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알레르기 접촉피부염 환자에서 피지오겔(R) 크림의 임상적 적용에 관한 연구
권혁부 ( Hyok Bu Kwon ),김범준 ( Beom Joon Kim ),이승호 ( Seung Ho Lee ),이애영 ( Ai Young Lee ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.11
Background: A allergic contact dermatitis has been increasing in the world. The first choice of treatment for the allergic contact dermatitis is topical steroids, but application of topical steroids may lead to many side effects. Physiogel(R) cream, made of ceramide, triglyceride, squalene and others is a moisturizer without any fragnance or preservatives which has effects of normalizing the damaged skin barrier and soothing troubled skin. Objectives: We carried out this study to evaluate the effects of the Physiogel(R) cream in the treamemt of the allergic contact dermatitis. Methods: Among the patients clinically suspected to have allergic contact dermatitis due to fragnance or perservatives, patients already diagnosed with allergic contact dermatitis were included. On the skin lesions of the right side of individual patients the Physiogel(R) cream was applied twice a day. No topical agents were applied to the lesions of the left side. Two weeks later the clinical improvement of skin lesions was compared. Results: In fourteen (61%) out of 23 patients the Physiogel(R) cream-applied lesions showed significant clinical improvement compared with the control lesions. In cases of atopic dermatitis or seborrheic dermatitis, the ratio of patients in whom the Physiogel(R) cream was efficacious, was 80% or 70% respectively. The skin lesions of all patients of 2nd and 3rd decades were significantly improved by the Physiogel(R) cream. In patients whose skin lesions were not responsive to the Physiogel(R) cream, patch test results showed the highest positive response rate against nickel (20%) and formaldehyde (20%). Conclusion: Physiogel(R) cream could be used as well as topical steroids in the treatment of allergic contact dermatitis reducing the risk of side effects due to long-term use of topical steroids. (Korean J Dermatol 2007;45(11):1139∼1143)
권혁부 ( Hyok Bu Kwon ),이준호 ( Joon Ho Lee ),최윤석 ( Yun Seok Choi ),이애영 ( Ai Young Lee ),이승호 ( Seung Ho Lee ),최종순 ( Jong Sun Choi ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.5
Pancreatic endocrine tumors (PET) are rare neoplasms of the pancreas and account for less than 5% of all primary pancreatic malignancies. Included in this group are insulinomas, gastrinomas, glucagonomas and somatostatinomas. Collectively, these neoplasms are classified as functional PETs. When a PET is not associated with a clinical syndrome due to hormone oversecretion, it is referred to as a non-functional PET. Non-functional PETs are pancreatic tumors with endocrine differentiation but lack a clinical syndrome of hormone hypersecretion. Although a pancreatic carcinoma shows aggressive biological behavior, a cutaneous metastasis from a pancreas carcinoma is rare. We report a case of a case of a cutaneous metastasis from an endocrine pancreatic carcinoma in a 50-year-old female that clinically manifested as a painful firm nodule on the back. (Korean J Dermatol 2009;47(5):592~595)
권혁부 ( Hyok Bu Kwon ),이준호 ( Joon Ho Lee ),최윤석 ( Yun Seok Choi ),이애영 ( Ai Young Lee ),이승호 ( Seung Ho Lee ) 大韓皮膚科學會 2009 대한피부과학회지 Vol.47 No.9
Hidradenoma papilliferum is a benign, cystic, papillary tumor that occurs almost exclusively in women on the skin of the anogenital region and this is usually a slow-growing cystic dermal mass that can be either asymptomatic or it can ulcerate and bleed, and it represents an adenoma with apocrine differentiation. Nonanogenital (ectopic) hidradenoma papilliferum is rare. We present here a case of hidradenoma papilliferum in a 52-year old male with an erythematous to brownish nodule on the left cheek and the lesion had the typical histopathological findings of hidradenoma papilliferum. (Korean J Dermatol 2009;47(9):1080∼1082)
접촉 피부염 환자에서 첩포 검사 양성률에 관한 역학적 연구
김범준 ( Beom Joon Kim ),권혁부 ( Hyok Bu Kwon ),이준호 ( Joon Ho Lee ),이승호 ( Seung Ho Lee ),이애영 ( Ai Young Lee ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.10
Background: The common allergens for patients with allergic contact dermatitis (ACD) have changed with the passage of time. Ammoniated mercury was the most common allergen in the 1980s, but it has been replaced by nickel sulphate. Objective: We wanted to delineate the recent alterations of common allergens of Korean ACD patients. Methods: We retrospectively reviewed the medical recordings of the patients who were diagnosed with ACD and we performed patch tests on these patients from July 2005 to May 2008. A total of 676 patients were enrolled in this study and the medical records included the patients` age and gender, the site of ACD, the clinical pictures and the results of a Korean standard series of patch tests. Results: The male to female ratio was 1.62 and the mean age of onset was 41.2±16.5 years. The most common ages of the ACD patients were the forties for males and the thirties for females. The most prevalent sites for ACD were the face, scalp and hands in males, while those for females were the face, hands and arms in order of frequency, respectively. The most common allergens were nickel sulfate for females and mercury ammonium chloride for males. Conclusion: For ACD, the relative proportion of male patients has recently been markedly enlarged. This phenomenon might be related to the increased use of men`s cosmetic products, and the market for these products had tremendously expanded during the last decade. (Korean J Dermatol 2008;46(10):1362∼1368)
젊은 여성의 목에 발생한 탄력섬유거짓황색종양 유두진피 탄력섬유용해증
이준호 ( Joon Ho Lee ),권혁부 ( Hyok Bu Kwon ),이애영 ( Ai Young Lee ),이승호 ( Seung Ho Lee ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.4
Pseudoxanthoma elasticum-like papillary dermal elastolysis (PXE-like PDE) is a rare acquired elastolytic disorder that clinically resembles pseudoxanthoma elasticum. The pathogenesis of this disease is uncertain, but it seems to be related to intrinsic aging, abnormal elastogenesis, a genetic predisposition and exposure to ultraviolet radiation. It generally develops on the sides of the neck and supraclavicular regions in elderly persons. Histologically, the characteristic features are the loss of elastic fibers in the papillary dermis and no solar elastosis. We report here on a case of PXE-like PDE in a 26-year-old female whose skin lesion developed 9 years previously. Despite the preferential occurrence at an old age, our patient was young. (Korean J Dermatol 2009;47(4):431~434)
표면에 다수의 작은 구진을 동반한 결절모양의 피부 국소 점액증
이준호 ( Joon Ho Lee ),진상윤 ( Sang Yun Jin ),최윤석 ( Yun Seok Choi ),권혁부 ( Hyok Bu Kwon ),이애영 ( Ai Young Lee ),이승호 ( Seung Ho Lee ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.10
Cutaneous focal mucinosis is a rare condition that manifests with asymptomatic small white to flesh-colored papules on the face, neck, trunk and extremities. Johnson and Helwig first described it in 1961 and it is histologically characterized by localized accumulation of mucin in the upper and mid-dermis with scattered spindle-shaped fibroblasts. We report here on a case of cutaneous focal mucinosis that presented as a nodule with several small papules on it on the face. (Korean J Dermatol 2010;48(10):869~871)
이준호 ( Joon Ho Lee ),최윤석 ( Yun Seok Choi ),권혁부 ( Hyok Bu Kwon ),이애영 ( Ai Young Lee ),이승호 ( Seung Ho Lee ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.12
Papillomatous melanocytic nevus is a clinical type of melanocytic nevus, and this has also been described as keratotic melanocytic nevus or seborrheic wart-like melanocytic nevus. Although the pathogenesis of this phenomenon is not well recognized, some hypotheses do exist, such as it is an abnormality that occurs at some stages in embryonic development. There is also the possibility that dermo-epidermal interactions exist. On our review of the medical literature, there are only four Korean cases of intradermal nevus that have developed as papillomatous melanocytic nevi. We report here on a Korean case of a compound nevus with features of papillomatous melanocytic nevus. (Korean J Dermatol 2009;47(12):1389∼1391)
최윤석 ( Yun Seok Choi ),이준호 ( Joon Ho Lee ),권혁부 ( Hyok Bu Kwon ),이애영 ( Ai Young Lee ),이승호 ( Seung Ho Lee ),최종순 ( Jong Sun Choi ) 대한피부과학회 2010 大韓皮膚科學會誌 Vol.48 No.3
Clear cell syringoma has two distinct features from typical syringomas: histological predominance of clear cells and a correlation with diabetes mellitus. Otherwise it is similar to ordinary syringomas in age, sex, site, and clinical manifestations. We here report a 49-year-old male with clear cell syringoma accompanied with diabetes mellitus. Histological examination revealed numerous, variable-sized, well-defined tumor nests composed largely of clear cells that stained positive with PAS (Periodic Acid Schiff) before diastase digestion and negative after diastase digestion. (Korean J Dermatol 2010;48(3):246~249)
진상윤 ( Sang Yun Jin ),최윤석 ( Yun Seok Choi ),이준호 ( Joon Ho Lee ),권혁부 ( Hyok Bu Kwon ),이애영 ( Ai Young Lee ),이승호 ( Seung Ho Lee ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.7
Pityriasis rotunda is a rare disease characterized by round to oval, sharply defined, hypopigmented or hyperpigmented, scaly patches of variable number and size located trunk and extremity. The etiology is unknown but it has been associated with a variety of systemic illnesses, such as tuberculosis, malnutrition and malignancy. The first case was a 28-year-old male who presented with a 2-year history of multiple round shaped hyperpigmented patches on the trunk. The second-case was a 38-year-old female who presented with a 2-month history of circular, sharply defined multiple patches with ichthyosiform scaling on the trunk. Both patients had no systemic disease or familial history. We experienced 2 cases of pityriasis rotunda on the trunk without underlying systemic illnesses or familial association.