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강종순 외 전남대학교 수산과학연구소 2003 수산과학연구소논문집 Vol.12 No.-
This study was conducted to investigate effects of dietary recombinant bovine somatotropin (rBST) to moist pellet (MP) diet on growth and body composi선on of olive flounder (Para1ich챙s oliψ'aceus). Experimental fish (average body weight: 25 g) were divied into 4 groups, and each group was fed MP (raw fish and commercial compound meal was 7: 3) with rBST addition levels 0, 2, 4 and 6 ppmJkg for 8 weeks. The growth and feed efficiency of the rBST addition groups was significantly higher than that of the control group (P<0.05), and there were no significant difference with the rBST addition levels. Moisture, crude protein, crude lipid and crude ash content of whole body and liver in olive flounder were not si힘lificant1y different between experimental groups. But crude lipid content of dorsal muscle and viscera of rBST addition groups were significantly lower than that of the control group. HSI (hepatosomatic index), VSI (visceralsomatic index), CF (condition factor), Ht (hematocrit) and Hb (hemoglobin) were not significantly different between experimental groups. The results indicate that the addition of 2 ppmJkg MP diet can improve growth and feed efficiency.
강종순(Jong Soon KANG),지승철(Seung Cheal Ji),이시우(Si Woo LEE),정관식(Gwan Sik JEONG) 전남대학교 수산과학연구소 2003 수산과학연구소논문집 Vol.12 No.-
This study was conducted to investigate effects of dietary recombinant bovine somatotropin (rBST) to moist pellet (MP) diet on growth and body composition of olive flounder (Paralichtys olivaceus). Experimental fish (average body weight:25 g) were divided into 4 groups, and each group was fed MP (raw fish and commercial compound meal was 7:3) with rBST addition levels 0, 2, 4 and 6 ppm/㎏ for 8 weeks. The growth and feed efficiency of the rBST addition groups was significantly higher than that of the control group (P〈0.05), and there were no significant difference with the rBST addition levels. Moisture, crude protein, crude lipid and crude ash content of whole body and liver in olive flounder were not significantly different between experimental groups. But crude lipid content of dorsal muscle and viscera of rBST addition groups were significantly lower than that of the control group. HSI (hepatosomatic index), VSI (visceralsomatic index), CF (condition factor), Ht (hematocrit) and Hb (hemoglobin) were not significantly different between experimental groups. The results indicate that the addition of 2 ppm/㎏ MP diet can improve growth and feed efficiency.
강무림,강종순,이창우,윤지은,오수진,박성규,이기호,김환묵,한상배,김형진 한국독성학회 2012 Toxicological Research Vol.28 No.1
In this study, we investigated the effect of methanolic extract isolated from the root of Lycoris aurea (LA) on the growth of cancer cells and the tube formation activity of endothelial cells. Various cancer cells were treated with LA at doses of 0.3, 1, 3, 10 or 30 μg/ml and LA significantly suppressed the growth of several cancer cell lines, including ACHN, HCT-15, K-562, MCF-7, PC-3 and SK-OV-3, in a dose-dependent manner. We also found that LA induced cell cycle arrest at G2/M phase in ACHN renal cell adenocarcinoma cells. Further study demonstrated that LA concentration-dependently inhibited the tube formation, which is a widely used in vitro model of reorganization stage of angiogenesis, in human umbilical vein endothelial cells. Collectively, these results show that LA inhibits the growth of cancer cells and tube formation of endothelial cells and the growth-inhibitory effect of LA might be mediated, at least in part, by blocking cell cycle progression.
Hepatoprotective Effect of Aged Black Garlic Extract in Rodents
신정혜,강종순,이창우,오수진,윤지은,강무림,한상배,박형식,정재철,정윤호 한국독성학회 2014 Toxicological Research Vol.30 No.1
In this study, we investigated the hepatoprotective effects of aged black garlic (ABG) in rodent models of liver injury. ABG inhibited carbon tetrachloride-induced elevation of aspartate transaminase (AST) and alanine transaminase (ALT), which are markers of hepatocellular damage, in SD rats. D-galactosamineinduced hepatocellular damage was also suppressed by ABG treatment. However, ABG does not affect the elevation of alkaline phosphatase (ALP), a marker of hepatobilliary damage, in rats treated with carbon tetrachloride or D-galactosamine. We also examined the effect of ABG on high-fat diet (HFD)-induced fatty liver and subsequent liver damage. ABG had no significant effect on body weight increase and plasma lipid profile in HFD-fed mice. However, HFD-induced increase in AST and ALT, but not ALP, was significantly suppressed by ABG treatment. These results demonstrate that ABG has hepatoprotective effects and suggest that ABG supplementation might be a good adjuvant therapy for the management of liver injury.
Antidiabetic Activity of Angelan Isolated from Angelica gigas Nakai
김환묵,강종순,박송규,이기호,김연진,홍진태,김영수,김지윤,한상배 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.11
Angelan isolated from Angelica gigas Nakai inhibits tumor growth and metastasis by enhancing immune functions of macrophages, dendritic cells, and B cells. Here, we report that angelan can inhibit autoimmunity in non-obese diabetic (NOD) mice. Although 80% of the NOD mice had developed diabetes by 24 weeks of age, none of the angelan-treated NOD mice developed diabetes. The mean glucose levels were 118 mg/dl in angelan-treated mice and 506 mg/dl in control NOD mice. Histological examination of the pancreatic islets revealed that most of the islets isolated from angelan-treated mice were less infiltrated with lymphocytes compared with those of control mice. Spleen cells from diabetic NOD mice could adaptively transfer diabetes into NOD.scid mice, but those from angelan-treated NOD mice did not, suggesting that angelan caused the spleen cells to lose the ability to destroy β cells. However, angelan did not affect cytokine production of spleen cells. These results suggest that angelan has dual immunomodulatory functions, i.e., immunostimulation in tumor-bearing mice and immunosuppression in autoimmune diabetic mice.
Inhibition of Human Ovarian Tumor Growth by Cytokine-induced Killer Cells
김환묵,강종순,임재승,박성규,이기호,윤여대,이창우,이기훈,한균희,양규환,김연진,김영수,한상배 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.11
Despite the recent improvement in the treatment of ovarian cancer, this disease is still leading cause of cancer death in women. In this study, the anti-tumor activity of cytokine-induced killer (CIK) cells against human ovarian cancer was evaluated in vitro and in vivo. Although CD3+CD56+ cells were rare in fresh human peripheral blood mononuclear cells, they could expand more than 1,000-fold on day 14 in the presence of anti-CD3 antibody plus IL-2. At an effector-target cell ratio of 30:1, CIK cells destroyed 45% of SK-OV-3 human ovarian cancer cells, which was determined by the 51Cr-release assay. In addition, CIK cells at a dose of 23 million cells per mouse inhibited 73% of SK-OV-3 tumor growth in nude mouse xenograft assay. This study suggests that CIK cells may be used as an adoptive immunotherapy for patients with ovarian cancer.