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Background: Pityrosporum yeast is a resident microflora of the normal skin and abundant in seborrheic dermatitis. In pathologic conditions, pityrosporum yeast is converted into hyphal form. Previous studies showed that this hyphal form could be found on clinically normal skin too. Objectives : We compared the incidence of Pityrosporum infection of the external ear canal in normal controls with that in patients with seborrheic dermatitis. Methods : Seborrheic dermatitis, 258 subjects and normal person, 362 subjects were studied. Ear wax specimens were stained with 20% Parker ink-KOH(P-KOH) solution. The number of pityrosporal hyphae were graded according to hyphal index(1+ to 3+). Results : The incidence of Pityrosporum infection of the external ear canal is 28.7% in patients with seborrheic dermatitis and 24.6% in normal controls, Amounts of pityrosporal hyphae are similar between two groups too. According to age group, incidence of PV of the external ear canal in patients with seborrheic dermatitis is statistically significantly higher than in normal controls. Female with seborrheic dermatitis have more Pityrosporum infection of the external ear canal than normal female controls. Pityrosporum infection of the external ear canal in patients with seborrheic dermatitis is prevalent in summer and spring in contrast to normal controls who have high incidence in spring. Among patients with Pityrosporum infection of the external ear canal, asymtomatic cases amount up to 70%. Conclusion : The results of this study showed that the incidence of Pityrosporum infection of the external ear canal in patients with seborrheic dermatitis and normal person is similar, but according to the age, sex and season, there were some differences between two groups. (Kor J Dermatol 1996;34(4): 515-520)
Background: Onychomycosis is common nail problem and requires administration of antifungal agent for long period. But several cutaneous diseases can produce similar nail changes and an inexpensive, quick and sensitive test is essential for screening nail specimens. Recently, there have been several reports of new method for diagnosing onychomycosis and Fungi-Fluor?? stain, which had been used to detect fungal elements in the tissue, was not used for diagnosing onychomycosis. Objective: This study was undertaken to evaluate the usefulness of the new method using Fungi-Fluor?? solution for the diagnosis of onychomycosis, and compare with other methods. Methods: During the study period, nail samples obtained from 72 patients with onychomycosis were tested for Fungi-Fluor?? solution and the results of that were compared with those of KOH smear, fungal colure and KONCPA test. Results: The results of this study are summarized as follows: 1. The positive rates of conventional KOH nail scraping preparation, fungal culture, KONCPA and Fungi-Fluor?? staining were 47.2%, 40.3%, 77.8%, and 86.1%, respectively. 2. Fungi-Fluor?? staining proved to be less time-consuming than KONCPA test. 3. Compared to KONCPA and Fungi-Fluor?? staining, KOH preparation and fungal culture showed high false positive rate. 4. Though both KONCPA and Fungi-Fluor?? staining showed higher positive rate in toenail than fingemail, there were no statistic significance. Conclusion: The Fungi-Fluor?? solution staining is rapid, inexpensive, and highly sensitive method to detect fungal elements in the nails.
The clinical investigation was performed regarding cutaneous manifestations in 495 patients with thyroid disorders who had visited Pusan National University Hospital from January, 1979 to April, 1984. The results of this study were as follows: I. Of the 495 patients with thyroid disorders, 417 patients(84. 2%) showed various cutaneous manifestations. Among the cutaneous manifestations presented in the 176 patients with hyperthyroidism, hyperhidrosis was the most common(24. 2%), followed by pruritus (42. O%), chronic urticaria(29, 5%), bronze appearance(21. 6%), sparsity of hair (20. 5%), soft and friable nail(17. 6%). 3. Among the cutaneous manifestations presented in the 57 patients with hypothyroidism, pruritus was the most common(26. 3%), followed by sparsity of hair (21. 1%,), chronic urticaria(19. 3%), soft and friable nail(14. 0%). 4. In patients with Graves disease, cutaneous manifestations were more frequently observed than those of other thyroid disorders. 5, Autoimmune thyroid disorders such as Graves' di ease and Hashimotos thyroiditis were rarely associated with vitiligo(only 2 cases) and alopecia areata(only 1 case).