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Promethazine이 사염화탄소에 의한 간손상에 미치는 영향
강진무 慶北大學校 醫科大學 1970 慶北醫大誌 Vol.11 No.2
The experiment was carried out to clarify the intriguing "protective" effects of promethazine on ultrastructural alterations in the hepatic cells exposed to carbon tetrachloride. The carbon tetrachloride and promethazine hydrochloride were administered into the albino rats, either singly or combined. carbon tetrachloride was given subcutaneously with a dose of 0.5ml per kg of body weight and promethazine was injected intraperitoneally with a dose of 25.0㎎ per kg of body weight. Hepatic lesions were examined histopathologically by the measure of both light and electron microscopes with the following concluions. 1. Light-microscopically, hepatic tissue of animals receiving carbon tetrachloride alone revealed marked degenerative changes and frank necrosis in the central zone of lobules, while the hepatic tissue of animals which received both carbon tetrachloride and promethazine revealed only minimal changes. Hepatic tissue of the animals fed only with basal diet or of those which received promethazine alone revealed no significant pathologic changes. 2. Electron-microscopically, hepatic cells affected by carbon tetrachloride revealed a wide range of ultrastructural changes. The nucleus-appears to be considerably active, and roughsurfaced endoplasmic reticulum revealed variable changes evidenced by swelling of this organel and shedding of ribosomes. The mitochondria later underwent swelling with loss of cristae. Animals which received both promethazine and carbon tetrachloride revealed relatively milder changes than in those which were treated only with carbon tetrachloride, and almost completely recovered within twentyfour hours. The animals which received promethazine alone revealed no significant ultrastructural changes in their hepatic cells. 3. promethazine, therefore, was thought to have significant protective effects upon hepatic injury produced by carbon tetrachloride.
강진무 啓明大學校 醫科大學 1984 계명의대학술지 Vol.3 No.1
소아 급성 임파성백혈병은 좋은 protocol을 바탕으로한 화학요법제의 적절한 조합과 감염의 예방 및 적절한 치료로서 현재는 치유 가능한 질환으로 만들고 있다. 많은 연구 team 들은 5년간생존율 80%를 10년간생존율 80%로 만들것을 목적하고 있다.
뇌막염이 의심되는 환아에 있어서 뇌척수액 검사소견의 분석
강진무,김준식,이상락,손성민 啓明大學校 醫科大學 1992 계명의대학술지 Vol.11 No.1
Lumbar puncture is the widely used diagnostic procedure for the meningitis and is performed whenever meningitis is even minimally suspected but it does involves some risk. Although the value of the lumbar puncture in diagnosing meningitis is established and emphasize the importance of performing it in any child suspected of having meningitis,there is no data on the reliability of the signs commonly associated with the disease. An analysis of the cerebrospinal fluid for 500 children subjected to lumbar puncture on the suspicion of meningitis for 5 years period was undertaken to determine the characteristics of patients with and without meningitis, and evaluate the precictive value of symptoms and signs of meningitis. The following results were obtained. The incidence of positive lumbar puncture was 42.4% and increased with patient's age. Vomiting irritability and headache showed high incidence of positive lumbar puncture. 56.0%, 63.8% and 78.4% respectively. The incidence of positive lumbar puncture was also higher in patients with nuchal rigidity and kernig's sign and the higher incidence of these symptoms and signs observed among patients with meningitis. Fever, convulsion with or without fever, and lethargy were not specific. ESR over 20mm/hr had higher incidence of posivive lumbar puncture and the incidence increased as ESR rises. Leukocytes and absolute granulocyte count in peripheral blood were not specific. The most common conditions that mimic meningitis and led to lumbar puncture in this study were febrile convulsion, acute gastroenteritis, upper respiratory infection, pneumonia and acute pharyngotonsillitis in order. The results of this study suggested that vomiting irritability headache nuchal rigidity and kernig's sign proved to be more sensitive indicators of meningeal infection. Older age and elevated ESR also had high predictive value for lumbar puncture in patient suspected meningitis.
강진무,황종문,권태찬,권치한 啓明大學校 醫科大學 1990 계명의대학술지 Vol.9 No.2
Doxorubicin is effective chemotherapeutic agent in the treatment of various solid tumor and hematologic malignancies. Because of its cardiotoxicity, however, early inappropriate discontinuation of doxorubicin therapy in unavoidable and may minimize its therapeutic efficacy in may patients. Doxorubicin cardoptpxicity is dose related and the cardiomyopathy is fatal in over half the cases. Authers have experienced a case of doxorubicin induced cardiomyopathy in a 4 years old girl who diagnosed dose is 345mg/M?. She also had right nephrectomy and irradiation to the right kidney area. Brief review of the literature was made.
김흥식,강진무 啓明大學校 醫科大學 1986 계명의대학술지 Vol.5 No.1
Authors experienced a case of Neurofibromatosis in a 13 years old boy who had over six large various shaped cafe-au-lait spots since birth. H also had scoliosis with intermittent exertional dyspnea and chest pain for about several months. Chest X-ray and chest C-T scan showed a mass in posterior mediastinum along 4th through 7th thoracic spine which had been confirmed as neurofibroma by biopsy. A brief review of literature was made.