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권동득,이재환,한동엽,서일영,박승철,정희종,양윤식,채수천,나경숙,모금자,김정중,임정식 대한비뇨의학회 2011 Investigative and Clinical Urology Vol.52 No.4
Purpose: The glutathione-S-transferase (GST)P1, GSTM1, and GSTT1 genotypes have been associated with an increased risk of prostate, bladder, and lung cancers. The aim of this study was to investigate the association between the GSTP1, GSTM1, and GSTT1 genotypes and the risk of prostate cancer in Korean men. Materials and Methods: The study group consisted of 166 patients with histologically confirmed prostate cancer. The control group consisted of 327 healthy, cancer-free individuals. The diagnosis of prostate cancer was made by transrectal ultrasound-guided biopsy. Patients with prostatic adenocarcinoma were divided into organ-confined (≤pT2) and non-organ-confined (≥pT3) subgroups. The histological grades were subdivided according to the Gleason score. The GSTP1, GSTM1, and GSTT1 genotypes were determined by using polymerase chain reaction-based methods. The relationship among GSTP1, GSTM1, and GSTT1 polymorphisms and prostate cancer in a case-control study was investigated. Results: The frequency of the GSTM1 null genotype in the prostate cancer group (54.2%) was higher than in the control group (odds ratio=1.53, 95% confidence interval=1.20- 1.96). The comparison of the GSTP1, GSTM1, and GSTT1 genotypes and cancer prognostic factors, such as staging and grading, showed no statistical significance. Conclusions: An increased risk for prostate cancer may be associated with the GSTM1 null genotype in Korean men, but no association was found with the GSTT1 or GSTP1 genotypes.
Impact of Overactive Bladder on Sexual Function in Women: A Prospective Comparison Study
권동득,김선옥,김준석 대한배뇨장애요실금학회 2009 International Neurourology Journal Vol.13 No.2
Purpose: Several reports have showed that female lower urinary tract symptoms affect health related quality of life and sexual function. However, there is lack of data proving the overactive bladder (OAB) on sexual function. We evaluated the impact of OAB on sexual function. Materials and Methods: We included 82 women from 18 to 65 years old with overactive bladder symptoms including urinary frequency and urgency. A control group was recruited at the Health Care Center for health medical examination of our hospital. All patients were asked to complete the Koran version of Female Sexual Function Index (FSFI) to assess sexual function. Results: The Mean age was 47.37±8.73 and 49.90±5.36 in OAB and Control group. Each of the dimension scores in FSFI represents worse sexual function in patients with OAB than the control group. The total scores of the FSFI were significantly decreased in the OAB group 20.10±4.10 than 24.64±3.91 (p<0.05). Among the six subdomains of FSFI, four domains of desire (4.92±1.59 vs 6.80±2.19), arousal (9.87±2.87 vs 11.50±2.44), orgasm (7.22±2.09 vs 9.52±2.96), satisfaction (6.95±2.09 vs 8.45±2.28) scores were significantly decreased in the OAB group (P<0.05) than control group. But, there was no statistically significant differences in domain of lubrication (11.12±2.80 vs 11.72±2.56) and pain (6.85±1.91vs 6.92±1.92) between the OAB group and control group. Conclusion: In this study, OAB syndrome was found to cause greater deterioration in sexual function. These results suggest that OAB symptoms have a significant impact on women’s sexual function.