한약 탕제분획의 항 Herpes simplex virus 활성에 관한 연구

강봉주,고병섭,양기상,박갑주 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

Herpes simplex viruses(HSV) are one of the most common infectious virus of man. Though chemotherapies and antiviotics against HSV have been developed in many countries, but anti-HSV agents were not satisfactory to mankind by their toxic reaction and side effects. In order to search for anti-HSV agents from Korean traditional prescriptions, we extended the number of specimens. Both methanol extract and boiling water extract of the Korean traditional prescriptions were screened to detect anti-HSV activities by MTT assay. Korean traditional prescriptions showing anti-HSV activities as methanol extracts were Paekyo˘psan, Chesu˘pwilyu˘ngtang, Yongdamsangantang, and prescription 11. Four methanol extracts showing anti- HSV activities were fractionated by hexane and their efficacies were tested. Hexane fractionations of Paekyo˘psan, Chesu˘pwilyu˘ngtang, and prescription 11 showed in anti-HSV in tissue culture and their selectivity indexes (SI) were 19.50, 3.32 and 42.90, respectively. Methanol fractionation of Paekyo˘psan showed anti-HSV activities and its SI was 1.40. Especially Paekyo˘psan showed anti-HSV activities both haxane and methanol fractionation.

ICQ-MRA 호혜주의 확산을 통한 인정제도의 발전방안 : WTO/FTA TBT와 미중 디지털 표준화 경쟁 가속화를 중심으로

강봉주,이양기 한국무역통상학회 2021 무역통상학회지 Vol.21 No.4

Manufacturing companies whose main purpose is to export are recognizing the importance of utilizing knowledge-based resources as a means to replace their very scarce resources and capabilities and are increasingly emphasizing them. This research studied the contribution and expansion strategies of companies that obtained international certification qualification to trade export performance due to the conclusion of the ICQ-MRA mutual reciprocity agreement. There are a number of AEO-MRA researches in the previous studies that reviewed MRA, but relatively a few researches specifically identified the actual relationship to ICQ international certified exporters through the conclusion of ICQ-MRA. Therefore, this thesis has been researched to present the effects that companies can actually feel from the economic point of view.

Herpes simplex 바이러스의 유전학적 특성에 관한 연구

강봉주,최환수,최선미,신현규,조동욱,박갑주,Kang, Bong-Joo,Choi, Whan-Soo,Choi, Sun-Mi,Shin, Hyun-Kyoo,Cho, Dong-Wuk,Park, Kap-Joo 한국한의학연구원 1995 한국 한의학연구소 논문집 Vol.1 No.1

In order to facilitate the molecular characterization of the Herpes simplex Virus types 1 and types 2 genome DNAs, a gene library of cloned restriction frtgments have been produced. The Vero cells were infected with HSV-1 and HSV-2. 48 hours after infection, the infected cells Ivere Iysed, and multinucleated giant cells were observed approximately at seventy-two hours postinfection. The multiplication of HSV-1 and HSV-2 was observed in Vero cells using electromicroscopy. The nucleocapsids in nuclei were obseryed, and the assembled virions were budded out through the vacuole, and the virions were released from the cells. HSV-1 and HSV-2 was analyzed by digestion of their genome DANs with restriction ensymes. HSV-1 and HSV-2 genome DNAs were digested with BarnHI, Bgfl respectively. The BarnHI rlestriction fragments of HSV-1 and HSV-2 genome DNAs were twenty-seven fragments and thair molecular sizes were ranging $0.70{\sim}15.08$, $4.4{\sim}31.0$ tilobases. The BglII restriction fragments of HSV-1 and HSV-2 genome DNAs were sixteen, eighteen fragments and thair molecular sizes were ranging $4.8{\sim}30.0$, $1.2{\sim}25.0$ kilobases. And then BglII restriction frgments were cloned in Escherichia coli(E.coil) using the plasmid vector pBacPAK9.

이슈 포커스 : IIF, 신흥국 자금유입 회복세 지속 전망1 (10.14)

강봉주,강영숙 국제금융센터 2013 국제금융 Vol.2013 No.11

관상피내암의 조영 후 자기공명영상 소견

강봉주,차은숙,김현숙,서영진,최현주 대한영상의학회 2006 대한영상의학회지 Vol.55 No.2

Purpose: The purpose of this study is to describe characteristic contrast enhanced MR mammographic findings of ductal carcinoma in situ (DCIS) and also DCIS with microinvasion. Materials and Methods: From January 2000 to July 2005, 32 women with 33 lesions affected by DCIS or DCIS with microinvasion underwent contrast enhanced MRI, and they were then retrospectively evaluated. All the patients had previously undergone mammography and ultrasonography. All the findings of mammography, ultrasonography (US), and MRI were analyzed by using an ACR BI-RADS lexicon. Results: All 33 cases were enhanced on the enhanced MR images. A smooth margined homogeneous enhanced mass was seen in the two (2/33) cases, and nonmass enhancement was seen in 31 (31/33) cases. Among the non-mass enhancement, focal enhancement (7/31), ductal enhancement (5/31), segmental enhancement (9/31), and regional enhancement (10/31) were observed. On the kinetic study, a wash-out pattern (10/33), a plateau pattern (20/33), and a persistent pattern (3/33) were demonstrated. No significant differences were noted between the pure and microinvasive DCIS. Conclusion: There is no significant difference between pure and microinvasive DCIS. However, contrast enhanced MR images can demonstrate occult foci, multifocal lesion and the tumor extent of DCIS on mammogram or ultrasonogram. 목적: 관상피내암과 미세침윤을 동반한 관상피내암의 조영 후 자기공명영상 소견의 특징을 알아보고자 하였다. 대상과 방법: 2000년 1월부터 2005년 7월까지 관상피내암이나 미세침윤을 동반한 관상피내암으로 진단되고 자기공명영상을 시행한 32명의 환자의 33 증례를 대상으로 후향적으로 분석하였다. 이들 환자에서 자기공명영상과 검사 전에 시행한 유방촬영영상과 초음파 영상은 ACR BI-RADS에 따라 분류하였다. 결과: 자기공명영상검사에서 역동적 조영검사시에는 33예인 모든 병변이 조영증강 되었다. 전체 33예 중 명확한 경계의 균일하게 조영 되는 종괴가 2예였고, 비종괴성 조영 병변이 31예였다. 비종괴성 조영 병변 31예 중 국소 조영 증강 병소가 7예, 관상 병소가 5예, 구역성 병소가 9예, 지역성 병소가 10예였다. Time-signal intensity curve 에서, 조기 조영 후 소실되는 경우가 10예, 평탄형을 보이는 경우가 20예, 지속적인 조영을 보이는 경우가 3예였다. 관상피내암과 미세침윤을 동반한 관상피내암의 자기공명영상 소견의 차이는 뚜렷하지 않았다. 결론: 관상피내암과 미세침윤을 동반한 관상피내암의 자기공명영상 소견의 뚜렷한 차이는 없었다. 그러나 조영 후 자기공명 영상은 유방촬영영상이나 초음파 검사에서 보이지 않는 관상피내암을 진단하거나, 다발성 병변을 찾거나, 관상피내암의 범위를 확인하는데 이용될 수 있다.

뇌출혈 동물모델에서 육미지황원의 효과 연구

강봉주,조동욱 한국한의학연구원 2001 한국한의학연구원논문집 Vol.7 No.1

Intracerebral hemorrhage(ICH) is associated with a considerable proportion of strokes and head injuries. The mechanism of brain cell injury associated with hemorrhage may be different from that due to pure ischemia. Therefore, it is essential that models of intracerebral hemorrhage be developed and well characterized in animal model. Yukmijihwangwon (YM) has been known to reinforce the vital essence and have antioxidant activities. In this study, the protective effects of YM was investigated against ICH in animal models. Adult rats had 2 microliters saline containing 0.5 and 5 unit bacterial collagenase ifused into the right caudate nucleus. It was found out that YM was effective in protecting brain against ICH.

Characteristics of efficient few-cycle terahertz radiation generated in as-grown nonlinear organic single crystals

강봉주,백인형,정재혁,김지수,이승헌,권오필,이상민 한국물리학회 2014 Current Applied Physics Vol.14 No.3

We investigated efficient terahertz wave generation by optical rectification in as-grown nonlinear organic single crystal HMQ-T (2-(4-hydroxy-3-methoxystyryl)-1-methylquinolinium 4-methylbenzene sulfonate). Optimal thickness of crystals directly available by a slow cooling method in methanol solution enabled us to achieve high-field few-cycle THz waves at 800-nm pumping. With 95-mW pumping at 1-kHz repetition rate, an optical-to-THz conversion efficiency of 2.7 104 was achieved and the THz electric field strength, measured by electro-optic sampling, was as high as 110.1 kV/cm. Such an efficient THz source based on as-grown HMQ-T crystals can be used for investigation of various nonlinear phenomena in the THz spectral region.

04~06년 미(美)금리인상기 외국인 주식자금흐름 분석 (7.24)

강봉주 국제금융센터 2015 국제금융 Vol.2015 No.9

이슈 포커스(ISSUE FOCUS) 1 : 신흥국 자금유출의 국별,항목별 분석 및 시사점 (6.18)

강봉주 국제금융센터 2015 국제금융 Vol.2015 No.7

ISSUE FOCUS 이슈 포커스 : 최근 프론티어 시장 자금유입 증가와 시사점(6.2)

강봉주 국제금융센터 2014 국제금융 Vol.2014 No.7