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고정민 한국피부과학연구원 2013 대한피부미용학회지 Vol.11 No.4
Women’s endless anxiety that pursues beauty leads the nail industry to be improved and life-quality of women to be raised, which expands to influence on the nail skill. As the result, the nail skill becomes an external expression and then becomes a management or correction for nails, as well as becomes an psychological treatment so that the nail industry is being improved rapidly. With the rapid growth of the nail industry, the nail skill can be had a deep relationship with women’s daily life and can be catched on with trend, which helps lead women to realize importance and necessity of the nail skill. It is the time that requires for women to learn rightly the nail skill that allows them to represent effectively. This research is so studied as to help your comprehending of the nail skill through constructing relative theory with general classification, and as to contribute to setting identification of the skill. Performing infinite endeavor to acquire well-trained skill needs to be done, because the nail skill will apply into an organ of the human body and breath a new life into the fingertips and tiptoes. To please women’s demand that becomes complicated, it must be performed to dedicate to development in the nail industry and acquirement of faithful skills in a such way that adds expert knowledge and information into the nail skill. It is tried to approach to the nail skills with academic perspective. Giving quality improvement for the nail skill and theoretical data for further studies are the intention of this approach.
골다공증 동물 모델에서 알파 리포산이 골 대사에 미치는 작용
고정민,이희숙,김덕재,김기수 대한내분비학회 2005 Endocrinology and metabolism Vol.20 No.5
Background: Growing evidence has shown a biochemical link between increased oxidative stress and reduced bone density. In our previous study, α-lipoic acid (α-LA), a thiol antioxidant, suppressed both osteoclastogenesis and bone resorption, and also prevented TNF-α-induced apoptosis of osteoblast lineages. The effects of α-LA were investigated on bone metabolism in rats with a low bone mass. Methods: An ovariectomy (OVX) or Talc injection (inflammation-mediated osteopenia, IMO) was performed in 12 week old female Sprague-Dawley rats. Diets containing either 0.3%, 0.5% or 1.0% α-LA were administered to the OVX rats for 16 weeks, and to the IMO rats for 21 days. The bone mineral densities (BMD) of the anterior-posterior lumbar spine and total femur were measured using dual-energy X-ray absorptiometry (Hologic QDR 4500-A), with small animal software. The plasma bone specific alkaline phosphatase activity (BSAP) and urinary free deoxypyridinoline concentration (DPD) were determined using enzyme immunoassay methods. Results: The body weights were significantly decreased in the OVX rats on the diets containing 0.3 and 0.5% α-LA than in the OVX control. No significant differences in the BMD at either site were noted between rats administered the diets with or without α-LA. However, the administration of various doses of α-LA noticeably decreased the level of urinary DPD in both the OVX and IMO rats. High doses of α-LA (0.5% and/or 1.0%) also decreased the levels of plasma BSAP in both models. Conclusion: Although no increase in BMD was demonstrated by the administration of α-LA, these results suggest that α-LA suppresses the rates of bone turnover in rats with a low bone mass 연구배경: 최근 산화 스트레스가 골 대사에 나쁜 작용을 일으킨다고 알려지고 있다. 저자들은 항산화제인 알파 리포산이 파골세포의 형성 및 골 흡수를 떨어뜨리고 TNF-α에 의한 조골 계열세포의 세포자멸사를 억제함을 관찰하여 이를 보고한 바 있다. 저자들은 알파 리포산이 생체에서도 이와 같은 작용을 가지고 있는지 보고자 본 실험을 기획하였다. 방법: 암컷 Sprague-Dawley 백서를 12주령에 난소 절제와 Talc 주입(inflammation-mediated osteopenia, IMO)을 하여 골다공증 동물 모델을 만들었다. 표준 식이에 0.3%와 0.5%의 알파 리포산을 섞어 난소 절제 백서에 16주간, 0.3%~1.0%의 알파 리포산을 IMO 백서에 21일간 투여하였다. 투여 종료 후 이중 에너지 흡수 계측기를 이용하여 요추와 대퇴부의 골밀도를 측정하였고, 효소 면역분석법으로 혈장과 소변에서 골특이 알칼리성 인산화 효소 활성도(BSAP)와 유리 데옥시피리디놀린 농도(DPD)를 측정하였다. 결과: 난소 절제 백서에 0.3%와 0.5% 알파 리포산을 투여한 경우 난소 절제 대조군에 비해 체중이 유의하게 감소되었다. 골밀도는 두 동물 모델 모두에서 알파 리포산 투여 후 유의한 변화를 보이지 않았다. 그러나, 요중 DPD 농도는 난소 절제 대조군 및 IMO 대조군에 비해 알파 리포산을 투여한 경우 현저한 감소를 보였으며, 혈장 BSAP도 고농도 알파 리포산을 투여하였을 때 유의한 감소를 보였다. 결론: 비록 알파 리포산 투여 후 골밀도의 증가를 관찰할 수 없었지만, 본 연구의 결과 알파 리포산은 생체에서 골 교체율을 억제하는 작용을 가지고 있는 것으로 판단되었다.
고정민,정민희,홍정수,박형주,장재석,신형두,김신윤,김기수 대한의학회 2004 Journal of Korean medical science Vol.19 No.3
Recently, It has been reported that the LDL receptor-related protein 5 (LRP5) reg-ulates bone formation, and that mutations of the gene cause osteoporosis-pseudo-glioma syndrome or high bone mass phenotypes. However, the mutations cannot explain a genetic trait for osteoporosis in the general population because of their rarity. From 219 Korean men aged 20-34 yr, we looked for six known polymorphisms causing amino acid changes in the LRP5 coding region, and investigated their asso-ciation with bone mineral density (BMD) at the following anatomical sites: lumbar spine (L2-L4) and the left proximal femur (femoral neck, Ward’s triangle, trochanter and shaft). We found that the Q89R polymorphism was significantly associated with BMD at the femoral neck and Ward’s triangle (p=0.004 and <0.001, respectively). However, after adjusting for age, weight and height, a statistically significant associa-tion only occurred at the Ward’s triangle (p=0.043), and a marginal association was observed at the femoral neck (p=0.098). No A400V, V667M, R1036Q and A1525V polymorphisms were found, and no statistically significant association was found between the A1330V polymorphism and BMD at any sites. Although we failed to demonstrate a clear association between the LRP5 polymorphism and peak bone mass in young men, the present study suggests that larger-scale studies on the Q89R polymorphism need to be performed.
Identification of a Novel Mutation of CFTR Gene in a Korean Patient with Cystic Fibrosis
고정민,김구환,김경모,홍수종,유한욱 대한의학회 2008 Journal of Korean medical science Vol.23 No.5
Cystic fibrosis (CF) is the most common lethal autosomal recessive disease in Caucasians, but rare in Asians. The mutations of cystic fibrosis transmembrane conductance regulator (CFTR) gene are responsible for CF. To date, less than 5 cases of CF have been reported and a few of them diagnosed based on the genotype of the CFTR gene in Korea. We encountered a 4-month-old Korean infant with CF and the diagnosis was confirmed by CFTR gene mutation analysis. The patient underwent surgical operation, due to meconium ileus at birth. He suffered by recurrent respiratory infections, failure to thrive, fatty liver with hepatomegaly, and cholestasis. The mutations of the CFTR gene were identified in the patient and his parents. The patient was a compound heterozygote with a nonsense mutation of c.263T>G, resulting in an amino acid change of p.Leu88X in exon 3. It was previously described in a Korean patient with CF. The other is a novel mutation; c.2089-2090insA mutation (p.Arg697LysfsX33) in exon 13. The mutation c.263T>G was inherited from his father, and the c.2089-2090insA mutation from his mother. Respiratory infection was recovered by supportive care, and cholestasis was improved slowly with sufficient feeding and supplementation of pancreatic exocrine enzymes. He is 19- month old now and shows catch-up growth. We report a novel CFTR mutation in a Korean infant with CF.
조형요소인 점, 선, 면을 적용한 네일아트 디자인 연구
고정민,Ko, Jung-Min 중소기업융합학회 2020 융합정보논문지 Vol.10 No.11
본 연구는 네일아트의 시각적 표현을 위해 공간을 구성하는 조형의 기본요소인 점, 선, 면을 적용한 네일아트를 제시하여 네일아트 디자인의 창의적인 발상과 예술적인 영역의 확대에 도움이 되고자 한다. 연구방법은 전문서적과 선행연구, 인터넷 웹사이트를 통해 조형요소의 개념과 특성을 고찰하였다. 다양한 표현 기법과 함께 점, 선, 면의 특성이 네일아트에 어떻게 적용되며 시각메세지로 표현되고 있는지를 각 특성에 따라 분석하여 총 6작품을 제작하였다. 본 연구는 조형요소인 점, 선, 면이 가지는 특성을 예술적으로 접근하여 재해석함으로써 네일아트 표현에 대한 시각을 새롭게 모색하고 이를 활용하여 네일아트 디자인의 무한한 가능성을 높이는데 기여하고자 한다. This study aims to help the creative idea of nail art design and the expansion of artistic realm by presenting nail art applied with dot, line, and plane, which are the basic elements of the sculpture that make up the space for visual expression of nail art. The research method considered the concepts and characteristics of the molding elements through professional books, prior research, and Internet website. Along with various expression techniques, the characteristics of dot, line, and plane were applied to nail art and expressed as visual messages, and a total of six works were produced according to each characteristic. This research aims to find a new perspective on nail art expression by reinterpreting the characteristics of dot, line, and plane, which are formative elements, in an artistic approach, and to contribute to enhancing the infinite possibilities of nail art design by utilizing them.
Genetic Syndromes associated with Congenital Heart Disease
고정민 대한심장학회 2015 Korean Circulation Journal Vol.45 No.5
Recent research has demonstrated that genetic alterations or variations contribute considerably to the development of congenital heart disease. Many kinds of genetic tests are commercially available, and more are currently under development. Congenital heart disease is frequently accompanied by genetic syndromes showing both cardiac and extra-cardiac anomalies. Congenital heart disease is the leading cause of birth defects, and is an important cause of morbidity and mortality during infancy and childhood. This review introduces common genetic syndromes showing various types of congenital heart disease, including Down syndrome, Turner syndrome, 22q11 deletion syndrome, Williams syndrome, and Noonan syndrome. Although surgical techniques and perioperative care have improved substantially, patients with genetic syndromes may be at an increased risk of death or major complications associated with surgery. Therefore, risk management based on an accurate genetic diagnosis is necessary in order to effectively plan the surgical and medical management and follow-up for these patients. In addition, multidisciplinary approaches and care for the combined extra-cardiac anomalies may help to reduce mortality and morbidity accompanied with congenital heart disease.