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각종 신질환의 단백뇨에 대한 Captopril 의 치료 효과
윤경우,고명구 대한신장학회 1988 Kidney Research and Clinical Practice Vol.7 No.1
The effect of angiotensin converting enzyme inhibitor captopril on proteinuria was evaluated in 10 patients with renal disease of different etilogy. Captopril (37.5 mg given daily in 3 divided doses) was administered for 8 weeks. In heavy proteinuria (more than 1 g/day> group (N = 5), 24 hours urinary protien decreased significantly on the 6th weeks after captopril treatment (from 7.0± 3.0 g to 1.6±1.1 g, p< 0.05). But in low proteinuria (less than 1 g/day) group (N =5), the proteinuria-decreasing effect of captopril was not evident during the study period. Serum creatinine, albumin, electrolytes, and blood pressure did not change significantly during the study period. In conclusion, the proteinuria-decreasing effect of captopril is significantly good in heavy proteinuria patients but not evident in low proteinuria patients.
신동구,김종설,고명구,윤경우 영남대학교 의과대학 1986 Yeungnam University Journal of Medicine Vol.3 No.1
Behcet씨 병의 경우 중추 신경계 침범여부는 조기에 진단 치료되어야 할 정도로 불량한 예후를 나타내는 지표로써 아프타성 구내염, 생식기 궤양, 표피성 혈관염, 포도막염, 활막염 등 전신적 증상에 주의를 기울임으로써 조기 진단 및 치료를 하여야 예후의 호전에 기여할 것으로 생각된다. 저자들은 51세 여자 환자에서 중추 신경계증상을 동반한 Behcet씨 병 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Beh,cet's disease was origianlly described as a triple symptom complex of oral aphthous ulceration,genital ulceration, and hypopyon iritis. It is now known to have a side systemic manifestations. Among them, the central nervous system involvement should be diagnosed earlier because of it's lethal potential. Recently the authors experienced a case of Beh,cet' disease with CNS involvement. A 51-year-old female patient was admitted due to deterioration of mentality and generallized ache since 2 years prior to admission. The finding on physical examination were compatible with Beh,chet's disease, but without cerebrospinal pleocytosis. The manifestations were improved with mediications of prednicolone, chlorambucil, colchicine, but relapsed 2 months later during subsequent tapering of prednisolone and chlorambucil. The patient is now on medication again. A case of Beh,cet's disease with CNS manifestations is reported with review of literature.
급성 심근경색증 환자에서 QRS 점수제와 총 Creatine Kinase 및 Creatine Kinase MB 유리량과의 관계
이영곤(Young Gon Lee),고명구(Myeong Ku Ko),김영조(Young Jo Kim),심봉섭(Bong Sup Shim),김종설(Chong Shul Kim) 대한내과학회 1988 대한내과학회지 Vol.34 No.4
N/A The QRS scoring system using observations of Q and R wave duration and R/Q and R/S amplitude ratios in the standard electrocardiogram is useful in estimating the size of myocardial infarcts. This study was undertaken to compare QRS system and total CK and CK-MB release for estimating myocardial infarct size in 26 patients with acute myocardial infarction. The overall correlation between QRS scores and total CK-MR release (r=0.717, p<0.01) were good. The better relations between QRS score and total CK and CK-MB release in the patients with anterior AMI (r=0.647, r=0.636, independently) were showed. These data suggest that QRS scoring system will be clinically useful in estimating myocardial infarct size and assessing prognosis and efficacy of tretment in patient with AMI.