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韓國型 出血熱自然界動物宿主Apodemus agrarius coreae에서의 virus 增殖 및 抗體形成에 關한 硏究
權富鉉 고려대학교 의과대학 1980 고려대 의대 잡지 Vol.17 No.3
Lee et al. discovered the etiologic agent and animal reservoir host of Korean hemorrhagic fever(KHF) and perfected a serologic test for diagnosis of the disease. Growth of Hantaan virus, etiologic agent of KHF, and antibody response to the virus in the natural reservoir host of KHF, Apodemus agrarius, was investigated by inoculating intramuscularly 1,000 ID_(50) of virus (76/118 strain 8th Apodemus passage) into Apodemus mice. Presence of Hantaan virus in various tissues of Apodemus was examined at certain intervals after inoculation of the virus. Viremia was first demonstrable 7 days after inoculation of the virus and it persisted for a few days. Virus multiplication was demonstrated in lung tissues and parotid glands as well as in liver and kidneys. It was demonstrated that immune complex was coexisted with KHF virus in the lung tissues of Apodemus mice for a long period of time after infecting. The detection of fluorescent antibodies after inoculating the virus into Apodemus mice showed that antibodies began to appear after 2 weeks, reached a maximum titer at 3 weeks and then declined slowly thereafter.