火傷의 輪液療法

閔丙哲 대한의학협회 1963 대한의학협회지 Vol.6 No.7

위선암에서 p53과 P-glycoprotein의 분포에 관한 연구

김대중,김의한,강상균,양승하,민병철 순천향의학연구소 1996 Journal of Soonchunhyang Medical Science Vol.2 No.1

Gastric adenocarcinoma express many oncogenes, such as p53, c-erbB, k-sam, etc. The p53 especially acts as tumor suppressor in normal tissue and various mutational changes. of p53 are known as doing important role in carcinogenesis of gastric adenocarcinoma. P-glycoprotein, as a pleotrophic membrane transport protein, shows specific distribution in many normal tissues and malignant tumors. This protein, produced by MDR gene, shows multidrug resistance to anticancer drug by pumping out intracellular drug. resulting in resistance to chemotherapeutics. The expression of p53 and P-glycoprotein according to clincopathologic findings in gastric adenocarcinoma has been studied, even though their results are controversial. To observe the relationship between both antigens and clinicopathologic findings of gastric adenocarcinoma. we were analysesed 40 cases gastric adenocarcinoma then processed for immunohistochemical stain by SLAB method using p53 and JSB-1 monoclonal antibodies. The results were as followings: 1) The p53 and P-glycoprotein showed positive in 20 cases(50%) and 21 cases(52.5%) of 40 cases respectively, and 10 cases(25%) showed positive reaction to both antigens. 2) p53 revealed higher positive rate in intestinal type(54.6%), differentiated form(57.1%), advanced form(58.1%) compared to diffuse type(28.6%), poorly differentiated form(42.1%), early cancer(22.2%), but no difference according to age, sex, lymphatic metastasis and signet ring cell within tumor. 3) P-glycoprotein revealed higher positive rate in interstinal type(54.6%), differentiated form(61.9%), advanced form(58.1%), absence of signet ring cell (63.3%) compared to diffuse type (28.6%), poorly differentiated form (36.8%), early cancer(33.3%), presence of signet ring cell(20.0%), but no difference according to sex, age, lymphatic metastasis. 4) Positive rate in intestinal type, differentiated form, advanced form, and presence of signet ring cells in gastric adenocarcinoma showing both positive reaction of p53 and P-glycoprotein, are higher, but no difference according to age, sex, lymphatic metastasis. 5) In noneoplastic mucosa adjacent to cancer, p53 revealed negative reaction in all cases. P-glycoprotein showed positive reaction in all metaplastic glands 33 cases and parietal cells 17 cases, and in 16 cases(40%) of 40 cases of luminal surface and gastric glandular epthelium, and showed negative reaction in all 12 cases of chief cell. Above results revealed that positive rates of p53 and P-glycoprotein in gastric adenocarcinoma are almost same and there is no relationships between both antigens. Both antigens showed simillar high positive rate in intestinal type, differentiated form and advanced form, indicating association with these clinicopathologic findings.

셀프리더십의 영향요인과 효과: 의료기관 조직구성원을 중심으로

민병철,임성원,김한결,이현실 한국보건행정학회 2013 보건행정학회지 Vol.23 No.1

The purpose of this empirical study is to investigate the factors of self-leadership depending on individual characteristics, job characteristics, and qualities of leader-member exchange. Additionally, this study aims to discover the effect of self-leadership’s outcome factors on organizational citizenship behavior and innovative activities. In order to verify research model and hypothesis, questionnaires were collected from department members working at general hospitals, hospitals, and clinics in metropolitan area of Seoul, which were 85 departments and 344 respondents. Collected data were analyzed with SPSS ver. 19.0 and Amos ver. 18.0 statistical package using Structural Equation Model. The results of the analysis showed that both individual characteristics and job characteristics have significant positive effect on self-leadership. Also, self-leadership had significant positive relationship on innovative action and organizational citizenship behavior. The implications of this study are as follow. First, this study empirically explained how self-leadership is applied in healthcare organizations. Second, it verified the relationship between causal factors and outcome factors of self-leadership. Also, prior researches of self-leadership have been conducted on business companies, but this study explored self-leadership at healthcare organizations, which increased external validity. Nowadays, many people are interested in the effect of leadership in order to overcome issues coming from enlarged organizations and to improve performance. Self-leadership will contribute to maximizing voluntary efforts of human resources and performance in a rapidly changing healthcare industry.

腎臟移植의 오늘

閔丙哲 醫藥係社 1964 綜合 醫學 Vol.9 No.9

Quad-rotor UAV의 동역학적 모델링과 비행자세 최적화를 위한 PID 제어기 설계

민병철,조찬호,최경민,김동한 경희대학교 경희정보통신 SoC연구소 2008 경희정보통신SOC연구소 논문집 Vol.9 No.-

In this paper, we present a design of quad-rotor aircraft that is a type of unmanned air vehicle (UAV)because of their strong advantages of minimized size and their powerful capabilities for monitoring environment. The nonlinear model of 6 degrees of freedom (6 DOF) quad-rotor aircraft in air is derived on the basis of the Newton-Euler formalism. Because the derived model that comprises translational and rotational subsystems is dynamically unstable, we set on a nonlinear control strategy for the quad-rotor aircraft. The control strategy includes PID controller that is common in the nonlinear control for the translational subsystem and the rotational subsystem of the quad-rotor aircraft. The optimal coefficients of PTD controller are measured by the computer simulation and the results verify the effectiveness of the proposed control strategy for the quad -rotor aircraft. Finally we demonstrate experimentally stability of the small-scale quad-rotor aircraft by using a wireless camera on it to get distinct images of surrounding environment. The manufactured aircraft is equipped with four rotors generating various dynamics, two embedded controllers using PID controller, and a navigation system based on gyro sensors, an accelerometer sensor and an ultrasonic sensor.

臟器移植의 전망에 관하여

閔丙哲 대한의학협회 1970 대한의학협회지 Vol.13 No.10

청소년의 정보통신 윤리의식 수준과 선플활동 경험과의 관계

민병철,오경숙 사단법인 인문사회과학기술융합학회 2019 예술인문사회융합멀티미디어논문지 Vol.9 No.8

본 연구는 청소년의 정보통신 윤리교육의 방법으로 선플달기 캠페인은 물론 다양한 청소년 체험활동을 통한 교육방법을 모색하는데 그 목적을 두고 청소년들의 정보통신 윤리의식 수준은 어떠하며, 이는 성별과 선플활동 경험에 따른 청소년의 정보통신 윤리의식 수준을 분석하였다. 이를 위해 전국의 초, 중, 고등학교에 재학 중인 2231명의 청소년을 연구대상으로 하였다. 수집된 자료는 SPSS 21.0프로그램을 사용하여 t검증과 일원변량 분석을 실시하였다. 본 연구에서는 정보통신 윤리의식을 존중, 정의, 예절, 자율, 책임의 5개 요인으로 설명하였다. 연구결과, 청소년의 정보통신 윤리의식은 매우 높은 수준이었고, 여학생이 남학생보다 정보통신 윤리의식 수준이 높았다. 6개월 이상의 선플활동 경험을 한 청소년들의 정보통신 윤리의식이 높았으며, 특히 ‘정의’, ‘예절’, ‘책임’에서 선플 활동 경험이 많을수록 높은 결과를 나타냈다. 본 연구의 결과는 청소년의 정보통신 윤리의식 교육에 있어 선플활동과 같은 학생 참여 프로그램이 정보통신 윤리의식을 높여줄 수 있다는 시사점을 도출하였다. The following study investigates the level of ethical sense amongst teenagers regarding information and communications, and how differences are constructed depending on gender and experiences on commenting activities. In order to do so, 2231 students in elementary, middle, and high schools nationwide took part in the study. The gathered information was analyzed with the t-test and one way analysis of variance was conducted through the SPSS 21.0 program. The study further explained ethical senses of information and communication with 5 different factors: respect, justice, manners, autonomy, and responsibility. The analysis showed that ethical senses of communication and information amongst teenagers were high, and female students tend to have a higher level of ethical sense than male students. Students that had the experience of writing positive comments for more than 6 months tend to have higher senses, and in particular, the more experience of writing positive comments in the areas of ‘justice’, ‘manners’, and ‘responsibility’, results showed higher ethical senses. The results of the following study drew out implications that student participatory programs such as writing positive comments can increase ethical senses amongst teenagers in the education of communication and information ethical senses of students.

섬유근육통 환자의 부교감신경 긴장도 감소와 위 내용배출시간 지연과의 관련성

민병철,이정욱 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1

배경: 섬유근육통 환자들은 자율신경계기능장애 및 근육계통의 불편감을 호소한다. 섬유근육통은 위장관 증상 및 징후의 위험도를 증가시킨다. 위 내용배출시간 섬광 조영술은 가장 널리 이용되는 위장관 운동 측정 방법이다. 심장박동수 변이의 주파수 영역 분석에서 고주파 영역은 부교감신경 활성도를 나타내고 저주파는 부분적으로 교감신경 활성도를 나타낸다. 목적: 섬유근육통 환자의 위 내용배출시간 검사에 영향을 미치는 상태 및 인자에 대해 평가해보고자 한다. 방법: 36명(여자: 33명, 평균연령 41±13세)의 섬유근육통 환자와 나이 및 성별을 고려한 30명의 건강한 성인을 대상으로 방사성 동위원소 함유 고형음식물사용하여 위 내용배출시간 및 야간 공복 상태의 심장박동수 변이를 비교하였다. 모든 환자를 대상으로 혈청 및 침샘 cortisol, 섬유근육통 영향도 설문조사(FIQ), 시각 통증 척도(VAS), 상태-특성불안 검사(STAI), Beck 우울 검사(BDI) 압통점 수(Tender points count)를 측정하였고 심장박동수 변이는 주파수 영역으로 분석하였다. 결과: 섬유근육통 환자군은 대조군보다 고형음식물 위 내용 배출 검사상의 유의한 시간 지연이 있었다. 지연 시간(56.7±15.4분 vs 28.8±13.0분, p<0.005) 위 내용물 절반 배출시간(T1/2) (155.4±85.6분 vs 77.0±15.4분, p<0.001) 120분 위 내용물 저류(59.4±17.7% vs 23.4±8.1%, p <0.001) 120분 위 내용물 저류는 Cortisol level, 섬유근육통 영향도 설문조사(FIQ), 압통점 수(Tender point count), 상태-특성불안 검사(STAI), Beck 우울검사(BDI) 및 심장박동수 변이의 주파수 영역과는 특별한 연관성이 없었다. 결론: 섬유근육통 환자군은 건강대조군과 비교하여 위 내용 배출 시간상 유의하게 지연되어 있었으며 이는 부교감신경 긴장도와 연관되어 있을 것으로 추측된다.

e-beam 증발법으로 제조된 비정질 WO₃박막과 전해질 계면으로 삽입되는 리튬의 층간 반응에 관한 전기화학적 특성

민병철,손태원,주재백,Min, Byoung-Chul,Sohn, Tae-Won,Ju, Jeh-Beck 한국공업화학회 1997 공업화학 Vol.8 No.6

본 연구에서는 1M $LiClO_4/PC$ 유기 용액 중에 존재하는 리튬 이온의 층간 반응에 의하여 전기 발색 현상을 나타내는 전자-선 증발법으로 제조된 비정질의 텅스텐 산화물 박막과 전해질 계면에서의 전기화학적 특성들을 연구하기 위하여 음극 Tafel 분극법, 순환 전류-전위법 및 전기량 적정법 등의 전기화학 측정법과 X선 회절 분석법을 이용한 박막의 결정 상태 조사 등이 수행되었다. 특히 다중 순환 전류-전위 곡선으로부터 리튬 이온의 층간 반응은 발색 반응에 대한 인가 과전압이 약 1.0V 이내에서는 안정된 소 발색의 가역적 현상을 나타내었으나, 발색 반응에 대한 인가 과전압이 1.5V일 때는 발색 시 삽입된 박막 내부의 리튬이 소색 시 완전히 빠져 나오지 못하여, 박막 내부에 리튬이 축적되는 현상을 나타내었으며, 적은 순환 횟수임에도 불구하고 소 발색의 전류 밀도가 감소되는 것이 조사되어 발색에 필요한 인가 과전압의 한계가 존재함을 알 수 있었다. This work was performed to study the characteristics of electrochemical intercalation reactions occurring at the interface between the organic electrolyte and tungsten trioxide thin film (thickness of $4000{\AA}$) prepared by e-beam evaporation method as cathodically coloring oxide with regard to the electrochromism by the intercalating reactions of the lithium cation in the 1M $LiClO_4/PC$ organic solution. The characteristics of electrochemical intercalation reactions were investigated by various DC electrochemical methods such as cathodic Tafel polarization test, multiple and the single sweep cyclic voltammetry and the coulomety titrations method. The surfaces of thin films were observed with the patterns of X ray diffraction after the coloring and bleaching reactions. In comparison with the previous results that $WO_3$ thin film intersely detached from the surface of electrode when the hydrogen cation was intercalated into $WO_3$ thin film in the o.1N $H_2SO_4$ aqueous solution, the intercalation reaction of lithium cation into $WO_3$ thin film in the 1M $LiClO_4/PC$ organic solution was shown that the stable bleaching and coloration was appeared within 1.0V of the applied overpotential. When the overpotential of electrochromic reaction for lithium cation in the 1M $LiClO_4/PC$ organic solution had been applied up to 1.5V, the accumulation phenomenon of lithium in amorphous $WO_3$ thin film layer occurred because the inserted lithium into amorphous $WO_3$ thin layer for coloring process was not fully removed from the thin layer to the electrolyte during bleaching process. It was found that there is a limitation of applied overpotential for coloring process by the reduction of the current densities of bleaching and coloration after few number of coloring and bleaching cycles.

癌 轉 移 : 外科醫의 立場에서 A Surgeon's view

閔丙哲 대한의학협회 1970 대한의학협회지 Vol.13 No.4