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고창순,정준기,이명철,김지열,범희승 대한핵의학회 1987 핵의학 분자영상 Vol.21 No.1
Attenuated end-diastolic and end-systolic left ventricular counts which obtained from cardiac gated blood poo1 scan were corrected using experimentally calculated attenuation coefficient (μ=0.13/cm) and depth of center of left ventricle. This method was confirmed to be correct experimentally using phantom balloon. To compare the accuracy of attenuated and attenuation- corrected left ventricular volume measurement authors studied 10 patients with ischemic heart disease who underwent both gater blood pool sca and X-ray contrast ventriculography within a week. The attenuated and attenuation-corrected left ventricular volume measured by count method correlated with contrast ventriculographic volumes; however, attenuation corrected measurement was correlated more closely.
경도 갑상선기능항진증환자에서 TRH 자극시험과 T3 억제시험과의 비교연구
고창순,최성재 대한핵의학회 1980 핵의학 분자영상 Vol.14 No.1
임상적으로 갑상선기능항진증이 의심되나 일상갑상선기능검사에서 거의 정상으로 나타나는 13예에서 TRH 자극시험과 T3 억제시험을 시행하고 이 두 검사방법의 장단점을 비교하여 다음과 같은 결과를 얻었다. 1) T3 억제시험에 정상으로 나타나는 6예에는 모두 TRH 자극시험에도 정상으로 정상갑상선기능증으로 확진할 수 있었다. 2) T3 억제시험에서 이상으로 나타나는 7예는 모두 TRH 자극시험에 대한 혈청 TRH 반응이 없어 용이하게 갑상선기능항진증으로 확진할 수 있었다. 이상과 같은 성적으로 보아 TRH 자극시험은 T3 억제시험에 비해 간편신속하고 환자에 별 부담없이 경도 또는 조기의 갑상선기능항진증을 진단할 수 있는 유용한 검사방법이라 할 수 있다. TRH stimulation tests and T3 suppression tests were done in 13 patients with clinically suspected mild or early hyperthyroidism who were all conventional thyroid function tests gave results within the accepted normal range. The results were as follows 1) 6 paatients with normal T3 suppression test revealed normal TRH stimulation test and could be easily diagnosed as euthyroidism 2) 7 patients with abnormal T3 suppression test exhibited rao TSH response to TRH stimulation test and could be easily diagnosed as hyperthyroidism. The TRH stimulation test is a single, sensitive and reliable test of thyroid function and can well replace T3 suppression test in the diagnosis of marginal hyperthyroidism.
주사용(走査用) $^{113m}In$ 교질(膠質)의 조제(調製) 및 흰쥐에서의 장기분포(臟器分布)에 관(關)한 연구(硏究)
고창순,이종헌,장고창,홍창기,Koh, Chang-Soon,Rhee, Chong-Heon,Chang, Ko-Chang,Hong, Chang-Gi D. 대한핵의학회 1969 핵의학 분자영상 Vol.3 No.1
The newly developed diagnostic method with application of $^{113}Sn-^{113m}In$ cow system ($^{113}Sn:\;T\frac{1}{2}$ 118 days, $^{113m}In:\;T\frac{1}{2}$ 1.7 hrs, 390 Kev, Single ${\gamma}$) has the remarkable advantages such as increased diagnostic ability by single large dose administration of $^{113m}In$ with no subsequent radiation hazard and shortened examining time. We reformed the research of following scope with the use of developed $^{113}Sn-^{113m}In$ cow (25 mCi) generator: The sizes of particles produced under various conditions were investigated, and possibility for application to the scannings of various organs such as brain, liver, lung, bone marrow and blood pool etc. were studied. Results: $^{113m}InCl_3$ solution eluted from diluted HCl solution (pH 1.5) passed through $^{113}Sn-^{113m}In$ generator, and there can be produced various sized particles of colloidal indium. And there observed the state of distribution of $^{113m}In$ in each organ which showed many differences according to the particle sizes of colloidal indium. The results are stated as follows: 1. The adjustment of pH is the most important factor in making the desirable particle size of colloidal indium. The colloid for blood pool showed the highest level as 7.1%/gm blood, at pH 1.7, the colloid of pH 3.5 for liver scanning showed the highest level, 88.4%, in the liver, the colloid pH 6 showed the highest level, 3.1%, in the spleen, and the colloid of pH 11.0 showed the highest level, 85.3%/gm, in the lung. 2. The colloid for liver scanning made with NaCl-NaOH system showed the highest liver uptake at pH 7.2, and at either higher or lower pH than 7.2 showed decrease of liver uptake more or less. 3. The activity of $^{113m}In$ eluted through $^{113}Sn-^{113m}In$ generator indicated over 90% in the initial 4 ml, and particularly 88.1%-86.0% in the initial 2 ml. 4. The incubation time, tempertaure and mechanical irritation related to colloid formation and coating of colloid were not the definite condition of influence.