공작기계산업에서의 품질관리 사례 연구

권혁무 釜山工業大學校 1995 論文集 Vol.37 No.-

地域社會矯正의 理論과 效率性 提高方案

권혁무 강원행정학회 2004 한국행정과 정책연구 Vol.2 No.2

대용변수를 이용한 상태기반 보전방식의 설계

권혁무,홍성훈,이민구,장현애 한국품질경영학회 2021 한국품질경영학회 학술대회 Vol.2021 No.-

시스템의 상태를 점검하여 사전에 보전을 실시함으로써 고장발생을 예방하는 상태기반 보전방식은 1940년대 말부터 있었던 전통적 개념이다. 그러나 과거에는 시스템 상태 점검의 물리적인 어려움이나 경제성 측면에서 상태기반보전의 응용은 제한적이었다. 최근 센서와 IT기술의 발전과 더불어 시스템 상태 자료의 보다 경제적인 수집이 가능해졌다. 이에 따라 상태기반보전 방식은 시스템의 경제적인 운용과 보전의 수단으로 재조명되고 있다. 상태기반보전은 시스템의 고장이 순간적으로 발생하는 하나의 사건이 아니라 시스템 성능이 시간을 두고 점진적으로 저하되어가는 과정이라는 인식에 근거한다. 고장은 시스템 성능이 어느 수준 이상으로 떨어질 때 발생하는 것으로 이해하는 것이다. 이와 같은 관점에서 시스템의 성능저하 과정을 묘사한 것이 P-F간격 모형이다. 그런데 시스템의 성능 저하과정은 직접 관측할 수 없어 센서를 이용하여 간접 관측할 경우가 많다. 여기서 간접 관측되는 변수를 성능변수에 대비하여 대용변수라고 하는데 대용변수의 관측 값이 어느 수준에 이르렀을 때 시스템을 보전할 것인가가 위험방지 측면이나 경제적인 측면에서 매우 중요한 문제가 된다. 본 연구에서는 이와 같이 성능 변수와 상관관계를 가진 대용변수를 이용하여 상태기반보전방식을 결정하는 문제를 취급한다. 먼저 시스템 성능저하에 관해 P-F 간격 모형을 전제하고 성능변수(성능저하량)와 대용변수 간의 관계를 모형화한 다음 보전을 위한 최적 기준치를 설정하는 방법을 제시한다. 예제를 통해 해를 구하는 과정을 보여주고 수치적인 분석을 통해 민감도, 강건성 등에 대해서도 살펴본다.

경영성과 척도로서의 시그마 수준과 문제점

권혁무,김상부,홍성훈,이민구 대한산업공학회 1998 대한산업공학회 추계학술대회논문집 Vol.1998 No.10

Infectious bursal disease virus(국내분리주)의 variable VP2 gene의 분석

권혁무,김대규,성환우,Kwon, Hyuk-moo,Kim, Dae-kyu,Seong, Hwan-woo 대한수의학회 1999 大韓獸醫學會誌 Vol.39 No.3

A 474-base pair segment covering the hypervariable region of VP2 gene from six Korean infectious bursal disease virus(K-IBDV) isolates(K1, K2, SH/92, 225, 269, 310) and one attenuated IBDV(DAE) were amplified using RT-PCR, sequenced, and compared with published sequences for IBDV. K-IBDV isolates(K1, K2, SH/92, 225, 269) and foreign very virulent(vv) IBDV strains had 94.93~100% amino acid sequence similarity. K-IBDV isolate 310 and other K-IBDV isolates had 84.31~86.07% amino acid sequence similarity. Attenuated strain(DAE), like other attenuated strain, has substitution at positions 279(D to N) and 284(A to T) as well as in the serine-rich heptapeptide region. Five K-IBDV isolates except 310 isolate share unique amino acid residues at positions 222(A), 256(I), 294(I) which are not present in other standard and attenuated strains. At the two hydrophilic region, K-IBDV isolates except 310 isolate had identical amino acids comparing with Belgium vv IBDV 894VB but had four amino acid substitutions comparing with Chinese vv IBDV F9502. The SWSASGS heptapeptide is conserved in all K-IBDV isolates. The sequence of K-IBDV isolate 310 was markedly different from other IBDV strains, evolving from a separate lineage than the others. By phylogenetic analysis, Five K-IBDV isolates except 310 isolate were categorized in one group with foreign vv IBDV isolates but K-IBDV isolate 310 was categorized in a separate group which was differentiated from other compared IBDV strains.

ISO 9000 시리즈 인증제도에 대하 올바른 이해

권혁무 부산공업대학교 산업대학원 1996 大學院論文集 Vol.2 No.-

돼지 전염성 위장염 바이러스(국내분리주)의 분자생물학적 특성 규명

권혁무,피재호,Kwon, Hyuk-moo,Pi, Jae-ho 대한수의학회 1998 大韓獸醫學會誌 Vol.38 No.2

Sixteen Korean field transmissible gastroenteritis viruses (TGEVs) were isolated using swine testicular cell (STC) and the genomic diversity of them was analyzed. All TGEV isolates produced a typical cytopathic effect in STC and were confirmed as TGEV by immunofluorescence assay using monoclonal antibody against TGEV and PCR using TGEV specific primers. RNAs from TGEV field isolates and vaccine TGEV were extracted and amplified by RT and PCR. The RT-PCR products were digested with selected restriction enzymes and analyzed RFLP patterns. The N-terminal end region of S gene and ORF 3 and 3-1 genes of TGEV amplified by TGEV specific primer pairs seemed to be conserved. Most specific variations were detected in S gene amplified by TGEV 4/6 primer pairs which includes antigenic sites A and D. When the PCR products were treated with Sau3AI and Ssp I, Bvac(vaccine strain), field isolates 133 and 347 were differentiated from Miller and Purdue types. In the case of D5 field isolates, it was classified into Purdue type by Sau 3AI but classified into independent TGEV by Ssp I. Two different TGEV strains from D2 sample were confirmed by plaque purification and RT-PCR-RFLP analysis. To investigate the change occurring in TGEV genome after serial passage, the TGEV P44 strain was passaged through STC. There were specific changes in S gene and a large deletion was observed in ORF 3 and 3-1 genes. These studies showed that a distinct difference in genome exists among TGEV field isolates.

국내분리 돼지 전염성 위장염 바이러스의 antigenic site A와 D를 포함하는 spike gene의 염기서열 분석

권혁무,피재호,성환우,Kwon, Hyuk-moo,Pi, Jae-ho,Seong, Hwan-woo 대한수의학회 1998 大韓獸醫學會誌 Vol.38 No.2

The nucleotide sequences of spike (S) glycoprotein containing antigenic sites A and D of TGEV isolated in Korea were determined and compared with published sequences for TGEVs. The TGEV 133 and DAE5 strains had 97.40% nucleotide sequence similarity. The overall nucleotide sequence similarity of the 133 and DAE5 strains compared with other TGEV strains was between 96.86% and 99.15%. The similarity of the predicted amino acid sequence of the 133 and DAE5 strains was 94.93%. The TGEV 133 and DAE5 strains had 94.93-98.61% amino acid similarity with published sequences of other TGEV strains. The sequences of amino acid codons in the antigenic sites A and D were identical among all the viruses although there were several nucleotide changes in region containing antigenic sites A and D of Korean TGEV isolates. By phylogenetic analysis of the sequences, two Korean isolates 133 and DAE5 seemed to be derived from different lineages. These studies showed that a distinct difference in genome exists among TGEV field strains isolated in Korea.

PCR과 RFLP분석을 이용한 transmissible gastroenteritis virus의 spike glycoprotein gene과 nonstructural protein gene의 분석

권혁무,Kwon, Hyuk-moo 대한수의학회 1996 大韓獸醫學會誌 Vol.36 No.3

To analyze the genomic diversity of transmissible gastroenteritis virus (TGEV), the N-terminal half of the spike (S) glycoprotein gene and nonstructural protein gene (open reading frames 3 and 3-1) were amplified by reverse transcriptase reaction and polymerase chain reaction (RT-PCR), and analyzed using restriction fragment length polymorphism (RFLP) patterns of the amplified DNA. In this study, TGEV Miller (M6) and Purdue (P115) strains were used as reference strains, and two vaccine strains (MSV and STC3) and four Korea isolates (P44, VRI-WP, VRI-41, and VRI-48) were analyzed. All TGEV strains were amplified with three TGEV primer pairs. Although there was some exception in RFLP analysis, this method differentiated TGEV strains into following groups : Miller group (M6 and MSV), Purdue group (PUS, STC3, P44, VRI-WP, VRI-41, and VRI-48). Using Sau3AI and SspI, VRI-48 was differentiated from the Miller and Purdue type viruses. The RT/PCR in conjuction with RFLP analysis was a rapid and valuable tool for differentiating several strains of TGEV. This study revealed the occurences of distinct difference in genome of TGEV strains.

FMEA에서 고장발생 및 탐지시간을 고려한 고장원인의 위험평가 척도

권혁무,홍성훈,이민구 한국품질경영학회 2019 품질경영학회지 Vol.47 No.3

Purpose: To develop a risk metric for failure cause that can help determine the action priority of each failure cause in FMEA considering time sequence of cause- failure- detection. Methods: Assuming a quadratic loss function the unfulfilled mission period, a risk metric is obtained by deriving the failure time distribution. Results: The proposed risk metric has some reasonable properties for evaluating risk accompanied with a failure cause Conclusion: The study may be applied to determining action priorities among all the failure causes in the FMEA sheet, requiring further studies for general situation of failure process.