Herbal Medicine for Liver Cancer: A Protocol for Systematic Review and Meta-Analysis

권승원,송가연,양승보 대한한방내과학회 2022 大韓韓方內科學會誌 Vol.43 No.4

Introduction: The aim of this systematic review is to provide evidence confirming the efficacy and safety of herbal medicines used in the treatment of liver cancer. Methods: The review will include randomized clinical trials that compared herbal medicines used as treatments for liver cancer with other therapies, such as placebos and Western medicine. Only randomized controlled trials will be included in this review, and all types of herbal medicine will be evaluated. Eleven electronic databases will be searched from the inception date: the Cochrane Database of Systematic Reviews, MEDLINE, EMBASE, AMED, CINAHL, one Chinese database (CNKI), and five Korean databases (OASIS, DBpia, RISS, KISS, and NDSL). The selection of studies, data extraction, and management will be performed independently by four researchers. Methodological quality, including the risk of bias, will be assessed using the Cochrane risk-of-bias assessment tool. Results: The review of current evidence for the effectiveness of herbal medicine for liver cancer will be summarized and quantitatively analyzed. Conclusions: Our systematic review will provide evidence of the efficacy of herbal medicines as treatments for liver cancer. This evidence will provide useful information for practitioners and patients in the fields of oncology and complementary medicine. Systematic review registration: 2021 CRD42021268386

Could herbal medicine (Soshihotang) be a new treatment option for COVID-19?: a narrative review

권승원,Wonhaeng Lee,Chul Jin,장인수,정우상,문상관,조기호 한국한의학연구원 2020 Integrative Medicine Research Vol.9 No.3

Background: While the world struggles under the coronavirus disease 2019 (COVID-19) pandemic, a variety of antiviral agents and symptomatic treatments are being administered to patients and urgent clinical trials are underway. Under these circumstances, it is important to explore various possibilities for the treatment of COVID-19 including herbal medicines. Among various herbal medicines, Soshihotang (SSHT, Xiao Chai Hu Tang in Chinese) has been prescribed to treat various viral diseases and is used in combination with other herbal medicines depending on the patient’s symptoms. Methods: For conducting the present review, we searched electronic databases focusing on the antiviral effect of SSHT in experimental and clinical study until April 2020. The search keywords included SSHT, constituents of SSHT, and antiviral effect. We also searched for materials related to topic directly from websites and published books. Based on these search results, we summarized the results of the included materials in the form of a narrative review. Results: In a number of recent clinical studies, treatment with SSHT improved the infection status of the respiratory and hepatobiliary systems, and experimental studies demonstrated the antiviral effect of SSHT and its components. Furthermore, SSHT are being used in China—where COVID-19 outbreak first took place—and offer a new option to treat COVID-19. Conclusion: Based on the present evidences, it is believed that SSHT is likely to be a new therapeutic option for COVID-19. Conducting further studies might provide improved understanding regarding the use of SSHT in treating COVID-19.

An herbal medicine prescription (Oreongsan) developed as a new alternative treatment in patients with chronic subdural hematoma: a narrative review

권승원,Chul Jin,조기호 한국한의학연구원 2019 Integrative Medicine Research Vol.8 No.1

An herbal medicine prescription, Oreongsan (ORS), which is composed of Polyporus, Alismatis Rhizoma, Atractylodis Rhizoma, Poria (Hoelen), and Cinnamomi Cortex Spissus, has been used as treatment in patients with various symptoms such as thirst, diminished urination, edema, hangover, and diarrhea. ORS is the representative prescription of the ’inducing diuresis’ (isu) effect, which traditionally means the effect of controlling the water balance. Advancement of modern science has enabled the determination of the action mechanism of herbal medicine complexes. As a result, ORS has been used in the treatment of patients with chronic subdural hematoma (CSDH), representing a novel indication. ORS inhibits the upregulation of aquaporin-4, which is involved in the development of brain edema in the central nervous system. Both aquaporin-1 and aquaporin-4 are expressed in the outer membrane of the CSDH; through its effect as aquaporin-4 inhibitor, ORS prevents the inflow of fluid into the hematoma, thereby preventing the development and recurrence of hematoma. In this study, we reviewed the relationship between the inducing diuresis effect of ORS and aquaporin, conservative treatment approach in patients with CSDH, and the prevention of recurrence in patients undergoing combined burr hole surgery and treatment with ORS.

Warfarin 복용시 인삼(人蔘)이 포함된 한약처방이 PT INR에 미치는 영향 - 10 증례보고 -

권승원,박주영,변형식,윤승규,서유리,정우상,문상관,조기호,김영석,Kwon, Seung-Won,Park, Joo-Young,Byeon, Hyung-Sik,Yoon, Seung-Kyu,Seo, Yu-Ri,Jung, Woo-Sang,Moon, Sang-Kwan,Cho, Ki-Ho,Kim, Young-Suk 대한한방내과학회 2010 大韓韓方內科學會誌 Vol.31 No.3

Objective : Interaction of warfarin with herbal medicines still remains controversial. The aim of this study was to examine the effect of herbal medicines which contain ginseng on PT INR in patients being treated with warfarin. Method : We studied patients who take herbal medicines which contain ginseng with warfarin during their hospitalization. We retrospectively investigated the effect of herbal medicines which contain ginseng. 10 patients were assigned to receive one of the following adjuncts: Group A (n=4) that received Bojungikkitang-gagam, Group B (n=2) that received Ukgunjatang-gagam, and Group C (n=4) that received Shihogyeji-tang, Gamiondam-tang, Gwininaanshim-tang, and Saengpe-san together. We then investigated changes of PT INR in each group. Result : In group A, there were diminutions of PT INR in 3 cases, and increment in 1 case. In group B, there were increments of PT INR in both cases. In group C, there were increments of PT INR in 3 cases and there was no big change in 1 case. Conclusion : In this study, we found that the interaction of combined herbal medicine is very complicated. So, we must study further more study about interactions of combined herbal medicine on PT INR.

An Exploratory Study of the Effect of Ongyeong-tang Administration on Insomnia Disorder in Patients with Neurological Diseases: A Retrospective Chart Review Study

권승원,이한결,정우상,문상관,조기호 대한한방내과학회 2022 大韓韓方內科學會誌 Vol.43 No.6

Objectives: The aim of this study was to retrospectively evaluate the efficacy and safety of Ongyeong-tang (OGT) in the treatment of insomnia in patients afflicted with neurological diseases, according to the medical records of one medical institution. OGT is a herbal prescription that originates from the “Synopsis of Prescriptions of the Golden Chamber” and has been used for menopausal symptoms, uterine diseases, skin diseases, insomnia, and other neuropsychiatric symptoms. Methods: Medical records of patients who visited Kyung Hee University Korean Medicine Hospital from January 1, 2021 to June 30, 2022, received outpatient or inpatient treatment, and met the inclusion criteria were used in this study. Results: Twenty-four patients satisfied the inclusion criteria and were included. The Pittsburgh Sleep Quality Index-Korean version (PSQI-K) score was used to evaluate the outcomes before and after treatment. After an average of 14.42±9.2 days of OGT extract intake, 20 patients (83.3%) experienced improvement. The remaining four (16.7%) had no change in their symptoms, but none demonstrated worsening of symptoms. The total PSQI-K score showed a statistically significant decrease from 13.08±4.54 to 10.42±4.58 (p<0.001). Sleep quality, sleep duration, sleep disturbance, use of sleeping medications, and daytime dysfunction also showed statistically significant improvements. Conclusions: Administration of OGT extract may be a relatively safe and effective therapeutic option for insomnia in patients with neurological diseases.

The role of Korean Medicine in the post-COVID-19 era: an online panel discussion part 1 – clinical research

권승원,HeebumChung,YounggunKang,Insoo Jang,Jun-Yong Choi,정인철,박재우,이향숙 한국한의학연구원 2020 Integrative Medicine Research Vol.9 No.3

Background As it is predicted that large-scale viral diseases will occur more frequently in the future, there are voices that Korean Medicine (KM) community need to discuss the role of KM and what to prepare to play a significant part of national disease control system in the post-Coronavirus Disease 2019 (COVID-19) era. Methods This paper summarizes the edited highlights of an online video meeting by Google meet on 23 April 2020, organized by the Korean Medicine Convergence Research Information Center. Six speakers who are experts in respiratory medicine, cardiology and neurology, gastroenterology, and neuropsychiatry presented what KM community should prepare for the future acute infectious disease outbreaks by learning from experiences of KM teleconsultation center for COVID-19. Results Unlike in the past infectious disease outbreaks, KM community has played a bigger part in COVID-19 pandemic in spite of regulatory challenges via activities of KM teleconsultation centers. Telemedicine in pandemic could be more actively utilized in light of the present KM teleconsultation center’s achievements. Data from KM teleconsultation centers would be useful to establish an evidence-base for effectiveness and safety of KM treatments if they are properly collected and analyzed. It might be beneficial to adopt an integrative medicine approach in response to acute viral infectious diseases in the future but the inclusion of KM in the national disease control system is required. Conclusion The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era.

뇌졸중 환자의 실어증에 대한 언어치료시 한방치료가 병행되었을 때의 효과

권승원(Seung-Won Kwon),박주영(Joo-Young Park),변형식(Hyung-Sik Byeon),윤승규(Seung-Kyu Yoon),서유리(Yu-Ri Seo),정우상(Woo-Sang Jung),문상관(Sang-Kwan Moon),조기호(Ki-Ho Cho),김영석(Young-Suk Kim) 대한한의학회 2010 대한한의학회지 Vol.31 No.4

MMORPG 게임 내 캐릭터 커스터마이징과 게임 스토리 제공이 게임태도 및 각성(SCR)에 미치는 영향

권승원 ( Seung Won Kwon ),김지호 ( Gho Kim ) 한국소비자학회 2014 소비자학연구 Vol.25 No.3

게임을 하는 것은 다양한 감정반응을 유발하게 되며 이 감정 반응에 따라 사람들은 그 게임을 재미있어하고 더 오래하게 된다. 이런 감정반응은 게임을 다시 하도록 만드는데 중요하며 특히 즐거움과 각성이 매우 중요하다고 알려져 있다. 이런 감정 반응과 관련하여 본 연구에서는 게임 스토리와 캐릭터 커스터마이징의 영향을 확인하였고, 동시에 감정반응이 게임 구매에 어떤 영향을 미치는지 확인하였다. 연구결과, 캐릭터 커스터마이징에 노력을 기울일수록 피부전기반응이 높게 나타났고 자기보고식 정서반응도 긍정적인 것으로 나타났다. 다음으로 게임 스토리의 경우, 단순히 스토리를 읽는 것에 따른 피부전기반응 및 자기보고식 정서반응에 대한 영향은 없었다. 하지만 캐릭터 커스터마이징에 노력을 많이 기울인 경우에는 게임스토리를 읽은 참가자가 더 긍정적인 감정을 응답하는 것으로 확인되었다. 마지막으로 게임 구매와 관련한 결과에서는 게임태도, 구매의도는 자기보고식 정서반응이 긍정적일 때 높게 나타났고, 지불의사가격은 피부전기반응이 높을 때 높게 응답하는 것으로 확인되었다. 본 연구는 기존의 게임관련 연구에서 다룬 주제를 특정 게임 장르에 집중하여 적용하였다는 장점을 가지며, 기존 연구와는 다르게 지불의사가 격과 피부전기반응의 관계를 확인했다는 차별점을 가진다. 따라서 본 연구는 게임 스토리, 캐릭터 커스터마이징의 의미와 그 역할에 대한 시사점을 제공한다. 또한 본 연구의 결과는 각 컨텐츠의 소비 심리적 요소를 해석하여 더욱 다양한 적용점을 제시하기 때문에 특정 게임 장르뿐만 아니라 다양한 게임 장르에 활용될 수 있을 것이다. Playing game sets off many emotional responses and people tend to affect by these response. Emotion responses are important in making one to play again. Especially, pleasure and arousal are particular to this matter. Concerning emotional responses, this study has found the effect of game story and character customizing. And how the emotional responses affect game purchasing. Our research shows that the high effort in making game character is relates higher Skin Conductance Response(SCR) and self-reporting emotional response. And game story didn``t have effect on SCR and self-reporting emotional response. But in case of putting in effort to make game character, those who had read the game story reported more positive emotion. In an analysis of game attitude and purchasing intention, when self-reporting emotional response was positive, participants respond positive game attitude and purchasing intention. But willingness to pay(WTP) was reported high if the SCR was high. These results shows that positive emotional response was relates higher game attitude and purchasing. In this study, we tried to find the game content``s effect in specific game genre. In this reason, our results can be apply to real MMORPG game. And this study can be differentiated with other studies because we confirmed the relation betweenWTP and SCR. Our research implies the meaning of the game-story and character customizing and presents how to use these game-contents.

이기종 스마트워치의 라이프로그 수집을 위한 관계형 데이터베이스 모델

권승원(Seungwon Kwon),이석훈(Sukhoon Lee) 한국정보기술학회 2018 한국정보기술학회논문지 Vol.16 No.9

Recently, the market for wearable devices has been growing, and many researches have been worked to collect lifelog using smart watches. However, it is difficult to collect lifelog on each device as various smart watch manufacturers such as Fitbit, Apple, Samsung, and Xiaomi serve on different platforms. Therefore, this paper proposes a system that collects lifelog generated from heterogeneous smart watches and a database model that can manage life logs integrally. The proposed model is based on a relational database and focuses on scalability for heterogeneous smart watches. This paper also builds a life log collector on each smart watch platform and builds a proposal database model. For evaluation, We define two types of database models which store lifelog and evaluate their extensibility. In addition, we show the superiority of the proposed database model by comparing each lifelog collector by smart watches.

자가 처방 감초 다량 복용 후 발생한 저칼륨성 하지마비 1례

권승원(Seung-won Kwon),정환용,윤승규(Seung-kyou Yoon),서유리(Yu-ri Seo),박준영(Joon-Young Park),임진욱(Jin-Wook Im),정우상(Woo-Sang Jung),문상관(Sang-Kwan Moon),조기호(Ki-Ho Cho),김영석(Young-Suk Kim) 대한한의학회 2011 대한한의학회지 Vol.32 No.5