악성 임파종에서 혈청 β2-microglobulin 에 관한 연구

고은희,김현숙,한지숙,김주항,이삼열,김병수,고윤웅,윤진우,전상일 대한내과학회 1986 대한내과학회지 Vol.30 No.4

Rata 2 microglobulin, a low molecular weight polypeptide, exists in the plasma membrane of all nucleated cells and its normal serum concentration, in free form, is in the range of 1, 500 to 2,000 μg/L, Serum β2-microglobulin is increased in malignant tumors especially in B-cell lymphopro-liferative disorders, and thus the serum concentration is of help for the diagnosis, therapeutic response and prognosis of these disorders. The author attempted to correlate the serum β2-microglobulin levels and the clinical courses of malignant Iymphomas, in 35 patients with malignant lymphoma showing normal BUN and serum creatinine levels. These patients were collected from the in-patients of Severance Hospital, Yonsei Medical Center during September 1984 to July 1985. As a control group, the serum β2-microglobulin levels of 38 healthy subjects were also measured. The following results were obtained: 1) The serum β2-microglobulin in 38 healthy subjects was 1,827±546 μg/L. The serum β2-mic-roglobulin of 35 patients with malignant lymphoma revealed 2.298±1.117μg/L. The serum p, microgiobulin in 35 patients with malignant lymphoma was higher than that of control group significantly(p$lt;0.05). 2) The serum β2-microglobulin level according to clinical stage showed increasing tendency with higher with higher stages. Fourteen patients of stage I or II showed the mean serum β2-microglobulin level of 1,660±688 μg/L and 19 patients of stage g or p showed 2,754±1,196 μg/L. The statistical difference he tween those 2 groups was significant(p$lt;0.005), The serum β2-microglobulin was increased($gt;2,000ug/L) in 35.7% of stage I and g, and 77.8% of stage g and IV untreated active malignant lymphoma. Among the non-Hod-gkin's lymphoma group(n=29), serum β2-microg-lobulin was increased in 35.7% of patients of stage I and in 78.5% of those of stage III and IV. The same increased level was observed in 75.0Fo of Hodgkin's disease(n=4) of stage III and IV. 3) The serum β2-microglobulin level of 16 patients with the systemic symptoms(B symptom) was 2,870±1,203ug/L and 17 patients without B symptom was 1,744±765ug/L(pg0,005). 4) In 13 Patients. serum β2-microglobulin levels were monitored prior to and after the treatment. Six of these patients were responsive to the treatment and their serum β2-microglobulin levels prior to treatment were rather lower than normal. Serum β2-microglobulin level decreased as their clinical courses improves. On the other hand, the other 7 patients who had considerably high serum β2-microglobulin levels showed the increasing tendency of its levels inspite of the treatment. Based on these studies, it can be suggested that the serum β2-microglobulin determination is a valuable laboratory study in following up malignant lymphoma.

기업가정신교육에서의 Design Thinking 효과성 분석을 위한 구성요인에 관한 연구

고은희,나건 한국디자인리서치학회 2019 한국디자인리서치 Vol.4 No.3

This study was conducted as a previous study to analyze the effectiveness of Design Thinking for entrepreneurship education. It is considered that the restructuring is necessary for the individuals who are educated because the constituent factors as the evaluation index of the entrepreneurship currently being used is the corporation based on the value orientation of entrepreneurship. This study was based on five dimensions- autonomy, informativeness, risk taking, preactiveness, achievement desire(competitiveness aggressiveness) of Lumpkin and Dess which are widely used as the evaluation index. As the analysis method, Verimax with Kaiser normalization was used, as a result, the new constituent factor, achievement desire, goal orientation, and autonomy were presented. It can be used as new constituent factors to analyze the effectiveness of entrepreneurship education using Design Thinking forward. 본 연구는 기업가정신교육에 있어서 Design Thinking 활용의 효과성을 분석하기 위한 선행 연구로서 진행하였다. 현재 활용되고 있는 기업가정신의 평가지표로서의 구성요인은 기업가정신의 가치 지향성에 의거한 기업을 대상으로 하고 있어, 교육을 받는 개인을 대상으로 하기에 재구성이 필요하다고 판단된다. 평가 지표로서 널리 활용되고 있는 Lumpkin 와 Dess의 혁신성, 위험감수성, 진취성, 성취욕구, 자율성이라는 구성요인을 기반으로 실험을 진행 하였다. 타당성 검증을 위한 요인 추출 방법으써의 주성분 분석을 진행하였고, 회전방법으로 카이저 정규화가 있는 베리멕스(Verimax)를 활용하여, 주성분을 도출 후 주성분을 토대로 MECE(Mutually Exclusive Collectively Exhaustive)원칙에 부합하도록 구성요인을 재구성하였다. 그 결과, 재분류된 구성요인에 해당하는 새로운 구성요인으로 진취성, 목표지향성, 자율성을 제시하였다. 향우 연구에서는 새롭게 제시한 구성요인을 활용하여 기업가정신교육에 있어서 Design Thinking이 미치는 영향 및 효과성에 대한 실증연구를 진행하도록 하겠다.

우울, 주의집중의 어려움, 인터넷 사용빈도 및 교사/친구관계가 청소년 사이버비행에 미치는 영향: 조절된 매개효과 검증

고은희,김은정 한국청소년학회 2015 청소년학연구 Vol.22 No.3

The purpose of this study was to investigate the effect of depression on cyber delinquency in adolescents on the basis of the mediating role of inattention and internet use and the moderating role of social support between internet use and cyber delinquency. Based on the literatures, a moderated mediation model was proposed, in which both mediating and moderating effect could be evaluated as a whole. Data consisted of 2,122 middle school students taken from the National Youth Policy Institute were analysed. Results of this study were as follows. First, a moderated mediation model revealed a close fit to the data on adolescent cyber delinquency. Second, inattention and internet use showed a sequentially significant mediating effect on the relation between depression and cyber delinquency, and depression also showed a direct effect on cyber delinquency. Third, a moderating effect of the teacher-student/peer relationships between internet use and cyber delinquency was significant. Finally, the implications for cyber delinquency prevention and limitations of this study were discussed. 본 연구에서는 청소년 사이버비행에 영향을 미치는 심리ㆍ사회관계 변인을 규명하기 위해서, 우울과 주의집중의 어려움과 같은 개인내적 심리적 변인과 인터넷 사용빈도 및 교사/친구관계로 측정된 사회관계 변인들 간의 관계를 살펴보았다. 구체적으로, 우울이 청소년 사이버비행에 미치는 영향에서 주의집중의 어려움과 인터넷 사용빈도가 순차적으로 매개하는지와 인터넷 사용빈도에서 사이버비행으로 가는 경로에서 교사/친구관계가 조절하는지를 알아보았다. 이를 위해 조절된 매개모형을 설정하고 경로분석, Sobel 검증 및 Ping의 조절효과검증을 실시하였다. 그 결과, 우울에서 청소년 사이버비행으로 가는 직접효과와 주의집중의 어려움과 인터넷 사용빈도의 매개변인들을 경유한 간접효과는 모두 유의미 하였다. 즉, 우울 수준이 높을수록 주의집중의 어려움도 높아지며, 인터넷 사용빈도를 높여 사이버비행에 영향을 미치는 것으로 나타났다. 아울러 인터넷 사용빈도가 사이버비행에 미치는 영향력의 정도는 교사/친구관계 수준에 의해 조절되는 것으로 나타났다. 끝으로, 조절된 매개효과 결과와 관련하여 청소년 사이버비행에 대한 개입의 가능성과 본 연구의 제한점들을 논의하였다.

Pt/Al2O3 및 Pt/SiO2의 합성과 MEK 저온 산화반응에 활용

고은희,부진호,권병찬,박노국,강도형,윤대식 한국에너지기후변화학회 2022 에너지기후변화학회지 Vol.17 No.1

γ-Al2O3 and silica were used as supporting materials of Pt-based catalysts for low-temperature oxidation of volatile organic compounds. While Pt/γ-Al2O3 was synthesized using alumina powder by an impregnation method, Pt/SiO2 was prepared using silica-sol. As this time, the content of Pt was 1 wt% of the total catalyst weight. The concentration of the slurry to coat honeycomb with Pt-based catalysts was optimized as 30 wt%. Honeycomb catalysts coated with Pt/γ -Al2O3 and Pt/SiO2 were tested for low-temperature oxidation of methyl ethyl ketone. The catalytic activity of Pt/SiO2 was higher than that of Pt/γ-Al2O3 in the low-temperature region below 200 °C. This might be due to the smaller size of Pt particles on silica than γ-Al2O3 supports. In addition, it can be seen that this is because the stable reaction activity of silica suppresses inactivation due to the low acid point of silica.

금융 및 디지털 금융 역량과 삶의 만족도 관련 요인 분석

고은희 가정과삶의질학회 2022 가정과삶의질학회 학술발표대회 자료집 Vol.2022 No.10

소와성 두개 1례

고은희,고창우,이동환,신상만,이상주 순천향대학교 1997 Journal of Soonchunhyang Medical Science Vol.3 No.2

[2011년 부산일보 신춘문예 : 신작] 참깨꽃 언어가 속삭이다

고은희 고요아침 2011 시조시학 Vol.- No.-

減價償却方法 變更이 株價에 미치는 영향 - 準强型 效率性 檢證을 中心으로--

高恩嬉 대한사립학교장회(구 대한사립중고등학교장회) 1986 私學 Vol.36 No.-

<출판저널> 연중기획-'이달의 책, 이달의 저자' "식물성의 사유" 편집기획자의 말

고은희,Go, Eun-Hui 대한출판문화협회 2003 출판저널 Vol.333 No.-

Alpha-lipoic acid에 의한 대사증후군의 개선

고은희,이우제,김민선,박중열,이기업 대한내분비학회 2004 Endocrinology and metabolism Vol.19 No.3