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權澤孚,宋貞玉,申東春,林正均 최신의학사 1976 最新醫學 Vol.19 No.4
Chronic myelocytic leukemia is one of rare type of leukemia in childhood. Frequent presenting initial symptoms are intermittent fever with unknown origin, abdominal distention, .hepatosplenomegaly, bleeding tendency, recurrent infection and generalized lymphadenopathy. The case was ten years old male child who was admitted with symptoms of abdominal distention, fever, and hepatosplenomegaly. He was confirmed by bone marrow aspiration and hematologic studies. We reviewed the literature about the etiology incidence, clinical symptoms, physical findings, hematologic findings, prognosis and management of chronic myelocytic leukemia briefly.
權澤孚 고려대학교 의과대학 1975 고려대 의대 잡지 Vol.12 No.1
Most authors have found considerable variations in the reticulocyte count in different infants, and the values found by different authors are extremely variable. The present study had been carried out in order to investigate the influence of gestational age and delivery method on the reticulocyte level in the newborn infant. Ninety-eight newborn infants who were born at the Woo-Sok Hospital Korea University College of Medicine have been studied and the results obtained were as follows: 1. In the circulating blood of the normal newborn infants, there were found an average of 7.02% of vitally stainable reticulocytes, with the maximal limit of 11.2% and the minimum of 4.1%, during the first 24 hours of life. 2. There seems to be ascertain relation between the number of reticulocytes and gestational age, that is, prematury born infant had higher reticulocyte counts than postmatury born infants. Low birth weight infants showed the same relation as seen in the premature infants. 3. Reticulocyte counts was somewhat lower in the newborn delivered by cesarean section or face & breech than normal vagianl, although definite conclusions are not warranted from a small series such as is here reported. 4. There were no sex difference, and no correlation between the number of reticulocytes and gravida.
한의학(韓醫學)에서 분류하는 사상체질(四象體質)에 따른 이식항원(移植抗原) HLA-DR 유전자(遺傳子) polymorphism에 관한 연구
권택부(Taek Boo Kwon),황치원(Chee Won Whang),설인찬(In Chan Sul),이경옥(Kyung Ok Lee),황규원(Kyu Yoon Hwang),양동호(Dong Ho Yang),홍세용(Sae Yong Hong) 대한내과학회 2000 대한내과학회지 Vol.58 No.1
N/A Background : In Korean traditional medicine, human beings are classified into 4 groups accordance with the characteristics of physical constitution, named ; Taeum, Taeyang, Soum, and Soyang. Most of Korean traditional doctors believe that the back ground of pathophysiology is differ among each group in many diseases. HLA is the most polymorphic gene and related with human immune response. It has been used for determination of individual identification, genetic diversity and a study of disease association in different ethnic group. It has well known that the most human inflammatory disease which thought to have some autoimmune basis are in some way promoted by genes of the HLA region. The purpose of this study is to observe the distribution of HLA-DR genotypes in 4 types of physical constitution in Korean traditional medicine. Methods : Three hundred and ten Korean subjects(Soyang : 58cases, Soum :142cases, Taeum : 92cases, Taeyang : 18cases) were enrolled for this study. Genomic DNAs extracted by phenol/chroloform were amplified with allele specific primers and determined by 2% agarose gel electrophoresis with ethidium bromide staining for analysis of HLA-DR polymorphism. Results : The genotype frequency of HLA-DR in a total or 310 Koreans was DR1 ; 7.2%, DR 2; 10.5%, DR 3;1.7%, DR 4; 19.9%, DR 5; 11.9%, DR 6;19.9%, DR 7; 7.0%, DR 8; 10.6%, DR 9; 8.7%, DR10;1.9%. There was no significant diffrence of HLA-DR genotype distribution among four physical constitution groups classified by Korean traditional medicine. Conclusion : Our results suggest that the classification of physical constitution in Korean traditional medicine is not related to HLA-DR genotypes.(Korean J Med 58:91-101, 2000)
식육 중 잔류물질 스크리닝법인 EEC-4 Plate Test와 Charm II Test 비교
함희진,김두환,권택부,이정학,Ham Hee-jin,Kim Doo-whan,Kweon Taek-boo,Lee Jung-hark 한국식품위생안전성학회 2004 한국식품위생안전성학회지 Vol.19 No.4
잔류물질 간이 시험법으로 EEC-4 plate test와 Charm II test가 항생물질과 합성항균제 잔류검사에 널리 이용되고 있는 바, 이들 상호간의 결과 수치를 비교, 분석한 결과 다음과 같은 결론을 얻었다. EEC-4 plate혹은 Charm II 에서 양성으로 나타난 돈육 71건에 대하여 HPLC로 정량 분석한 결과, only tetracyclines 46건, only sulfonamides와 solfonamides+tetracyclines가 각각 4건씩, amphenicols+tetracyclines와 amphenicols+sulfonamides+tetracyclines가 각각 1건씩 검출되었고, 15건에서는 검출되지 않았다. Sulfonamides 계열에서 검출된 9건의 경우, Charm-II test 결과 수치가 낮은 경우에 정량 검출량이 높게 나타났고, EEC-4 plate test 결과 pH 6.0, pH 7.2, pH 8.0 모두에서 양성으로 나타나는 등 두 시험방법 간에 연관성이 있었고, chloramphenicols 계열에서 검출된 2건과 검출되지 않은 7건의 경우, Charm-II test결과 수치가 낮은 경우에는 오히려 정량 검출되지 않았으나, control point 근방의 양성 수치에서는 검출량이 높게 나타날 뿐 아니라 EEC-4 plate test에서도 pH6.0, pH7.2, pH8.0 모두에서 양성으로 나타나는 등 두 시험방법 간에 연관성이 있었다. 한편, tetracycline계열의 경우, EEC-4 plate와 Cham-II간에 연관성은 없었다. 또한, EEC-4 plate와 Charm II에서 각각 양성을 나타내었으나 HPLC에서는 검출되지 않는 경우는 tetracyclines계열에서는 $10.5\%(6/57)$, sulfonamides계열의 경우는 없었고, chloramphenicols계열의 경우는 $81.8\%(9/11)$로 각각 나타나 EEC-4 plate와 Charm II가 세 가지 잔류물질 시험에 대한 screening method로서 적합함을 알 수 있었다. It was carried out to compare the relationship of EEC 4-plate test method and Charm II test method by HPLC. 46 only tetracyclines, 4 only sulfonamides, 4 sulfonamides+tetracyclines, one amphenicols+tetracyclines, and one amphenicols+sulfonarnides+tetracyclines, it was detected on 71 porks of EEC 4-plate positive or Charm II positive by HPLC. In case of sulfonamides and chloramphenicols, two test methods had related with each other, but had no relation in tetracyclines. Also, it was $10.5\%(6/57)$ tetracyclines, $81.8\%(9/11)$ chloramphenicols that were EEC 4 plate positive or Charm II positive, but not detectrd by HPLC. Consequently, EEC 4-plate test method and Charm II test method were suitable by screening test on antibiotics and sulfonamides etc.
HPLC-MSD를 이용한 식육 중 합성항균제의 동시분석
홍인석 ( In Suk Hong ),최윤화 ( Yoon Hwa Choi ),권택부 ( Taek Boo Kwon ),이정학 ( Jung Hark Lee ) 한국가축위생학회 2006 韓國家畜衛生學會誌 Vol.29 No.3
This study was conducted to develop the analytical method about simultaneous determination for synthetic antimicrobials in muscle by high performance liquid chroma-tography-mass selective detector(HPLC-MSD). Solid phase extraction(SPE), matrix solid phase dispersion(MSPD) and liquid-liquid extraction(LLE) have been adapted as pretreatment procedures for HPLC-MSD. Among various solvent tested, methanol was chosen for extraction of synthetic antimicrobials in muscles. For the optimized response, the values of various MS parameters including fragment voltage, drying gas flow, nebulizer pressure, drying gas temperature were verified. The average recovery rates using MSPD and SPE for muscles of bovine and pork were 78.9-127.1% and 78.3-121.7%, respectively. This method was verified the satisfactory performance for fourteen synthetic antimicrobials excepting carbadox in muscle of pork as detection limit of 0.05 ㎍/g on API/ES SIM mode.
Gas chromatograph-mass selective detector를 이용한 식육 중 잔류농약의 동시분석
홍인석 ( In Suk Hong ),최윤화 ( Yoon Hwa Choi ),권택부 ( Taek Boo Kweon ),이정학 ( Jung Hark Lee ) 한국가축위생학회 2005 韓國家畜衛生學會誌 Vol.28 No.3
This study was conducted to investigate the extraction method for the determination of organochlorine, organophosphorus and synthetic pyrethroid pesticide residues in beef fat by gas chromatography-mass selective detector(GC-MSD). Twenty one pesticide residues in fat were determined using a simple and rapid procedure based on solid-phase extraction(SPE) clean-up cartridges with octadecyl(C18)-bonded porous silica, florisil, 10% deactivated florisil, a tandem C18 and florisil and a tandem C18 and 10% deactivated florisil. Solvent-solvent extraction using acetonitrile was not satisfied to eliminate fat interference for pesticide residue analysis by GC-MSD, and the recoveries of the method in fat ranged from 16.2 to 57.3% except DDT(83.2%). The recoveries of SPE methods using a tandem C18 and Florisil was 59.6~123.8% except fenitrothion(135.2%), the SPE method was verified the satisfactory performance of pre-treatment for pesticide residues analysis in fat by GC-MSD. The efficiency of florisil deactivated with 10% water has been not proved significantly on recoveries of pesticide residues in fat.
시판 식육가공품(햄류, 소시지류 등)에 대한 최근 4년간(2000-2003) 아질산이온 함량
함희진 ( Hee Jin Ham ),홍인석 ( In Suk Hong ),임홍규 ( Hong Kyu Lim ),양윤모 ( Yoon Mo Yang ),최윤화 ( Yoon Hwa Choi ),김창기 ( Chang Gi Kim ),권택부 ( Taek Boo Kweon ),이정학 ( Jung Hark Lee ) 한국가축위생학회 2004 韓國家畜衛生學會誌 Vol.27 No.2
Contents of nitrites was tested in 2,290 meat products during 2000-2003, in Seoul by Diazoa method. It was detected over 40 ppm NO2 contents in 20 hams, 7 sausages, one bacon, and one crushed meat product respectively. Also, over 20ppm nitrites was 21.8%(240/1,103) in hams, 20.7%(122/589) in sausages, 6.8%(14/205) in crushed meats, and in 6.0%(5/83) bacons respectively. In case of average contents and contents range, 0.012 g/kg, ND-0.116 g/kg in hams, 0.012 g/kg, ND-0.066 g/kg in sausages, 0.010 g/kg, 0.001-0.089 g/kg in bacons, and 0.006 g/kg, ND-0.040 g/kg in crushed meats etc. Specially, in sausages, it was increased continually by years, in not only average nitrites contents but also their contents range, also, in case of bacons, increased continually by years on only average nitrites contents. According to results, the NO2 contents monitoring for the processed meat products must be reinforced to supply safety food for the citizens.
소와 돼지도체에서 Listeria monocytogenes의 분리 및 PCR 검출 방법에 관한 연구
채희선 ( Hee Sun Chae ),김두환 ( Doo Hwan Kim ),김규현 ( Gu Hyun Kim ),신방우 ( Bang Woo Shin ),조미영 ( Mi Yoeng Jo ),권택부 ( Taek Boo Kweon ),이정학 ( Jung Hak Lee ) 한국가축위생학회 2003 韓國家畜衛生學會誌 Vol.26 No.2
From February 2000 to December 2001, A total of 1,785 samples was taken from beef and pork carcasses in Seoul. Seven(0.69%) Listeria spp. were isolated from the 1,014 of beef carcasses, and five(0.65%) were isolated from the 771 of pork carcasses. The isolates were identified L monocytogenes by API listeria, and VIDAS LMO kit, serological test and PCR assay were performed. A total 12 strains of L monocytogenes were isolated form samples tested and all of the strains were classified into serotype 1. PCR primers are selected to amplify a 520-base pair(bp) DNA fragment from the listeolysin O gene(hlyA) of Listeria monocytogenes. A 520-bp product was detected in PCR with DNA from L monocytogenes, but not from the other Listeria species tested.