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Radiographic study of dermal fillers in the facial area: A series of 3 cases
권영은,안창현,최갑식,이두형,안서영 대한영상치의학회 2018 Imaging Science in Dentistry Vol.48 No.3
In recent years, as interest in maintaining beauty and a youthful appearance has grown, filler procedures such as soft tissue augmentation have become more popular. These fillers are sometimes seen as radiopaque shadows on radiographic images, either due to the fillers themselves or because of secondary reactions; such findings may present a diagnostic challenge to dentists. The present report describes 3 cases of dermal fillers observed in panoramic and cone-beam computed tomographic (CBCT) images. All 3 elderly female patients had filler injected into their cheeks and chin area for cosmetic purposes decades ago. On panoramic images, multiple symmetric radiopacities were observed in the facial area; on CBCT, these calcifications were seen in the subcutaneous tissue in various shapes and with varying density. In conclusion, dentists should be aware of the imaging characteristics of dermal filler, and should be able to differentiate dermal filler from other pathological findings.
권영은,김연숙,서길희 노인간호학회 2006 노인간호학회지 Vol.8 No.2
Purpose: The purpose of the study is to investigate the cognitive function and depression of the elderly in a community setting. Method: The subjects of this study were 234 aged over 65 in Seongnam city. The data were collected from July 25th to October 27th, 2005. The measures were Korean version of Mini-Mental State Examination(MMSE-K) and Short Form of Geriatric Depression(SGDS). Collected data were analyzed using SPSS 12 version to obtain summary statistics for the descriptive analysis, t-test, ANOVA and Pearson Correlation. Results: 1. The mean score of cognitive function was 21.95±3.54. The prevalence of cognitive impairment was estimated as 73.1% by MMSE-K≤23 point. 2. The mean score of depression was 5.35±2.12. The elderly with depression was estimated as 15.4% by SGDS≥8 point. 3. The cognitive function of the subjects were significantly negative correlated with depression(-.165*, p=.012). 4. The general characteristic which affected the cognitive function scores of the elders were gender, age, and spouse. The general characteristic which affected the depression scores of the elders were gender and age. Conclusion: The findings of this study will provide practical guidelines for developing cognitive nursing interventions.
권영은,전윤화,이경은 사단법인 인문사회과학기술융합학회 2019 예술인문사회융합멀티미디어논문지 Vol.9 No.2
According to the World Health Organization (WHO), health means a state of complete physical, mental, and social well-being, not merely disease-free or fragile. Among the elements that violate well-being status, Desstress is used as a sub-concept of depression and anxiety, which is confined to psychological distress. In nursing, it is mainly used as a negative concept related to stress on cancer patients. Thus, in this study, it was attempted to establish a theoretical basis in nursing practice by clarifying the clear attributes of the concept of detress, which is understood in many senses according to a vague and subjective interpretation. The data were analyzed using Walker and Avant conceptual analysis methods. The results were as follows: 1) unpleasant feelings, 2) Negative consequences of various aspects, 3) Stress recognized by subjective symptoms, 4) Condition that the necessity of treatment is accepted. Distress, as seen by the above attributes, is an unpleasant emotion that results in negative consequences due to perceived stress from various aspects, and can be defined as being medically acceptable. Prerequisites for the stress are physical problems such as fatigue and pain, Emotional problems such as anxiety, depression, loss of self-esteem, spiritual and religious problems, social prejudice, family conflict, etc. were identified as social, family problems and everyday problems. Consequences were poor quality of life, negative disease prognosis, psychiatric problems, and waste of time and money. In conclusion, based on the results of this study, it can be suggested that the concept of distress provides the rationale for nursing practice and provides basic data for the development of scale for distress intervention. 건강이란 세계보건기구(WHO)에 따르면 단순히 질병이 없거나 허약하지 않은 것만이 아닌 신체적, 정신적, 사회적으로 완전한 안녕상태를 의미한다. 이러한 안녕상태를 침해하는 요소 중 디스트레스는 심리적 디스트레스에 국한되어 우울, 불안 등의 하위개념으로 사용되고 있으며, 간호학에서는 주로 암환자를 대상으로 한 스트레스 관련한 부정적 개념으로 사용하고 있다. 이에 본 연구에서는 디스트레스에 대한 개념 확립이 불명확하고 주관적인 해석에 따라 여러 의미로 이해되고 있는 디스트레스 개념의 명확한 속성 규명을 통하여 간호 실무에서의 이론적 근거를 마련하고자 시도되었다. 자료는 Walker & Avant(2005)의 개념분석 절차에 따라 진행되었고, 디스트레스의 속성은 4가지로 유쾌하지 못한 감정, 다양한 측면의 부정적 결과, 자각증상으로 인지되는 스트레스, 치료의 필요성이 수용되는 상태로 확인되었다. 이상의 속성을 통해 살펴본 디스트레스는 다양한 측면에서 인지하게 되는 스트레스로 인해 부정적인 결과를 초래하는 유쾌하지 않은 감정이며, 치료적으로 수용되는 것으로 정의할 수 있다. 디스트레스에 대한 선행요인은 피로, 통증과 같은 신체적 문제, 불안, 우울, 자존감 상실 등의 정서적 문제, 영적․종교적 문제, 사회적 편견, 가족갈등 등의 사회적, 가족문제, 일상생활 문제로 파악되었다. 그 결과는 삶의 질 저하, 부정적 질병의 예후, 정신과적 문제, 시간 및 비용의 낭비로 나타났다. 이에 본 연구 결과를 토대로 디스트레스 개념이 간호 실무에서 이론적 근거를 제공하고, 디스트레스 중재를 위한 척도 개발의 기초자료를 제공할 수 있으리라 본다.
중국 내 고등학교의 한국어교육 현황과 활성화 방안 -하남성 초작시 제일고등학교 한국대학 진학반을 중심으로-
권영은,권대혁,황미혜 부산외국어대학교 다문화연구소 2023 다문화사회와 교육연구 Vol.13 No.-
The purpose of this study is to introduce in detail the current status of Korean language education in high schools in China and to suggest future directions for improvement. Currently, in China, the first city in Henan Province, China, which is receiving attention as a Korean language education area in high schools rather than Korean language education in universities. As a result of interviews with students who wish to enter Korean universities, some problems and improvement plans were found. The focus of this thesis is on Korean language education at NO.1 High School. Therefore, this thesis aims to do a basic research on the current status of Korean language education at NO.1 High School in Jiazuo City, Henam. 본 연구는 중국의 고등학교 한국어교육 현황을 자세히 소개하고 앞으로의 개선 방향을 제시하는 것을 목적으로 한다. 현재 중국에서 한국어교육은 주로 대학에서 많이 이루어지고 있다. 반면 본 연구에서는 대학 중심의 연구에서 벗어나 중국 내 고등학교에서 운영되고 있는 한국어교육을 살펴보고자 한다. 고등학교 한국어교육 사례로 중국 하남성 초작시 제일고등학교 한국대학 진학반의 한국어교육에 초점을 두었다. 아울러 초작시 제일고등학교 한국대학 진학반 학생들의 진로 동기, 한국어교육 등에 관한 인터뷰 내용 결과 몇 가지 문제점과 개선 방향을 찾을 수 있었다. 따라서 본 논문은 하남성 초작시 제일고등학교 한국대학 진학반의 한국어교육 현황을 살펴보고 중국 내 고등학교의 한국어교육 활성화 방안에 대해 기초 연구를 제시하는 것을 목표로 한다.
권영은,문정환,유희주,백성훈,김군보,임기병 한국원예학회 2017 Horticulture, Environment, and Biotechnology Vol.58 No.2
Gene-based markers are useful tools for genetic background surveys and comparative genome analysis dueto their ease of application across closely related species. We developed gene-based DNA markers for Phalaenopsis‘KS Little Gem’, a new Phalaenopsis variety with excellent ornamental traits, based on a genome-wide comparisonof chloroplast and nuclear sequences with those of orchids as well as monocot species, including rice and banana, toestablish a molecular basis for species identification. Sequence comparisons of chloroplast DNA from P. ‘KS LittleGem’ with those of P. aphrodite and P. equestris identified six variable genic regions of the chloroplast genome inwhich an intron of rpl16 was the most polymorphic between related orchid species. To develop conserved orthologset (COS) markers, we compared transcriptome unigenes of P. ‘KS Little Gem’ with the P. equestris, rice, andbanana genomes and identified 582 Phalaenopsis COS candidates with at least two exons. PCR application usingprimer sets targeting six variable regions of the chloroplast genome and introns of 45 randomly selected COScandidate genes showed 92-98% amplification in three Phalaenopsis species. Among the candidate genes, wedeveloped rpl16 and three COS genes as diagnostic cross-species markers for P. ‘KS Little Gem’ and diverse,related orchids. The gene-based molecular markers developed in this study will play an important role in speciesidentification to facilitate the protection of P. ‘KS Little Gem’ variety rights, as well as breeding and genetic studiesof Phalaenopsis orchids.
당뇨병이 없는 한국 성인 남성에서 고감도 C-반응 단백과 인슐린저항성과의 연관성
권영은,이상화,이홍수,심경원,변아리,박선영 대한가정의학회 2019 Korean Journal of Family Practice Vol.9 No.2
Background: Insulin resistance syndrome is recognized as a risk factor for cardiovascular disease (CVD) and type 2 diabetes mellitus (DM). Even though early management and prevention during the pre-DM stage is emphasized, few studies have investigated the risk of insulin resistance and CVD in individuals with normal blood glucose. This study investigates the effectiveness of the high sensitivity C-reactive protein (hs-CRP) test as a preventative measure by examining the relationship between hs-CRP and a homeostasis model assessment of insulin resistance (HOMA-IR) in adult men without DM. Methods: Our study included 1,924 men who were ≥20 years of age, from the 2015 Korean National Health and Nutrition Examination Survey. Based on fasting glucose levels, subjects were divided into two categories: normal and impaired fasting glucose (IFG). Results: Student’s t-test was used to compare the means of the normal and IFG categories, and hs-CRP and HOMA-IR showed significantly lower values for all variations, except height and smoking, at a significance level of 0.001. All subjects were classified into quadrant groups according to hs-CRP values, and ANCOVA was performed to compare the HOMA-IR average of each group. The mean IR did not significantly differ between cohorts, except for in the IFG category of one group. Conclusion: In adult men without DM, hs-CRP did not significantly correlate with HOMA-IR, except in the IFG category. This indicates that the risk of CVD increases continuously in the normal blood sugar range. Further studies are needed to improve the usefulness of the high sensitivity hs-CRP test. 연구배경:인슐린저항증후군은심혈관질환과제2형당뇨병의위험인자로 인식되고 있다. 당뇨병 전 단계에서부터 관리 및 예방이 중요함에도 정상 혈당범위에서 인슐린저항성과 심혈관계 질환의 위험성에관한연구는많지않다. 본연구에서당뇨병이없는성인남성에서고감도 C-반응단백과 HOMA-IR의 연관성을 살펴봄으로써 예방차원에서고감도 C-반응단백검사의유용성을알아보고자하였다. 방법: 2015년 제6기 3차 국민건강영양조사자료를 이용하여 분석을시행하였다. 분석 대상은 20세이상 성인남성으로 총 3,374명 중 고감도 C-반응단백, 인슐린, 공복혈당수치가 있는 1,924명의 최종대상자가 선정되었다. 모든 대상자들은 공복혈당, 인슐린, 혈중 지질농도,고감도 C-반응단백, 체질량지수를 측정하였고 인슐린 저항성은HOMA-IR 지표를 이용하였다. 공복혈당에 따라 정상군, 공복혈당장애군 2군으로 나누어(당뇨병 진단 기준에 해당하는 자는 제외) 비교하였다. 결과: 정상군과 공복혈당장애군 간의 평균을 비교하기 위해 t검정을 실시하였고 고감도 C-반응단백, HOMA-IR은 신장과 흡연을 제외한 모든 변인에서 수치가 정상군이 공복 혈당 장애군에 비해 유의하게 낮은 것으로 나타났다. 정상군의 25, 50, 75 백분위수에 해당하는고감도 C-반응단백값에 따라 전체 대상군을 사분위군으로 분류한뒤 각 집단의 HOMA-IR 평균 비교를 위해 공분산분석을 실시하였고집단간 HOMA-IR의평균은공복혈당장애군의한군을제외하고는 유의한 차이를 보이지 않았다. 결론: 당뇨병이 없는 성인 남성에서 고감도 C-반응단백은 HOMAIR과 유의한 상관성을 보이지 않았으며 공복혈당장애군의 경우에서만 고감도 C-반응단백수치가 높은 집단일수록 HOMA-IR수치가높아지는 경향성을 나타냈다. 이는 정상 범위의 혈당에서도 심혈관질환의 위험이 연속적으로 증가함을 어느정도 시사하고 있지만 고감도 C-반응단백검사가 유용하게 사용될 수 있기 위해서는 추가적인 연구가 더 필요하다.
바이오 헬스케어 분야 국가연구개발 특허성과 네트워크 분석
권영은,김재수 한국융합학회 2018 한국융합학회논문지 Vol.9 No.12
본 논문은 바이오 헬스 분야의 기술융합구조와 핵심기술 연구 분야를 파악하기 위해 국가R&D 수행으로 창출된 특허성과를 기반으로 네트워크 분석을 실시한 논문으로서, 이를 위한 기반 연구인 특허네트워크 분석을 실시하여 이에 대한 문제점을 도출하고 NTIS로부터 데이터를 수집하여 연구프레임 네트워크를 기반으로 바이오 헬스케어 분야 국가R&D 특허 현황 분석과 IPC 네트워크 분석을 통해 도출된 5개의 그룹을 바이오 헬스케어 분야 기술체계 기준으로 주제를 선정하였다. 분류된 것을 대상으로 기술 파급효과가 가장 높은 기술을 도출하여 다른 분야의 비교를 통해 국가R&D 분야의 연구비 투자에 대한 방향을 제시하였다. 향후 해외특허자료 분석을 추가적으로 실시하고, 기술융합과 정부투자 연구비의 상관분석을 보완하여 연구비투자 방향성 모색에 기여할 것으로 판단된다. This study attempted to analyze technology convergence structure and key technology research sectors in bio-health. For this, network analysis was performed based on the patent outcomes achieved through national R&Ds. Then, a patent network was analyzed to derive problems and collect data from the National Science & Technology Information Service. With the five groups obtained through the analysis of IPC network and national R&D patents in bio-health based on a research frame network, topics were chosen based on the bio-healthcare technology system. Then, the technology with the greatest ripple effects was derived and compared to other sectors, suggesting a direction for national R&D investments. It is anticipated that this study would make a contribution to a search for R&D investment direction by additionally analyzing overseas patent data and improving correlation analysis between technology convergence and government-led R&D expenses.
Nuclear Localization of Chfr Is Crucial for Its Checkpoint Function
권영은,Ye Seul Kim,Young Mi Oh,Jae Hong Seol 한국분자세포생물학회 2009 Molecules and cells Vol.27 No.3
Chfr, a checkpoint with FHA and RING finger domains, plays an important role in cell cycle progression and tumor suppression. Chfr possesses the E3 ubiquitin ligase activity and stimulates the formation of polyubiquitin chains by Ub-conjugating enzymes, and induces the proteasome-dependent degradation of a number of cellular proteins, including Plk1 and Aurora A. While Chfr is a nuclear protein that functions within the cell nucleus, how Chfr is localized in the nucleus has not been clearly demonstrated. Here, we show that nuclear localization of Chfr is mediated by nuclear localization signal (NLS) sequences. To reveal the signal sequences responsible for nuclear localization, a short lysine-rich stretch (KKK) at amino acid residues 257-259 was replaced with alanine, which completely abolished nuclear localization. Moreover, we show that nuclear localization of Chfr is essential for its checkpoint function but not for its stability. Thus, our results suggest that NLS-mediated nuclear localization of Chfr leads to its accumulation within the nucleus, which may be important in the regulation of Chfr activation and Chfr-mediated cellular processes, including cell cycle progression and tumor suppression.