http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Plate assay에 의한 Lactobacillus casei YIP 9018과 Bifidobacterium spp.의 항암효과에 관한 연구
高時煥,朴相瑨,李明燮,白永振,朴芝賢,金昌漢 건국대학교 생명과학연구원 1994 생명과학지 Vol.1 No.-
발효유 제품의 제조에 사용되고 있는 Lactobacillus casei YIT 9018(LC9018)과 장내 유용균인 Bifidobacterium bifidum 그리고 Bifidobacterium OLS1, OLS2, OLS3 및 OLS4의 인체암에 대한 in vitro 항암효과를 알아보기 위하여 plate assay를 실시한 결과 LC 9018의 균체를 동결건조하여 100㎍/㎖의 농도로 암세포에 처리하였을 때 폐암새포인 CALU-3과 SKMES-1, 유방암세포 HS-578T, 임파암세포 RAJI 및 색소암세포 FARROW에 대하여 직접적인 강한 항압활성을 나타내었다. 한편 In vitro 항균활성 조사에서는 공시균주 모두 그람양성균인 Sarcina lutea에 미약한 항균활성을 나타내었다. This study was carried out for investigating antitumor activity against human tumor cell lines of Lactobacillus casei YIT 9018(LC9018) which is in use to fermented milk products and Bifidobacterium spp. which is beneficial intestinal bacteria. Antitumor effects were examined by in vitro soft agar plate assay. Lyophilized mycelia of LC 9018(100㎍/㎖) had direct strong antitumor activity against human tumor cell lines, CALU-3, SKMES-1(lung cancer), HS-578T(breast cancer), RAJI(lymphoma cancer) and FARROW(melanoma cancer), but Bifidobacterium spp. did not show antitumor activity at all. On the other hand, att tested strains in vitro showed very weak antibacterial activety against Sarcina lutea.
저신장을 주소로 내원한 환아에서 발견된 기질성 원인 질환에 대한 임상적 고찰
고시환,이동환 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.1
Background: Growth is a sensitive index, which reflects the health status, nutrition and hereditary background of children. If a growth pace deviates from the normal, it could be a warning that represent s congenital or secondary diseases. A lot of research and clinical have been done since Raben reported the treatment of dwarfism using growth hormone for the first time in 1958. Recently, the interest in the growth is more and more increasing, which results in a lot of request. It is usually known that it is rare most children with short stature have abnormality in other internal organs except endocrine or congenital problems . Sometimes, however, the short height itself could be manifestation of major diseases caused by the problem of other internal organs. Accordingly, this study reports the cases of unexpected major diseases found in patients with short stature who have been observed in the outpation clinic and emphasizes the importance of early diagnosis of the diseases. Methods: The retrospective study has been done with the records of patients who were diagnosed as short sture with a basis of below 2 SD (Standard Deviation) or 3 percentile in the pediatric clinic of the Samsung seoul hospital from January of 1996 to July of 1997. The study excludes children patients who indicated vomiting, headache and other nervous diseases-related symptoms except short stature among brain tumor patients. Results : The results were as follows 1) Major internal organ problems have been found in 5 of 52 cases which were diagnosed as short stature after visiting the outpatient clinic with the chief complaint of growth retardation. 2) 2 of the 5 cases were diagnosed chronic renal failure and started dialysis treatment after several months. No specific problems were found in the urinalysis till the term of renal failure. 3) The problems on the Sella MRI test were found in 3 cases of 1 case craniopharyngioma, 1 case histiocytosis X and 1 case focal mass in the pituitary body. Conclusion: Although a few children have the problems in the major internal organs among patients who were diagnosed as short stature, major diseases were found in all 5 cases who have problem Accordingly, it is considered to be necessary to estimate other internal organs minutely.
주택과 고층 아파트 주거 아동의 행동 발달 상태에 대한 연구 : Between a separate dwelling and apartment
고시환,오경환,이우령,박재옥,이상주 순천향대학교 1993 논문집 Vol.16 No.2
The social and the physical environment, especially residential environment as a primary living space, have great influence on children's behavior development. So it is necessary to compare the differences according to children's residential environments. The purpose of this study is intended to find the influence of physical and social dwelling environments due to the difference between a separate dwelling and an apartment of the characteristics on children's behavior development. The subject of this study was 471 children(separate dwelling=297, apartment=174). The data of this study was obtained by questionnaire that administered to the sample.
이준구,고시환,송정식,황재하,백용한,장윤수,김대중,배상욱,박중원,홍천수 ( Jun Gu Lee,Shi Hwan Ko,Jung Sik Song,Jae Ha Hwang,Yong Han Park,Yoon Soo Jang,Dae Jung Kim,Sang Wook Bae,Jung Woon Park,Chein Soo Hong ) 대한천식알레르기학회 1998 천식 및 알레르기 Vol.18 No.3
Human seminal fiuid (HSP) hypersensitivity is rare, but possibly a life-threatening disease. The pathogenesis of seminal plasma hypersensitivity and the exact nature of the HSP allergens remains to be clarified. We report a case of 25-year-old female patient who complained of severe itching sensation, flushing and edema of external genitalia, facial edema and dyspnea after sexual intercourse. The diagnosis was established by skin pr ick test with her husbands diluted semen. Intravaginal desensitization was performed by modified Matloffs method. Dilutions was made with sterile human serum albumin(0.2%) and 0.4% pheno1-0.9% saline solution. Two ml each of progressively greater concentrations of semen dilutions(1: 100,000 v/v, 1: 10,000 v/ v, 1:1,000 v/v, 1:100 v/v, 1:10 v/v) were inserted intravaginally at 45-min intervals, followed by an undiluted specimen. The patient was successfully desensitized and could have unprotected intercourse without anaphylaxis.