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장액망막박리가 동반된 레버 특발성 성상 신경망막염에서 안내 베바시주맙 주사 효과 1예
이동현,고형준,김성수,이성철,김민,Dong Hyun Lee,Hyoung Jun Koh,Sung Soo Kim,Sung Chul Lee,Min Kim 대한안과학회 2014 대한안과학회지 Vol.55 No.10
Purpose: To report the effectiveness of intravitreal bevacizumab treatment for serous retinal detachment associated with Leber’s idiopathic stellate neuroretinitis. Case summary: A 56-year-old male visited our clinic complaining of visual disturbance for three days in his right eye. His best corrected visual acuity was 0.5. Relative afferent pupillary defect and pain when moving eyes were noted in his right eye as well as inflammatory cells in the vitreous cavity. On funduscopic examination, disc swelling with hemorrhage and stellate-shaped hard exudates were noted at the perifovea. Ishihara color vision test showed anomalous trichromacy in his right eye. Hyperfluorescence around the disc was observed on fundus fluorescein angiography. Optical coherence tomography showed disc swelling with serous retinal detachment at the fovea. Inferior altitudinal scotoma was noted on visual field examination. The patient underwent intravitreal bevacizumab injection and topical steroid medication. After six days, the patient’s symptoms and disc swelling improved, and decreased subretinal fluid was observed. After six weeks, his best corrected visual acuity was 1.0. Nine weeks later, visual field examination showed nonspecific scotoma. Conclusions: Intravitreal bevacizumab injection is useful for treating serous retinal detachment associated with Leber’s idiopathic stellate neuroretinitis. J Korean Ophthalmol Soc 2014;55(10):1562-1566
병적 근시와 동반된 맥락막 신생혈관에서 광역학 치료의 임상 적용
정은지,오현섭,고형준,이성철,권오웅.Eun-Jee Chung. M.D.. Hyun-Sub Oh. M.D.. Hyoung-Jun Koh. M.D.. Sung-Chul Lee. M.D.. Oh-Woong Kwon. M.D. 대한안과학회 2005 대한안과학회지 Vol.46 No.4
Purpose: To evaluate the effects of photodynamic therapy with verteporfin on visual acuity and fluorescein angiography in choroidal neovascularization (CNV) associated with pathologic myopia and to determine if this treatment could reproduce the results achieved in the Verteporfin in Photodynamic Therapy (VIP) Trial in Korean patients. Methods: Forty-two eyes of 39 patients with CNV secondary to pathologic myopia were included. A retrospective review of their clinical records and fluorescein angiography was done. The patients underwent photodynamic therapy with verteporfin and were followed up for more than 6 months after the therapy. The change in best corrected visual acuity (BCVA) and leakage in fluorescein angiography were evaluated. Results: The mean age of the patients was 39.6 and mean follow-up period was 23.5 months. The BCVA of the patients improved in 22 (52.4%) eyes, was unchanged in 13 (30.9%), and worsened in 7 (16.7%). The leakage in fluorescein angiography decreased in 25 (59.5%) eyes. Conclusions: Photodynamic therapy with verteporfin for myopic CNV in Korean patients appeared to be effective in stabilization of the lesions and improvement of visual acuity.
배정훈,송원경,고형준,권오웅,이성철,Jeong Hun Bae,M,D,Won Kyung Song,M,D,Hyoung Jun Koh,M,D,Oh Woong Kwon,M,D,Sung Chul Lee,M,D 대한안과학회 2008 대한안과학회지 Vol.49 No.8
Purpose: To investigate the epidemiologic and clinical features of uveal melanomas in Korean patients. Methods: The medical records of 35 patients (35 eyes) with the diagnosis of uveal melanoma between September 2004 and December 2006 were reviewed retrospectively. Results: Of the 35 patients, 22 were males (62.9%) and 13 were females (37.1%), with a mean age at diagnosis of 48.2±14.1 years (range, 24-82 years). Decreased visual acuity was the most common symptom in 23 patients (65.7%), while 6 patients (17.1%) were detected without prior symptoms. The shape of the uveal melanoma was dome-shaped in 27 eyes (77.1%) and mushroom-shaped in 8 eyes (22.9%). The mean largest basal diameter of the tumors was 9.0±3.3 mm (2.4-19.0 mm), and the mean apical height was 6.2±2.6 mm (1.1-13.0 mm). The tumors were classified according to their size; a small melanoma was found in 4 eyes (11.4%), a medium melanoma in 29 eyes (82.9%), and a large melanoma in 2 eyes (5.7%). Conclusions: Uveal melanomas manifest earlier in Korean patients than in Caucasian patients. At the time of diagnosis, 33 eyes (94.3%) had small or medium melanomas that could be treated. J Korean Ophthalmol Soc 49(8):1289-1296, 2008
흰쥐를 이용한 실험적 맥락막신생혈관 모델에서 유리체강내 양막 주입의 효과
이종현,정재림,홍사민,고형준,Jong Hyun Lee,Jae Lim Chung,Samin Hong,Hyoung Jun Koh 대한안과학회 2008 대한안과학회지 Vol.49 No.7
Purpose: To evaluate the effects of an intravitreal amniotic membrane (AM) injection on a rat model of laser-induced choroidal neovascularization (CNV). Methods: Intravitreal injection of AM (12.5 µg/mL) into the left eyes and phosphate-buffered saline into the fellow eyes of 15 rats was performed immediately after laser injury. At week 2, after angiography, the rats were sacrificed, and histopathologic analysis was performed. Angiographic and histopathologic assessments of the effects of AM injection on CNV growth were compared between the two groups. Results: CNV thickness was found to have increased more in the AM treatment group (141.54±8.12 µm) than in the experimental control group (65.23±16.90 µm) (p=0.010). Conclusions: Intravitreal AM injection demonstrated histopathologic pro-angiogenic properties in a rat model of CNV. J Korean Ophthalmol Soc 49(7):1154-1158, 2008