A clinical study of cervical pregnancy in CUMC

고현선 ( Hyun Sun Ko ),( In Yang Park ),( Hyun Young Ahn ),( Hee Joong Lee ),( Young Lee ),( Yoon Sung Jo ),( Soo Pyung Kim ),( Jong Chul Shin ) 대한산부인과학회 2004 대한산부인과학회 학술대회 Vol.90 No.-

태아에서 발생한 양성 낭성 복막 중피종 ( Benign cystic peritoneal mesothelioma ) 1 예

고현선(Hyun Sun Ko),강대호(Dae Ho Kang),이지현(Jee Hyun Lee),문희봉(Hee Bong Moon),노승혜(Seung Hye Rho),백은정(Eun Jung Baik),정대영(Dae Young Chung),신종철(Jong Chul Shin),김수평(Soo Pyg Kim) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.10

It is stated in many reports that the most frequent cause among abdominal masses in fetus and neonates is congenital renal lesion including hydronephrosis and multicystic kidneys. Other causes are masses originated from gastrointestinal tract, retroperitoneum, or female genital tract. Which almost are benign but about 2% of cases have malignant course. Benign cytic peritoneal mesotheliomas are tumors of peritoneum characterized by thin-walled cyst lined by benign mesothelial cells. Despite the marked tendency to occur, no malignant degeneration or metastasis was reported. It occurs predominantly in females of reproductive age and is rare in male. We experienced a case of male fetus with a huge abdominal mass and severe secondary hydronephrosis which result to be a benign cytic peritoneal mesothelioma, a rare entity in male fetus and rarer in fetal period

Biocontrol of Phytophthora Blight (Phytophthora capsici) in Pepper by Lysobacter antibioticus HS124

Hyun-Sun Ko(고현선),Rong-De Jin(김영덕),Seong-Jun Kang(강성준),Kil-Yong Kim(김길용) 한국토양비료학회 2009 한국토양비료학회 학술발표회 초록집 Vol.2009 No.5

임신 중기에 발생한 림프구성 뇌하수체염

고현선 ( Hyun Sun Ko ),이희중 ( Hee Joong Lee ),이근호 ( Keun Ho Lee ),장은덕 ( Eun Deok Chang ),강석구 ( Seok Gu Kang ),신종철 ( Jong Chul Shin ),박태철 ( Tai Churl Park ) 대한주산의학회 2005 Perinatology Vol.16 No.4

Lymphocytic hypophysitis, a rare inflammatory disorder in the pituitary gland that is often associated with pregnancy, is caused by autoimmune destruction of the pituitary gland evidenced by diffuse lymphocytic infiltration in the pituitary gland. We report a case of lymphocytic hypophysitis in a 38-year-old woman presenting with aggravating headache and sudden visual loss during pregnancy, which was misdiagnosed as pituitary adenoma before neurosurgery. Magnetic resonance imaging, with enhancement, showed an expanding 2.5×2.0×1.7 cm sized sellar mass. The patient underwent transsphenoidal surgery with a preoperative diagnosis of pituitary macroadenoma. A histological examination revealed diffuse lymphocytes and fibrosis of adenohypophysis with atrophy, which are characteristic of lymphocytic hypophysitis. We report a case of lymphocytic hypophysitis occurred during pregnancy with a brief review of literatures.

최신임상강좌 : 갑상샘기능항진증을 동반한 임신의 주산기 예후

고현선 ( Hyun Sun Ko ),장동규 ( Dong Gyu Jang ),신재은 ( Jae Eun Shin ),김연희 ( Yeon Hee Kim ),박인양 ( In Yang Park ),신종철 ( Jong Chul Shin ) 대한산부인과학회 2010 Obstetrics & Gynecology Science Vol.53 No.9

목적: 갑상샘기능항진증을 동반한 임신 및 신생아의 주산기 예후를 알아보고, 임신 기간 동안의 항갑상샘호르몬 투약 여부 및 갑상샘기능 유지 여부가 이에 미치는 영향을 평가하기 위해 본 연구를 시행하였다. 연구 방법: 2000년 1월 1일부터 2010년 03월 31일까지 갑상샘기능항진증으로 진단받은 산모들 중 가톨릭대학교 부속병원에서 분만한 163예의 임신을 대상으로 산과, 내과 및 신생아의 병력기록지를 후향적으로 조사하였다. 결과: 갑상샘기능항진증을 동반한 163예의 임신 중 103예가 항갑상샘호르몬 치료를 받았으며, 109예가 임신 중 정상갑상샘기능을 유지하였다. 약제군과 비약제군에서 산모의 합병증 발생은 유의한 차이가 없었으나, 신생아의 갑상샘기능 검사 시 비정상소견은 약제군에서 높게 나타났다 (58% vs 24.5%, P<0.0001). 임신 중 갑상샘기능비정상군은 정상군에 비하여 임신 입원을 요하는 임신오조의 빈도와 신생아의 비정상갑상샘기능의 빈도가 더 높게 나타났다 (21.7% vs 4.6%, P=0.0146; 66.7% vs 39.4%, P=0.0223). 결론: 갑상샘기능항진증 산모에서 임신 중 갑상샘기능이 정상으로 유지되지 않거나, 항갑상샘호르몬 치료를 받는 경우에는 신생아의 갑상샘기능에 영향을 줄 수 있으므로, 임신 중 태아의 갑상샘기능이상을 조기에 발견하여 치료하기 위한 적극적 모니터링이 필요할 수 있다. Objective: To evaluate the maternal and neonatal outcomes of pregnancies complicated with hyperthyroidism, according to the maternal treatment and thyroid function status during pregnancy. Methods: This retrospective study was conducted on women complicated by hyperthyroidism who delivered between January 2000 and March 2010, at Catholic University Medical Center. The baseline characteristics as well as maternal and fetal outcomes were analyzed and compared according to maternal antithyroid medication and thyroid function status. Results: Among 163 pregnant women complicated with hyperthyroidism, 103 women received antithyroid medication and 109 women showed euthyroid status during pregnancy. The mean gestational age and fetal birth weight at delivery were 38.2±2.9 weeks and 2.99±0.64 kg. There was no statistical difference in maternal complications between the medication group (n=103) and the non-medication group (n=59), while neonatal thyroid dysfunction including transient hypothyroidism was significantly higher in the medication group than the non-medication group (58% vs 24.5%, P<0.0001). The incidence of admission due to hyperemesis and neonatal thyroid dysfunction were significantly higher in the thyroid dysfunction group than the euthyroid group (21.7% vs 4.6%, P=0.0146; 66.7% vs 39.4%, P=0.0223, respectively). Conclusion: Maternal antithyroid medication as well as thyroid dysfunction during pregnancy could indicate the careful fetal thyroid monitoring to prevent neonatal thyroid dysfunction.

태아치료의 현재와 향후 전망

고현선 ( Hyun Sun Ko ),신종철 ( Jong Chul Shin ) 대한주산의학회 2011 Perinatology Vol.22 No.2

Advances in prenatal diagnosis have led to the prenatal management of a variety of congenital diseases. Fetal surgery was born of clinical necessity. Observations by pediatric surgeons and neonatologists of neonates that were born with irreversible organ damage led to the conclusion that one possible approach to prevent this alteration of developmental physiology, was fetal surgical intervention. The demonstration in animal models that the correction of an anatomical defect could reverse the associated pathophysiology led to the first systematic application of fetal surgery at the University of California, San Francisco, in the early 1980s . There has been a dramatic improvement in our ability to diagnose, select and safely operate on an expanding number of fetal anomalies. Many fetal interventions remain investigational but for a number of conditions randomized trials have established the role of in utero surgery, making fetal surgery a clinical reality in a number of fetal therapy programs. Although prenatal stem cell and gene therapy await clinical application, they offer tremendous potential for the treatment of many genetic disorders. Here we review the prenatal evaluation, current status and future potential of various prenatal operative approaches, such as open hysterotomy, fetoscopy, and percutaneous, including tissue engineering, and prenatal cellular and genetic therapy.

선천성 질환 태아를 가진 예비부모에 대한 원스톱 통합상담의 의의

고현선 ( Hyun Sun Ko ),위지선 ( Ji Sun We ),김연희 ( Yeon Hee Kim ),박인양 ( In Yang Park ),이영 ( Young Lee ),이귀세라 ( Gui Se Ra Lee ),신종철 ( Jong Chul Shin ) 대한산부인과학회 2010 Obstetrics & Gynecology Science Vol.53 No.8

목적: 이 연구는 임신 중 진단된 태아의 선천성 질환에 대한 부모의 불안도 및 이에 대한 원스톱 통합상담진료의 역할 및 만족도를 알아보고자 계획되었다. 연구 방법: 이 연구는 2009년 5월부터 2010년 3월까지 가톨릭 선천성질환센터에서 통합상담진료를 받은 예비부모 32쌍을 대상으로 하였다. 연구에 동의한 예비부모에게 상태-특성 불안척도 (State-Trait Anxiety Inventory, STAI)를 이용하여 통합상담진료 전후의 불안도를 측정하였고, 만족도 설문을 실시하였다. 결과: 통합상담진료의 평균 시간은 58.0±36.9분이었고, 참여한 전문 의료진의 수는 평균 3.5±1.1명이었다. 대상질환은 심혈관계(36.1%)와 비뇨생식기계 (25.0%) 질환이 가장 많았다. STAI로 측정한 예비부모의 불안도는 통합상담진료 전에 비하여 시행 후 유의하게 감소하였다 (43.5±5.9 vs 36.9±6.0, P=0.0007). 이 중 산모가 미산모이거나 (P=0.0005), 35세 미만이거나 (P=0.0014), 종교를 가지고 있거나 (P=0.0014), 통합상담진료 시간이 40분 이상인 경우 (P=0.0027), 통합상담진료 이후 불안도가 유의하게 감소하였다. 만족도 설문에서 나타난 평균만족도는 85.6%였다. 결론: 임신 중 진단된 태아의 선천성 질환 시 통합상담진료는 예비부모의 불안도에 긍정적 영향을 주었으며, 전반적으로 높은 만족도를 나타내었다. 태아 질환의 특성을 고려할 때, 향후 환자 중심의 진료체계 확립과 지원을 위해 더욱 많은 연구와 사회적 노력이 필요할 것으로 생각된다. Objective: This exploratory study was undertaken to analyze the anxiety of parents of prenatally diagnosed fetal congenital disease and satisfaction after the multidisciplinary counseling. Methods: The study included 32 prospective parents of antenatally diagnosed congenital disease fetus who received multidisciplinary counseling at The Catholic Congenital Disease Center (CCDC) for the period from May, 2009 through March, 2010. The Korean version of the Spielberger State-Trait Anxiety Inventory (STAI) was utilized to assess parental anxiety. Categories of satisfaction survey were classified into accessibility, professionalism, empathy, recoverability, satisfaction, and expectation after counseling. Results: The mean time and number of medical professionals for each counseling were 58.0±36.9 min and 3.5±1.1 persons. Most common congenital diseases were cardiovascular (36.1%) and urogenital diseases (25.0%). STAI scores were significantly decreased after than before counseling (43.5±5.9 vs 36.9±6.0, P=0.0007). STAI scores after counseling showed significant decrease in prospective mothers who were nulliparous (P=0.0005), less than 35 years old (P=0.0014), had religion (P=0.0014) and counseled more than 40 minutes (P=0.0027). The mean rate of positive satisfactory response about multidisciplinary counseling was 85.6% in satisfaction survey. Conclusion: This study provides evidence of the positive impact on the prospective parental anxiety of a multidisciplinary counseling in prenatal management of fetal congenital diseases.

공유 디스크 기반의 다중 서버 DBMS를 위한 효율적인 버퍼 일관성 관리

고현선(Hyun-Sun Ko),김이른(Yi-Reun Kim),이민재(Min-Jae Lee),황규영(Kyu-Young Whang) 한국정보과학회 2009 정보과학회논문지 : 데이타베이스 Vol.36 No.5

In a multiple-server DBMS using the share-disk model, when a server process updates data, the updated ones are not immediately reflected to the buffers of the other server processes. Thus, the other server processes may read invalid data. In this paper, we propose a novel method to solve this problem. In this method the server process stores the identifiers and timestamps of the pages that have been updated during a transaction into the coherency volume when the transaction commits. Then, the server process invalidates its buffers of the pages updated by the other server processes by accessing the coherency volume when the lock is acquired, and, subsequently, read the up-to-date versions of the pages from disk. This method needs only a very small coherency volume and shows a good performance because the amount of data that need to be accessed is very small. 공유디스크 모델을 사용하는 다중 서버 DBMS에서는 서버 프로세스들이 서로 독립된 메모리를 가지므로, 특정 서버 프로세스가 데이터베이스를 수정하더라도 다른 서버 프로세스들의 버퍼에는 수정된 내용이 반영되지 않는다. 따라서, 다른 서버 프로세스들이 수정되기 전 내용에 대하여 데이터 처리 요청을 수행하면 문제가 발생한다. 본 논문에서는 큰 단위의 로크(여기서는 볼륨 로크)를 사용하는 DBMS에서 이러한 문제를 해결하기 위한 새로운 방법을 제안한다. 이 방법에서는 서버 프로세스가 트랜잭션을 커밋할 때 수정한 페이지의 식별자와 타임스탬프를 일관성 볼륨에 저장하고, 이 정보를 통하여 다른 서버 프로세스가 로크를 획득하는 시점에 일관성 볼륨에서 다른 프로세스가 먼저 수정하였는지 여부를 확인하여 해당 페이지를 버퍼에서 무효화시켜 디스크에서 최신의 버전을 새로 읽어 들인다. 이 방법은 매우 작은 크기의 일관성 볼륨만을 사용하고, 액세스하는 데이터의 양이 적어서 성능이 매우 빠르다.

인유두종 바이러스가 양성인 자궁경부 병변치료에서 녹차추출물 (Polyhpenon E, EGCG)의 효과

고현선 ( Hyun Sun Ko ),허승원 ( Seung Won Huh ),배수미 ( Su Mi Bae ),손승애 ( Seung Ae Son ),정재은 ( Jae Eun Chung ),진동근 ( Dong Kun Jin ),이인수 ( In Su Lee ),신정임 ( Jeong Im Sin ),이준모 ( Joon Mo Lee ),남궁성은 ( Sung Eun N 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.2

목적 : 인유두종 바이러스가 양성인 자궁경부 이형증 환자에 있어서 녹차 추출물 (Poly E, EGCG)을 국소 및 경구투여한 후 임상경과를 보고자 하였다. 연구 방법 : 자궁경부의 병변을 가지고 있는 환자 (chronic cervicitis, mild dysplasia, moderate dysplasia, severe dysplasia)를 4군으로 나누어 Poly E 연고를 주 2회, 27명, Poly E 연고 주 2회와 Poly E capsule 2 Objective : We tried to confirm the effects of green tea extracts (polyphenon E, EGCG) in patients with human papilloma virus (HPV) positive cervical lesion. Methods : We divided 51 HPV positive cervical lesion patients (chronic cervicitis, mild dysplasia

가족성 Silver-Russell 증후군

고현선 ( Hyun Sun Ko ),김연희 ( Youn Hee Kim ),안현영 ( Hyun Young Ahn ),박인양 ( In Yang Park ),이영 ( Young Lee ),김사진 ( Sa Jin Kim ),신종철 ( Jong Chul Shin ),김수평 ( Soo Pyung Kim ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.10

The Silver-Russell syndrome (SRS) is characterized by severe asymmetric intrauterine growth restriction, with a preserved head circumference, leading to a lean body habitus and short stature. Facial dysmorphism and asymmetry are considered typical feature