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고원건,Woojin Lee,Tae Gyu Lee 한국공업화학회 2007 Journal of Industrial and Engineering Chemistry Vol.13 No.7
The modification of the protein-repellent poly(ethylene glycol) (PEG) hydrogel surface was achieved by a two-step process using immobilization of benzophenone on the PEG hydrogel as surface initiator and subsequent surface-initiated graft polymerization of acrylic acid by UV irradiation. Formation of poly(acrylic acid) (PAA) layer on the PEG hydrogel was demonstrated by confirming the presence of carboxyl groups in the poly(acrylic acid) (PAA) with FTIR/ATR spectroscopy and measuring the height of PAA layers with alpha-step surface profiler. In the grafted region, PAA and PEG hydrogel formed an interpenetrating polymer network extending 200 m into PEG hydrogel and homo PAA protruded 14∼17 m above the PEG hydrogel surface. Activation of the carboxyl groups in PAA allowed covalent immobilization of collagen, a cell adhesion protein, on the PAA-grafted PEG hydrogel, which was demonstrated with FTIR/ATR spectroscopy by confirming the formation of a new amide bond. Surface-initiated graft polymerization combined with photolithography produced well-defined PAA micropatterns on the PEG hydrogels and collagen was immobilized only on the PAA region due to the lack of adhesion for proteins to PEG, producing protein micropattern on the PEG hydrogel.