoperatively. The Conjunctival injection were minimal, adhesion power ranged from 420 to 600 gram gravity, which is sufficient in withstand the normal pull of human extraocular muscle. In microscopic exam, some Inflammatory cells and fibrosis were found. The new device was technically easy, fast, and accurate, so it may be useful in stabismus surgery.
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민병무,김용백,박근성,송규상,양준묵,이성복,조항진,길숙종,김승영,김학용 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1
An improved retinal tack can be used to fix the retina in complicated retinal detachment and proliferative vitreoretinopathy. We used the retinal tack made by biodegradable polyglycolic acid, polylactic acid and copolymers. The tacks with polyglycolic acid were placed in the retina the right eyes of 10 rabbits as group 1, with polylactic-polyglycolic acid copolymers as group 2 in each left eyes. We examined the absorption rates and degree of intraocular inflammation at 1 day, 1, 2, 4, and 8 weeks and compared both eyes. The tacks were absorbed with time in both eyes, but more rapid in copolymers. And there was no inflammation in both eyes. Now, this study will be a base on the drug delivery system in intraocular pharmacological and surgical management.
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鄭鎭一,劉肅種,吳明圭,白南玄,高在權,李載吉 韓國作物學會 2002 한국작물학회지 Vol.47 No.6
비염해지인 육답에 대한 간척답의 염농도가 0.2%, 0.3%, 0.4%인 지역에서 수도 생육 및 수량반응을 비교 검토하여 수도의 내염성 및 품종육성의 기초자료를 얻고자 일반계 품종 6품종 통일형 5품종을 공시한 결과는 다음과 같다. 1. 출수지연 정도는 육답 대비 0.2%포장에서는 일반계 품종은 2일, 통일형품종은 3일이 지연되었고, 0.3%포장에서는 일반계품종이 5일, 통일형품종이 8일, 그리고 0.4%포장에서는 각각 10일과 13일이 지연되었다. 2. 간장은 일반계품종이 13-39%, 통일형품종이 12-35% 감소율을 보였고, 수수는 일반계품종이 16-40%, 통일형품종이 14-35% 감소율을 나타내어 간장 및 수수의 감소율은 일반계 품종이 더 심하였다. 3. 수당립수는 일반계품종과 통일형품종 공히 10-40%의 감수율을 보였으나, 등숙율은 일반계품종 20-48%와 통일형품종 19-52%의 감수율을 보여, 통일형품종이 더 심하였다. 4. 천립중은 23% 이내의 비교적 적은 감소율을 보인 반면, 수량은 일반계 품종은 20-62%, 통일형품종은 25-68%의 감소율을 보여 통일형품종이 더 컸다. In other to find out the basic information on cultivation and breeding for salt tolerance in rice, these studies were conducted at salinity paddy fields containing 0.2, 0.3, 0.4% of salt and normal paddy field using 6 Japonica type, 5 Tonsil type varieties and Annapurna. On these fields a series of investigation was made for the responses of rice growth and yield to salt content of saline sails. The heading dates of the rice cultivated at salinity 0.2, 0.3 and 0.4% were delayed compared by 2 or 3,5 or 8 and 10 or 13 days respectively in Japonica and Tonsil type varieties to those at the normal paddy fields. The culm length at salinity paddy fields decreased by 13-39% in Japonica type and 14-35% in Tongil type varieties. But the number of panicles per hill decreased by 16-40% in Japonica type and by 14-35% in Tongil type varieties. The number of grains per panicle in saline paddy fields decreased by 10 to 40% in all varieties, but the percent ripened grain decreased by 20-48% in Japonica type and by 19-51% in Tongil type varieties. 1000 grains weight was decreased by lower than 23% in all varieties, but yield was reduced to 20-62% in Japonica and 25-67% in Tongil type varieties
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