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천식 환자에서 증상의 정도에 따른 IL-4 유전자 다형에 관한 연구
강세용 ( Sea Yong Kang ),심재정 ( Jae Jeong Shim ),조재연 ( Jae Yun Cho ),권영환 ( Young Hwan Kwon ),이승룡 ( Seung Yong Lee ),김제형 ( Je Hyeong Kim ),이상엽 ( Sang Youb Lee ),이소라 ( So Ra Lee ),한선애 ( Seon Ae Han ),김한겸 ( 대한결핵 및 호흡기학회 1998 Tuberculosis and Respiratory Diseases Vol.45 No.3
보행용 MBT신발과 일반 신발 보행 시 에너지 소비량과 근 활성도의 비교 분석
윤범철,강세용,김애정,유민호,이미정,김난수,Yoon, Bum-Chul,Kang, Se-Yong,Kim, Yae-Jung,Yu, Min-Ho,Lee, Mi-Jung,Kim, Nan-Soo 대한물리치료과학회 2006 대한물리치료과학회지 Vol.13 No.3
This study was to find out whether MBT shoes were more effective than general sporting shoes on the kinematic physiology. We comparatively analyzed energy consumption, heart rates, rating of perceived exertion, lactic acid density in blood and muscle activity with EMG. The subjects were 10 regular students of K Univ.(5 male and 5 female). They wore the general sporting shoes for stage 1(group 1), the MBT walking shoes for stage 2(group2) under the same conditions. There was one week interval between stages. 1. There was no significant difference in the energy consumption and the heart rates between two groups. Group 1 showed a higher energy consumption and heart rates than Group 2 under the speed of 4.0 mph. On the other hand, Group 2 showed higher ones over the speed of 4.0 mph. 2. There was no significant difference in the rating of perceived exertion and lactic acid density in blood between two groups. But Group 2 showed a lower fatigue strength than Group 1. 3. Group 2 showed a higher muscle activity with EMG than group 1, especially at the speed of 2.0, 2.5, 3.0, 3.5 mph in quadratus lumborum muscle and at 4.0mph in tibialis anterior muscle. In conclusion, we are less tired in MBT shoes than in general sporting shoes. Also, we can dorsiflex better in the ankle joint, straighten the lumbar region well and walk erect in MBT shoes. Specially, when it walks slowly, it is favorable in an erection walk and when it walks quickly, we have advantage of obesity management.
최윤상,강세용,우흥정,신상원,김우주,최석주,김민자,박승철 대한화학요법학회 1990 대한화학요법학회지 Vol.8 No.2
Ceftazidime is a '3rd grenration' cephalosporin which possesses broad spectrum activity and high activity against Pseudomonas aeruginosa. To evaluate the clinical effecacy of ceftazidime, the drug was administered parenterally to a total 26 patients with various bacterial infection; 15 with urinary tract infection, 8 with respiratory tract infection, 2 with acute cholecystitis, and 1 with cellulitis. The results were as follows: 1. The clinical response was satisfactory in 15(100%) of 15 patients with urinary tract infection, 6(75%) of 10 with pneumonia, 1(50%) of Overall, ceftazidime was effetive in 88.5%(23/26) of all patients treated. 2. In 19 bacteriologically proven cases, 18 orgainsms except one were eradicated during treatment. 3. Adverse effects were observed in 3(11.5%) of 26 patients; skin rash (1 patient) and nausea(2 patients).
당뇨병 환자에서 말초혈액 중성구의 Superoxide Anion 생성능에 대한 연구
신상원,유재명,강세용,우흥정,김우주,박승철 대한감염학회 1992 감염 Vol.24 No.4
It is generally believed that diabetics have increased susceptibility to infections, and have worse prognosis than nondiabetic population. But there is no evidence that immunologic competence is impaired in patients with diabetes. This study was designed to investigate the association of the superoxide anion production by peripheral blood neutrophild with the infections and other complications in diabetic patient. Superoxide anion production by peripheral neutrophils in 19 healthy subjects, and 40 diabetic patients(15 with infection and 25 without infection) were measured. The superoxide anion production, measured by spectrophotometric assay was expressed in absorbance at 550nm. The results were as follows: 1) After stimulation with ?? FMLP(N-formyl methionyl leucyl phenylalanine), the superoxide production by neutrophil was higher in normal control group (17.14±3.54 nmole/30 min/1×?? neutrophils) than diabetic patient group of diabetic patients with group(14.58±3.55 nmol/30 min/1×?? neutrophils). 2) Superoxide anion production was lower in the group of diabetic patients with infections(14.58±3.55 nmole/30 min/1×?? neutrophils) than the normal control group(17.14±3.54 nmole/30 min/1×?? neutrophils). 3) Superoxide anion production was lower in the group of diabetic patients with complication(14.13±3.33 nmol/30 min/1×?? neutrophils) than the group of diabetic patients without complication(17.05±4.45 nmol/30 min/1×?? neutrophils). In conclusion, the superoxide anion production defect in diabetic patient have associated with development of infections. And superoxide anion production may appear to have influence on the development of diabetic complication.
염색체 DNA 제한효소 절편분석 및 Southern hybridization 을 이용한 병원 칸디다 감염증의 역학적 연구
김우주,박승철,정희진,유철웅,강세용,우흥정 대한내과학회 1999 대한내과학회지 Vol.57 No.2
$quot;Background : Candida species are not only the leading cause of nosocomial fungal infections but also the important cause of infections in the immunocompromised hosts. Epidemiologic study of nosocomial candidiasis has been difficult because of the lack of a reliable typing system. We performed molecular epidemiologic study by using RFA and Southem hybridization for typing of candida isolates from patiients. Methods : A total of 27 candida isolates from 19 immunocompromised patients were studied. Morphotyping and biotyping were done by germ tube test and API 20C system, respectively. Candidial chromosomal DNA was extracted, digested with EcoRI, HindalII and RFA was done. Southem hybridization of chromosomal DNA was also done with digoxigen-labelled Candial albicans-specific DNA probe. Results : The time-period of development of oral candidiasis after admission was 5-14 days (mean : 8 days). C.albicans was the most common species (19), followed by C tropiadis (2), C glabn#zta (2), C.paratropicalis (2), and C parapsilosis (1). The subtypes of Candida species by RFA of chromosomal DNA were C. albieans, 12 types , C tropicalis, 2 types, C glabrata, 2 types ; C.parapsilasis, 1 type ; C. paratropicalis, 1 type. For 7 (87.5%) of 8 patients, RFA pattern of one isolate was identical to that of the other isolates. Conclusion : RFA of candidial chromosomal DNA results were obtainable within days. RFA showed high reproducibility, typeability and good discrimination power between isolates, provided a robust system that may be used rapidly to identify outbreaks of nosocomial candidiasis.$quot;
반복성 기흉(氣胸)을 유발한 원발성 폐(肺) 조직구증-X
강경호,유세화,인광호,구양서,강세용 대한내과학회 1992 대한내과학회지 Vol.43 No.1
Pulmonary histiocytosis X can be associated with disseminated histiocytosis X, but isolated case in the lung parenchyme is rare. We report a case of primary pulmonary histiocytosis X with recurrent pneumothoraces. A 36-year-old man was referred because of recurrent pneumothorax. He had been suffered from dry cough and exertional dyspnea for 4 years. He was a heavy smoker. Plain chest X-ray and chest CT scan revealed thin-walled cysts of various sizes in both lungs. Open lung biopsy was performed. Light microscopic examination revealed proliferation arid infiltration of Langerhans'cells. Immunohistochemically, Langerhans`cells showed strong cytoplasmic staining with S-100 protein and electronmicroscopic examination showed Birbeck granules in Langerhans`cell. He was treated with bleb resection and pleurodesis, but pneumothorax recurred 1 month later.