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cellulose nanocrystal 기반 AgNPs의 녹색합성
권성영,이우석,고성혁 한국공업화학회 2020 한국공업화학회 연구논문 초록집 Vol.2020 No.-
cellulose nanocrystal (CNC)을 활용한 silver nanoparticles (AgNPs)의 수열합성을 수행하고 AgNPs의 생성 특성을 조사하였다. CNC-AgNPs 현탁액의 UV-Vis 흡수스펙트럼 분석 결과 400-450 nm 파장 영역에서 국소 표면 플라즈몬 공명에 기인한 강한 흡수 피크가 관찰됨으로써 AgNPs의 성공적 합성을 확인하였다. 또한 생성된 AgNPs의 TEM분석 결과 합성반응에 사용된 질산은의 농도 범위에 따라 AgNP 입자 형태는 10-20 nm의 구형에서 확산-제한 응집현상으로 인한 수지상 구조까지 다양한 형상이 발견되어 AgNPs의 형상 조절이 가능한 합성법임을 확인하였다. 이와 함께 제조된 CNC-AgNP 복합필름의 X선 회절 분석을 통해 AgNPs가 CNC 구조 내 결정상으로 존재함을 검증함으로써 CNC가 은이온(Ag<sup>+</sup>)의 금속은(Ag<sup>0</sup>)으로 녹색합성에 필요한 환원제 역할 뿐만 아니라 AgNPs의 생성과 분산을 위한 친환경 바이오플랫폼으로서 기능함을 알 수 있었다. 본 연구의 CNC-AgNPs 나노복합물질은 차세대 바이오-금속나노 하이브리드 복합소재로서 기능성ㆍ지능형 패키징과 같은 다양한 분야에 응용 가능할 것으로 기대된다.
이가현,권성영,손규열,박승조,이주환,조경오,민정준,최지혜 대한수의학회 2016 Journal of Veterinary Science Vol.17 No.2
This report describes the usefulness of positron emission tomography-computed tomography (PET-CT) for evaluating recurrent or residual tumors following surgery. CT and 18F-fluorodeoxyglucose PET-CT were pre- and post-operatively applied to multiple masses in a dog with hemangiosarcoma. The distinction between the left subcutaneous mass and the peritoneum was clarified on pre-operative CT examination, and malignancy was suspected based on PET-CT. A recurrent or residual tumor in the left subcutaneous region was suspected on post-operative PET-CT, and confirmed through histopathologic examination.
Positron Emission Tomography/Computed tomography를 이용한 개 림프종의 영상 평가
박승조,권성영,민정준,최지혜 한국임상수의학회 2016 한국임상수의학회지 Vol.33 No.1
In this study, the features of canine lymphoma on fluorine-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) were evaluated in three small breed dogs. In case 1, ultrasonography and CT indicated neoplastic involvement of the sternal, right axillary, submandibular, lower cervical, tracheobronchial, mesenteric, and sublumbar lymph nodes; spleen; and liver. However, intense FDG uptake on PET/CT images was detected only for the lymph nodes and spleen. No FDG uptake by the liver was detected for case 1 despite the confirmation of lymphoma by cytology. In case 2, ultrasonography and CT indicated neoplastic involvement of the axillary, mesenteric, and sublumbar lymph nodes and the spleen, while intense FDG uptake on PET/CT images was detected for the axillary and a few mesenteric lymph nodes, and the spleen. FDG uptake was additionally observed from popliteal lymph nodes, however there was no uptake by the sublumbar lymph nodes and some mesenteric lymph nodes. In case 3, neoplastic changes in the splenic, mesenteric, and sublumbar lymph nodes and spleen were suspected on ultrasonography, and lower cervical and popliteal lymph node involvements were additionally detected on PET/ CT. Compared to ultrasonography, repeated PET/CT showed increased FDG uptake by the lymph nodes at an earlier stage after chemotherapy in case 3. This study illustrated the features of PET/CT in canine lymphomas and compared those to ultrasonography and CT findings. FDG uptakes were not detected from some lesions which were suspected to be neoplastic involvement in case 1 and 2. We could not clearly explain the reason of this result in the present study because cytological or histological examination was not performed for lesions that showed different results on ultrasonography, CT, and PET/CT. Further studies on the subclassification of canine lymphoma and the sensitivity and specificity of PET/CT for the detection of canine lymphoma are required. PET/CT data can provide useful information for predicting the therapeutic response at an early stage after treatment.