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Plant Nanobionics: Engineering plants using Nanotechnology
곽선영 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.1
My talk will introduce a new research area ‘Plant Nanobionics’ to create the interface between living plants or plant organelles and functional nanomaterials. We found that nanoparticles have a unique ability to cross the plant cell membrane and even the double lipid bilayers of chloroplasts. This work led us to develop a mathematical model capable of guiding the rational design of nanoparticles for targeted delivery into specific compartments without the use of chemical or mechanical aid, which was well correlated with experimental results. By introducing rationally designed functional nanomaterials, we engineered wild-type plants to serve as self-powered photonic devices or environmental sensors. These research efforts showed that Plant nanobionics can be a starting platform of new technology using plants existed abundantly in nature.
복수저자기반 동시인용분석을 활용한 지적구조 분석: 경제학 분야를 중심으로
곽선영,정은경 한국정보관리학회 2012 정보관리학회지 Vol.29 No.1
The author co-citation analysis is generally based on the frequency of the first author because most citation databases include only the first author in the bibliographic information. In this sense, the purpose of this study is to provide a better knowledge structure by utilizing the multiple authorship of author co-citation analysis. To achieve the purpose of this study, four different data sets are prepared: (1) counting the first author, (2) counting all the author without limiting the total frequency, (3) counting all the author with limiting the total frequency, and (4) counting adjusted frequencies based on the order of author subscription. The findings of this study show that there are clear differences between the knowledge structure counting all the author and the one counting only the first author. In addition, depending on the different methods, there are subtle changes of cluster members for authors. 전통적인 저자동시인용분석은 인용색인 데이터베이스가 색인하는 제 1저자만을 대상으로 하기 때문에 제1저자 이외의 저자의 기여도가 제외된다는 한계를 지니고 있다. 본 연구의 목적은 경제학 분야를 대상으로 하여 복수저자기반의 저자동시인용분석을 활용하여 해당 학문분야의 지적구조를 제시하고자 한다. 이를 위하여 네 가지 실험집단을 구성하였다. (1) 인용된 문헌의 제 1저자만을 고려한 저자동시인용분석, (2) 문헌당 총합 제한 없이 복수저자에게 동일한 인용빈도 부여한 저자동시인용분석, (3) 문헌당 총 합을 제한하여 인용빈도를 부여한 저자동시인용분석, (4) 저자기입 순서를 고려하여 인용빈도를 부여한 저자동시인용분석. 본 연구의 결과는 크게 제 1저자만 고려한 방식과 복수저자를 모두 고려한 방식에 따라 군집형성에 있어서 차이를 보였다. 또한 복수저자의 인용빈도를 구하는 방식에 따라서 군집의 소속이 달라지는 변화를 찾아볼 수 있다. 이러한 결과는 공동저작이 증가하는 학문적 추세에 비추어서 학문의 지적구조를 밝히기 위해서는 복수저자가 고려된 저자동시인용분석이 중요하다는 점을 시사한다.
관상 동맥 질환에서 아포 E 지단백 유전자 다형성과 혈청 지질치와의 관계
곽선영,김성구,정호석,이유경,이광희,김철현,최태명,현민수,권영주 순천향의학연구소;Soonchunhyang Medical Research Institute 2000 Journal of Soonchunhyang Medical Science Vol.6 No.1
Background and aims: The Apolipoprotein E is a ligand of both the protein component LDL receptor as well as the apo E LDL-Receptor related protein (LRP). It modulates the receptor binding of lipoproteins, with the apolipoprotein E found on cell surfaces as its component, thus serving an important role in the lipid metabolism by carrying out the intracellular transport of cholesterol in lipoproteins. The gene for apolipoprotein E is the product of three common genotypes as well as many more rare alleles. The common genotypes are ε2, ε3, and ε4, and are expressed in the three phenotype isoforms of E2, E3, and E4. In the event that E4 is the main component, a rise in the cholesterol level, as the result of down-regulation of the LDL receptor, is observed. Therefore, those samples with E4 genotypes are known to be in much higher risk of coronary artery disease than those with ε3/ε3, while those with ε2 are in low risk (with the exception of hypertiglyceremai Ⅲ). The aim of this study is to analyze in patients with ischemic heart disease the role of aplipoprotein E alleles in order to seek its correlation with coronary artery disease, as well as to seek whether the polymorphism of apo E produces any differences in the severity of coronary artery disease according to plasma lipid levels. Methods: The subjects for study were 273 patients admitted to the Internal Cardiology Division of the Soonchunhyang University Hospital form December 1998 to February 1999. The subjects were divided into the two groups of which one was ischemic heart disease (IHD) experiment group totaling 105 (avg.60.1 years of age, male/female ratio = 69/36) and the control group totaling 168 (avg. 59.7 years of age, male/female = 73:95). The coronary angiogram was given to 127 subjects, and of this total, 94 have developed significant stenosis in the coronary artery. The stages of the analyzing of the apo E phenotype was first, the separation of DNA from the blood samples, subjecting it to the PCR from with 228 base pairs of expanded products were obtained. The band was determined by means of the reverse hybridization principle on the nitrocellulose strip. Results: From the 105 patients the distributions of apo E phenotypes were as follows: ε3/2(5.7%), ε4/2(1.9%), ε3/3(70%), ε4/3(20%), ε4/4(1.9%). The relative frequencies of each allele are as follow: ε2 (0.038), ε3 (0.833), ε4 (0.128). The results show as follows: ⅰ) The IHD experiment group to have a higher occurrence of ε4/3 phenotypes as well as ε4 alleles than the control group. ⅱ) Both the control group and IHD group showed the largest distribution of ε3/3 for phenotypes, and ε4 for alleles. ⅲ) The IHD group showed less ε2/3 phenotypes as well as significantly less allele frequency of ε3 in comparison to the control group. ⅳ) the IHD group showed a much lower level of HDL in comparison to the control group, while the LDL was significantly higher; samples including the apo ε2 showed a significantly higher level of HDL than those without. Among the control group, samples including apo ε2 showed a significantly higher level of TG (triglyceride) than samples without. No significant difference was found between the experiment apo ε4 sample and the control plasma lipid sample. ⅴ) No significant correlation was found between an apo E polynorphism and the number of involved arteries of a coronary angiogram. Conclusion: Between the experiment IHD group and control group were found differences in the frequency of alleles. The polymorphism of apo E alleles may contribute as a risk factor to the development of heart disease by involving itself in the metabolism and modulation of plasma lipids.