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권혁년,유일수,정훈,김경선,김은숙,이종순,김옥경 한국인체미용예술학회 2014 한국인체미용예술학회지 Vol.15 No.1
The cosmetics industry has recently become interested in adding active constituentsthat contain natural plant extracts to cosmetic creams to improve the signs of skin aging.This study investigated the physicochemical and morphological stability of five basic creams containing Curcumae longae Radix extract. The creams were prepared from one basic recipe by adding five different concentrations of C. longae Radix extract. The basic creams that were formed with W/O have excellent water resistance and durability. The stability of the particles size in the creams was densely 3.5 ㎛ by polarized optical microscope and ELS-800. Also, the change of pH in the creams showed no significant change over several days(1, 7, 14, 28, 40 days). After exposing the creams to an artificial lamp test(30 min, 1, 3, 6, 10 h) to sunlight(7, 14, 40 days) and to various temperatures (0℃, 24℃, 40℃). there were no significant differences in flavor, acidity, rancidity and discoloration. Thus, it is expected that C. longae Radix extract will be a very useful additive to cosmetics for improving skin aging.
상백피 추출물의 나노입자화와 에탄올 추출물의 항산화 효과 비교
권혁년 한국피부과학연구원 2013 대한피부미용학회지 Vol.11 No.4
Nanoencapsulation is the coating of various substances within another material at sizes on the nanoscales and it is prospected in all kinds of industries especially cosmetics, pharmaceutics, and food manufacturing. This study was performed to investigate the antioxidant activities as comparing ethanol extracts (ME) and nano-encapsulation of Mulberry Root Bark Extracts by lecithin and cholesterol (NM). DPPH radical scavenging activity of both extracts are almost identical for the 250 ug/ml samples. Also, the effects on nano-encapsulated extracts (NM) and ethanol extracts (ME) on the generation (induction) of Reactive Oxygen Species (ROS)by adding LPS to induce oxygen stress into the cell was that the both extracts in adding sample (500 ㎍/㎖)or (1000 ㎍/㎖) showed similar to oxidative stresses inhibition compared to 50% of control. ln addition, cell viability of the nano-encapsulated extracts (NM) was measured on RAW 264.7 cells and showed higher than that of ethanol extract (ME) in each concentration. The size of the nano-encapsulated extracts (NM) was an average diameter of range of 200-400 nm so they can effectively penetrate cell more than ethanol extract (ME)as nano-encapsulated extracts (NM) have great mobility and affinity for cell because of their small size. it was observed by confocal laser scanning microscope.
권혁년 한국인체미용예술학회 2013 한국인체미용예술학회지 Vol.14 No.3
Today, such factors as environmental pollution, stress caused by business, uneasiness and depression are having an unhealthy effect on the hair and scalps of many and could be related to sensitive scalps. The effects of using a product containing extracts of Asteraceae (which has been used in traditional medicine to reduce inflammation, cure ulcers and treat skin wounds) on sensitive scalps were investigated. Ten respondents (patients) confirmed to be suffering from a sensitive scalp and who practiced scalp treatment once a week for four weeks were tested. It was found that after scalp massages they experienced relaxation and comfort. Specifically, before scalp care, sebum and keratin lumps were tangled, making the scalp pores untidy with small blood vessels, inflammation and flushing also present. After four weeks of intensive care, the scalp pores opened, and itchiness, inflammation and flushing decreased. Also, most of the respondents reported being satisfied after the scalp treatment.
보문 : 화장품 소재를 위한 오디 발효 추출물의 항산화 효과
권혁년 ( Hyuk Nyun Kwon ) 대한미용학회(구 대한미용과학회) 2013 대한미용학회지 Vol.9 No.3
The present study aims to evaluate and compare the fermented (FEEM-fermented extract from mulberry produced by EM) and unfermented (WE-water extract from mulberry) extracts from mulberry in activities of antioxidant and antiinflammation as a functional ingredient for cosmetic products. Effective microorganism fermented extract was produced by fermentation of effective microorganisms (EM) containing more than one hundred bacterial strains, including photosynthetic bacteria, lactic acid producing bacteria and yeast. WE has been added to the EM at the concentrations of 0.1~2.5 mg/mL and then they were incubated to make FEEM at 37℃for 7 days. Cell viability of FEEM was measured on RAW 264.7 cells through MTT assay and it showed higher than that of WE in each concentration. Also, the generation of reactive oxygen species by RAW 264.7 cells was measured using flow cytometry caliber (FACS) analysis. FEEM resulted in lesser generation of ROS than WE as revealed by decrease in dichlorofluorescein (DCF) fluorescence. Electron donating abilities (EDA) and nitrite scavenging activities of FEEM were 7~12%, 11~20% respectively and these values were higher than WE at each concentration. In SOD-like activity, FEEM (46.91%) was 11.28% higher than WE (35.63%) at the 2.5 mg/mL concentration and they were lower than L-ascorbic acid at the same concentration. This study showed that FEEM improved the activities of antioxidant and anti-inflammation, and which can be further developed as a functional additive to cosmetics.
보문 : 참당귀 추출물의 나노입자를 통한 피부 미백 효과 연구
권혁년 ( Hyuk Nyun Kwon ) 대한미용학회(구 대한미용과학회) 2014 대한미용학회지 Vol.10 No.3
Angelica gigas (AG) root extract is one of the most widely used herbal medicines in Asia and is known to have antioxidant activity and skin whitening effect. This study was carried out to evaluate skin-whitening effects of nanoparticles of AG root extract on cell penetration by comparison with AG root extract, and lecithin and cholesterol were used to encapsulate AG root extract to make nanoparticles. Nanoparticles were spherical liposomes by SEM (scanning electron microscope) and varied in size from a range of approximately 100~500 nm compared to 1,000~5,000 nm for ethanol extracts as measured by ELS (electrophotonetic light scattering spectrophotometer). Cell viability of the nanoparticles in NIH/3T3 fibroblasts was similar to that of the extract. Mushroom tyrosinase inhibition activity of nanoparticles was lower than the extract. Confocal fluorescence micrographs using fluorescent dye showed that the nanoparticles more effectively penetrated into NIH/3T3 fibroblasts than the ethanol extract with higher affinity and mobility to the cells. From these results, it is speculated that nanoparticles could be applied as additive in cosmetics.
Lipopolysaccharide가 Lymphokine의 합성에 미치는 영향
박영순,권혁년 圓光大學校 基礎自然科學硏究所 1996 基礎科學硏究誌 Vol.14 No.2
Bacterial lipopolysaccharide(LPS)가 림프구의 lymphokine 합성과 분비능에 미치는 영향을 연구하고자 in vitro 및 in vivo로 LPS를 투여한 결과 다음과 같은 결과를 얻었다. 1. In vitro LPS 와 lymphokine합성과 분비능은 영향을 받지 않았으나 in vitro 투여 후에는 IL―2 및 γ―IFN의 분비능은 감소하고 IL―4의 분비능은 증가 하였다. 2. E.coli LPS 와 salmonella LPS의 lymphokine 생성능은 동일하였고 가열한 것과 비가열한 것의 결과도 동일 하였다. 3. LPS 장기 투여로 탈 감작화된 mouse의 lymphokine생성에 대한 효과도 동일 하였으며 in vitro RU486 처치 후에는 lymphokine생성능이 억제 되었다. 이상의 결과를 종합하면 LPS는 IL―2 및 γ―IFN의 합성과 생성능은 감소시킨 반면 IL―4의 생성능은 증가시켰으며, 이들은 glucocorticosteroid 분비에 의해 중재됨을 추측 할 수 있었다. This study was undertaken to evaluate the immunomodulatory properties of the bacterial lipopolysaccgaride(LPS) on the lymphokine production in vivo and in vitro. The results are follows: 1. There was no differences on the lymphokine secretion by the in vitro treatment of LPS, however, in vitro LPS treatment decreased the production of IL―2 and γ―IFN, whereas it increased the IL―4 production. 2. There were no differences on the lymphokine production between E.coli and salmonella LPS, and between heated and non heated LPS. 3. Lymphokine production of mice which were desensitized by the long term treatment was not different from control and in vitro treatment with HU486 can block the alterations of lymphokine production after the treatment of LPS. By the summarizing of these results, LPS decreased the secretion of IL―2 and γ―IFN ana increased the secretion of IL―4 through the endogenous secretion of glucocorticoids.
^60Cobalt γ-선 조사로 유발된 백서의 유방 종양
신대균,권혁년,황호원,최찬,문형배 圓光大學校 醫科學硏究所 1992 圓光醫科學 Vol.8 No.1-2
This study was aimed at examining the incidence and histological type of the breast tumors of rat induced by ^60Co γ-ray irradiation. Twenty Sprague-Dawley rats were given 0.9 Gy of ^60Co γ-ray for 6 weeks (0.15 Gy per week), and were killed 46 weeks after the end of irradiation. Juvenile fibroadenoma(JFA) was the most frequent tumor(18 of 20), and adenoma(2 of 20) was the second frequent one. The 18 cases of JFAs showed broad spectrum of morphologic changes. The 2 cases revealed massive fibrosis of intralobular stroma(JFA with massive fibrosis), the 6 cases typical JFA, the 6 cases showed focal alveolar hyperplasia(JFA with focal alveolar hyperplasia), and the rest 4 cases showed diffuse alveolar hyperplasia(JFA with diffuse alveolar hyperplasia). Although the rats were not pregnant nor lactating, 2 cases of adenoma were morphologically identical with lactating adenoma. These results suggest that the responsiveness of breast tissue to the radiation is different even in the same species of animals. JFA can be easily made in Sprague-Dawley rats by ^60Co γ-ray irradiation, and this method can be used as a good experimental model in studying the JFA.