부분심내막상 결손증의 교정수술치험 1

기노석 대한흉부심장혈관외과학회 1984 Journal of Chest Surgery (J Chest Surg) Vol.17 No.2

Surgical treatment of partial endocardial cushion defect was accomplished in Feb. 1984 in this department. The 5 year old male patient had history of frequent upper respiratory tract infection and since his age of 3 years dyspnea on exertion and palpitation were noted but there were no cyanosis and clubbing. A thrill was palpable on the apex and grade IV/IV harsh systolic ejection murmur and diastolic murmur was audible on it. Liver was palpable about 3 finger breadths and no ascites. Chest X-ray revealed increased pulmonary vascularity, moderate cardiomegaly [C-T ratio; 0.69], and enlarged left atrium. EKG showed first degree heart block, RVH, LVH, and LAD. Echocardiogram showed paradoxical ventricular septal movement and abnormal diastolic movement of the anterior leaflet of mitral valve. Right heart catheterization resulted left to right shunt [Qp:Qs:2.1:1 ] and moderate pulmonary hypertension [60/40 mmHg]. Left ventriculogram showed mitral regurgitation [Grade III/IV] and filling of left atrium and right atrium nearly same time. Operative findings were: 1.Primum type atrial septal defect [3x2 cm] 2.Cleft on the anterior leaflet of mitral valve. 3.No interventricular communication and cleft of tricuspid valve leaflet. The mitral cleft was repaired with 4 interrupted sutures. The primum type atrial septal defect was closed with Dacron patch intermittently at endocardial cushion and continuously remainder. The post operative course was uneventful and discharged on 22nd postoperative day in good general conditions.

수은에 의한 마우스의 면역반응 조절장애

기노석,고대하,김종서,이정상,김남송,이황호,Ki, No-Suk,Koh, Dai-Ha,Kim, Chong-Suh,Lee, Jung-Sang,Kim, Nam-Song,Lee, Hwang-Ho 대한예방의학회 1994 Journal of Preventive Medicine and Public Health Vol.27 No.1

수은($HgCl_2$)이 마우스의 면역계에 미치는 영향을 밝히고자 Balb/c 마우스를 대상으로 시험관내 및 생체내 단계적 시험을 실시하였다. Lipopolysaccharide, pokeweed mitogen 및 phytohemagglutinin 등의 미토겐(mitogen)에 대한 비장세포의 반응성은수은농도에 의존적으로 억제되었다. 수은에 의한 비장세포의 증식반응억제는 배양기간 중 수은 노출시기에 관계 없었으며 수은 전처치에 의해서도 그 증식반응은 억제되었다. 그러나 수은은 pokeweed mitogen으로 유도한 비장세포의 항체생산은 항진시켰다. 실험동물을 음용에 의하여 수은에 3주간 노출시켰을 때 투여기간 중 체중의 증가는 현저히 둔화되었으나, 흉선 및 비장의 무게, 신장, 골수, 비장 및 슬와 림프절의 병리학적 변화는 유발되지 않았다. 그러나 혈청 면역 글로불린(immunoglobulin) 농도는 현저히 증가되었다. 증가된 혈청 $IgG_1$및 IgE농도는interleukin-4 (IL-4)에 대한 항체투여로 현저히 감소되었다. 수은투여 마우스의 면양적혈구(SRBC)에 대한 항체반응을 측정한 결과 면양적혈구에 대한 총응집소가에는 대조군의 그것과 차이가 없었으나 혈청 IgM 및 IgG농도는 오히려 대조군의 그것보다 현저히 높았다. 이상의 성적들은 수은의 면역계에 대한 독작용은 그 측정방법에 따라 다를 수 있으며, 수은노출에 따른 림프조직의 병변이 발생하기 전에 면역계의 기능적 변화가 일어나고, 수은에 의한 혈청 면역 글로불린 농도의 증가는 특정항원에 대한 항체반응과는 무관할 수 있는 등 수은이 면역반응에 이상을 초래함을 시사한다. The studies reported here were undertaken to investigate the effects of mercury chloride on immune system of Balb/c mouse employing a flexible tier of in vitro and in vivo assays. Mercury chloride inhibited the proliferative responses of spleen cells to lipopolysaccharide, pokeweed mitogen, and phytohemagglutinin as a dose-dependent manner. This inhibitory effect was observed not only when $HgCl_2$ was added 2nd or 3rd day of 3 days culture period but also when spleen cells was pretreated with $HgCl_2$ for 2 hours. Mercury chloride, however, potentiated the production of IgM and IgG from spleen cells. During the $HgCl_2$ administration by drinking for 3 weeks, the weight gain of mice was significantly blunted than that o control group mice, while no overt signs related to mercury toxicity were noted in any mice of experimental group. There was no change in thymus and spleen weights, and in histological findings of kidney, bone marrow of femur, thymus, spleen, and popliteal lymph node after 3 weeks of mercury exposure. However, $HgCl_2$ induced a significant increase of total serum IgM, IgG including $IgG_1,\;IgG_{2a}\;and\;IgG_{2b}$, and IgE in Balb/c mice. Treatment in vivo with anti-IL-4 monoclonal antibody significantly abrogated the $HgCl_2$-induced increase in total serum IgG1 and IgE. Whereas $HgCl_2$ potentiated total serum IgM and IgG, there was no difference in total serum hemagglutinin to SRBC (Sheep Red Blood Cell) between experimental and control group mice when these mice were immunized with SRBC. All these findings observed in Balb/c mice suggest that mercury perturbates well-orchestrated regulation of immune responses before developing histopathological changes in lymphoid tissues.

藥物中毒患者에 關한 疫學的調査硏究

奇老錫 전북대학교 의과학연구소 1978 全北醫大論文集 Vol.2 No.-

The author carried out the epidemiological study on 275 cases of acute drug intoxication admitted to the emergency room of Jeonbug National University Hospital, from January to December of 1976, to obtain the data for the measures of this field.

유기용재에 노출된 근로자들의 자매염색분체교환의 빈도에 관한 연구

기노석,고대하,이유용,박철훈,박철희 의과학연구소 1991 全北醫大論文集 Vol.15 No.4

To determine whether the frequency of sister-chromatid exchanges(SCEs) has been changed by the exposure to toluene, the SCEs were observed in metaphase lymphocytes which were cultured and stained by the fluorescence-plus-Giemsa technique for the five workers working in a shoes-maker who were exposed to toluene and compared with that of five normal controls selected by matching of age and sex. Also in experiments in vitro the effects of four organic solvent, toluene, benzene, xylene, and acetone, were investigated with their several concentrations for the frequency of SCEs on normal human lymphocytes. The SCE frequencies of the toluene workers were not significantly different from those of healthy donors, except a natched case. And the frequency of SCEs per one metaphase cell is believed statistically to follow the normal distribution with the estimated normal ranges of 6.02-6.52 and 5.94-6.60 in 95% and 99% confidence intervals. In experiments of adding several orgnaic solvents in vitro, though the mitotic indices are decreased and the cell kinetics are delayed in the higher concentrations of toluene and benzene, which suggests that the cell growth is inhibited, neither toluene nor other solvents change the number of SCEs on lymphocytes cultured in any concentrations of them.

某國民學校 新入兒童의 新入初의 缺席에 關한 調査

奇老錫 全南大醫大 1973 전남의대학술지 Vol.10 No.3

急性蟲垂炎患者의 在院期間에 關聯된 諸要因 分析

奇老錫,黃淨淵 전북대학교 의과학연구소 1985 全北醫大論文集 Vol.9 No.1

This study was an analysis for several factors affecting the hospital stay in the patients of acute appendicitis. From Jan. to Dec. 1983, 166 patients, who underwent appendectomy under the impression of acute appendicitis and were confirmed appendicitis postoperatively in Chonbuk National University Hospital, have been investigated to the relationship between the hospital stay and their personal charactersitics including medico-social factors. The results were as follows ; 1. In the age and sex distributions, the proportions of age group 10-19 years(22.9%) and 20-29 years(25.3%) were higher than other age groups(p<0.05), and the sex ratio was 1.1:1(male;87 cases, female ; casas) which difference was not significant(p>0.05). 2. Average hospital stay was 8.3±5.0 days that were not affected by sex, medical insurance, andeducational levels(p>0.05). In the simple correlation analysis, the main factors than affect hospital stay in the patients of acute appendicitis were postoperative diagnosis(r=+0.672), type of appendectomy(r=+0.640), interval between the symptom onset and admission(r=+0.412), and age of patient(r=+0.260). 3. In the multiple regression analysis, the prediction equation of the duration of hospital stay was; Y=-0.079+0.093×1+0.076×2-0.003×3+0.288×4+0.670×5+0.521×6 where X_1=age, X_2=resident area, X_3=education, X_4=interval between the symptom onset and admission, X_5=type of appendectomy, and, X_6=postoperative diagnosis. The overall accuracy of the prediction equation was reflected by R-square=55%(F-ratio 6,159=32.31, p<0.01).

島嶼地域 學齡前兒童의 營養狀態에 關한 調査硏究

奇老錫 전북대학교 의과학연구소 1979 全北醫大論文集 Vol.3 No.-

A survey on nutritional status of pre-school children in We-do area was carried out from 29 July to 4 August 1977. 89 children(3, 4, 5 years old) were randomly sampled to determine socioeconomic bacgkround, physical development, hematological findings, parasitic infection, clinical sign of malnutrition and food intakes. The results are summarized as follows : 1. Socio-economic status 1) 2.2 per cent of the children were from households of high living standard, 50.6 per cent of them low living standard by the index we used. 2) The educational level of their fathers were higher than that of their mothers. 77.5 per cent of their mothers were primary school level or below. 3) 32.6 per cent of the household heads' occupation were fishing, 24.7 per cent farming, 36.0 per cent retailer or thers. Occupations were different by area, such as finishing, farming and retails respectively. 4) The birth-order of the children were 3.37±1.85 and the boy-preference in this area was high. 5) The basic environmental sanitations including water supply, night-soil & waste disposal and kitchen sanitation was very poor. 2. Physical development, Hematological findings, Parasitic infection and Clinical sign of malnutrition. 1) Physical development ; Body height, weight and head girth of the children were under the Korean standards, and chest girth and upper arm girth were same as Korean standards. 2) Mean skinfold thickness of subscapular in 3, 4 & 5 years old children were 5.1±1mm, and 4.6±0.9mm respectively. those of abdominal portion were 3.8±0.8mm, 3.7±0.8mm and 3.6±0.8mm respectively. The skinfold thickness showed decline trend by age increase. 3) Hematological findings of the children including hemoglobin, hematocrit and total blood protein reached the Korean standards. 4) Prevalence rate of parasitic infection was 76.0 per cent, infection of round-worm(Ascaris lumbricoides) 62.9 per cent, whip-worm(Trichuris trichura) 47.0 per cent. This prevalence rate of parasitic infection was higher than that of Korean. 5) The incidence of cheilosis was 27.0 per cent. The incidence rate was higher in boys than that in girls. 3. Status of Pood Intake 1) The average amount of daily food intake was 639.8±156.4 grams. The amount of food intake by meal-time was 21.3 per cent, 20.1 per cent and 19.9 per cent respectively. meanwhile the amount of food intake in between-meal was 38.9 per cent. 2) The average amount of food intake by age 624.4±161.5 grams in three years old of age, 629.9±128.8 grams in four, 663.9±172.7 grams in five, In higher age group, the amount of food intake in three meals were increased, however, the amount of between-meal decreased in high age group. 3) In the amount of food intake by food group, carbohydrate food were 53.8 per cent, vitamins & mineral food 35.2 per cent, protein food 5.3 per cent, calcium food 4.3 per cent and fat & oil 1.3 per cent. 4) In the proprtion of nurtients for calory, carbohydrate were 85.1 per cent, proteins 11.5 per cent and lipids 3.4 per cent. 5) 23.2 per cent of the total protein was composed of animal protein. 6) When the average day calory intake was compared with the R.D.A. (Recommended Daily Dietary Allowance) by age, the average calory intake was 96.6 per cent in three years old, 75.5 per cent in four years old and 81.4 percent in five years old. 7) Average protein intake was 100.6 per cent with exceding R.D.A. in three years old, 77.8 per cent in four years old and 87.8 per cent in five years old. 8) Average calcium intake of the children was four or five times to compare with R.D.A. 9) All kind of vitamins intake was below the R.D.A. except niacin.

島嶼地域 可姙女性의 家族計劃實態에 關한 調査硏究

奇老錫 전북대학교 의과학연구소 1979 全北醫大論文集 Vol.3 No.-

Author has conducted this survey in order to evaluate the activities of family planning and those related factors to secure effective achievement of family planning in island area, located in Jeonra-bugdo. 300 married women of a age 20 to 49 were subjected to this survey during the period from August 10 to 16, 1978. Socio-demographic characteristics, first marital age, family planning were involed in this survey. The result obtained were concluded as follows; 1. Socio-demographic characteristics. a. Average number of family per household was 5.1 persons. b. Age distribution of the respondents showed 24% in 30-34, 21% in 35-39, 1.7% in 25-29, respectively. c. Primary school graduate occupied 65% of the total woman, the highest rate, while in husband middle school graduates 41%. d. The rate of the respondents having a religion was 16% in women and 18.7% in husband, which composed of buddhist 8.3%, protestant 7.7%, Especially 84% of the woman and 81.3% of husband did not have any religions. e. Monthly regular incomes per household were under 50,000 won with 59.3%. By classification of there occupations, fishery occupied 49.3%, agriculture 19.3%, daily labors 13.3%, respectively. 2. First marital age was 19-24with 84.9% and the most frequent age was 21-22 with 31.6%, 23-24with 28%, and 19-20 with 25.3%, On the otherhand, among the respondents, the duration of marital life was 5-9 years with 22%, 10-14 years with 21.7%, and 20-24years with 1%. 3. Average number of living children was 3.5. 4. Average ideal number of children was 3.7(son;2.2. daughter;1.5). 5. Status of family planning pratice. a. Knowledge about family planning. It was observed that 62.4% of total had some knowledges about family planning. In channel of communication, health center worker occupied 61.8%, neighbors 16.3% and radio 10.3%. b. Attitude toward family planning. Out of total, 48.3% had an experience of family planning while 19.3% against it. c. Practice toward family planning.

某國民學校 兒童의 養護室利用에 關한 調査

奇老錫 全南大醫大 1973 전남의대학술지 Vol.10 No.4

一部 島嶼地域 住民의 死亡樣相에 關한 調査硏究(第2報)

奇老錫 全北大學校 醫科大學附設 看護專門大學 1981 논문집 Vol.7 No.-

This study carried out to evaluate the leading cause of death and mortality patterns of inhabitants in an Island area, which was isolated from mainland and was comptelely in defferent living status. There were consisted of 802 households comprising 4,078 persons and Forty-two events of death were occured during one year from January to December 1980 in this area. The results summarized were as follows ; 1. The composition of population by age-group was 41.2% in under 14 years old, 51.3% in 15~59years old, and was 7.5% in over 60 years old. Sex-ratio of inhabitant was 96.9, while total dependency ratio was 95.0. 2. Mean age of death was higher 54.7±20 years old in male than 41.5±29 years old in female. 3. In the educational level of death, males who were deal in group of no education were 50%, 46.2% in primary school, while females were 62.5% in primary school, 37.5% in no education. Especailly there were no females who graduated middle school. 4. Occupational status of death was 42.9% in no education, 30.9% in fishery and 24.1% in farming. 5. Comprehensive indicator of the level of health, PMI (Proportional Mortality Indicator) was 59.5% (male : 70.3%, female : 40.0%). It was higher in male than in female and revealed progressive promotion of level of health in Korea between 1960 to 1980. 6. Mortality patterns based on the cause of death showed that A group of international classification of disease, infectious diseases were 38.1%, B group, chronic regressive diseases were 54.8%, and D group, accidents poisonings, etc were 7.1%, respectively. 7. Main leading causes of death were apoplexy, pulmonary tuberculosis, liver cirrhosis, senility, malignant tumor, and accidents in order. 8. Exposure groups to physician during the period of onset of cause of death were 16 cases(38.2%) and non exposured groups were 26 cases (61.8%). 9. Types of therapy were each 33.3% in pharmacy and falk medicine, 21.5% in hospital or clinic and 4.8% in herb medicine, respectively. 10. Status of death registration showed that non medical certificate was the most at the rate of 92.9%, medical certificate was only 7.1%. 11. In the interval between onset of death and report to the authority by cause of death, 78.6% of all were reported within statutory period(1 month), 16.7% within 6 months and 4.7% over 7 months.